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MT2A Gene

protein-coding GIFtS: 56

GC16P042512

metallothionein 2A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MT2)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
metallothionein 2A¹ ²		metallothionein-2²
MT2² ³ ⁵		metallothionein-II²
MT-2² ³		Metallothionein-2A³
MT-II² ³		CES1³
metallothionein-2A²		Metallothionein-II³

External Ids:	HGNC: 7406¹	Entrez Gene: 4502²	Ensembl: ENSG00000125148⁷	UniProtKB: P02795³

Export aliases for MT2A gene to outside databases

Previous GC identifers: GC16P047025 GC16P056693 GC16P056376 GC16P056417 GC16P055199 GC16P056642

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795

Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are

transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT2A (Metallothionein 2A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MT2A gene promoter:
         AP-1   c-Myc   Max   CREB   STAT5A   GR-alpha   GR-beta   NF-1   deltaCREB   p53
         Other transcription factors

Search SABiosciences Chromatin IP Primers for MT2A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13 Ensembl cytogenetic band: 16q12.2 HGNC cytogenetic band: 16q13

MT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT2A gene location

GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P042512: view genomic region (about GC identifiers)

Start:	42,512,001 bp from pter
End:	42,512,932 bp from pter
Size:	932 bases
Orientation:	plus strand

1 alternative location:

Chr16+ 56,642,111-56,643,409

RefSeq DNA sequence:

NC_000016.9 NT_010498.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795 (See protein sequence)

Recommended Name: Metallothionein-2

Size: 61 amino acids; 6042 Da

Miscellaneous: This metallothionein binds zinc

PDB structure from and Proteopedia :

1MHU (3D)

2MHU (3D)

Secondary accessions: Q14823 Q2HXR9 Q53XT9

Explore the universe of human proteins at neXtProt for MT2A: NX_P02795

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_005944.1

ENSEMBL proteins:

ENSP00000245185

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for MT2A
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MT2A
	GenScript Custom Purified and Recombinant Proteins Services for MT2A
	Novus Biologicals Protein for MT2A
	Novus Biologicals Lysate for MT2A
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

Antibodies for MT2A:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for MT2A
	Browse antibodies at Epitomics

Assays for MT2A:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MT2A
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MT2A for domains About GeneDecksing

4 InterPro domains/families:

IPR000006 Metallothionein_vert

IPR018064 Metallothionein_vert_metal_BS

IPR003019 Metallothionein_sfam_euk

IPR017854 Metallothionein_sfam

Graphical View of Domain Structure for InterPro Entry P02795

ProtoNet protein and cluster: P02795

1 Blocks protein family: IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795

Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of

the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the

corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines

Similarity: Belongs to the metallothionein superfamily. Type 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795

Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are

transcriptionally regulated by both heavy metals and glucocorticoids

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for MT2A Sigma-Aldrich shRNA for MT2A
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MT2A OriGene shRNA RFP (see all 2): MT2A OriGene basic RS shRNA (see all 2): MT2A OriGene siRNA (see all 2): MT2A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MT2A

miRNA:		Sigma-Aldrich microRNA Mimics for MT2A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MT2A
		Search SABiosciences for Assays for microRNAs that regulate MT2A

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: MT2A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: MT2A OriGene untagged cDNA clones in CMV expression vector: MT2A OriGene 3'-UTR clone: MT2A Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for MT2A
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for MT2A

Genatlas biochemistry entry for MT2A:

metallothionein 2

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	15541360
GO:0046872	metal ion binding	IEA	--

About this table

MT2A for ontologies About GeneDecksing

Animal Models: 15/21 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Mt2) (see all 21):

behavior/neurological	cardiovascular system	cellular	endocrine/exocrine gland	growth/size
hematopoietic system	homeostasis/metabolism	immune system	lethality-postnatal	lethality-prenatal/perinatal
life span-post-weaning/aging	limbs/digits/tail	liver/biliary system	nervous system	normal

MT2A for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

MT2A for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for MT2A

Oncostatin M Signaling

SABiosciences Pathway-Focused PCR Arrays including MT2A: PAHS-002A PAHS-003A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MT2A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for MT2A

