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MYL1 Gene

protein-coding   GIFtS: 55

GC02M203000
myosin, light chain 1, alkali; skeletal, fast
(Previous names: myosin, light polypeptide 1, alkali; skeletal, fast )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
myosin, light chain 1, alkali; skeletal, fast1 2     A2 catalytic2
myosin, light polypeptide 1, alkali; skeletal, fast1 2     MLC1F2
Myosin light chain A1/A22 3     MLC3F2
Myosin light chain alkali 1/22 3     myosin light chain 1/3, skeletal muscle isoform2
MLC1F/MLC3F2 3     A1 catalytic2
MLC1/MLC32 3     

External Ids:    HGNC: 75821   Entrez Gene: 46322   Ensembl: ENSG000001685307   UniProtKB: P059763   

Export aliases for MYL1 gene to outside databases

Previous GC identifers: GC02M209430 GC02M209879 GC02M211118 GC02M211357 GC02M210980 GC02M210863


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for MYL1:
Myosin is a hexameric ATPase cellular motor protein. It is composed of two heavy chains, two nonphosphorylatable alkali
light chains, and two phosphorylatable regulatory light chains. This gene encodes a myosin alkali light chain
expressed in fast skeletal muscle. Two transcript variants have been identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976
Function: Regulatory light chain of myosin. Does not bind calcium

summary for MYL1:
Myosins are a large family of motor proteins that share the common features of ATP hydrolysis, actin binding
and potential for kinetic energy transduction. Originally isolated from muscle cells (hence the name),
almost all eukaryotic cells are now known to contain myosins. Structurally, mysoins contain a head domain
that binds to actin filaments (microfilaments) and is the site of ATP hydrolysis. The tail domain interacts
with cargo molecules, and the neck acts as a linker between the head and tail and is the site of regulatory
myosin light chain binding. There are 17 myosin families and the most well characterized is myosin II.
Myosin II is found predominantly in myocytes and mediates plus-ended movement along microfilaments. It is
involved in muscle contraction through cyclic interactions with actin-rich thin filaments, creating a
contractile force. It is regulated by phosphorylation via myosin light chain kinase (MLCK) and by
intracellular Ca2+ concentrations.

Gene Wiki entry for MYL1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYL1 gene promoter:
         RSRFC4   ARP-1   SRF   Nkx2-2   MEF-2A   POU2F1   C/EBPalpha   CHOP-10   Nkx6-1   FOXC1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MYL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34   Ensembl cytogenetic band:  2q34   HGNC cytogenetic band: 2q33-q34

MYL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYL1 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M203000:  view genomic region     (about GC identifiers)

Start:
203,000,114 bp from pter
End:
203,025,138 bp from pter
Size:
25,025 bases
Orientation:
minus strand

1 alternative location:
Chr2- 211,154,874-211,179,914     
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976 (See protein sequence)
Recommended Name: Myosin light chain 1/3, skeletal muscle isoform  
Size: 194 amino acids; 21145 Da
Subunit: Myosin is an hexamer of 2 heavy chains and 4 light chains
Secondary accessions: B2R4N6 B2R4T6 P06741 Q6IBD5
Alternative splicing: 2 isoforms:  P05976-1   P05976-2, P06741-1   

Explore the universe of human proteins at neXtProt for MYL1: NX_P05976 

Post-translational modifications:

  • Isoform MLC3 is acetylated at position 2 (By similarity)1


  • REFSEQ proteins (2 alternative transcripts): 
    NP_524144.1  NP_524146.1  


    ENSEMBL proteins: 
    ENSP00000307280 ENSP00000343321 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: MYL1
    OriGene Protein Over-expression Lysate: MYL1
    GenScript Custom Purified and Recombinant Proteins Services for MYL1 
    Novus Biologicals Proteins for MYL1
    Novus Biologicals Lysates for MYL1
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for MYL1

