Aliases &
Descriptions
for NDUFA3 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa1 2 | | NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3 (9kD, B9)1 | | B91 2 | | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 32 | | Complex I-B92 3 | | OTTHUMP000001977102 | | CI-B92 3 | | OTTHUMP000001949742 | | NADH-ubiquinone oxidoreductase B9 subunit2 3 | | complex I B9 subunit2 |
Export aliases for NDUFA3 gene to outside databasesPrevious GC identifers: GC19P055251 GC19P055030 GC19P059282 GC19P059297 GC19P054590 |
Summaries
for NDUFA3 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NDUA3_HUMAN, O95167Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
|
Genomic Views
for NDUFA3 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NDUFA3 gene promoter:
CUTL1 NF-kappaB1 POU2F1 RFX1 c-Myb AP-1 STAT3 STAT1beta STAT2 STAT5B
Other transcription factors
Search SABiosciences Chromatin IP Primers for NDUFA3
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NDUFA3  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.42 Ensembl cytogenetic band: 19q13.42 HGNC cytogenetic band: 19q13.42NDUFA3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P050923: view genomic region
(about GC identifiers)
Start:
|
50,922,024 bp from pter |
End:
|
50,926,151 bp from pter |
Size:
|
4,128 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr19+ 54,606,036-54,614,898 |
RefSeq DNA sequence:- NC_000019.9 NT_011109.16
|
Proteins
for NDUFA3 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NDUA3_HUMAN, O95167 (See
protein sequence)Recommended Name: NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 Size: 84 amino acids; 9279 Da
Subunit: Complex I is composed of 45 different subunits
Subcellular location: Mitochondrion inner membrane; Single-pass membrane proteinExplore the universe of human proteins at neXtProt for NDUFA3: NX_O95167
REFSEQ proteins: NP_004533.1
ENSEMBL proteins: ENSP00000412325 ENSP00000398290 ENSP00000418438 ENSP00000375642 ENSP00000410453 ENSP00000375643 ENSP00000375644 ENSP00000407335 ENSP00000394383 ENSP00000410363
Human Recombinant Proteins
5/6 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 6): About this table
NDUFA3 for ontologies About GeneDecksing
Antibodies for NDUFA3:
Assays for NDUFA3: |
Protein
Domains/
Families
for NDUFA3 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: O95167 UniProtKB/Swiss-Prot: NDUA3_HUMAN, O95167Similarity: Belongs to the complex I NDUFA3 subunit family |
Gene Function
for NDUFA3 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NDUA3_HUMAN, O95167Function: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that isbelieved not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to therespiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
NAS | 9878551 |
About this table
NDUFA3 for ontologies About GeneDecksing
|
Pathways & Interactions
for NDUFA3 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
NDUFA3 for pathways About GeneDecksing
3  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for NDUFA3
5  Kegg Pathways (Kegg details for NDUFA3):
SABiosciences Pathway-Focused PCR Array including NDUFA3: PAHS-008A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for NDUFA3
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NDUFA3
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
NDUFA3 for ontologies About GeneDecksing
|
Drugs & Compounds
for NDUFA3 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NDUFA3
|
Transcripts
for NDUFA3 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NDUFA3 gene: NM_004542.3 Additional cDNA sequence: AF044955.1 AF070653.1 AK289489.1 BC011021.1 BC022369.1 BC061644.1 CR542143.1 15 DOTS entries: DT.447997 DT.97804952 DT.100735816 DT.121451717 DT.100785884 DT.95270160 DT.121451743 DT.86835744 DT.91967036 DT.121451833 DT.91837942 DT.75105106 DT.95287028 DT.92428332 DT.95270166 24/160 AceView cDNA sequences (see all 160): AA255573 AI885387 BU838806 AW002081 AI300545 F25043 BE741214 AI362796 BQ884126 C01859 AI342995 BC061644 AA946903 AI417419 CA312034 AI675759 AA255557 AI499736 F31172 BF939295 F26119 BM805609 BE855858 AA970515
 highest scoring ESTs for NDUFA3:T95412 AA255573 AA405901 AA480432 AA482817 AA492039 AA548657 AA552841 AA552854 AA652602 Unigene Cluster for NDUFA3: NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 3, 9kDa Hs.198269 [show with all ESTs]Unigene Representative Sequence: CD248715
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for NDUFA3
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | |
About this scheme
ECgene alternative splicing isoforms for NDUFA3
16 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417903(uc002qdf.2) ENST00000419113(uc002qde.2) ENST00000485876
ENST00000391762 ENST00000471292 ENST00000451517 ENST00000391763 ENST00000391764
ENST00000484103 ENST00000303553 ENST00000422029 ENST00000420296 ENST00000484360
ENST00000480713 ENST00000482960 ENST00000417328
|
Expression
for NDUFA3 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NDUFA3 expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching NDUFA3 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 63791_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
T95412 |
1.00 |
1.00 |
1.00 |
1 |
| 72138_at2, 3
|
U95-E |
1 |
0.75 |
1.00 |
0.11 |
0.25 |
AA629629 |
0.40 |
1.00 |
0.76 |
1 |
| 218563_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_004542 |
0.60 |
1.00 |
0.82 |
1 |
| 218563_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NDUFA3 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CCCGACGTGC
SOURCE GeneReport for Unigene cluster: Hs.198269
SABiosciences Expression via Pathway-Focused PCR Array including NDUFA3: PAHS-008A
|
Orthologs
for NDUFA3 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NDUFA3 gene from 5/6 species (see all 6)
About this table Species with no ortholog for NDUFA3
ENSEMBL Gene Tree for NDUFA3 (if available) |
Paralogs
for NDUFA3 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Pseudogenes
- 5 related pseudogenes
|
Genomic Variants
for NDUFA3 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 19 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NDUFA3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NDUFA3
1 CNV: 50206 | | QIAGEN SeqTarget long-range PCR primers for resequencing NDUFA3 |
|
Disorders & Mutations
for NDUFA3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NDUFA3 for disorders About GeneDecksing
OMIM: 603832
Human Genome Epidemiology (HuGE) Navigator: NDUFA3 (5 documents)
Export disorders and mutations for NDUFA3 gene to outside databases
|
Medical News
for NDUFA3 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NDUFA3 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for NDUFA3 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with NDUFA3)- cDNA of eight nuclear encoded subunits of NADH:ubiquinone oxidoreductase: human complex I cDNA characterization completed. (PubMed id 9878551)1, 2, 3 Loeffen J.L....Smeitink J.A. (1998)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification. (PubMed id 12611891)1, 2 Murray J.... Capaldi R.A. (2003)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)1, 2 Zhang Q.-H.... Chen Z. (2000)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010 Nov 3)
- Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1 Hendrickson S.L....O'Brien S.J. (2010)
- Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. (PubMed id 19343046)1 Saito A....Kamatani N. (2009)
- Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey. (PubMed id 18977241)1 Starr J.M....Deary I.J. (2008)
- A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition. (PubMed id 17601350)1 Harris S.E....Deary I.J. (2007)
- The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974)2 Sjoeblom T.... Velculescu V.E. (2006)
|
External Searches for NDUFA3 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NDUFA3 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NDUFA3 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NDUFA3 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NDUFA3 gene:
Search GeneIP for patents involving NDUFA3
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NDUFA3 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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