Aliases &
Descriptions
for MYRIP gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| myosin VIIA and Rab interacting protein1 2 | | FLJ440252 | | SLAC2C1 2 3 5 | | MGC1300342 | | DKFZp586F10181 2 | | synaptotagmin-like protein homologue lacking C2 domains-c2 | | exophilin-81 2 | | rab effector MyRIP2 | | SLAC2-C1 2 | | Slp homologue lacking C2 domains2 | | Myosin-VIIa- and Rab-interacting protein2 3 | | OTTHUMP000002092072 | | Slp homolog lacking C2 domains c2 3 | | MGC1300352 | | MyRIP1 | | SlaC2-c3 | | OTTHUMP000002092092 | | Exophilin-83 |
Export aliases for MYRIP gene to outside databasesPrevious GC identifers: GC03P039190 GC03P039084 GC03P039664 GC03P039811 |
Summaries
for MYRIP gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and themotor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments (By similarity)
|
Genomic Views
for MYRIP gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the MYRIP gene promoter:
E4BP4 CUTL1 Chx10 MyoD Egr-1 Cdc5 POU2F1 E47 Pax-5 Arnt
Other transcription factors
Search SABiosciences Chromatin IP Primers for MYRIP
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for MYRIP  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3p22.1 Ensembl cytogenetic band: 3p22.1 HGNC cytogenetic band: 3p21.33MYRIP Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P039826: view genomic region
(about GC identifiers)
Start:
|
39,850,405 bp from pter |
End:
|
40,301,812 bp from pter |
Size:
|
451,408 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000003.11 NT_022517.18
|
Proteins
for MYRIP gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9 (See
protein sequence)Recommended Name: Rab effector MyRIP Size: 859 amino acids; 95706 Da
Subunit: Binds MYO5A, MYO7A and F-actin (By similarity). Binds RAB27A that has been activated by GTP-binding via itsN-terminus
Subcellular location: Cytoplasm (By similarity). Note=In pre- and post-synaptic areas in photoreceptor cells and in thebasal microvilli of retinal pigment epithelium cells. Associated with melanosomes. Colocalizes with actin filaments(By similarity)
Secondary accessions: Q569F7 Q8IUF5 Q9Y3V4Explore the universe of human proteins at neXtProt for MYRIP: NX_Q8NFW9
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_056275.2
ENSEMBL proteins: ENSP00000398665 ENSP00000301972 ENSP00000389323 ENSP00000400916 ENSP00000413392 ENSP00000379519
Human Recombinant Proteins
5 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
MYRIP for ontologies About GeneDecksing
Antibodies for MYRIP:
Assays for MYRIP: |
Protein
Domains/
Families
for MYRIP gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
MYRIP for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NFW9ProtoNet protein and cluster: Q8NFW9 1 Blocks protein family: IPB000306 Zn-finger
UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9Similarity: Contains 1 FYVE-type zinc fingerSimilarity: Contains 1 RabBD (Rab-binding) domain |
Gene Function
for MYRIP gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9Function: Rab effector protein involved in melanosome transport. Serves as link between melanosome-bound RAB27A and themotor proteins MYO5A and MYO7A. May link RAB27A-containing vesicles to actin filaments (By similarity)
5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6): About this table
MYRIP for ontologies About GeneDecksing
|
Pathways & Interactions
for MYRIP gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for MYRIP
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for MYRIP
4 Interacting proteins for MYRIP (Q8NFW91, 2) via UniProtKB, MINT, and/or STRINGAbout this table
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006886 | intracellular protein transport |
IEA | -- |
About this table
MYRIP for ontologies About GeneDecksing
|
Drugs & Compounds
for MYRIP gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for MYRIP
|
Transcripts
for MYRIP gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for MYRIP gene: NM_015460.2 Additional cDNA sequence: AB083783.1 AF396687.1 AK125334.1 AK126013.1 AK294714.1 AK310972.1 AK312412.1 AK316068.1 AL050090.1 BC092512.1 BC109311.1 BC109312.1 6 DOTS entries: DT.411498 DT.99954773 DT.120871429 DT.40246508 DT.439321 DT.75104804 24/51 AceView cDNA sequences (see all 51): AB083783 F07858 AW237186 AA195295 AL050090 AW665105 AA455367 AA258345 AA974678 AI827924 AA323164 BF478223 AW594282 F01507 AA579870 Z45990 AV692363 CF138044 AK125334 AK126013 AA317752 AA318334 Z41987 AI434843
