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MTIF2 Gene

protein-coding   GIFtS: 56

GC02M055198
mitochondrial translational initiation factor 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
mitochondrial translational initiation factor 21 2     OTTHUMP000002007732
IF-2mt1 2     translation initiation factor IF-2, mitochondrial2
IF-2(Mt)2 3     IF-2Mt3
IF2(mt)2 3     

External Ids:    HGNC: 74411   Entrez Gene: 45282   Ensembl: ENSG000000857607   UniProtKB: P461993   

Export aliases for MTIF2 gene to outside databases

Previous GC identifers: GC02M055501 GC02M055649 GC02M055438 GC02M055375 GC02M055317 GC02M055463


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MTIF2:
During the initiation of protein biosynthesis, initiation factor-2 (IF-2) promotes the binding of the initiator tRNA to
the small subunit of the ribosome in a GTP-dependent manner. Prokaryotic IF-2 is a single polypeptide, while
eukaryotic cytoplasmic IF-2 (eIF-2) is a trimeric protein. Bovine liver mitochondria contain IF-2(mt), an 85-kD
monomeric protein that is equivalent to prokaryotic IF-2. The predicted 727-amino acid human protein contains a
29-amino acid presequence. Human IF-2(mt) shares 32 to 38% amino acid sequence identity with yeast IF-2(mt) and
several prokaryotic IF-2s, with the greatest degree of conservation in the G domains of the proteins. Two transcript
variants encoding the same protein have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199
Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from
spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP
during the formation of the 70S ribosomal complex

Gene Wiki entry for MTIF2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MTIF2 gene promoter:
         Cart-1   Elk-1   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   POU3F2   HNF-1A   CUTL1   Sox9   MEF-2A   SRF   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MTIF2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MTIF2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p16.1   Ensembl cytogenetic band:  2p16.1   HGNC cytogenetic band: 2p16.1

MTIF2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MTIF2 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M055198:  view genomic region     (about GC identifiers)

Start:
55,198,510 bp from pter
End:
55,231,124 bp from pter
Size:
32,615 bases
Orientation:
minus strand

1 alternative location:
Chr2- 55,463,731-55,496,483     
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199 (See protein sequence)
Recommended Name: Translation initiation factor IF-2, mitochondrial precursor  
Size: 727 amino acids; 81317 Da
Subunit: Monomer
Subcellular location: Mitochondrion

Explore the universe of human proteins at neXtProt for MTIF2: NX_P46199 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (2 alternative transcripts): 
    NP_001005369.1  NP_002444.2  


    ENSEMBL proteins: 
    ENSP00000393025 ENSP00000400778 ENSP00000416057 ENSP00000388640 ENSP00000399531 ENSP00000383880 
    ENSP00000403492 ENSP00000403237 ENSP00000378099 ENSP00000384481 ENSP00000393337 ENSP00000263629 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: MTIF2
    GenScript Custom Purified and Recombinant Proteins Services for MTIF2 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622 intracellular IEA--
    GO:0005739 mitochondrion ISS--
    About this table

    MTIF2 for ontologies           About GeneDecksing



    Antibodies for MTIF2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MTIF2
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for MTIF2 
    Browse antibodies at Epitomics

    Assays for MTIF2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MTIF2 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MTIF2 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MTIF2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR000795 ProtSyn_GTP-bd
     IPR023115 TIF_IF2_dom3
     IPR005225 Small_GTP-bd
     IPR004161 Transl_elong_EFTu/EF1A_2
     IPR015760 TIF_IF2

    Graphical View of Domain Structure for InterPro Entry P46199

    ProtoNet protein and cluster: P46199

    UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199
    Similarity: Belongs to the IF-2 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199
    Function: One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from
    spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP
    during the formation of the 70S ribosomal complex

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MTIF2
    Sigma-Aldrich shRNA for MTIF2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MTIF2
    OriGene shRNA RFP (see all 2): MTIF2
    OriGene basic RS shRNA (see all 2): MTIF2
    OriGene siRNA (see all 2): MTIF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MTIF2 
    miRNA:Sigma-Aldrich microRNA Mimics for MTIF2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MTIF2 
    Search SABiosciences for Assays for microRNAs that regulate MTIF2

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MTIF2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MTIF2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): MTIF2
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MTIF2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MTIF2 

    Genatlas biochemistry entry for MTIF2:
    mitochondrial translational initiation factor 2,catalyzing the binding of initiation tRNA to mitochondrial 28S
    ribosomes

    5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0003743 translation initiation factor activity IEA--
    GO:0003924 GTPase activity IEA--
    GO:0005525 GTP binding IEA--
    GO:0008135 translation factor activity, nucleic acid binding ISS--
    About this table

    MTIF2 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for MTIF2 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MTIF2