    5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829 cytosol TAS--
    GO:0005859 muscle myosin complex NAS3904738
    GO:0016459 myosin complex IEA--
    GO:0030016 myofibril IDA8145163
    GO:0030017 sarcomere NAS3904738
    About this table

    MYL1 for ontologies           About GeneDecksing



    Antibodies for MYL1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for MYL1
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for MYL1 
    Novus Biologicals Antibodies for MYL1
    Browse antibodies at Epitomics

    Assays for MYL1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for MYL1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for MYL1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    MYL1 for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR011992 EF-hand-like_dom
     IPR002048 EF_hand_Ca-bd
     IPR018249 EF_HAND_2

    Graphical View of Domain Structure for InterPro Entry P05976

    ProtoNet protein and cluster: P05976

    UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976
    Similarity: Contains 3 EF-hand domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: MYL1_HUMAN, P05976
    Function: Regulatory light chain of myosin. Does not bind calcium

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MYL1
    Sigma-Aldrich shRNA for MYL1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MYL1
    OriGene shRNA RFP (see all 2): MYL1
    OriGene basic RS shRNA (see all 2): MYL1
    OriGene siRNA (see all 2): MYL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MYL1 
    miRNA:Sigma-Aldrich microRNA Mimics for MYL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MYL1 
    Search SABiosciences for Assays for microRNAs that regulate MYL1

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MYL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MYL1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): MYL1
    OriGene 3'-UTR clone (see all 2): MYL1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MYL1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for MYL1 

    Genatlas biochemistry entry for MYL1:
    myosin,light polypeptide 1,alkali;skeletal,fast,same as MLC1-F & MLC3-F

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774 motor activity IEA--
    GO:0005509 calcium ion binding IEA--
    GO:0008307 structural constituent of muscle NAS3904738
    About this table

    MYL1 for ontologies           About GeneDecksing

    Animal Models: 10 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Myl1):

    behavior/neurologicalcellularembryogenesisgrowth/sizelethality-prenatal/perinatal
    life span-post-weaning/agingmusclenervous systemnormalskeleton

    MYL1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    MYL1 for pathways           About GeneDecksing

    5/7 Millipore Pathways for MYL1 (see all 7)
        Cell adhesion Integrin-mediated cell adhesion and migration
    Cell adhesion Tight junctions
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases
    Immune response CCR3 signaling in eosinophils

    5/17 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for  MYL1 (see all 17)
        Phospholipase C Signaling
    ILK Signaling
    Hepatic Fibrosis / Hepatic Stellate Cell Activation
    Calcium Signaling
    Protein Kinase A Signaling

        SABiosciences Custom Pathway-Focused PCR Arrays for MYL1 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for MYL1
        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYL1

    5/33 Interacting proteins for MYL1 (ENSP000003072803) via UniProtKB, MINT, and/or STRING (see all 33)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ACTN2ENSP000003555373STRING: ENSP00000355537
    DMDENSP000003549233STRING: ENSP00000354923
    MYBPC1ENSP000003548493STRING: ENSP00000354849
    MYBPC2ENSP000003503323STRING: ENSP00000350332
    MYBPC3ENSP000002569933STRING: ENSP00000256993
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006936 muscle contraction IDA8145163
    GO:0007517 muscle organ development NAS--
    GO:0030049 muscle filament sliding TAS--
    GO:0060048 cardiac muscle contraction IEA--
    About this table

    MYL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for MYL1 available from Tocris Bioscience
    CompoundAction CAS number
    (S)-(-)-BlebbistatinSelective inhibitor of myosin II. Active enantiomer of Cat. No. 1760[856925-71-8]
    ()-BlebbistatinSelective inhibitor of myosin II[674289-55-5]
    About this table




