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MYO15B Gene

pseudogene   GIFtS: 40

GC17P069007
myosin XVB pseudogene
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
myosin XVB pseudogene1 2     myosin XVB2
MYO15BP1 2 3     FLJ226862
KIAA17832 3     FLJ216062
FLJ444942     Myosin XVBP3
FLJ405772     Unconventional myosin-15B3

External Ids:    HGNC: 140831   Entrez Gene: 800222   Ensembl: ENSG000001881267   UniProtKB: Q96JP23   

Export aliases for MYO15B gene to outside databases

Previous GC identifers: GC17P073562 GC17P076610 GC17P074048 GC17P074182 GC17P074214 GC17P071096


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Function: Unknown, due to the absence of a functinal motor domain


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the MYO15B gene promoter:
         NF-1   SRF   AREB6   Arnt   AhR   CUTL1   GR-beta   GR-alpha   PPAR-gamma2   PPAR-gamma1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for MYO15B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q25.1   Ensembl cytogenetic band:  17q25.1   HGNC cytogenetic band: 17q25

MYO15B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
MYO15B gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P069007:  view genomic region     (about GC identifiers)

Start:
69,007,946 bp from pter
End:
69,046,780 bp from pter
Size:
38,835 bases
Orientation:
plus strand

1 alternative location:
Chr17+ 73,592,471-73,616,761     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2 (See protein sequence)
Recommended Name: Putative myosin-XVB  
Size: 1530 amino acids; 167118 Da
Subcellular location: Cytoplasm (Potential)
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=BAB47412.1; Type=Erroneous initiation;
PDB structures from and Proteopedia :
2DLP (3D)    

Explore the universe of human proteins at neXtProt for MYO15B: NX_Q96JP2 



ENSEMBL proteins: 
ENSP00000293201 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
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Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for MYO15B 
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005737 cytoplasm ----
GO:0005856 cytoskeleton ----
GO:0016459 myosin complex ----
About this table

MYO15B for ontologies           About GeneDecksing



Antibodies for MYO15B: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for MYO15B 
Browse antibodies at Epitomics

Assays for MYO15B: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for MYO15B 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

MYO15B for domains           About GeneDecksing

5 InterPro domains/families:
 IPR001452 SH3_domain
 IPR011511 SH3_2
 IPR000857 MyTH4_dom
 IPR000048 IQ_motif_EF-hand-BS
 IPR001609 Myosin_head_motor_dom

Graphical View of Domain Structure for InterPro Entry Q96JP2

ProtoNet protein and cluster: Q96JP2

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Similarity: Contains 1 IQ domain
Similarity: Contains 1 myosin head-like domain
Similarity: Contains 1 MyTH4 domain
Similarity: Contains 1 SH3 domain


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Function: Unknown, due to the absence of a functinal motor domain

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): MYO15B
OriGene shRNA RFP (see all 4): MYO15B
OriGene basic RS shRNA (see all 4): MYO15B
Browse OriGene siRNA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MYO15B 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MYO15B 
Search SABiosciences for Assays for microRNAs that regulate MYO15B

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene untagged cDNA clones in CMV expression vector: MYO15B
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for MYO15B 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for MYO15B 

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0003774 motor activity ----
GO:0005524 ATP binding ----
About this table

MYO15B for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

    SABiosciences Custom Pathway-Focused PCR Arrays for MYO15B 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for MYO15B

5/762 Interacting proteins for MYO15B (Q96JP22) via UniProtKB, MINT, and/or STRING (see all 762)
InteractantInteraction Details
GeneCardExternal ID(s)
ABCF1Q8NE712MINT-7945693 MINT-7947479
ABCF3Q9NUQ82MINT-7945693 MINT-7947479
ACTBP607092MINT-7945693 MINT-7947479
ACTL6AO960192MINT-7945693 MINT-7947479
ACTR1AP611632MINT-7945693 MINT-7947479
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for MYO15B


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Browse siRNA at Sigma-Aldrich
Browse shRNA at Sigma-Aldrich
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): MYO15B
OriGene shRNA RFP (see all 4): MYO15B
OriGene basic RS shRNA (see all 4): MYO15B
Browse OriGene siRNA
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of MYO15B 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of MYO15B 
Search SABiosciences for Assays for microRNAs that regulate MYO15B
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene untagged cDNA clones in CMV expression vector: MYO15B
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for MYO15B 
Primers: OriGene genome-wide validated SYBR primer pairs: MYO15B
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for MYO15B: PPH58350A

Additional cDNA sequence: 

AB058686.1 AF418286.1 AF418287.1 AF418288.1 AF418289.1 AF418290.1 AF418291.1 AF418292.1 
AF418293.1 AK021565.1 AK025259.1 AK026339.1 AK074680.1 AK096869.1 AK097896.1 AK126458.1 
AL713730.1 BC027875.1 BC033247.1 BC128044.1 

24/25 DOTS entries (see all 25):

DT.91698295  DT.95219972  DT.95128851  DT.100839076  DT.97762728  DT.92016722  DT.446323  DT.100788332 
DT.91877344  DT.120933939  DT.120933861  DT.91938197  DT.120933718  DT.305713  DT.91677389  DT.95219967 
DT.95219969  DT.97786836  DT.120933767  DT.91824797  DT.91839463  DT.95219957  DT.95248710  DT.75101229 

24/186 AceView cDNA sequences (see all 186):

AW339946 BM791149 BM977966 AI537992 CB155174 CA412202 CD244282 AI569620 
BU615924 AB058686 BX504202 AI344135 BM996595 BC027875 BE501985 AI283270 
AV649878 BF899041 BQ574071 BI766913 BF476683 AI825877 AL713730 AA292802 

highest scoring ESTs for MYO15B:

AI671062 AA335984 AA448391 AA448394 AB058686 AF418292 AF418293 AI023330 AI283270 AI344135 

Unigene Cluster for MYO15B:

Myosin XVB pseudogene
Hs.390817  [show with all ESTs]
Unigene Representative Sequence: AF418290


GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for MYO15B (see all 22)

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^
SP1:        -     -                 -                                         -     -                             -     -                                       
SP2:                                                                                                                                                            
SP3:                                                                                                                                                            
SP4:                                                                                                                                                            
SP5:                                                                                                                                                            

ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23a · 23b ^ 24 ^ 25 ^ 26 ^ 27 ^ 28a · 28b · 28c ^ 29a · 29b · 29c · 29d ^ 30a · 30b ^ 31a · 31b · 31c ^ 32 ^ 33a · 33b ^ 34 ^
SP1:                                                                                                                                                            
SP2:                                                                                                                                                            
SP3:                                -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -   
SP4:                                                                                                        -                             -                     
SP5:                                                                                                                                      -                     

ExUns: 35a · 35b · 35c ^ 36a · 36b · 36c ^ 37a · 37b ^ 38a · 38b ^ 39a · 39b ^ 40 ^ 41 ^ 42a · 42b · 42c ^ 43 ^ 44a · 44b · 44c ^ 45a · 45b ^ 46 ^ 47 ^ 48a ·
SP1:                                                                                                                                                            
SP2:                                                                                                                    -     -                                 
SP3:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -         
SP4:  -                                                                                                                                                         
SP5:  -                                                                                                                                                         

ExUns: 48b ^ 49 ^ 50 ^ 51 ^ 52 ^ 53 ^ 54 ^ 55 ^
SP1:                                                
SP2:                                                
SP3:                                                
SP4:                                                
SP5:                                                

About this scheme

ECgene alternative splicing isoforms for MYO15B
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000293201(uc002jom.1 uc002jon.1 uc002joo.1 uc010dgh.2 uc010wse.1 uc002joq.2 uc010dgi.1 uc002jor.1 uc010dgj.1)


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

MYO15B expression in normal and diseased human tissues

1  / 2  / 3

9 probe-sets matching MYO15B gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
50958_s_at2, 3 U95-C 2 1.00 0.97 0.90 0.90 AI671062 0.80 1.00 0.91 1
59375_at2, 3 U133-C 2 1.00 0.84 0.96 1.15 AI825877 0.60 0.62 0.61 1
86896_at2, 3 U95-D 1 0.44 1.00 -0.01 0.95 AA806396 0.60 0.75 0.68 1
59375_at2, 3 U133-A 2 1.00 0.84 -- -- AI825877 0.60 0.62 0.61 1
219173_at2, 3 U133-A 2 1.00 0.68 -- -- NM_024957 0.20 1.00 0.72 1
227743_at2, 3 U133-B 3 0.91 0.77 -- -- AI671062 0.80 1.00 0.91 1
59375_at2 U133Plus2 2 1.00 0.84 -- -- -- -- -- -- --
219173_at2 U133Plus2 2 1.00 0.68 -- -- -- -- -- -- --
227743_at2 U133Plus2 3 0.91 0.77 -- -- -- -- -- -- --
About this table

MYO15B for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
MYO15B gene expression
MYO15B gene electronic northern expression
MYO15B gene sage expression
About these images

CGAP SAGE TAG: GGAGAAACAG

SOURCE GeneReport for Unigene cluster: Hs.390817

UniProtKB/Swiss-Prot: MY15B_HUMAN, Q96JP2
Tissue specificity: Detected in brain, stomach and kidney

Primers: OriGene genome-wide validated SYBR primer pairs: MYO15B
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for MYO15B: PPH58350A
    SABiosciences Custom PCR Arrays for MYO15B 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for MYO15B gene from 1 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
mouse
(Mus musculus)
Myo15b5 11 (80.91 cM) myosin XVB   -- BF581819 
About this table        Species with no ortholog for MYO15B

ENSEMBL Gene Tree for MYO15B (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
  --

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for MYO15B
     7 CNVs: 53444 5031 49926 30025 30024 49928 29672
Search QIAGEN SeqTarget long-range PCR primers for resequencing for MYO15B 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

8 PubMed articles for MYO15B gene integrated from 7 sources:
(articles sorted by number of sources associating them with MYO15B)
  1. A millennial myosin census. (PubMed id 11294886)1, 2, 3 Berg J.S.... Cheney R.E. (2001)
  2. Human myosin XVBP is a transcribed pseudogene. (PubMed id 11964073)1, 2, 7 Boger E.T.... Friedman T.B. (2001)
  3. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11347906)1, 2 Nagase T.... Ohara O. (2001)
  4. Exploration of human ORFeome: high-throughput prepara tion of ORF clones and efficient characterization of their protein products. (PubMed id 18316326)1 Nagase T....Ohara O. (2008)
  5. Towards a proteome-scale map of the human protein-protein interaction network. (PubMed id 16189514)1 Rual J.F....Vidal M. (2005)
  6. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)1 Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 80022 HGNC: 14083 AceView: MYO15B Ensembl:ENSG00000188126 euGenes: HUgn80022
ECgene: MYO15B H-InvDB: MYO15B

(According to HUGE)
About This Section
HUGE: KIAA1783

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
  --

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for MYO15B gene:
Search GeneIP for patents involving MYO15B

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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