Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



NACA Gene

protein-coding   GIFtS: 53

GC12M054144
nascent polypeptide-associated complex alpha subunit
(Previous name: nascent-polypeptide-associated complex alpha polypeptide )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
nascent polypeptide-associated complex alpha subunit1 2     alpha-NAC2
NACA11 2     MGC1172242
nascent-polypeptide-associated complex alpha polypeptide1 2     Alpha-NAC3
NAC-alpha2 3     Allergen Hom s 23
nascent polypeptide-associated complex subunit alpha2     

External Ids:    HGNC: 76291   Entrez Gene: 46662   Ensembl: ENSG000001965317   UniProtKB: Q137653   

Export aliases for NACA gene to outside databases

Previous GC identifers: GC12M057078 GC12M057330 GC12M056820 GC12M055392


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765
Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to
nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition
particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of
ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN,
binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters

Gene Wiki entry for NACA

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NACA gene promoter:
         p53   GR-beta   GR-alpha   AP-1   YY1   PPAR-gamma2   PPAR-gamma1   LUN-1   MIF-1   FOXL1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for NACA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q23-q24.1   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q23-q24.1

NACA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NACA gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M054144:  view genomic region     (about GC identifiers)

Start:
54,144,919 bp from pter
End:
54,157,979 bp from pter
Size:
13,061 bases
Orientation:
minus strand

1 alternative location:
Chr12- 57,094,565-57,119,326     
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765 (See protein sequence)
Recommended Name: Nascent polypeptide-associated complex subunit alpha  
Size: 215 amino acids; 23384 Da
Subunit: Interacts with TBP and JUN (By similarity). Part of the nascent polypeptide-associated complex (NAC),
consisting of NACA and BTF3. NAC associates with ribosomes through the BTF3 subunit. Both subunits can contact nascent
polypeptide chains. Interacts with ASFV protein H339R
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Also found in nucleus
Allergen: Causes an allergic reaction in human. Binds to IgE from atopic dermatitis (AD) patients. Identified as an IgE
autoantigen in atopic dermatitis (AD) patients with severe skin manifestations
Sequence caution: Sequence=AAV83778.1; Type=Erroneous initiation;
PDB structures from and Proteopedia :
3LKX (3D)    3MCB (3D)    3MCE (3D)    
Secondary accessions: Q3KQV4 Q53A18 Q53G46

Explore the universe of human proteins at neXtProt for NACA: NX_Q13765 

Post-translational modifications:

  • Phosphorylation of Ser-43 by ILK during cell adhesion may promote nuclear localization. Phosphorylation of Thr-159 by
  • GSK3B may promote proteasome mediated degradation (By similarity). Phosphorylated upon DNA damage, probably by ATM or
    ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001106672.1  NP_001106673.1  NP_001106674.1  NP_005585.1  


    ENSEMBL proteins: 
    ENSP00000397352 ENSP00000377469 ENSP00000401911 ENSP00000403817 ENSP00000349212 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NACA
    GenScript Custom Purified and Recombinant Proteins Services for NACA 
    Novus Biologicals Protein for NACA
    Novus Biologicals Lysate for NACA
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005854 nascent polypeptide-associated complex TAS8047162
    About this table

    NACA for ontologies           About GeneDecksing



    Antibodies for NACA: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NACA
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for NACA 
    Novus Biologicals Antibody for NACA
    Browse antibodies at Epitomics

    Assays for NACA: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NACA 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NACA for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR016641 Nas_poly-pep-assoc_cplx_asu
     IPR002715 Nas_poly-pep-assoc_cplx

    Graphical View of Domain Structure for InterPro Entry Q13765

    ProtoNet protein and cluster: Q13765

    UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765
    Similarity: Belongs to the NAC-alpha family
    Similarity: Contains 1 NAC-A/B (NAC-alpha/beta) domain
    Similarity: Contains 1 UBA domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765
    Function: Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to
    nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition
    particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of
    ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN,
    binding to DNA and stabilizing the interaction of JUN homodimers with target gene promoters