4 Interacting proteins for MT2A (ENSP00000245185³ P02795^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SPINK7	P58062¹	STRING: ENSP00000274565 EBI-996616,EBI-1182445
CXorf40A	Q8TE69¹	EBI-996616,EBI-996609
PRKD1	Q15139¹	EBI-996616,EBI-1181072
GPR50	Q13585²	MINT-2836197 MINT-2836127

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006878	cellular copper ion homeostasis	TAS	6719135

About this table

MT2A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

MT2A for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MT2A
10/23 Novoseek chemical compound relationships for MT2A gene (see all 23)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
zinc	67.3	29	19097988 (3), 17308060 (2), 16087360 (2), 12566070 (2) (see all 17)
cadmium	66.6	23	16600086 (3), 18755257 (2), 17485079 (2), 16087360 (2) (see all 12)
cdcl2	64	6	10403520 (2), 9545559 (2), 16402917 (1), 12566070 (1)
copper	42	12	8552721 (5), 2066364 (2), 10471781 (1)
arsenite	34.8	6	15725085 (3), 7999084 (2)
n acetylcysteine	33.3	8	9545559 (2), 19097988 (1), 18586083 (1), 15725085 (1)
silver nitrate	30.2	6	18586083 (4), 17308060 (1)
cisplatin	27.1	6	10422815 (1)
cysteine	23.8	1	16556599 (1)
oligonucleotide	19.8	4	12173077 (1), 8134403 (1), 15583813 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for MT2A Sigma-Aldrich shRNA for MT2A
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MT2A OriGene shRNA RFP (see all 2): MT2A OriGene basic RS shRNA (see all 2): MT2A OriGene siRNA (see all 2): MT2A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MT2A

miRNA:		Sigma-Aldrich microRNA Mimics for MT2A Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MT2A
		Search SABiosciences for Assays for microRNAs that regulate MT2A

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: MT2A OriGene Myc/DDK tagged cDNA clones in CMV expression vector: MT2A OriGene untagged cDNA clones in CMV expression vector: MT2A OriGene 3'-UTR Clone: MT2A Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for MT2A

Primers:		OriGene genome-wide validated SYBR primer pairs: MT2A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MT2A: PPH01518A

REFSEQ mRNAs for MT2A gene:

NM_005953.3

Additional cDNA sequence:

BC007034.1 BC062435.1 BC070289.1 BT007315.1 CR595825.1 CR621046.1 CR625648.1 M26637.1

S52379.1 V00594.1 X97260.1

24/27 DOTS entries (see all 27):

DT.100058622 DT.91888226 DT.100893285 DT.101985063 DT.85102758 DT.100059597 DT.419190 DT.121273946

DT.87013827 DT.91641761 DT.120684886 DT.100685880 DT.100893311 DT.100893315 DT.91705372 DT.120684782

DT.120684958 DT.95200190 DT.97862507 DT.120684992 DT.95190527 DT.95190547 DT.120684982 DT.120685031

24/231 AceView cDNA sequences (see all 231):

BQ181970 BX356856 F30198 BX458790 BU179329 BU179032 CB118333 BU176013

BQ640055 BX281399 CA446192 AW275159 AV702264 D28442 AU107621 BQ182739

AJ713317 BX396503 BQ225213 CR625648 BQ050782 BQ430119 BM818033 NM_005954

highest scoring ESTs for MT2A:

AA037443 AA303505 AA341593 AA503124 AA507495 AA508039 AA526822 AA531236 AA535641 AA552820

Unigene Cluster for MT2A:

Metallothionein 2A

Hs.647371 [show with all ESTs]

Unigene Representative Sequence: BF131637

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000245185(uc002ejh.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MT2A expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching MT2A gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39081_at²^{, 3}	U95-A	1	0.31	1.00	1.00	1.00	AI547258	0.60	1.00	0.82	1
212185_x_at²^{, 3}	U133-A	10	1.00	0.62	--	--	NM_005953	0.60	0.71	0.66	1
212185_x_at²	U133Plus2	10	1.00	0.62	--	--	--	--	--	--	--