 highest scoring ESTs for MYRIP:AL050090 AA195099 AA195295 AA258345 AA258393 AA455367 AA579870 AA857208 AA974678 AI434843 Unigene Cluster for MYRIP: Myosin VIIA and Rab interacting protein Hs.594535 [show with all ESTs]Unigene Representative Sequence: BC092512
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for MYRIP
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | · | 17c |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for MYRIP
9 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000444716 ENST00000302541(uc003cka.2 uc010hhu.2 uc010hhv.2 uc010hhw.2 uc011ayz.1)
ENST00000425621 ENST00000458441 ENST00000458292 ENST00000475082(uc010hhx.1)
ENST00000459828 ENST00000482033 ENST00000396217
|
Expression
for MYRIP gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| MYRIP expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching MYRIP gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39602_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
1.00 |
1.00 |
AL050090 |
1.00 |
1.00 |
1.00 |
1 |
| 214156_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
AL050090 |
1.00 |
1.00 |
1.00 |
1 |
| 214156_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
MYRIP for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTATATGCAC
SOURCE GeneReport for Unigene cluster: Hs.594535
Expression variation in blood from EXPOLDB for MYRIP UniProtKB/Swiss-Prot: MYRIP_HUMAN, Q8NFW9Tissue specificity: Detected in brain, skin, heart, adrenal medulla, pancreas, intestine, liver, kidney, muscle andtestis
SABiosciences Custom PCR Arrays for MYRIP
|
Orthologs
for MYRIP gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for MYRIP gene from 5/7 species (see all 7)
About this table Species with no ortholog for MYRIP
ENSEMBL Gene Tree for MYRIP (if available) |
Paralogs
for MYRIP gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for MYRIP gene
- MLPH2 MOBP2
MYRIP for paralogs About GeneDecksing
|
Genomic Variants
for MYRIP gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for MYRIP (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for MYRIP
1 CNV: 91287
1 Indel: 42611 | | QIAGEN SeqTarget long-range PCR primers for resequencing MYRIP |
|
Disorders & Mutations
for MYRIP gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
MYRIP for disorders About GeneDecksing
OMIM: 611790
Human Genome Epidemiology (HuGE) Navigator: MYRIP (2 documents)
Export disorders and mutations for MYRIP gene to outside databases
|
Medical News
for MYRIP gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for MYRIP gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/21 PubMed articles for MYRIP gene, integrated from 7 sources (see all 21):
(articles sorted by number of sources associating them with MYRIP)- Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. (PubMed id 12221080)1, 2, 3, 7 Fukuda M. and Kuroda T.S. (2002)
- MyRIP, a novel Rab effector, enables myosin VIIa recruitment to retinal melanosomes. (PubMed id 11964381)1, 2, 3 El-Amraoui A.... Petit C. (2002)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
- Genome-wide association identifies SKIV2L and MYRIP a s protective factors for age-related macular degeneration. (PubMed id 20861866)1 Kopplin L.J....Iyengar S.K. (2010)
- Rab27a and MyRIP regulate the amount and multimeric s tate of VWF released from endothelial cells. (PubMed id 19270261)1 Nightingale T.D....Cutler D.F. (2009)
- Intramanchette transport during primate spermiogenesis: expression of dynein, myosin Va, motor recruiter myosin Va, VIIa-Rab27a/b interacting protein, and Rab27b in the manchette during human and monkey spermiogenesis. (PubMed id 18478159)1 Hayasaka S....Okamura K. (2008)
- Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. (PubMed id 17287340)2 Molina H.... Pandey A. (2007)
- MyRIP anchors protein kinase A to the exocyst complex. (PubMed id 17827149)1 Goehring A.S....Scott J.D. (2007)
- Genome-wide association of sleep and circadian phenotypes. (PubMed id 17903308)1 Gottlieb D.J....Wilk J.B. (2007)
|
External Searches for MYRIP gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing MYRIP gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing MYRIP gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing MYRIP gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for MYRIP gene:
Search GeneIP for patents involving MYRIP
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for MYRIP gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for MYRIP |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for MYRIP |
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