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MT2A Gene

protein-coding   GIFtS: 56

GC16P042512
metallothionein 2A
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: MT2)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
metallothionein 2A1 2     metallothionein-22
MT22 3 5     metallothionein-II2
MT-22 3     Metallothionein-2A3
MT-II2 3     CES13
metallothionein-2A2     Metallothionein-II3

External Ids:    HGNC: 74061   Entrez Gene: 45022   Ensembl: ENSG000001251487   UniProtKB: P027953   

Export aliases for MT2A gene to outside databases

Previous GC identifers: GC16P047025 GC16P056693 GC16P056376 GC16P056417 GC16P055199 GC16P056642


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
transcriptionally regulated by both heavy metals and glucocorticoids

Gene Wiki entry for MT2A (Metallothionein 2A)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MT2A gene promoter:
         AP-1   c-Myc   Max   CREB   STAT5A   GR-alpha   GR-beta   NF-1   deltaCREB   p53   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MT2A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q13   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

MT2A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MT2A gene location

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P042512:  view genomic region     (about GC identifiers)

Start:
42,512,001 bp from pter
End:
42,512,932 bp from pter
Size:
932 bases
Orientation:
plus strand

1 alternative location:
Chr16+ 56,642,111-56,643,409     
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MT2_HUMAN, P02795 (See protein sequence)
Recommended Name: Metallothionein-2  
Size: 61 amino acids; 6042 Da
Miscellaneous: This metallothionein binds zinc
PDB structure from and Proteopedia :
1MHU (3D)    2MHU (3D)    
Secondary accessions: Q14823 Q2HXR9 Q53XT9

Explore the universe of human proteins at neXtProt for MT2A: NX_P02795 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_005944.1  

    ENSEMBL proteins: 
    ENSP00000245185 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for MT2A
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MT2A
    GenScript Custom Purified and Recombinant Proteins Services for MT2A 
    Novus Biologicals Protein for MT2A
    Novus Biologicals Lysate for MT2A
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins


    Antibodies for MT2A: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for MT2A 
    Browse antibodies at Epitomics

    Assays for MT2A: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MT2A 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MT2A for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR000006 Metallothionein_vert
     IPR018064 Metallothionein_vert_metal_BS
     IPR003019 Metallothionein_sfam_euk
     IPR017854 Metallothionein_sfam

    Graphical View of Domain Structure for InterPro Entry P02795

    ProtoNet protein and cluster: P02795

    1 Blocks protein family: IPB002400 Growth factor cystine knot superfamily signature

    UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
    Domain: Class I metallothioneins contain 2 metal-binding domains: four divalent ions are chelated within cluster A of
    the alpha domain and are coordinated via cysteinyl thiolate bridges to 11 cysteine ligands. Cluster B, the
    corresponding region within the beta domain, can ligate three divalent ions to 9 cysteines
    Similarity: Belongs to the metallothionein superfamily. Type 1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: MT2_HUMAN, P02795
    Function: Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are
    transcriptionally regulated by both heavy metals and glucocorticoids

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MT2A
    Sigma-Aldrich shRNA for MT2A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MT2A
    OriGene shRNA RFP (see all 2): MT2A
    OriGene basic RS shRNA (see all 2): MT2A
    OriGene siRNA (see all 2): MT2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MT2A 
    miRNA:Sigma-Aldrich microRNA Mimics for MT2A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MT2A 
    Search SABiosciences for Assays for microRNAs that regulate MT2A

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: MT2A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: MT2A
    OriGene untagged cDNA clones in CMV expression vector: MT2A
    OriGene 3'-UTR clone: MT2A 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MT2A 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MT2A 

    Genatlas biochemistry entry for MT2A:
    metallothionein 2

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI15541360
    GO:0046872 metal ion binding IEA--
    About this table

    MT2A for ontologies           About GeneDecksing

    Animal Models: 15/21 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Mt2) (see all 21):

    behavior/neurologicalcardiovascular systemcellularendocrine/exocrine glandgrowth/size
    hematopoietic systemhomeostasis/metabolismimmune systemlethality-postnatallethality-prenatal/perinatal
    life span-post-weaning/aginglimbs/digits/tailliver/biliary systemnervous systemnormal

    MT2A for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    MT2A for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  MT2A
        Oncostatin M Signaling

        SABiosciences Pathway-Focused PCR Arrays including MT2A: PAHS-002A PAHS-003A 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MT2A
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MT2A

    4 Interacting proteins for MT2A (ENSP000002451853 P027951, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SPINK7P580621STRING: ENSP00000274565 EBI-996616,EBI-1182445
    CXorf40AQ8TE691EBI-996616,EBI-996609
    PRKD1Q151391EBI-996616,EBI-1181072
    GPR50Q135852MINT-2836197 MINT-2836127
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006878 cellular copper ion homeostasis TAS6719135
    About this table