    1 Interacting protein for MTIF2 (P461992) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NFKBIBQ156532MINT-47860
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006413 translational initiation ----
    GO:0006446 regulation of translational initiation ISS--
    GO:0007264 small GTPase mediated signal transduction ----
    About this table

    MTIF2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    MTIF2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for MTIF2
    7 Novoseek chemical compound relationships for MTIF2 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    poly aug 95.6 2 12095986 (1)
    thiostrepton 74.9 6 14698286 (5)
    gtp 69.5 17 19837086 (5), 16968770 (3), 20385143 (2), 10937868 (1) (see all 5)
    aminoacyl-trna 67.1 1 14698286 (1)
    gdp 55.3 7 19837086 (3)
    trna 50.9 2 10727773 (1), 16240709 (1)
    rrna 33.2 4 12869707 (2), 14698286 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MTIF2
    Sigma-Aldrich shRNA for MTIF2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MTIF2
    OriGene shRNA RFP (see all 2): MTIF2
    OriGene basic RS shRNA (see all 2): MTIF2
    OriGene siRNA (see all 2): MTIF2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MTIF2 
    miRNA: Sigma-Aldrich microRNA Mimics for MTIF2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MTIF2 
    Search SABiosciences for Assays for microRNAs that regulate MTIF2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MTIF2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MTIF2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): MTIF2
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): MTIF2 
    Primers: OriGene genome-wide validated SYBR primer pairs: MTIF2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MTIF2: PPH12765A

    REFSEQ mRNAs for MTIF2 gene (2 alternative transcripts): 

    NM_001005369.1  NM_002453.2  

    Additional cDNA sequence: 

    AF494407.1 AK225184.1 AK307993.1 BC002667.2 BC009845.2 BC017243.1 BC039848.1 BC054048.1 
    BC064977.1 BC067352.1 BC082973.1 BC143541.1 L34600.1 

    15 DOTS entries:

    DT.316190  DT.92005944  DT.92435754  DT.100036537  DT.95070852  DT.100036542  DT.100785719  DT.100785721 
    DT.100785722  DT.40106472  DT.95342069  DT.120977217  DT.120977225  DT.99939771  DT.100036540 

    24/212 AceView cDNA sequences (see all 212):

    F11408 AA459016 F04295 BU633170 T09028 BM766250 BQ883227 BU753417 
    W76546 BM888464 BM772446 BG623953 CA418093 BM773385 AI347617 BM541285 
    CB120990 AA427852 AA804327 AA164431 F08059 BU681583 BU684812 BQ774933 

    highest scoring ESTs for MTIF2:

    L34600 AA360846 AF494407 AU129148 AU137851 AU139983 BC002667 BC009845 BC017243 BC039848 

    Unigene Cluster for MTIF2:

    Mitochondrial translational initiation factor 2
    Hs.149894  [show with all ESTs]
    Unigene Representative Sequence: NM_001005369


    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for MTIF2 (see all 6)

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13
    SP1:        -           -                                                                                       
    SP2:                                                                                                            
    SP3:                    -                                                                                       
    SP4:                                            -     -                                                         
    SP5:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for MTIF2
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412530 ENST00000446660 ENST00000420637 ENST00000441307 ENST00000417363
    ENST00000404297 ENST00000418823 ENST00000417741 ENST00000394600 ENST00000403721(uc010yox.1)
    ENST00000366137 ENST00000263629(uc002ryn.2 uc002ryo.2 uc002ryp.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MTIF2 expression in normal and diseased human tissues

    1  / 2  / 3

    3 probe-sets matching MTIF2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    31836_at2, 3 U95-A 2 0.94 0.93 1.00 1.00 L34600 1.00 1.00 1.00 1
    203095_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002453 0.60 1.00 0.82 1
    203095_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    MTIF2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MTIF2 gene expression
    MTIF2 gene electronic northern expression
    MTIF2 gene sage expression
    About these images

    CGAP SAGE TAG: TAATTTGGAA

    SOURCE GeneReport for Unigene cluster: Hs.149894

    Expression variation in blood from EXPOLDB for MTIF2

    UniProtKB/Swiss-Prot: IF2M_HUMAN, P46199
    Tissue specificity: Expressed in all tissues examined. Highest level in skeletal muscle

