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NBR1 Gene

protein-coding   GIFtS: 55

GC17P037088
neighbor of BRCA1 gene 1
(Previous names: membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen CA125) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: M17S2)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
neighbor of BRCA1 gene 11 2     Protein 1A1-3B2 3
KIAA00491 2 3     CA1251
M17S22 3 5     FLJ982722
membrane component, chromosome 17, surface marker 2 (ovarian carcinoma antigen
CA125)1 2
     migration-inducing protein 192
1A1-3B1 2     next to BRCA1 gene 1 protein2
Neighbor of BRCA1 gene 1 protein2 3     FLJ553592
Cell migration-inducing gene 19 protein2 3     1A13B3
Membrane component chromosome 17 surface marker 22 3     

External Ids:    HGNC: 67461   Entrez Gene: 40772   Ensembl: ENSG000001885547   UniProtKB: Q145963   

Export aliases for NBR1 gene to outside databases

Previous GC identifers: GC17P9L0001 GC17P038578 GC17P041322


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NBR1:
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The
encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but
the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close
proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been
identified for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596
Function: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets

Gene Wiki entry for NBR1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NBR1 gene promoter:
         SRF   p53   FOXD1   POU2F1   Oct-B1   POU2F2B   oct-B2   oct-B3   POU2F2C   POU2F2 (Oct-2.1)   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for NBR1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

NBR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NBR1 gene location

GeneLoc gene densities for chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P037088:  view genomic region     (about GC identifiers)

Start:
37,088,806 bp from pter
End:
37,130,178 bp from pter
Size:
41,373 bases
Orientation:
plus strand

1 alternative location:
Chr17+ 41,322,498-41,363,706     
RefSeq DNA sequence:
NC_000017.10  NT_010783.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596 (See protein sequence)
Recommended Name: Next to BRCA1 gene 1 protein  
Size: 966 amino acids; 107413 Da
Subunit: Homooligomer and heterooligomer. Interacts with TRIM55 (By similarity). Interacts with SQSTM1, titin/TTN,
RNF29, USP8, SQSTM1, MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2. Binds to ubiquitin and
ubiquitinated proteins
Subcellular location: Cytoplasm. Cytoplasmic vesicle, autophagosome. Lysosome. Cytoplasm, myofibril, sarcomere, M-band
(By similarity). Note=In cardiac muscles localizes to the sarcomeric M-band (By similarity). Is targeted to lysosomes
for degradation
Caution: Was originally (PubMed:8069304) thought to be the ovarian carcinoma antigen CA125
Sequence caution: Sequence=BAA06417.2; Type=Erroneous initiation;
PDB structures from and Proteopedia :
1WJ6 (3D)    2BKF (3D)    2CP8 (3D)    2G4S (3D)    
Secondary accessions: Q13173 Q15026 Q5J7Q8 Q96GB6 Q9NRF7
Alternative splicing: 2 isoforms:  Q14596-1   Q14596-2   

Explore the universe of human proteins at neXtProt for NBR1: NX_Q14596 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_005890.2  NP_114064.1  NP_114068.1  


    ENSEMBL proteins: 
    ENSP00000373963 ENSP00000411250 ENSP00000343479 ENSP00000373962 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for NBR1
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: NBR1
    GenScript Custom Purified and Recombinant Proteins Services for NBR1 
    Novus Biologicals Proteins for NBR1
    Novus Biologicals Lysate for NBR1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005764 lysosome IEA--
    GO:0005770 late endosome ISS--
    GO:0005776 autophagic vacuole IEA--
    GO:0005829 cytosol IDA19250911
    About this table

    NBR1 for ontologies           About GeneDecksing



    Antibodies for NBR1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NBR1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for NBR1 
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for NBR1 
    Novus Biologicals Antibodies for NBR1
    Browse antibodies at Epitomics

    Assays for NBR1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NBR1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NBR1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NBR1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR009060 UBA-like
     IPR000270 OPR_PB1
     IPR015940 UBA/transl_elong_EF1B_N_euk
     IPR000433 Znf_ZZ

    Graphical View of Domain Structure for InterPro Entry Q14596

    ProtoNet protein and cluster: Q14596

    3 Blocks protein families:
    IPB000270 Octicosapeptide/Phox/Bem1p
    IPB000433 Zn-finger
    IPB000449 Ubiquitin-associated domain


    UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596
    Domain: The OPR domain mediates interaction with SQSTM1
    Similarity: Contains 1 OPR domain
    Similarity: Contains 1 UBA domain
    Similarity: Contains 1 ZZ-type zinc finger


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: NBR1_HUMAN, Q14596
    Function: Acts probably as a receptor for selective autophagosomal degradation of ubiquitinated targets

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NBR1
    Sigma-Aldrich shRNA Panels and shRNA for NBR1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): NBR1
    OriGene shRNA RFP (see all 4): NBR1
    OriGene basic RS shRNA (see all 4): NBR1
    OriGene siRNA (see all 4): NBR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NBR1 
    miRNA:Sigma-Aldrich microRNA Mimics for NBR1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NBR1 
    5 SABiosciences Assays for microRNAs that regulate NBR1:
    hsa-miR-548p hsa-miR-200c hsa-miR-369-3p hsa-miR-429 hsa-miR-211

