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NEK6 Gene

protein-coding   GIFtS: 55

GC09P096633
NIMA (never in mitosis gene a)-related kinase 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
NIMA (never in mitosis gene a)-related kinase 61 2     OTTHUMP000000221012
SID6-15121 2     OTTHUMP000000221002
Never in mitosis A-related kinase 62 3     OTTHUMP000000220982
Protein kinase SID6-15122 3     OTTHUMP000000220942
NimA-related protein kinase 62 3     serine/threonine-protein kinase Nek62
OTTHUMP000000220992     EC 2.7.11.13
putative serine-threonine protein kinase2     

External Ids:    HGNC: 77491   Entrez Gene: 107832   Ensembl: ENSG000001194087   UniProtKB: Q9HC983   

Export aliases for NEK6 gene to outside databases

Previous GC identifers: GC09P118134 GC09P118666 GC09P120473 GC09P122395 GC09P122396 GC09P124099 GC09P126059 GC09P127019


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NEK6:
The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation of
mitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggests
that NEKs perform functions similar to those of NIMA.(supplied by OMIM)

UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98
Function: Activated during M phase. Required for chromosome segregation at metaphase-anaphase transition and therefore
for mitotic progression. Inhibition of activity results in apoptosis. Phosphorylates KIF11 to promote mitotic spindle
formation

Gene Wiki entry for NEK6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEK6 gene promoter:
         MEF-2A   AhR   COUP-TF1   HNF-4alpha2   POU3F1   RSRFC4   HSF2   ISGF-3   STAT2   STAT5A   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for NEK6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.3-q34.11   Ensembl cytogenetic band:  9q33.3   HGNC cytogenetic band: 9q33.3-q34.11

NEK6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK6 gene location

GeneLoc gene densities for chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P096633:  view genomic region     (about GC identifiers)

Start:
96,633,275 bp from pter
End:
96,727,666 bp from pter
Size:
94,392 bases
Orientation:
plus strand

1 alternative location:
Chr9+ 127,019,885-127,115,586     
RefSeq DNA sequence:
NC_000009.11  NT_008470.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek6  
Size: 313 amino acids; 35714 Da
Cofactor: Magnesium
Subunit: Interacts with NEK9, predominantly in mitosis. Interacts with KIF11 (via C-terminus)
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAG13417.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAA85045.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH70247.1;
Type=Erroneous gene model prediction; Sequence=CAI10876.1; Type=Erroneous gene model prediction; Sequence=EAW87581.1;
Type=Erroneous gene model prediction;
Secondary accessions: Q5TBG3 Q5TBG9 Q6FG86 Q6IAR3 Q96E83 Q9ULX2

Explore the universe of human proteins at neXtProt for NEK6: NX_Q9HC98 

Post-translational modifications:

  • Autophosphorylated1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (7 alternative transcripts): 
    NP_001138473.1  NP_001159639.1  NP_001159640.1  NP_001159641.1  NP_001159642.1  NP_001159643.1  NP_055212.2  


    ENSEMBL proteins: 
    ENSP00000377749 ENSP00000389517 ENSP00000405215 ENSP00000403087 ENSP00000411401 ENSP00000362702 
    ENSP00000362705 ENSP00000362703 ENSP00000399847 ENSP00000319734 ENSP00000362698 ENSP00000403414 


    Human Recombinant Proteins 
    Millipore Purified and/or Recombinant NEK6 Protein
    Sigma-Aldrich Proteins for NEK6
    Browse R&D Systems for human recombinant proteins
    Enzo Life Sciences proteins for NEK6
    OriGene Purified Protein: NEK6
    OriGene Protein Over-expression Lysate: NEK6
    GenScript Custom Purified and Recombinant Proteins Services for NEK6 
    Novus Biologicals Proteins for NEK6
    Novus Biologicals Lysate for NEK6
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IDA12054534
    GO:0005737 cytoplasm IDA12054534
    About this table