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for NACA
    Sigma-Aldrich shRNA for NACA
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): NACA
    OriGene shRNA RFP (see all 4): NACA
    OriGene basic RS shRNA (see all 4): NACA
    OriGene siRNA (see all 4): NACA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NACA 
    miRNA:Sigma-Aldrich microRNA Mimics for NACA
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NACA 
    Search SABiosciences for Assays for microRNAs that regulate NACA

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: NACA
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NACA
    OriGene untagged cDNA clones in CMV expression vector (see all 4): NACA
    OriGene 3'-UTR clone (see all 4): NACA 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NACA 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for NACA 

    Genatlas biochemistry entry for NACA:
    nascent polypeptide-associated complex A/1.9.2,with two alternatively spliced isoform,acting as a muscle specific
    isoform

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677 DNA binding IEA--
    GO:0003713 transcription coactivator activity ----
    GO:0005515 protein binding ----
    GO:0017025 TATA-binding protein binding ----
    About this table

    NACA for ontologies           About GeneDecksing

    Animal Models: 1 MGI mutant phenotype (inferred from 1 allele(MGI details for Naca):

    skeleton

    NACA for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    NACA for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  NACA
        ILK Signaling

        SABiosciences Custom Pathway-Focused PCR Arrays for NACA 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for NACA
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NACA

    5/9 Interacting proteins for NACA (Q137652) via UniProtKB, MINT, and/or STRING (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APLP1P516932MINT-64152
    C1orf103Q5T3J32MINT-64156
    CCDC90BQ9GZT62MINT-64154
    FUNDC2Q9BWH22MINT-64155
    IGSF21Q96ID52MINT-64153
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006350 transcription IEA--
    GO:0006412 translation TAS8047162
    GO:0015031 protein transport IEA--
    GO:0044419 interspecies interaction between organisms IEA--
    About this table

    NACA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NACA


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for NACA
    Sigma-Aldrich shRNA for NACA
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): NACA
    OriGene shRNA RFP (see all 4): NACA
    OriGene basic RS shRNA (see all 4): NACA
    OriGene siRNA (see all 4): NACA
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NACA 
    miRNA: Sigma-Aldrich microRNA Mimics for NACA
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NACA 
    Search SABiosciences for Assays for microRNAs that regulate NACA
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: NACA
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NACA
    OriGene untagged cDNA clones in CMV expression vector (see all 4): NACA
    OriGene 3'-UTR Clone (see all 4): NACA 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NACA 
    Primers: OriGene genome-wide validated SYBR primer pairs: NACA
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NACA: PPH08978A

    REFSEQ mRNAs for NACA gene (4 alternative transcripts): 

    NM_001113201.1  NM_001113202.1  NM_001113203.1  NM_005594.4  

    Additional cDNA sequence: 

    AF054187.1 AK090650.1 AK096699.1 AK223085.1 AK293209.1 AK311904.1 AY034001.1 AY605660.1 
    AY911673.1 BC105120.1 BC105122.1 BC106041.1 CR450295.1 CR595197.1 CR599103.1 CR600016.1 
    CR600421.1 CR600671.1 CR603573.1 CR613486.1 CR618000.1 CR619360.1 CR624198.1 CR626308.1 
    X80909.1 

    24/75 DOTS entries (see all 75):

    DT.100889874  DT.91783886  DT.91733258  DT.97868164  DT.91840150  DT.91718355  DT.95228035  DT.452984 
    DT.121209295  DT.100889890  DT.91783876  DT.100889895  DT.121209326  DT.121209266  DT.121209229  DT.95228084 
    DT.121232286  DT.100889896  DT.92056217  DT.121209132  DT.95228072  DT.121209279  DT.86993099  DT.91807751 

    24/1512 AceView cDNA sequences (see all 1512):

    T34648 AI362603 CA388726 CD677734 AU139596 BM852633 BI042621 BF830829 
    BG319509 BU683252 CR600421 AW103530 AU077070 BF062247 AA670063 BU167524 
    BF093885 CR603573 BF857436 BE622578 BI858408 BU182929 BM850909 BP870848 

    highest scoring ESTs for NACA:

    AF054187 AA082652 AA309058 AA730378 AK090650 AK096699 AL544444 AL558962 AL570572 AL580672 

    Unigene Cluster for NACA:

    Nascent polypeptide-associated complex alpha subunit
    Hs.505735  [show with all ESTs]
    Unigene Representative Sequence: NM_001113203