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NBR1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NBR1
    OriGene untagged cDNA clones in CMV expression vector (see all 4): NBR1
    OriGene 3'-UTR clone (see all 3): NBR1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NBR1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for NBR1 

    4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI19250911
    GO:0008270 zinc ion binding IEA--
    GO:0043130 ubiquitin binding IDA19427866
    GO:0046872 metal ion binding IEA--
    About this table

    NBR1 for ontologies           About GeneDecksing

    Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Nbr1):

    hematopoietic systemimmune systemlimbs/digits/tailskeleton

    NBR1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for NBR1 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NBR1

    5/20 Interacting proteins for NBR1 (Q145961, 2) via UniProtKB, MINT, and/or STRING (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP1LC3AQ9H4921, 2EBI-742698,EBI-720768 MINT-7034375 MINT-7034418 MINT-7034400
    SQSTM1Q135011, 2EBI-742698,EBI-307104 MINT-8075920
    GABARAPO951661EBI-742698,EBI-712001
    GABARAPL1Q9H0R81EBI-742698,EBI-746969
    GABARAPL2P605201EBI-742698,EBI-720116
    About this table

    2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016236 macroautophagy IDA19250911
    GO:0051259 protein oligomerization IDA19250911
    About this table

    NBR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NBR1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NBR1
    Sigma-Aldrich shRNA Panels and shRNA for NBR1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): NBR1
    OriGene shRNA RFP (see all 4): NBR1
    OriGene basic RS shRNA (see all 4): NBR1
    OriGene siRNA (see all 4): NBR1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NBR1 
    miRNA: Sigma-Aldrich microRNA Mimics for NBR1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NBR1 
    5 SABiosciences Assays for microRNAs that regulate NBR1:
    hsa-miR-548p hsa-miR-200c hsa-miR-369-3p hsa-miR-429 hsa-miR-211
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NBR1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NBR1
    OriGene untagged cDNA clones in CMV expression vector (see all 4): NBR1
    OriGene 3'-UTR Clone (see all 3): NBR1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NBR1 
    Primers: OriGene genome-wide validated SYBR primer pairs: NBR1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NBR1: PPH22220A

    REFSEQ mRNAs for NBR1 gene (3 alternative transcripts): 

    NM_005899.3  NM_031858.2  NM_031862.2  

    Additional cDNA sequence: 

    AF227189.1 AK290005.1 AK297425.1 AK299328.1 AK308324.1 AY450308.1 BC009808.2 BC012591.1 
    BC012847.1 CR599421.1 CR604121.1 D30756.1 X76952.1 

    24/29 DOTS entries (see all 29):

    DT.101978440  DT.100822404  DT.102839957  DT.100022668  DT.444984  DT.100822409  DT.101983605  DT.100822401 
    DT.120910716  DT.100822407  DT.70103187  DT.75164881  DT.91855250  DT.91924762  DT.95105936  DT.100822408 
    DT.120910734  DT.120910757  DT.120910787  DT.120910809  DT.40245095  DT.429426  DT.95143835  DT.95203506 

    24/77 AceView cDNA sequences (see all 77):

    CB160484 AL039232 AF227189 BF724610 CF135984 AW025470 BU161042 AU140448 
    AU140463 CB988916 AW236032 CB989852 BQ924406 CF138277 BM459691 AL042510 
    M79023 AL044169 BM827388 AK128512 BX462113 CD655831 AA486002 BC012591 

    highest scoring ESTs for NBR1:

    D30756 AA028089 AA028090 AA046065 AA046348 AA069906 AA083814 AA126012 AA126134 AA126858 

    Unigene Cluster for NBR1:

    Neighbor of BRCA1 gene 1
    Hs.277721  [show with all ESTs]
    Unigene Representative Sequence: NM_031858


    GeneLoc Exon Structure

    5/17 Alternative Splicing Database (ASD) splice patterns (SP) for NBR1 (see all 17)

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b · 13c ^ 14a · 14b ^ 15 ^ 16a · 16b · 16c ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 17 ^ 18 ^ 19 ^ 20 ^ 21a · 21b ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b
    SP1:                                                                                                            
    SP2:                    -     -     -                                                                           
    SP3:        -     -                 -                                                                           
    SP4:                                                                                                            
    SP5:                                                                                                            

    About this scheme

    ECgene alternative splicing isoforms for NBR1
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000389312(uc010czd.2 uc010whx.1) ENST00000422280(uc010diz.2)
    ENST00000341165(uc010whv.1 uc010whw.1) ENST00000389311(uc010whu.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    NBR1 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching NBR1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    33444_at2, 3 U95-A 1 0.62 1.00 1.00 1.00 D30756 1.00 0.90 0.95 1
    201383_s_at2, 3 U133-A 1 1.00 1.00 -- -- AL044170 0.60 1.00 0.82 1
    201384_s_at2, 3 U133-A 1 0.64 1.00 -- -- NM_005899 0.60 1.00 0.82 1
    201383_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    201384_s_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    NBR1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    NBR1 gene expression
    NBR1 gene electronic northern expression
    NBR1 gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.277721

