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MTIF2 Gene

protein-coding GIFtS: 56

GC02M055198

mitochondrial translational initiation factor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
mitochondrial translational initiation factor 2¹ ²		OTTHUMP00000200773²
IF-2mt¹ ²		translation initiation factor IF-2, mitochondrial²
IF-2(Mt)² ³		IF-2Mt³
IF2(mt)² ³

External Ids:	HGNC: 7441¹	Entrez Gene: 4528²	Ensembl: ENSG00000085760⁷	UniProtKB: P46199³

Export aliases for MTIF2 gene to outside databases

Previous GC identifers: GC02M055501 GC02M055649 GC02M055438 GC02M055375 GC02M055317 GC02M055463

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTIF2:

During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to

the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while

eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD

monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a

29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and

several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript

variants encoding the same protein have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199

Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from

spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP

during the formation of the 70S ribosomal complex

Gene Wiki entry for MTIF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the MTIF2 gene promoter:
         Cart-1   Elk-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HNF-1A   CUTL1   Sox9   MEF-2A   SRF
         Other transcription factors

Search SABiosciences Chromatin IP Primers for MTIF2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MTIF2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1 Ensembl cytogenetic band: 2p16.1 HGNC cytogenetic band: 2p16.1

MTIF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTIF2 gene location

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M055198: view genomic region (about GC identifiers)

Start:	55,198,510 bp from pter
End:	55,231,124 bp from pter
Size:	32,615 bases
Orientation:	minus strand

1 alternative location:

Chr2- 55,463,731-55,496,483

RefSeq DNA sequence:

NC_000002.11 NT_022184.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199 (See protein sequence)

Recommended Name: Translation initiation factor IF-2, mitochondrial precursor

Size: 727 amino acids; 81317 Da

Subunit: Monomer

Subcellular location: Mitochondrion

Explore the universe of human proteins at neXtProt for MTIF2: NX_P46199

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_001005369.1 NP_002444.2

ENSEMBL proteins:

ENSP00000393025 ENSP00000400778 ENSP00000416057 ENSP00000388640 ENSP00000399531 ENSP00000383880

ENSP00000403492 ENSP00000403237 ENSP00000378099 ENSP00000384481 ENSP00000393337 ENSP00000263629

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: MTIF2
	GenScript Custom Purified and Recombinant Proteins Services for MTIF2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005739	mitochondrion	ISS	--

About this table

MTIF2 for ontologies About GeneDecksing

Antibodies for MTIF2:

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Assays for MTIF2:

	Browse Kits and Assays available from Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for MTIF2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for MTIF2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MTIF2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR000795 ProtSyn_GTP-bd

IPR023115 TIF_IF2_dom3

IPR005225 Small_GTP-bd

IPR004161 Transl_elong_EFTu/EF1A_2

IPR015760 TIF_IF2

Graphical View of Domain Structure for InterPro Entry P46199

ProtoNet protein and cluster: P46199

UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199

Similarity: Belongs to the IF-2 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199

Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from

spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP

during the formation of the 70S ribosomal complex

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for MTIF2 Sigma-Aldrich shRNA for MTIF2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MTIF2 OriGene shRNA RFP (see all 2): MTIF2 OriGene basic RS shRNA (see all 2): MTIF2 OriGene siRNA (see all 2): MTIF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MTIF2

miRNA:		Sigma-Aldrich microRNA Mimics for MTIF2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MTIF2
		Search SABiosciences for Assays for microRNAs that regulate MTIF2

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MTIF2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MTIF2 OriGene untagged cDNA clones in CMV expression vector (see all 2): MTIF2 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MTIF2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for MTIF2

Genatlas biochemistry entry for MTIF2:

mitochondrial translational initiation factor 2,catalyzing the binding of initiation tRNA to mitochondrial 28S

ribosomes

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003743	translation initiation factor activity	IEA	--
GO:0003924	GTPase activity	IEA	--
GO:0005525	GTP binding	IEA	--
GO:0008135	translation factor activity, nucleic acid binding	ISS	--

About this table

MTIF2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for MTIF2

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for MTIF2

1 Interacting protein for MTIF2 (P46199²) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NFKBIB	Q15653²	MINT-47860

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006413	translational initiation	--	--
GO:0006446	regulation of translational initiation	ISS	--
GO:0007264	small GTPase mediated signal transduction	--	--