    Primers: OriGene genome-wide validated SYBR primer pairs: MTIF2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MTIF2: PPH12765A
        SABiosciences Custom PCR Arrays for MTIF2 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MTIF2 gene from 5/20 species (see all 20)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MTIF21   -- mitochondrial translational initiation factor 2 89.55(n)
    85.14(a)
    474600  XM_531830.2  XP_531830.2 
    chimpanzee
    (Pan troglodytes)
    MTIF21   -- mitochondrial translational initiation factor 2 99.54(n)
    99.17(a)
    459239  XM_515483.2  XP_515483.2 
    cow
    (Bos taurus)
    MTIF21   -- mitochondrial translational initiation factor 2 88.54(n)
    85.01(a)
    281923  NM_174393.2  NP_776818.1 
    rat
    (Rattus norvegicus)
    Mtif21   -- mitochondrial translational initiation factor 2 85.74(n)
    83.36(a)
    305606  NM_001004254.1  NP_001004254.1 
    mouse
    (Mus musculus)
    Mtif21 , 5 11 (16.77 cM)5
    mitochondrial translational initiation factor 21, 5 85.42(n)1
    81.29(a)1
    767841  NM_133767.21  NP_598528.21 
     AI8755985  AK0107665  (see all 12)
    About this table        Species with no ortholog for MTIF2

    ENSEMBL Gene Tree for MTIF2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Pseudogenes
    1 related pseudogene



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/374 NCBI SNPs in MTIF2 are shown (see all 374)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs113571,2
    C,F,A,H,55470115(-) GTGATA/GTAAGT 4 I V mis1 ref119Minor allele frequency- G:0.43MN NS EA NA WA 1350
    rs7492211,2
    C,F,55496830(+) TGGCTC/ACTCTG 2 -- ng516Minor allele frequency- A:0.07MN NS EA WA 654
    rs10564451,2
    C,F,A,55490819(-) GCTCAA/CTGGGG 4 N T mis1 ref119Minor allele frequency- C:0.37MN NS EA NA WA 1292
    rs11347221,2
    C,F,55490788(-) CTTCTG/AGTAAC 4 /L ref1 syn18Minor allele frequency- A:0.33NS EA NA 584
    rs14373971,2
    C,F,H,55482576(-) ttataT/Cataat 2 -- int13Minor allele frequency- C:0.33NA 6
    rs18218321,2
    C55474604(-) tcaagC/Tgattt 2 -- int14Minor allele frequency- T:0.12NA WA 8
    rs18660341,2
    H55464618(+) AAATAC/GGTAAT 2 -- int14Minor allele frequency- G:0.00NS EA 418
    rs20437121,2
    C,F,55480022(-) TAGAAA/TTATGG 2 -- int119Minor allele frequency- T:0.18NS EA NA WA 1162
    rs22303701,2
    C,F,H,55481322(-) GATCCA/TGCTTT 4 P ref1 syn13Minor allele frequency- T:0.09MN NA 104
    rs25767081,2
    C,F,A,H,55475999(+) aggcaC/Tggtgg 2 -- int19Minor allele frequency- T:0.45NA EA WA 174
    About this table

    HapMap Linkage Disequilibrium images for MTIF2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MTIF2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing MTIF2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MTIF2 for disorders           About GeneDecksing

    OMIM: 603766

    1 Novoseek disease relationship for MTIF2 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 10651023 (1)
    About this table

    Human Genome Epidemiology (HuGE) Navigator: MTIF2 (3 documents)

    Export disorders and mutations for MTIF2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/44 PubMed articles for MTIF2 gene, integrated from 7 sources (see all 44):
    (articles sorted by number of sources associating them with MTIF2)
    1. Cloning and sequence analysis of the human mitochondrial translational initiation factor 2 cDNA. (PubMed id 7829522)1, 2, 3, 7 Ma L. and Spremulli L.L. (1995)
    2. The human mitochondrial translation initiation factor 2 gene (MTIF2): transcriptional analysis and identification of a pseudogene. (PubMed id 12932832)1, 2 Overman R.G. Jr....Farwell M.A. (2003)
    3. Assignment1 of the mitochondrial translational initiation factor 2 gene (MTIF2) to human chromosome 2 bands p16-->p14 by in situ hybridization and with somatic cell hybrids. (PubMed id 9925935)1, 3 Bonner D.S....Farwell M.A. (1998)
    4. Evidence for genes on chromosome 2 contributing to al cohol dependence with conduct disorder and suicide attempts. (PubMed id 20468071)1 Dick D.M....Bierut L. (2010)
    5. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
    6. Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study. (PubMed id 19209188)1 Reiling E....Dekker J.M. (2009)
    7. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    8. The balance between protein synthesis and degradation in chloroplasts determines leaf variegation in Arabidopsis yellow variegated mutants. (PubMed id 17416734)1 Miura E....Sakamoto W. (2007)
    9. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
    10. Identification of NPM-ALK interacting proteins by tandem mass spectrometry. (PubMed id 14968112)1 Crockett D.K....Lim M.S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4528 HGNC: 7441 AceView: MTIF2 Ensembl:ENSG00000085760 euGenes: HUgn4528
    ECgene: MTIF2 H-InvDB: MTIF2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for MTIF2 gene:
    Search GeneIP for patents involving MTIF2

    GeneCards and IP:
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     ELISAs and CLIAs for MTIF2
           

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