About this table

MT2A for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

MT2A gene electronic northern expression

About these images

CGAP SAGE TAG: GATCCCAACT

SOURCE GeneReport for Unigene cluster: Hs.647371

Expression variation in blood from EXPOLDB for MT2A

Primers:		OriGene genome-wide validated SYBR primer pairs: MT2A Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MT2A: PPH01518A

SABiosciences Expression via Pathway-Focused PCR Arrays including MT2A: PAHS-002A PAHS-003A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MT2A gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MT2A¹	--	metallothionein 2A	91.8(n) 96.72(a)	403768 NM_001003149.1 NP_001003149.1
chimpanzee (Pan troglodytes)	MT2A¹	--	metallothionein 2A	97.81(n) 100(a)	471221 XM_526603.2 XP_526603.2
cow (Bos taurus)	MT2A¹	--	metallothionein 2A	90.71(n) 91.8(a)	404070 XM_586929.3 XP_586929.3
mouse (Mus musculus)	Mt2⁵	8 (46.32 cM)	metallothionein 2	--	K02236
chicken (Gallus gallus)	MT4¹	--	metallothionein 4	72.22(n) 76.67(a)	396212 NM_205275.1 NP_990606.1

About this table Species with no ortholog for MT2A

ENSEMBL Gene Tree for MT2A (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for MT2A gene

MT1E² MT1F² MT1B² MT1CP² MT4² MT1M² MT1A² MT3²

MT1H²

MT2A for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 16 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs10636^1,2	C,F,A,	56643343(+)	`TGACCG/CTGACC`	1	--	ut3¹ ese³		18		MN NS EA NA WA	1144
rs1054503^1,2	C	56643310(+)	`CTTCCA/CCAAAC`	1	--	ut3¹ ese³		1		MN	184
rs1610216^1,2	C,F,A,H,	56642284(-)	`GCGCCT/CCGGGG`	1	--	ng5¹		8		MN EA NA WA	1566
rs1875223^1,2	C,F,A,	56643137(-)	`ACTAGC/GGACAC`	1	--	int¹		10		NA EA NS	640
rs7196503^1,2	C,F,A,	56640739(+)	`agtggC/Tcgagt`	1	--	ng5¹		12		NS EA NA WA	812
rs10852550^1,2	C,F,A,H,	56641603(+)	`TTCCCC/ACTCCC`	1	--	ng5¹		11		NS NA WA	206
rs11549675^1,2	--	56642507(+)	`CTCCTG/TCCAAG`	1	--	ut5¹		0	--	--	--	--
rs11549676^1,2	C	56642911(+)	`GACTCC/TTGCAC`	2	S	ref¹ syn¹		0	--	--	--	--
rs11865517^1,2	C,H	56640675(+)	`gatgaA/Gtaaac`	1	--	ng5¹		1		NA	2
rs13337282^1,2	C,F,	56643517(+)	`TTAAGA/GAAGAG`	1	--	ng3¹		9		NS NA WA	310

About this table

HapMap Linkage Disequilibrium images for MT2A (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MT2A: --

QIAGEN SeqTarget long-range PCR primers for resequencing MT2A

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MT2A for disorders About GeneDecksing

OMIM: 156360

10 Novoseek disease relationships for MT2A gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
breast cancer	21.3	7	11756227 (2), 11291768 (2), 15188022 (1), 15788722 (1) (see all 5)
nasopharyngeal carcinoma	19.8	1	15583813 (1)
shock	15.4	4	8552721 (1), 12016146 (1), 15734587 (1), 19540330 (1)
tumors	4.55	10	18755257 (2), 15188022 (1), 11756227 (1), 12646258 (1) (see all 7)
prostate cancer	3.62	2	10754528 (1), 14550308 (1)
cancer	3.52	2	11756227 (1), 18341518 (1)
asthma	0	1	16427169 (1)
inflammation	0	2	15541360 (1), 16215939 (1)
ovarian cancer	0	2	11077043 (1)
bladder cancer	0	4	11270423 (3)

About this table

Human Gene Mutation Database (HGMD): MT2A
Human Genome Epidemiology (HuGE) Navigator: MT2A (11 documents)

Export disorders and mutations for MT2A gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/190 PubMed articles for MT2A gene, integrated from 7 sources (see all 190):
(articles sorted by number of sources associating them with MT2A)