    MT2A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    MT2A for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MT2A
    10/23 Novoseek chemical compound relationships for MT2A gene (see all 23)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    zinc 67.3 29 19097988 (3), 17308060 (2), 16087360 (2), 12566070 (2) (see all 17)
    cadmium 66.6 23 16600086 (3), 18755257 (2), 17485079 (2), 16087360 (2) (see all 12)
    cdcl2 64 6 10403520 (2), 9545559 (2), 16402917 (1), 12566070 (1)
    copper 42 12 8552721 (5), 2066364 (2), 10471781 (1)
    arsenite 34.8 6 15725085 (3), 7999084 (2)
    n acetylcysteine 33.3 8 9545559 (2), 19097988 (1), 18586083 (1), 15725085 (1)
    silver nitrate 30.2 6 18586083 (4), 17308060 (1)
    cisplatin 27.1 6 10422815 (1)
    cysteine 23.8 1 16556599 (1)
    oligonucleotide 19.8 4 12173077 (1), 8134403 (1), 15583813 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MT2A
    Sigma-Aldrich shRNA for MT2A
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MT2A
    OriGene shRNA RFP (see all 2): MT2A
    OriGene basic RS shRNA (see all 2): MT2A
    OriGene siRNA (see all 2): MT2A
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MT2A 
    miRNA: Sigma-Aldrich microRNA Mimics for MT2A
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MT2A 
    Search SABiosciences for Assays for microRNAs that regulate MT2A
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: MT2A
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: MT2A
    OriGene untagged cDNA clones in CMV expression vector: MT2A
    OriGene 3'-UTR Clone: MT2A 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MT2A 
    Primers: OriGene genome-wide validated SYBR primer pairs: MT2A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MT2A: PPH01518A

    REFSEQ mRNAs for MT2A gene: 

    NM_005953.3  

    Additional cDNA sequence: 

    BC007034.1 BC062435.1 BC070289.1 BT007315.1 CR595825.1 CR621046.1 CR625648.1 M26637.1 
    S52379.1 V00594.1 X97260.1 

    24/27 DOTS entries (see all 27):

    DT.100058622  DT.91888226  DT.100893285  DT.101985063  DT.85102758  DT.100059597  DT.419190  DT.121273946 
    DT.87013827  DT.91641761  DT.120684886  DT.100685880  DT.100893311  DT.100893315  DT.91705372  DT.120684782 
    DT.120684958  DT.95200190  DT.97862507  DT.120684992  DT.95190527  DT.95190547  DT.120684982  DT.120685031 

    24/231 AceView cDNA sequences (see all 231):

    BQ181970 BX356856 F30198 BX458790 BU179329 BU179032 CB118333 BU176013 
    BQ640055 BX281399 CA446192 AW275159 AV702264 D28442 AU107621 BQ182739 
    AJ713317 BX396503 BQ225213 CR625648 BQ050782 BQ430119 BM818033 NM_005954 

    highest scoring ESTs for MT2A:

    AA037443 AA303505 AA341593 AA503124 AA507495 AA508039 AA526822 AA531236 AA535641 AA552820 

    Unigene Cluster for MT2A:

    Metallothionein 2A
    Hs.647371  [show with all ESTs]
    Unigene Representative Sequence: BF131637


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000245185(uc002ejh.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MT2A expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching MT2A gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39081_at2, 3 U95-A 1 0.31 1.00 1.00 1.00 AI547258 0.60 1.00 0.82 1
    212185_x_at2, 3 U133-A 10 1.00 0.62 -- -- NM_005953 0.60 0.71 0.66 1
    212185_x_at2 U133Plus2 10 1.00 0.62 -- -- -- -- -- -- --
    About this table

    MT2A for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MT2A gene expression
    MT2A gene electronic northern expression
    MT2A gene sage expression
    About these images

    CGAP SAGE TAG: GATCCCAACT

    SOURCE GeneReport for Unigene cluster: Hs.647371

    Expression variation in blood from EXPOLDB for MT2A

    Primers: OriGene genome-wide validated SYBR primer pairs: MT2A
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MT2A: PPH01518A
        SABiosciences Expression via Pathway-Focused PCR Arrays including MT2A: PAHS-002A PAHS-003A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MT2A gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MT2A1   -- metallothionein 2A 91.8(n)
    96.72(a)
    403768  NM_001003149.1  NP_001003149.1 
    chimpanzee
    (Pan troglodytes)
    MT2A1   -- metallothionein 2A 97.81(n)
    100(a)
    471221  XM_526603.2  XP_526603.2 
    cow
    (Bos taurus)
    MT2A1   -- metallothionein 2A 90.71(n)
    91.8(a)
    404070  XM_586929.3  XP_586929.3 
    mouse
    (Mus musculus)
    Mt25 8 (46.32 cM) metallothionein 2   -- K02236 
    chicken
    (Gallus gallus)
    MT41   -- metallothionein 4 72.22(n)
    76.67(a)
    396212  NM_205275.1  NP_990606.1 
    About this table        Species with no ortholog for MT2A

    ENSEMBL Gene Tree for MT2A (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MT2A gene
    MT1E2  MT1F2  MT1B2  MT1CP2  MT42  MT1M2  MT1A2  MT32  
    MT1H2  