    NEK6 for ontologies           About GeneDecksing



    Antibodies for NEK6: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NEK6
    Browse R&D Systems for Antibodies
    OriGene Antibodies (see all 4): NEK6
    GenScript Custom Superior Antibodies Services for NEK6 
    Novus Biologicals Antibodies for NEK6
    Browse antibodies at Epitomics

    Assays for NEK6: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEK6 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NEK6 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NEK6 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q9HC98

    ProtoNet protein and cluster: Q9HC98

    UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98
    Function: Activated during M phase. Required for chromosome segregation at metaphase-anaphase transition and therefore
    for mitotic progression. Inhibition of activity results in apoptosis. Phosphorylates KIF11 to promote mitotic spindle
    formation
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for NEK6
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NEK6
    Sigma-Aldrich shRNA Panels and shRNA for NEK6
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): NEK6
    OriGene shRNA RFP (see all 7): NEK6
    OriGene basic RS shRNA (see all 7): NEK6
    OriGene siRNA (see all 7): NEK6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NEK6 
    miRNA:Sigma-Aldrich microRNA Mimics for NEK6
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NEK6 
    8/9 SABiosciences Assays for microRNAs that regulate NEK6 (see all 9):
    hsa-miR-323-3p hsa-miR-188-5p hsa-miR-27a hsa-miR-200a hsa-miR-340 hsa-miR-141 hsa-miR-23b hsa-miR-23a

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NEK6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NEK6
    OriGene untagged cDNA clones in CMV expression vector: NEK6
    OriGene 3'-UTR clone (see all 7): NEK6 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NEK6 
    Sino Biological Human cDNA Clone for NEK6

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for NEK6 

    5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0000287 magnesium ion binding IDA14563848
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity IDA14563848
    GO:0004871 signal transducer activity IMP12761501
    About this table

    NEK6 for ontologies           About GeneDecksing

    Animal Models: 1 MGI phenotypic allele for Nek6 (no phenotypes)


    NEK6 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Pathway-Focused PCR Array including NEK6: PAHS-085A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEK6

    5/24 Interacting proteins for NEK6 (ENSP000003627023 Q9HC981) via UniProtKB, MINT, and/or STRING (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK9Q8TD191STRING: ENSP00000238616 EBI-740364,EBI-1044009
    CDC37Q165431EBI-740364,EBI-295634
    DYNLL1P631671EBI-740364,EBI-349105
    EML2O958341EBI-740364,EBI-1054588
    EML3Q32P441EBI-740364,EBI-1046713
    About this table

    5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation IDA14563848
    GO:0006915 apoptosis IEA--
    GO:0007049 cell cycle IEA--
    GO:0007059 chromosome segregation IDA14563848
    GO:0007067 mitosis IEA--
    About this table

    NEK6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEK6


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for NEK6
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NEK6
    Sigma-Aldrich shRNA Panels and shRNA for NEK6
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 7): NEK6
    OriGene shRNA RFP (see all 7): NEK6
    OriGene basic RS shRNA (see all 7): NEK6
    OriGene siRNA (see all 7): NEK6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NEK6 
    miRNA: Sigma-Aldrich microRNA Mimics for NEK6
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NEK6 
    8/9 SABiosciences Assays for microRNAs that regulate NEK6 (see all 9):
    hsa-miR-323-3p hsa-miR-188-5p hsa-miR-27a hsa-miR-200a hsa-miR-340 hsa-miR-141 hsa-miR-23b hsa-miR-23a
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 7): NEK6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 7): NEK6
    OriGene untagged cDNA clones in CMV expression vector: NEK6
    OriGene 3'-UTR Clone (see all 7): NEK6 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NEK6 
    Primers: OriGene genome-wide validated SYBR primer pairs: NEK6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NEK6: PPH18826A

    REFSEQ mRNAs for NEK6 gene (7 alternative transcripts): 

    NM_001145001.2  NM_001166167.1  NM_001166168.1  NM_001166169.1  NM_001166170.1  NM_001166171.1  NM_014397.5  

    Additional cDNA sequence: 