Human metallothionein genes -- primary structure of the metallothionein-II gene and a related processed gene. (PubMed id 7133118)^{1, 2, 3} Karin M. and Richards R.I. (1982)
Expression of human metallothionein-II fusion protein in Escherichia coli. (PubMed id 1339282)^{1, 2, 7} Yamazaki S.... Kagawa Y. (1992)
Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. (PubMed id 2388267)^{1, 2, 7} Messerle B.A.... Wuethrich K. (1990)
Comparison of the solution conformations of human [Zn7]- metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. (PubMed id 1593628)^{1, 2, 7} Messerle B.A.... Wuethrich K. (1992)
Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)^{1, 2} Kim S.C.... Zhao Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Changes in brain gene expression shared by scrapie and Alzheimer disease. (PubMed id 2780570)^{1, 2} Duguid J.R.... Tourtellotte W.W. (1989)
Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. (PubMed id 6896577)^{1, 2} Karin M. and Richards R.I. (1982)
Primary structure of human hepatic metallothionein. (PubMed id 913597)^{1, 2} Kissling M.M. and Kaegi J.H.R. (1977)
ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. (PubMed id 12646258)^{1, 7} Cui Y....Lu S.H. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4502	HGNC: 7406	AceView: MT2_	Ensembl:ENSG00000125148	euGenes: HUgn4502
ECgene: MT2A	H-InvDB: MT2A

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for MT2A	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/mt2a/

Intellectual Property for MT2A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for MT2A gene:
Search GeneIP for patents involving MT2A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Predesigned and custom siRNAs for MT2A		Browse antibodies at Sigma-Aldrich
	Super-pooled esiRNAs for MT2A		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for MT2A		microRNA Mimics for MT2A
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
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	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
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	Lysates
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	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MT2A
	SeqTarget long-range PCR primers for resequencing MT2A
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MT2A

	GenScript Custom Purified and Recombinant Proteins Services for MT2A		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for MT2A
	GenScript Custom Assay Services for MT2A		GenScript Custom Superior Antibodies Services for MT2A
	GenScript Custom overexpressing Cell Line Services for MT2A		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in MT2A promoter
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	RT² qPCR Primer Assay for MT2A
	GNC Network for MT2A
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	SABiosciences PCR Arrays including MT2A

Search Tocris compounds for MT2A

	Browse Sino Biological Proteins and Antibodies
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	Proteins for MT2A
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Proteins for MT2A
	Lysates for MT2A

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

Browse ELISAs and CLIAs at Uscn

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

MT2A gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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MT2A Gene

protein-coding GIFtS: 56

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Export list of displayed genes

MT2A Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor MT2A gene

Summariesfor MT2A gene

Genomic Viewsfor MT2A gene

Proteinsfor MT2A gene

Protein Domains/Familiesfor MT2A gene

Gene Functionfor MT2A gene

Pathways & Interactionsfor MT2A gene

Drugs & Compoundsfor MT2A gene

Transcriptsfor MT2A gene

Expression for MT2A gene

Orthologsfor MT2A gene

Paralogsfor MT2A gene

Genomic Variantsfor MT2A gene

Disorders & Mutationsfor MT2A gene

Medical Newsfor MT2A gene

Publicationsfor MT2A gene

External Searches for MT2A gene

Genome Databases showing MT2A gene

Other Databases showing MT2A gene

Specialized Databases showing MT2A gene

Intellectual Propertyfor MT2A gene

Productsfor MT2A gene

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Aliases &
Descriptions
for MT2A gene

Summaries
for MT2A gene

Genomic Views
for MT2A gene

Proteins
for MT2A gene

Protein Domains/
Families
for MT2A gene

Gene Function
for MT2A gene

Pathways & Interactions
for MT2A gene

Drugs & Compounds
for MT2A gene

Transcripts
for MT2A gene

Expression
for MT2A gene

Orthologs
for MT2A gene

Paralogs
for MT2A gene

Genomic Variants
for MT2A gene

Disorders & Mutations
for MT2A gene

Medical News
for MT2A gene

Publications
for MT2A gene

Intellectual Property
for MT2A gene

Products
for MT2A gene