Aliases &
Descriptions
for NACA gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| nascent polypeptide-associated complex alpha subunit1 2 | | alpha-NAC2 | | NACA11 2 | | MGC1172242 | | nascent-polypeptide-associated complex alpha polypeptide1 2 | | Alpha-NAC3 | | NAC-alpha2 3 | | Allergen Hom s 23 | | nascent polypeptide-associated complex subunit alpha2 | | |
Export aliases for NACA gene to outside databasesPrevious GC identifers: GC12M057078 GC12M057330 GC12M056820 GC12M055392 |
Summaries
for NACA gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds tonascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognitionparticle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity ofribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN,binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters
Gene Wiki entry for NACA |
Genomic Views
for NACA gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NACA gene promoter:
p53 GR-beta GR-alpha AP-1 YY1 PPAR-gamma2 PPAR-gamma1 LUN-1 MIF-1 FOXL1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NACA
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q23-q24.1 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q23-q24.1NACA Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M054144: view genomic region
(about GC identifiers)
Start:
|
54,144,919 bp from pter |
End:
|
54,157,979 bp from pter |
Size:
|
13,061 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr12- 57,094,565-57,119,326 |
RefSeq DNA sequence:- NC_000012.11 NT_029419.12
|
Proteins
for NACA gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765 (See
protein sequence)Recommended Name: Nascent polypeptide-associated complex subunit alpha Size: 215 amino acids; 23384 Da
Subunit: Interacts with TBP and JUN (By similarity). Part of the nascent polypeptide-associated complex (NAC),consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascentpolypeptide chains. Interacts with ASFV protein H339R
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus
Allergen: Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgEautoantigen in atopic dermatitis (AD) patients with severe skin manifestations
Sequence caution: Sequence=AAV83778.1; Type=Erroneous initiation;
PDB structures from  and Proteopedia  :3LKX (3D)
3MCB (3D)
3MCE (3D)
Secondary accessions: Q3KQV4 Q53A18 Q53G46Explore the universe of human proteins at neXtProt for NACA: NX_Q13765
Post-translational modifications:
Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 byGSK3B may promote proteasome mediated degradation (By similarity). Phosphorylated upon DNA damage, probably by ATM orATR1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (4 alternative transcripts):
NP_001106672.1 NP_001106673.1 NP_001106674.1 NP_005585.1
ENSEMBL proteins: ENSP00000397352 ENSP00000377469 ENSP00000401911 ENSP00000403817 ENSP00000349212
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
NACA for ontologies About GeneDecksing
Antibodies for NACA:
Assays for NACA: |
Protein
Domains/
Families
for NACA gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NACA for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13765ProtoNet protein and cluster: Q13765 UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765Similarity: Belongs to the NAC-alpha familySimilarity: Contains 1 NAC-A/B (NAC-alpha/beta) domainSimilarity: Contains 1 UBA domain |
Gene Function
for NACA gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds tonascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognitionparticle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity ofribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN,binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters
Genatlas biochemistry entry for NACA:nascent polypeptide-associated complex A/1.9.2,with two alternatively spliced isoform,acting as a muscle specificisoform4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
NACA for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Naca):
NACA for phenotypes About GeneDecksing
|
Pathways & Interactions
for NACA gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
NACA for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for NACA
SABiosciences Custom Pathway-Focused PCR Arrays for NACA
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for NACA
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NACA
5/9 Interacting proteins for NACA (Q137652) via UniProtKB, MINT, and/or STRING (see all 9)About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
NACA for ontologies About GeneDecksing
|
Drugs & Compounds
for NACA gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NACA
|
Transcripts
