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MT1B Gene

protein-coding   GIFtS: 44

GC16P042555
metallothionein 1B
(Previous name: metallothionein 1Q )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: MT1, MT1Q)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
metallothionein 1B1 2     MTP2
metallothionein 1Q1 2     metallothionein-1B2
MT-1B2 3     metallothionein 1B (functional)2
MT-IB2 3     metallothionein-IB2
MT1Q2 3     Metallothionein-IB3
MT12     

External Ids:    HGNC: 73941   Entrez Gene: 44902   Ensembl: ENSG000001696887   UniProtKB: P074383   

Export aliases for MT1B gene to outside databases

Previous GC identifers: GC16P047069 GC16M056736 GC16P056420 GC16P056443 GC16P056448 GC16P055231 GC16P055243 GC16P056685


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT1B

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT1B gene promoter:
         Sp1   HSF1 (long)   NF-1   deltaCREB   CREB   p300   TBP   USF1   POU2F1   c-Myb   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MT1B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT1B gene location

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P042555:  view genomic region     (about GC identifiers)

Start:
42,555,257 bp from pter
End:
42,556,561 bp from pter
Size:
1,305 bases
Orientation:
plus strand

1 alternative location:
Chr16+ 56,685,811-56,687,116     
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438 (See protein sequence)
Recommended Name: Metallothionein-1B  
Size: 61 amino acids; 6115 Da
Subunit: Monomer

Explore the universe of human proteins at neXtProt for MT1B: NX_P07438 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005938.1  

    ENSEMBL proteins: 
    ENSP00000334998 


    Human Recombinant Proteins 
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    OriGene Protein Over-expression Lysate: MT1B
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    1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm NAS--
    About this table

    MT1B for ontologies           About GeneDecksing



    Antibodies for MT1B: 
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    Uscn ELISAs and CLIAs for MT1B 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MT1B for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000006 Metallothionein_vert
     IPR018064 Metallothionein_vert_metal_BS
     IPR003019 Metallothionein_sfam_euk
     IPR017854 Metallothionein_sfam

    Graphical View of Domain Structure for InterPro Entry P07438

    ProtoNet protein and cluster: P07438

    UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of
    the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: MT1B_HUMAN, P07438
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
    transcriptionally regulated by both heavy metals and glucocorticoids

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MT1B
    Sigma-Aldrich shRNA for MT1B
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    OriGene basic RS shRNA: MT1B
    OriGene siRNA: MT1B
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    miRNA:Browse microRNA Mimics at Sigma-Aldrich
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MT1B 
    Search SABiosciences for Assays for microRNAs that regulate MT1B

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: MT1B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: MT1B
    OriGene untagged cDNA clones in CMV expression vector: MT1B
    Browse 3'-UTR reporter clones for miRNA target validation 
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    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MT1B 

    Genatlas biochemistry entry for MT1B:
    metallothionein 1B cluster

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005507 copper ion binding NAS--
    GO:0008270 zinc ion binding NAS--
    GO:0046870 cadmium ion binding NAS--
    GO:0046872 metal ion binding IEA--
    About this table

    MT1B for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for MT1B 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MT1B

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150 biological_process ND--
    About this table

    MT1B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    MT1B for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT1B
    1 Novoseek chemical compound relationship for MT1B gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cadmium 57 1 15952643 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MT1B
    Sigma-Aldrich shRNA for MT1B
    OriGene 29mer shRNA kits in GFP-retroviral vector: MT1B
    OriGene shRNA RFP: MT1B
    OriGene basic RS shRNA: MT1B
    OriGene siRNA: MT1B
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MT1B 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MT1B 
    Search SABiosciences for Assays for microRNAs that regulate MT1B
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: MT1B
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: MT1B
    OriGene untagged cDNA clones in CMV expression vector: MT1B
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MT1B 
    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MT1B: PPH09040A

    REFSEQ mRNAs for MT1B gene: 

    NM_005947.2  

    Additional cDNA sequence: 

    AF349000.2 AF479613.1 AY168638.1 BC069421.1 BC137478.1 BC137479.1 

    6 DOTS entries:

    DT.120684974  DT.406271  DT.100008764  DT.101982092  DT.100001400  DT.120684801 

    21 AceView cDNA sequences:

    H72723 BX118979 BC069421 BF973961 NM_176870 NM_005947 AY168638 AA370427 
    AI719425 BC028280 BU663337 BG217075 AF349000 R99207 H72722 BG183187 
    BG221550 BG192094 R99208 BG220590 BG195149 

    highest scoring ESTs for MT1B:

    M13485 AF349000 AY168638 BC069421 BX118979 H72723 BU663337 H72722 NM_005947 R99207 

    Unigene Cluster for MT1B:

    Metallothionein 1B
    Hs.656629  [show with all ESTs]
    Unigene Representative Sequence: BU663337


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000334346(uc002ejs.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MT1B expression in normal and diseased human tissues

    1  / 2  / 3

    2 probe-sets matching MT1B gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    73455_f_at2, 3 U95-E 10 0.93 0.41 0.99 1.07 H72723 0.40 0.67 0.55 1
    609_f_at2, 3 U95-A 14 0.69 0.60 0.96 0.93 M13485 0.20 1.00 0.72 1
    About this table

    MT1B for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MT1B gene expression
    MT1B gene electronic northern expression
    MT1B gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.656629

    Expression variation in blood from EXPOLDB for MT1B

    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MT1B: PPH09040A
        SABiosciences Custom PCR Arrays for MT1B 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MT1B gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    MT1B1   -- metallothionein 1B 98.36(n)
    98.36(a)
    467981  XM_001139997.1  XP_001139997.1 
    About this table        Species with no ortholog for MT1B

    ENSEMBL Gene Tree for MT1B (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MT1B gene
    MT1E2  MT1F2  MT2A2  MT1CP2  MT42  MT1M2  MT1A2  MT32  
    MT1H2  

    MT1B for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/69 NCBI SNPs in MT1B are shown (see all 69)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs9643721,2
    C,F,A,56686030(+) TCTTGG/CCCAAG 1 -- int115Minor allele frequency- C:0.24EA NA NS WA 1984
    rs9643741,2
    C,56686471(+) TTTTCG/TCTTCC 1 -- int14Minor allele frequency- T:0.40NA EA 164
    rs18752321,2
    C,F,A,56683911(+) tatcaG/Tctagg 1 -- ng518Minor allele frequency- T:0.38NS EA NA WA 514
    rs18752331,2
    C,F,A,56686704(+) CAGATA/GGGTCA 1 -- int122Minor allele frequency- N:0.00EA NA NS WA 1620
    rs20137751,2
    C,F,56686380(+) TCTGAT/CGGCTG 1 -- int110Minor allele frequency- C:0.32EA NS NA 2080
    rs20708381,2
    C,A,56686002(+) AACTCC/GTTAAC 1 -- int18Minor allele frequency- G:0.29NA EA WA 220
    rs20708391,2
    C,F,A,56686242(+) TCCAGC/TCCCAG 1 -- int116Minor allele frequency- T:0.45EA NA NS WA 2220
    rs46194001,2
    C,A,56686005(+) TCCTTA/TACTTT 1 -- int19Minor allele frequency- T:0.31NA EA WA 222
    rs64998481,2
    C,56684953(+) GAGACA/G/TAATAT 1 -- ng517NA EA WA 218
    rs64998491,2
    C,F,A,56687452(+) GATGAC/TGGGGT 1 -- ng318Minor allele frequency- T:0.14NA EA WA 356
    About this table

    HapMap Linkage Disequilibrium images for MT1B (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MT1B: --

    QIAGEN SeqTarget long-range PCR primers for resequencing MT1B 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MT1B for disorders           About GeneDecksing

    OMIM: 156349


    Export disorders and mutations for MT1B gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/13 PubMed articles for MT1B gene, integrated from 7 sources (see all 13):
    (articles sorted by number of sources associating them with MT1B)
    1. Structure and tissue-specific expression of the human metallothionein IB gene. (PubMed id 3785191)1, 2, 3 Heguy A....Karin M. (1986)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Human metallothionein genes are clustered on chromosome 16. (PubMed id 6089206)1, 3 Karin M....Shows T.B. (1984)
    4. Pathways and genes differentially expressed in the motor cortex of patients with sporadic amyotrophic lateral sclerosis. (PubMed id 17244347)1 Lederer C.W....Cavallaro S. (2007)
    5. HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages. (PubMed id 12539042)1 Izmailova E....Aldovini A. (2003)
    6. Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line. (PubMed id 15747776)1 Sun N.N....Witten M.L. (2003)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    8. Human metallothionein genes: structure of the functional locus at 16q13. (PubMed id 2286373)1 West A.K....Richards R.I. (1990)
    9. [Metallothionein and its isoform genes expression in the human pancreatic cancer cell strains and their function] (PubMed id 16274045)7 Xie Y....Li L.J. (2005)
    10. [Metallothionein isoforms gene expression induced by cadmium in human peripheral blood lymphocytes] (PubMed id 15952643)7 Chang X.L....Zhou Y.F. (2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4490 HGNC: 7394 AceView: MT1BandMT1K Ensembl:ENSG00000169688 euGenes: HUgn4490
    ECgene: MT1B H-InvDB: MT1B

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for MT1B gene:
    Search GeneIP for patents involving MT1B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     ELISAs and CLIAs for MT1B
           

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    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    MT1B gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4