    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NACA (see all 7)

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10
    SP1:                                -     -                 -     -     -                             -         
    SP2:              -     -           -     -                 -     -     -                                       
    SP3:                    -           -     -                 -     -     -                                       
    SP4:              -     -           -     -                                                                     
    SP5:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for NACA
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000435567(uc001slz.2) ENST00000393891(uc001sly.2) ENST00000450688
    ENST00000454682(uc009zoy.1 uc001smc.2 uc001sma.2 uc001smb.2 uc010squ.1)
    ENST00000356769

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    NACA expression in normal and diseased human tissues

    1  / 2  / 3

    7 probe-sets matching NACA gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    39740_g_at2, 3 U95-A 5 1.00 0.84 0.75 0.96 AF054187 1.00 0.77 0.89 1
    39739_at2, 3 U95-A 4 1.00 0.55 0.89 0.99 AF054187 1.00 0.77 0.89 1
    88137_at2, 3 U95-E 6 0.75 0.45 0.89 1.06 AI992187 0.60 0.83 0.73 1
    208635_x_at2, 3 U133-A 4 1.00 0.85 -- -- BF976260 0.40 0.75 0.60 1
    200735_x_at2, 3 U133-A 4 1.00 0.85 -- -- NM_005594 0.60 0.83 0.73 1
    208635_x_at2 U133Plus2 4 1.00 0.85 -- -- -- -- -- -- --
    200735_x_at2 U133Plus2 4 1.00 0.85 -- -- -- -- -- -- --
    About this table

    NACA for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    NACA gene expression
    NACA gene electronic northern expression
    NACA gene sage expression
    About these images

    CGAP SAGE TAG: TCACAAGCAA

    SOURCE GeneReport for Unigene cluster: Hs.505735

    Expression variation in blood from EXPOLDB for NACA

    UniProtKB/Swiss-Prot: NACA_HUMAN, Q13765
    Tissue specificity: Ubiquitously expressed

    Primers: OriGene genome-wide validated SYBR primer pairs: NACA
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NACA: PPH08978A
        SABiosciences Custom PCR Arrays for NACA 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for NACA gene from 5/17 species (see all 17)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC6130131   -- similar to nascent polypeptide-associated complex alpha more 95.97(n)
    100(a)
    613013  XM_850343.1  XP_855436.1 
    chimpanzee
    (Pan troglodytes)
    NACA1   -- nascent polypeptide-associated complex alpha subunit 92.83(n)
    92.06(a)
    452434  XM_509538.2  XP_509538.2 
    cow
    (Bos taurus)
    NACA1   -- nascent polypeptide-associated complex alpha subunit 95.5(n)
    99.53(a)
    513312  NM_001014916.2  NP_001014916.1 
    rat
    (Rattus norvegicus)
    Naca1   -- nascent-polypeptide-associated complex alpha polypeptide 84.34(n)
    91.16(a)
    288770  XM_213821.3  XP_213821.2 
    mouse
    (Mus musculus)
    Naca1 , 5 10 (76.39 cM)5
    nascent polypeptide-associated complex alpha polypeptide1, 5 90.23(n)1
    99.07(a)1
    179381  NM_013608.21  NP_038636.21 
     AI9562115  AK1461495  (see all 29)
    About this table        Species with no ortholog for NACA

    ENSEMBL Gene Tree for NACA (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for NACA gene
    NACAD2  NACA22  

    NACA for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/123 NCBI SNPs in NACA are shown (see all 123)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 12 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs47881,2
    C,F,A,H,57106660(-) GACATA/TGAATT 8 I syn1 ref1 ese313Minor allele frequency- T:0.29NA EA MN WA 1608
    rs49011,2
    --57107396(-) AATATC/ACTCTT 8 /I syn1 ref11Minor allele frequency- A:0.00MN 184
    rs49021,2
    C,F,57108203(-) GAAATA/C/G/
            