    AB026289.1 AF087909.1 AJ420460.1 AK294614.1 AK313071.1 AL832574.2 AY567967.1 BC000101.2 
    BC004174.2 BC004209.2 BC012761.2 CR457091.1 CR542222.1 CR608265.1 CR611916.1 CR614269.1 
    CR619855.1 

    22 DOTS entries:

    DT.85105540  DT.451785  DT.100793525  DT.99938623  DT.100793524  DT.100793530  DT.99934741  DT.404604 
    DT.100793528  DT.121148913  DT.121148643  DT.121148918  DT.99944232  DT.121148712  DT.86857274  DT.100793523 
    DT.100805605  DT.121148931  DT.121148940  DT.86851328  DT.95338501  DT.97845843 

    24/341 AceView cDNA sequences (see all 341):

    CA423501 BU501296 BQ941244 BQ375243 AI984544 AA451721 AA600235 AA969269 
    BM765808 BQ028289 AW188433 AA291952 CR611916 CR608265 AA463188 BU728776 
    CA418621 BE326807 AI673193 CB159544 CR619855 T11445 BQ772826 BU527818 

    highest scoring ESTs for NEK6:

    AA461376 AA031793 AA037273 AA147758 AA157070 AA263061 AA291952 AA360254 AA379372 AA424134 

    Unigene Cluster for NEK6:

    NIMA (never in mitosis gene a)-related kinase 6
    Hs.197071  [show with all ESTs]
    Unigene Representative Sequence: AL832574


    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NEK6 (see all 8)

    ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b · 16c
    SP1:              -     -     -     -     -           -                                                                           
    SP2:        -     -     -     -     -     -     -     -                                                                           
    SP3:              -     -     -     -     -     -     -                                                                           
    SP4:                                                                                                                              
    SP5:                    -     -     -     -     -     -                                                                           

    About this scheme

    ECgene alternative splicing isoforms for NEK6
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394199 ENST00000444973 ENST00000454453 ENST00000425237 ENST00000422297
    ENST00000373600(uc004boh.2 uc004bog.2 uc010mwj.2) ENST00000373603(uc004bof.2 uc010mwk.2 uc004boi.2)
    ENST00000373601 ENST00000423785 ENST00000320246 ENST00000373596 ENST00000447379


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    NEK6 expression in normal and diseased human tissues

    1  / 2  / 3

    5 probe-sets matching NEK6 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    58695_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AA461376 1.00 1.00 1.00 1
    223158_s_at2, 3 U133-B 1 1.00 1.00 -- -- BE616825 0.80 1.00 0.91 1
    223159_s_at2, 3 U133-B 1 1.00 1.00 -- -- BC000101 0.80 0.88 0.84 1
    223158_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    223159_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    NEK6 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    NEK6 gene expression
    NEK6 gene electronic northern expression
    NEK6 gene sage expression
    About these images

    CGAP SAGE TAG: TCACTGATGG

    SOURCE GeneReport for Unigene cluster: Hs.197071

    UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98
    Tissue specificity: Ubiquitous, with highest expression in heart and skeletal muscle

    Primers: OriGene genome-wide validated SYBR primer pairs: NEK6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NEK6: PPH18826A
        SABiosciences Expression via Pathway-Focused PCR Array including NEK6: PAHS-085A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for NEK6 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NEK61   -- NIMA (never in mitosis gene a)-related kinase 6 90.1(n)
    96.81(a)
    609003  XM_846279.1  XP_851372.1 
    chimpanzee
    (Pan troglodytes)
    NEK61   -- NIMA (never in mitosis gene a)-related kinase 6 98.83(n)
    99.04(a)
    737739  XM_001138236.1  XP_001138236.1 
    cow
    (Bos taurus)
    NEK61   -- NIMA (never in mitosis gene a)-related kinase 6 90.52(n)
    96.17(a)
    515816  XM_593903.3  XP_593903.3 
    rat
    (Rattus norvegicus)
    Nek61   -- NIMA (never in mitosis gene a)-related kinase 6 89.14(n)
    96.17(a)
    360161  NM_182953.1  NP_891998.1 
    mouse
    (Mus musculus)
    Nek61 , 5 2 (24.41 cM)5
    NIMA (never in mitosis gene a)-related expressed kinase more1, 5 88.6(n)1
    95.21(a)1
    591261  NM_021606.21  NP_067619.11 
     AA0001775  AA0300715  (see all 24)
    About this table        Species with no ortholog for NEK6