    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for MYL1
    Sigma-Aldrich shRNA for MYL1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): MYL1
    OriGene shRNA RFP (see all 2): MYL1
    OriGene basic RS shRNA (see all 2): MYL1
    OriGene siRNA (see all 2): MYL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MYL1 
    miRNA: Sigma-Aldrich microRNA Mimics for MYL1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MYL1 
    Search SABiosciences for Assays for microRNAs that regulate MYL1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): MYL1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): MYL1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): MYL1
    OriGene 3'-UTR Clone (see all 2): MYL1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for MYL1 
    Primers: OriGene genome-wide validated SYBR primer pairs: MYL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MYL1: PPH13937A

    REFSEQ mRNAs for MYL1 gene (2 alternative transcripts): 

    NM_079420.2  NM_079422.2  

    Additional cDNA sequence: 

    AK311892.1 AK311942.1 BC005318.1 CR456869.1 CR598137.1 M20643.1 X05451.1 

    11 DOTS entries:

    DT.451890  DT.100646912  DT.95136953  DT.120988964  DT.92458835  DT.100646906  DT.87046784  DT.100028901 
    DT.120988967  DT.120988980  DT.92012066 

    24/414 AceView cDNA sequences (see all 414):

    AU099573 BM720926 BM678600 F27414 F26328 F28438 BM667558 F35245 
    BU735911 W67279 F32732 F31356 F34713 F29169 N69926 AI800009 
    F30911 W92584 F31880 BU581571 AA993535 F31527 CR598137 F19305 

    highest scoring ESTs for MYL1:

    AA332405 AA346018 AL598805 AU099573 BF574382 BF574831 BF574852 BF693841 BG987664 BM697229 

    Unigene Cluster for MYL1:

    Myosin, light chain 1, alkali; skeletal, fast
    Hs.187338  [show with all ESTs]
    Unigene Representative Sequence: BF790783


    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for MYL1

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b
    SP1:                                                                        
    SP2:                    -     -     -                                       
    SP3:              -     -     -     -     -     -     -                     
    SP4:                          -                                             

    About this scheme

    ECgene alternative splicing isoforms for MYL1
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484290 ENST00000352451(uc002vec.2) ENST00000341685(uc002veb.2)
    ENST00000496436

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    MYL1 expression in normal and diseased human tissues

    1  / 2  / 3

    4 probe-sets matching MYL1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    40157_s_at2, 3 U95-A 1 0.88 1.00 0.99 1.30 X05451 0.60 1.00 0.82 1
    40158_r_at2, 3 U95-A 1 0.75 1.00 0.95 0.73 M20642 0.80 1.00 0.91 1
    209888_s_at2, 3 U133-A 1 0.73 1.00 -- -- M20643 0.60 1.00 0.82 1
    209888_s_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    MYL1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    MYL1 gene expression
    MYL1 gene electronic northern expression
    MYL1 gene sage expression
    About these images

    CGAP SAGE TAG: AATCAACAAA

    SOURCE GeneReport for Unigene cluster: Hs.187338

    Expression variation in blood from EXPOLDB for MYL1

    Primers: OriGene genome-wide validated SYBR primer pairs: MYL1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for MYL1: PPH13937A
        SABiosciences Custom PCR Arrays for MYL1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for MYL1 gene from 5/12 species (see all 12)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    MYL11   -- myosin, light chain 1, alkali; skeletal, fast 93.78(n)
    97.93(a)
    478896  XM_536054.2  XP_536054.2 
    chimpanzee
    (Pan troglodytes)
    MYL11   -- myosin, light chain 1, alkali; skeletal, fast 99.83(n)
    100(a)
    459915  XM_516064.2  XP_516064.2 
    cow
    (Bos taurus)
    MYL11   -- myosin, light chain 1, alkali; skeletal, fast 92.67(n)
    95.81(a)
    317657  XM_001249356.1  XP_001249357.1 
    rat
    (Rattus norvegicus)
    Myl11   -- myosin, light polypeptide 1 84.44(n)
    90.67(a)
    56781  NM_020104.1  NP_064489.1 
    mouse
    (Mus musculus)
    Myl11 , 5 1 (33.71 cM)5
    myosin, light polypeptide 11, 5 87.94(n)1
    94.15(a)1
    179011  NM_021285.21  NP_067260.11 
     AI3240235  AI3251075  (see all 18)
    About this table        Species with no ortholog for MYL1