    Expression variation in blood from EXPOLDB for NBR1

    Primers: OriGene genome-wide validated SYBR primer pairs: NBR1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NBR1: PPH22220A
        SABiosciences Custom PCR Arrays for NBR1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for NBR1 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NBR11   -- neighbor of BRCA1 gene 1 89.53(n)
    88.55(a)
    480509  XM_537628.2  XP_537628.2 
    chimpanzee
    (Pan troglodytes)
    NBR11   -- neighbor of BRCA1 gene 1 99.62(n)
    99.38(a)
    455047  XM_001155005.1  XP_001155005.1 
    cow
    (Bos taurus)
    NBR11   -- neighbor of BRCA1 gene 1 90.1(n)
    88.08(a)
    515032  XM_592972.3  XP_592972.2 
    rat
    (Rattus norvegicus)
    Nbr11   -- neighbor of Brca1 gene 1 87.36(n)
    85.65(a)
    303554  NM_001024765.1  NP_001019936.1 
    mouse
    (Mus musculus)
    Nbr11 , 5 11 (65.36 cM)5
    neighbor of Brca1 gene 11, 5 87.01(n)1
    85.89(a)1
    179661  NM_008676.21  NP_032702.11 
     AF2271885  AF4084365  (see all 20)
    About this table        Species with no ortholog for NBR1

    ENSEMBL Gene Tree for NBR1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/274 NCBI SNPs in NBR1 are shown (see all 274)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 17 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs13993231,2
    C,F,A,41332330(-) CCTATA/GAGCAA 3 -- int113Minor allele frequency- G:0.28NA NS EA WA 686
    rs15651631,2
    C,F41361342(-) tgaggT/Cgggcg 3 -- int15Minor allele frequency- C:0.40NA WA 10
    rs20113161,2
    H41320563(-) ttctcC/Atgcct 2 -- ng514Minor allele frequency- A:0.00NS EA 418
    rs22715721,2
    C41341153(-) CCAAGC/TGAGAC 3 -- int14Minor allele frequency- T:0.00NS EA 418
    rs22715731,2
    C,F,H,41327621(+) AAACAA/GTTCCT 3 -- int112Minor allele frequency- G:0.28NS EA NA WA 590
    rs22715741,2
    C,F,41327648(+) AAGTTT/CCGTAA 3 -- int17Minor allele frequency- C:0.28NS EA NA WA 402
    rs23068291,2
    C,F41353806(-) AGGCTG/AATCAT 3 -- int110Minor allele frequency- A:0.32EA NA WA 1428
    rs23563101,2
    C41359589(+) TTGCCT/CAGGGC 3 -- int14Minor allele frequency- C:0.12NA WA 8
    rs32152281,2
    --41327651(+) TTCGT-/TAAGAA 3 -- int10--------
    rs37442421,2
    C,F41346798(+) CTCTTT/CCCTGC 3 -- int1 trp35Minor allele frequency- C:0.34EA NA 1472
    About this table

    HapMap Linkage Disequilibrium images for NBR1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NBR1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing NBR1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NBR1 for disorders           About GeneDecksing

    OMIM: 166945

    Human Genome Epidemiology (HuGE) Navigator: NBR1 (1 document)

    Export disorders and mutations for NBR1 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/25 PubMed articles for NBR1 gene, integrated from 7 sources (see all 25):
    (articles sorted by number of sources associating them with NBR1)
    1. A novel gene encoding a B-box protein within the BRCA1 region at 17q21.1. (PubMed id 8069304)1, 2, 3 Campbell I.G....Black D.M. (1994)
    2. A role for NBR1 in autophagosomal degradation of ubiquitinated substrates. (PubMed id 19250911)1, 2 Kirkin V.... Johansen T. (2009)
    3. Interactions with LC3 and polyubiquitin chains link n br1 to autophagic protein turnover. (PubMed id 19427866)1, 2 Waters S....Gautel M. (2009)
    4. The kinase domain of titin controls muscle gene expression and protein turnover. (PubMed id 15802564)1, 2 Lange S.... Gautel M. (2005)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins. (PubMed id 12813044)1, 2 Lamark T.... Johansen T. (2003)
    7. Expression profiles and intergenic structure of head-to-head oriented Brca1 and Nbr1 genes. (PubMed id 11179671)1, 2 Dimitrov S.... Forejt J. (2001)
    8. Comparison of the positional cloning methods used to isolate the BRCA1 gene. (PubMed id 7581362)1, 2 Harshman K.... Kamb A. (1995)
    9. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2 Nomura N....Tabata S. (1994)
    10. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4077 HGNC: 6746 AceView: LOC439923 Ensembl:ENSG00000188554 euGenes: HUgn4077
    ECgene: NBR1 H-InvDB: NBR1

    (According to HUGE)
    About This Section
    HUGE: KIAA0049

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for NBR1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for NBR1 gene:
    Search GeneIP for patents involving NBR1

    GeneCards and IP:
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