    GATGA
    16 I M syn1 mis1 ref111MN NA EA WA 666
    rs8986091,2
    C,F,O,A,H,57106810(-) CTCGCT/CGTATA 4 -- int122Minor allele frequency- C:0.38MN NS EA NA WA 2796
    rs10786041,2
    C,F,57107154(+) tagggG/Tgtagt 4 -- int17Minor allele frequency- T:0.09NS EA MN NA WA 724
    rs10786051,2
    --57107267(+) agcagT/Cgctga 4 -- int11Minor allele frequency- C:0.00MN 184
    rs14663821,2
    C,F,O,A,57116834(-) GGTAGC/TGTTTT 4 -- int123Minor allele frequency- N:0.00MN NS EA NA WA 1470
    rs18023041,2
    --57106301(-) TTTTTC/TTGGTG 4 -- ut310--------
    rs22908941,2
    C,F,A,H,57108695(-) GATTAC/GTCCTC 4 -- int115Minor allele frequency- G:0.36EA NS NA WA 2132
    rs28604821,2
    C,A,H57105938(+) TTTCAC/ACGTGT 4 -- ng316Minor allele frequency- A:0.08NA WA 12
    About this table

    HapMap Linkage Disequilibrium images for NACA (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 9 variations for NACA
         8 CNVs: 86397 76054 76051 71518 86395 86396 76053 76052
         1 Indel: 45060

    QIAGEN SeqTarget long-range PCR primers for resequencing NACA 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NACA for disorders           About GeneDecksing

    OMIM: 601234

    2 Novoseek disease relationships for NACA gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hepatitis b 10.4 1 15986874 (1)
    tumors 0 1 9202657 (1)
    About this table


    Export disorders and mutations for NACA gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/56 PubMed articles for NACA gene, integrated from 7 sources (see all 56):
    (articles sorted by number of sources associating them with NACA)
    1. NACA is a positive regulator of human erythroid-cell differentiation. (PubMed id 15784678)1, 2, 7 Lopez S....Gomez S. (2005)
    2. Investigation of alpha nascent polypeptide-associated complex functions in a human CD8(+) T cell ex vivo expansion model using antisense oligonucleotides. (PubMed id 15196207)1, 2, 7 Al-Shanti N.... Rowbottom A.W. (2004)
    3. Activation of the JNK-AP-1 signal transduction pathway is associated with pathogenesis and progression of human osteosarcomas. (PubMed id 12689679)1, 2, 7 Papachristou D.J....Papavassiliou A.G. (2003)
    4. Emergence of young human genes after a burst of retroposition in primates. (PubMed id 16201836)1, 2 Marques A.C.... Kaessmann H. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. The alpha-chain of the nascent polypeptide-associated complex binds to and regulates FADD function. (PubMed id 12684039)1, 2 Stilo R.... Vito P. (2003)
    7. Novel products of the HuD, HuC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. (PubMed id 12209604)1, 2 Behrends U.... Mautner J.M. (2002)
    8. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
    9. The alpha and beta subunit of the nascent polypeptide-associated complex have distinct functions. (PubMed id 10982809)1, 2 Beatrix B.... Wiedmann M. (2000)
    10. A protein complex required for signal-sequence-specific sorting and translocation. (PubMed id 8047162)1, 3 Wiedmann B....Wiedmann M. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4666 HGNC: 7629 AceView: NACA Ensembl:ENSG00000196531 euGenes: HUgn4666
    ECgene: NACA H-InvDB: NACA

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for NACA Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for NACA gene:
    Search GeneIP for patents involving NACA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for NACA Antibodies for NACA
     Super-pooled esiRNAs for NACA Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NACA microRNA Mimics for NACA
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NACA
     SeqTarget long-range PCR primers for resequencing NACA
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NACA
     GenScript Custom Purified and Recombinant Proteins Services for NACA GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NACA
     GenScript Custom Assay Services for NACA GenScript Custom Superior Antibodies Services for NACA
     GenScript Custom overexpressing Cell Line Services for NACA CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NACA promoter
     Search Chromatin IP Primers for NACA
     RT2 qPCR Primer Assay for NACA
     GNC Network for NACA
     Search for Assays for microRNAs that regulate NACA
     SABiosciences Custom PCR Arrays for NACA
     Search Tocris compounds for NACA
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for NACA
     Proteins for NACA
     Lysates for NACA
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     Browse ELISAs and CLIAs at Uscn
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    NACA gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4