for NACA gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NACA gene (4 alternative transcripts): NM_001113201.1 NM_001113202.1 NM_001113203.1 NM_005594.4 Additional cDNA sequence: AF054187.1 AK090650.1 AK096699.1 AK223085.1 AK293209.1 AK311904.1 AY034001.1 AY605660.1 AY911673.1 BC105120.1 BC105122.1 BC106041.1 CR450295.1 CR595197.1 CR599103.1 CR600016.1 CR600421.1 CR600671.1 CR603573.1 CR613486.1 CR618000.1 CR619360.1 CR624198.1 CR626308.1 X80909.1 24/75 DOTS entries (see all 75): DT.100889874 DT.91783886 DT.91733258 DT.97868164 DT.91840150 DT.91718355 DT.95228035 DT.452984 DT.121209295 DT.100889890 DT.91783876 DT.100889895 DT.121209326 DT.121209266 DT.121209229 DT.95228084 DT.121232286 DT.100889896 DT.92056217 DT.121209132 DT.95228072 DT.121209279 DT.86993099 DT.91807751 24/1512 AceView cDNA sequences (see all 1512): T34648 AI362603 CA388726 CD677734 AU139596 BM852633 BI042621 BF830829 BG319509 BU683252 CR600421 AW103530 AU077070 BF062247 AA670063 BU167524 BF093885 CR603573 BF857436 BE622578 BI858408 BU182929 BM850909 BP870848
 highest scoring ESTs for NACA:AF054187 AA082652 AA309058 AA730378 AK090650 AK096699 AL544444 AL558962 AL570572 AL580672 Unigene Cluster for NACA: Nascent polypeptide-associated complex alpha subunit Hs.505735 [show with all ESTs]Unigene Representative Sequence: NM_001113203
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NACA (see all 7)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | - | | | | |
| SP2: | | | | | - | | - | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NACA
5 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000435567(uc001slz.2) ENST00000393891(uc001sly.2) ENST00000450688
ENST00000454682(uc009zoy.1 uc001smc.2 uc001sma.2 uc001smb.2 uc010squ.1)
ENST00000356769
|
Expression
for NACA gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NACA expression in normal and diseased human tissues
1 / 2 / 3 7 probe-sets matching NACA gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 39740_g_at2, 3
|
U95-A |
5 |
1.00 |
0.84 |
0.75 |
0.96 |
AF054187 |
1.00 |
0.77 |
0.89 |
1 |
| 39739_at2, 3
|
U95-A |
4 |
1.00 |
0.55 |
0.89 |
0.99 |
AF054187 |
1.00 |
0.77 |
0.89 |
1 |
| 88137_at2, 3
|
U95-E |
6 |
0.75 |
0.45 |
0.89 |
1.06 |
AI992187 |
0.60 |
0.83 |
0.73 |
1 |
| 208635_x_at2, 3
|
U133-A |
4 |
1.00 |
0.85 |
-- |
-- |
BF976260 |
0.40 |
0.75 |
0.60 |
1 |
| 200735_x_at2, 3
|
U133-A |
4 |
1.00 |
0.85 |
-- |
-- |
NM_005594 |
0.60 |
0.83 |
0.73 |
1 |
| 208635_x_at2
|
U133Plus2 |
4 |
1.00 |
0.85 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 200735_x_at2
|
U133Plus2 |
4 |
1.00 |
0.85 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NACA for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCACAAGCAA
SOURCE GeneReport for Unigene cluster: Hs.505735
Expression variation in blood from EXPOLDB for NACA UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765Tissue specificity: Ubiquitously expressed
SABiosciences Custom PCR Arrays for NACA
|
Orthologs
for NACA gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NACA gene from 5/17 species (see all 17)
About this table Species with no ortholog for NACA
ENSEMBL Gene Tree for NACA (if available) |
Paralogs
for NACA gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NACA gene
- NACAD2 NACA22
NACA for paralogs About GeneDecksing
|
Genomic Variants
for NACA gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 12 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NACA (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 9 variations for NACA
8 CNVs: 86397 76054 76051 71518 86395 86396 76053 76052
1 Indel: 45060 | | QIAGEN SeqTarget long-range PCR primers for resequencing NACA |
|
Disorders & Mutations
for NACA gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NACA for disorders About GeneDecksing
OMIM: 601234
2  Novoseek disease relationships for NACA gene
About this table
Export disorders and mutations for NACA gene to outside databases
|
Medical News
for NACA gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NACA gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/56 PubMed articles for NACA gene, integrated from 7 sources (see all 56):
(articles sorted by number of sources associating them with NACA)- NACA is a positive regulator of human erythroid-cell differentiation. (PubMed id 15784678)1, 2, 7 Lopez S....Gomez S. (2005)
- Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides. (PubMed id 15196207)1, 2, 7 Al-Shanti N.... Rowbottom A.W. (2004)
- Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. (PubMed id 12689679)1, 2, 7 Papachristou D.J....Papavassiliou A.G. (2003)
- Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function. (PubMed id 12684039)1, 2 Stilo R.... Vito P. (2003)
- Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PubMed id 12209604)1, 2 Behrends U.... Mautner J.M. (2002)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions. (PubMed id 10982809)1, 2 Beatrix B.... Wiedmann M. (2000)
- A protein complex required for signal-sequence-specific sorting and translocation. (PubMed id 8047162)1, 3 Wiedmann B....Wiedmann M. (1994)
|
External Searches for NACA gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NACA gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NACA gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NACA gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NACA gene:
Search GeneIP for patents involving NACA
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NACA gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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