    MT2A for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/39 NCBI SNPs in MT2A are shown (see all 39)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 16 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs106361,2
    C,F,A,56643343(+) TGACCG/CTGACC 1 -- ut31 ese318Minor allele frequency- C:0.32MN NS EA NA WA 1144
    rs10545031,2
    C56643310(+) CTTCCA/CCAAAC 1 -- ut31 ese31Minor allele frequency- C:0.00MN 184
    rs16102161,2
    C,F,A,H,56642284(-) GCGCCT/CCGGGG 1 -- ng518Minor allele frequency- C:0.41MN EA NA WA 1566
    rs18752231,2
    C,F,A,56643137(-) ACTAGC/GGACAC 1 -- int110Minor allele frequency- G:0.07NA EA NS 640
    rs71965031,2
    C,F,A,56640739(+) agtggC/Tcgagt 1 -- ng5112Minor allele frequency- T:0.06NS EA NA WA 812
    rs108525501,2
    C,F,A,H,56641603(+) TTCCCC/ACTCCC 1 -- ng5111Minor allele frequency- A:0.17NS NA WA 206
    rs115496751,2
    --56642507(+) CTCCTG/TCCAAG 1 -- ut510--------
    rs115496761,2
    C56642911(+) GACTCC/TTGCAC 2 S ref1 syn10--------
    rs118655171,2
    C,H56640675(+) gatgaA/Gtaaac 1 -- ng511Minor allele frequency- G:0.00NA 2
    rs133372821,2
    C,F,56643517(+) TTAAGA/GAAGAG 1 -- ng319Minor allele frequency- G:0.26NS NA WA 310
    About this table

    HapMap Linkage Disequilibrium images for MT2A (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MT2A: --

    QIAGEN SeqTarget long-range PCR primers for resequencing MT2A 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MT2A for disorders           About GeneDecksing

    OMIM: 156360

    10 Novoseek disease relationships for MT2A gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    breast cancer 21.3 7 11756227 (2), 11291768 (2), 15188022 (1), 15788722 (1) (see all 5)
    nasopharyngeal carcinoma 19.8 1 15583813 (1)
    shock 15.4 4 8552721 (1), 12016146 (1), 15734587 (1), 19540330 (1)
    tumors 4.55 10 18755257 (2), 15188022 (1), 11756227 (1), 12646258 (1) (see all 7)
    prostate cancer 3.62 2 10754528 (1), 14550308 (1)
    cancer 3.52 2 11756227 (1), 18341518 (1)
    asthma 0 1 16427169 (1)
    inflammation 0 2 15541360 (1), 16215939 (1)
    ovarian cancer 0 2 11077043 (1)
    bladder cancer 0 4 11270423 (3)
    About this table

    Human Gene Mutation Database (HGMD): MT2A
    Human Genome Epidemiology (HuGE) Navigator: MT2A (11 documents)

    Export disorders and mutations for MT2A gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/190 PubMed articles for MT2A gene, integrated from 7 sources (see all 190):
    (articles sorted by number of sources associating them with MT2A)
    1. Human metallothionein genes -- primary structure of the metallothionein-II gene and a related processed gene. (PubMed id 7133118)1, 2, 3 Karin M. and Richards R.I. (1982)
    2. Expression of human metallothionein-II fusion protein in Escherichia coli. (PubMed id 1339282)1, 2, 7 Yamazaki S.... Kagawa Y. (1992)
    3. Three-dimensional structure of human [113Cd7]metallothionein-2 in solution determined by nuclear magnetic resonance spectroscopy. (PubMed id 2388267)1, 2, 7 Messerle B.A.... Wuethrich K. (1990)
    4. Comparison of the solution conformations of human [Zn7]- metallothionein-2 and [Cd7]-metallothionein-2 using nuclear magnetic resonance spectroscopy. (PubMed id 1593628)1, 2, 7 Messerle B.A.... Wuethrich K. (1992)
    5. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. (PubMed id 16916647)1, 2 Kim S.C.... Zhao Y. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Changes in brain gene expression shared by scrapie and Alzheimer disease. (PubMed id 2780570)1, 2 Duguid J.R.... Tourtellotte W.W. (1989)
    8. Human metallothionein genes: molecular cloning and sequence analysis of the mRNA. (PubMed id 6896577)1, 2 Karin M. and Richards R.I. (1982)
    9. Primary structure of human hepatic metallothionein. (PubMed id 913597)1, 2 Kissling M.M. and Kaegi J.H.R. (1977)
    10. ECRG2, a novel candidate of tumor suppressor gene in the esophageal carcinoma, interacts directly with metallothionein 2A and links to apoptosis. (PubMed id 12646258)1, 7 Cui Y....Lu S.H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    Aliases
    Disorders
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4502 HGNC: 7406 AceView: MT2_ Ensembl:ENSG00000125148 euGenes: HUgn4502
    ECgene: MT2A H-InvDB: MT2A

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for MT2A Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/mt2a/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for MT2A gene:
    Search GeneIP for patents involving MT2A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
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     Novus Tissue Slides
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     Browse ELISAs and CLIAs at Uscn
           

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