    ENSEMBL Gene Tree for MYL1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for MYL1 gene
    MYL42  MYL6B2  MYL32  MYL62  

    MYL1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/251 NCBI SNPs in MYL1 are shown (see all 251)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs10572191,2
    --211163205(-) CGAGCT/CCTGGG 2 /A syn1 ref1 ese31Minor allele frequency- C:0.00MN 184
    rs10741581,2
    C,F,O,211175043(+) GTTTTA/GTCATA 1 -- int1101Minor allele frequency- G:0.43NA NS EA PA EU CA WA 6718
    rs11352541,2
    --211163265(-) CTCCTC/GTTTGA 2 L syn1 ref10--------
    rs14729551,2
    C,F,O,A,H,211168638(+) CTTAGA/GATTTC 1 -- int110Minor allele frequency- G:0.37NA NS EA WA 772
    rs18039841,2
    --211155064(-) ACTCCC/TTGAAT 1 -- ut310--------
    rs19630891,2
    C,A,H211157687(+) GCTTGA/GCTAAG 1 -- int13Minor allele frequency- G:0.12NA 8
    rs19958351,2
    C,F,A,H,211159509(+) TAAGTG/TTTAGC 1 -- int17Minor allele frequency- T:0.40NA EA WA 218
    rs19958361,2
    C,F,O,A,H,211159671(+) TTCCCG/TTTCTT 1 -- int119Minor allele frequency- T:0.46MN NS EA NA WA 1376
    rs20633101,2
    C,A,211163582(-) TCCAGG/ATTTCC 1 -- int16Minor allele frequency- A:0.44NA EA WA 216
    rs20633111,2
    C,F,A,211163574(-) TCCAGA/G/TCAGGT 1 -- int111MN NS EA NA WA 700
    About this table

    HapMap Linkage Disequilibrium images for MYL1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for MYL1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing MYL1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    MYL1 for disorders           About GeneDecksing

    OMIM: 160780


    Export disorders and mutations for MYL1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/23 PubMed articles for MYL1 gene, integrated from 7 sources (see all 23):
    (articles sorted by number of sources associating them with MYL1)
    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function. (PubMed id 2304459)1, 3 Hailstones D.L. and Gunning P.W. (1990)
    3. Identification of the functional promoter regions in the human gene encoding the myosin alkali light chains MLC1 and MLC3 of fast skeletal muscle. (PubMed id 2777779)1, 2 Seidel U. and Arnold H.H. (1989)
    4. Alkali myosin light chains in man are encoded by a multigene family that includes the adult skeletal muscle, the embryonic or atrial, and nonsarcomeric isoforms. (PubMed id 2458299)1, 2 Seidel U.... Arnold H.H. (1988)
    5. Assignment of the human fast skeletal muscle myosin alkali light chains gene (MLC1F/MLC3F) to 2q 32.1-2qter. (PubMed id 3422212)1, 3 Cohen-Haguenauer O....Frezal J. (1988)
    6. The complete nucleotide sequences of cDNA clones coding for human myosin light chains 1 and 3. (PubMed id 3601661)1, 2 Seidel U.... Arnold H.H. (1987)
    7. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
    9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    10. Interaction of ADP-ribosylated actin with actin binding proteins. (PubMed id 11707283)1 Ballweber E....Mannherz H.G. (2001)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4632 HGNC: 7582 AceView: MYL1 Ensembl:ENSG00000168530 euGenes: HUgn4632
    ECgene: MYL1 H-InvDB: MYL1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for MYL1 gene:
    Search GeneIP for patents involving MYL1

    GeneCards and IP:
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     ELISAs and CLIAs for MYL1
           

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