    ENSEMBL Gene Tree for NEK6 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for NEK6 gene
    NEK22  NEK102  NEK42  NEK92  NEK72  

    NEK6 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/904 NCBI SNPs in NEK6 are shown (see all 904)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 9 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs24161,2
    C,F,O,A,H,127113660(-) GATACC/TAAGAA 8 -- ut3127Minor allele frequency- N:0.00EA MN NA NS WA 3318
    rs134671,2
    C,F,O,127114489(-) CCCGAT/CGCCAG 8 -- ut315Minor allele frequency- C:0.16MN NA EA 414
    rs7486591,2
    C,F,A,127095703(-) TGACCC/TAGGGG 7 -- int111Minor allele frequency- A:0.02NA EA NS 776
    rs7486601,2
    C,F,127095649(-) TCACTG/CGGGGG 7 -- int113Minor allele frequency- C:0.22NS EA NA WA 722
    rs7486611,2
    C,F,O,A,127095574(-) TGTGAC/TGGCAA 7 -- int120Minor allele frequency- T:0.34NA EA NS WA 1202
    rs7487411,2
    C,F,A,H,127089775(-) CTGCAT/CGGTCA 7 -- int124Minor allele frequency- C:0.23EA NS NA WA 2882
    rs7493551,2
    C,F,O,A,127090122(+) CTGGCG/AGTTTT 7 -- int112Minor allele frequency- A:0.20NA EA MN NS 1150
    rs7537881,2
    C,F,A,127095039(+) GGAAGT/CGGGGC 7 -- int116Minor allele frequency- C:0.30NA EA NS WA 1006
    rs8676101,2
    C,F,A,127086129(+) TTCCCC/TGTGCA 7 -- int1 trp314Minor allele frequency- T:0.41EA NA NS WA 688
    rs8719981,2
    C,F,A,H,127057420(+) CTGCAT/CGGCCA 7 -- int115Minor allele frequency- C:0.44NA NS EA 846
    About this table

    HapMap Linkage Disequilibrium images for NEK6 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 4 variations for NEK6
         4 CNVs: 30333 30334 52708 30332

    QIAGEN SeqTarget long-range PCR primers for resequencing NEK6 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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    NEK6 for disorders           About GeneDecksing

    OMIM: 604884

    Human Genome Epidemiology (HuGE) Navigator: NEK6 (2 documents)

    Export disorders and mutations for NEK6 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/33 PubMed articles for NEK6 gene, integrated from 7 sources (see all 33):
    (articles sorted by number of sources associating them with NEK6)
    1. Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3-->q34.11 by radiation hybrid mapping. (PubMed id 10702691)1, 2, 3 Li M.Z.... Zhao S.Y. (1999)
    2. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. (PubMed id 14563848)1, 2, 7 Yin M.J.... Jallal B. (2003)
    3. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)1, 2 Rapley J....Roig J. (2008)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. (PubMed id 12054534)1, 2 Hashimoto Y.... Nakanishi M. (2002)
    6. Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. (PubMed id 12023960)1, 7 Lizcano J.M....Alessi D.R. (2002)
    7. Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. (PubMed id 17512906)1, 7 Lee E.J....Kang S.S. (2007)
    8. Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. (PubMed id 16476580)1, 7 Chen J....Yu L. (2006)
    9. Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. (PubMed id 11701951)1, 7 Kimura M. and Okano Y. (2001)
    10. Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. (PubMed id 20595392)1 Jeon Y.J....Dong Z. (2010 Sep 3)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10783 HGNC: 7749 AceView: NEK6 Ensembl:ENSG00000119408 euGenes: HUgn10783
    ECgene: NEK6 H-InvDB: NEK6

    (According to HUGE)
    About This Section
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    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
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    Patent Information for NEK6 gene:
    Search GeneIP for patents involving NEK6

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