About this table

MTIF2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

MTIF2 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MTIF2
7 Novoseek chemical compound relationships for MTIF2 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
poly aug	95.6	2	12095986 (1)
thiostrepton	74.9	6	14698286 (5)
gtp	69.5	17	19837086 (5), 16968770 (3), 20385143 (2), 10937868 (1) (see all 5)
aminoacyl-trna	67.1	1	14698286 (1)
gdp	55.3	7	19837086 (3)
trna	50.9	2	10727773 (1), 16240709 (1)
rrna	33.2	4	12869707 (2), 14698286 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for MTIF2 Sigma-Aldrich shRNA for MTIF2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MTIF2 OriGene shRNA RFP (see all 2): MTIF2 OriGene basic RS shRNA (see all 2): MTIF2 OriGene siRNA (see all 2): MTIF2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MTIF2

miRNA:		Sigma-Aldrich microRNA Mimics for MTIF2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MTIF2
		Search SABiosciences for Assays for microRNAs that regulate MTIF2

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MTIF2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MTIF2 OriGene untagged cDNA clones in CMV expression vector (see all 2): MTIF2 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MTIF2

Primers:		OriGene genome-wide validated SYBR primer pairs: MTIF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MTIF2: PPH12765A

REFSEQ mRNAs for MTIF2 gene (2 alternative transcripts):

NM_001005369.1 NM_002453.2

Additional cDNA sequence:

AF494407.1 AK225184.1 AK307993.1 BC002667.2 BC009845.2 BC017243.1 BC039848.1 BC054048.1

BC064977.1 BC067352.1 BC082973.1 BC143541.1 L34600.1

15 DOTS entries:

DT.316190 DT.92005944 DT.92435754 DT.100036537 DT.95070852 DT.100036542 DT.100785719 DT.100785721

DT.100785722 DT.40106472 DT.95342069 DT.120977217 DT.120977225 DT.99939771 DT.100036540

24/212 AceView cDNA sequences (see all 212):

F11408 AA459016 F04295 BU633170 T09028 BM766250 BQ883227 BU753417

W76546 BM888464 BM772446 BG623953 CA418093 BM773385 AI347617 BM541285

CB120990 AA427852 AA804327 AA164431 F08059 BU681583 BU684812 BQ774933

highest scoring ESTs for MTIF2:

L34600 AA360846 AF494407 AU129148 AU137851 AU139983 BC002667 BC009845 BC017243 BC039848

Unigene Cluster for MTIF2:

Mitochondrial translational initiation factor 2

Hs.149894 [show with all ESTs]

Unigene Representative Sequence: NM_001005369

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MTIF2 (see all 6)

ExUns:	1	^	2	^	3a	·	3b	^	4a	·	4b	^	5	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13
SP1:			-				-
SP2:
SP3:							-
SP4:															-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for MTIF2
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000412530 ENST00000446660 ENST00000420637 ENST00000441307 ENST00000417363

ENST00000404297 ENST00000418823 ENST00000417741 ENST00000394600 ENST00000403721(uc010yox.1)

ENST00000366137 ENST00000263629(uc002ryn.2 uc002ryo.2 uc002ryp.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MTIF2 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching MTIF2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
31836_at²^{, 3}	U95-A	2	0.94	0.93	1.00	1.00	L34600	1.00	1.00	1.00	1
203095_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002453	0.60	1.00	0.82	1
203095_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

MTIF2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

MTIF2 gene electronic northern expression

About these images

CGAP SAGE TAG: TAATTTGGAA

SOURCE GeneReport for Unigene cluster: Hs.149894

Expression variation in blood from EXPOLDB for MTIF2

UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199

Tissue specificity: Expressed in all tissues examined. Highest level in skeletal muscle

Primers:		OriGene genome-wide validated SYBR primer pairs: MTIF2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for MTIF2: PPH12765A

SABiosciences Custom PCR Arrays for MTIF2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MTIF2 gene from 5/20 species (see all 20)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	MTIF2¹	--	mitochondrial translational initiation factor 2	89.55(n) 85.14(a)	474600 XM_531830.2 XP_531830.2
chimpanzee (Pan troglodytes)	MTIF2¹	--	mitochondrial translational initiation factor 2	99.54(n) 99.17(a)	459239 XM_515483.2 XP_515483.2
cow (Bos taurus)	MTIF2¹	--	mitochondrial translational initiation factor 2	88.54(n) 85.01(a)	281923 NM_174393.2 NP_776818.1
rat (Rattus norvegicus)	Mtif2¹	--	mitochondrial translational initiation factor 2	85.74(n) 83.36(a)	305606 NM_001004254.1 NP_001004254.1
mouse (Mus musculus)	Mtif2^{1 , 5}	11 (16.77 cM)⁵	mitochondrial translational initiation factor 2^{1, 5}	85.42(n)¹ 81.29(a)¹	76784¹ NM_133767.2¹ NP_598528.2¹ AI875598⁵ AK010766⁵ (see all 12)

About this table Species with no ortholog for MTIF2

ENSEMBL Gene Tree for MTIF2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Pseudogenes

1 related pseudogene

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs11357^1,2	C,F,A,H,	55470115(-)	`GTGATA/GTAAGT`	4	I V	mis¹ ref¹		19	MN NS EA NA WA	1350
rs749221^1,2	C,F,	55496830(+)	`TGGCTC/ACTCTG`	2	--	ng5¹		6	MN NS EA WA	654
rs1056445^1,2	C,F,A,	55490819(-)	`GCTCAA/CTGGGG`	4	N T	mis¹ ref¹		19	MN NS EA NA WA	1292
rs1134722^1,2	C,F,	55490788(-)	`CTTCTG/AGTAAC`	4	/L	ref¹ syn¹		8	NS EA NA	584
rs1437397^1,2	C,F,H,	55482576(-)	`ttataT/Cataat`	2	--	int¹		3	NA	6
rs1821832^1,2	C	55474604(-)	`tcaagC/Tgattt`	2	--	int¹		4	NA WA	8
rs1866034^1,2	H	55464618(+)	`AAATAC/GGTAAT`	2	--	int¹		4	NS EA	418
rs2043712^1,2	C,F,	55480022(-)	`TAGAAA/TTATGG`	2	--	int¹		19	NS EA NA WA	1162
rs2230370^1,2	C,F,H,	55481322(-)	`GATCCA/TGCTTT`	4	P	ref¹ syn¹		3	MN NA	104
rs2576708^1,2	C,F,A,H,	55475999(+)	`aggcaC/Tggtgg`	2	--	int¹		9	NA EA WA	174

About this table

HapMap Linkage Disequilibrium images for MTIF2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for MTIF2: --

QIAGEN SeqTarget long-range PCR primers for resequencing MTIF2

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

MTIF2 for disorders About GeneDecksing

OMIM: 603766

1 Novoseek disease relationship for MTIF2 gene

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0	1	10651023 (1)

About this table

Human Genome Epidemiology (HuGE) Navigator: MTIF2 (3 documents)

Export disorders and mutations for MTIF2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/44 PubMed articles for MTIF2 gene, integrated from 7 sources (see all 44):
(articles sorted by number of sources associating them with MTIF2)

Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA. (PubMed id 7829522)^{1, 2, 3, 7} Ma L. and Spremulli L.L. (1995)
The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene. (PubMed id 12932832)^{1, 2} Overman R.G. Jr....Farwell M.A. (2003)
Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16-->p14 by in situ hybridization and with somatic cell hybrids. (PubMed id 9925935)^{1, 3} Bonner D.S....Farwell M.A. (1998)
Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)¹ Dick D.M....Bierut L. (2010)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)¹ Reiling E....Dekker J.M. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
The balance between protein synthesis and degradation in chloroplasts determines leaf variegation in Arabidopsis yellow variegated mutants. (PubMed id 17416734)¹ Miura E....Sakamoto W. (2007)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Identification of NPM-ALK interacting proteins by tandem mass spectrometry. (PubMed id 14968112)¹ Crockett D.K....Lim M.S. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 4528	HGNC: 7441	AceView: MTIF2	Ensembl:ENSG00000085760	euGenes: HUgn4528
ECgene: MTIF2	H-InvDB: MTIF2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for MTIF2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for MTIF2 gene:
Search GeneIP for patents involving MTIF2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for MTIF2		Antibodies for MTIF2
	Super-pooled esiRNAs for MTIF2		Browse proteins at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MTIF2
	SeqTarget long-range PCR primers for resequencing MTIF2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MTIF2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MTIF2

	GenScript Custom Purified and Recombinant Proteins Services for MTIF2		GenScript cDNA clones with any tag delivered in your preferred vector for MTIF2
	GenScript Custom Assay Services for MTIF2		GenScript Custom Superior Antibodies Services for MTIF2
	GenScript Custom overexpressing Cell Line Services for MTIF2		CloneReady with Over 120,000 Genes
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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ELISAs and CLIAs for MTIF2

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

MTIF2 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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MTIF2 Gene

protein-coding GIFtS: 56

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MTIF2 Gene

protein-coding GIFtS: 56

Aliases & Descriptionsfor MTIF2 gene

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Genomic Viewsfor MTIF2 gene

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Protein Domains/Familiesfor MTIF2 gene

Gene Functionfor MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

Expression
for MTIF2 gene

Orthologs
for MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

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for MTIF2 gene

Publications
for MTIF2 gene

Intellectual Property
for MTIF2 gene

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for MTIF2 gene