Aliases &
Descriptions
for NEK6 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| NIMA (never in mitosis gene a)-related kinase 61 2 | | OTTHUMP000000221012 | | SID6-15121 2 | | OTTHUMP000000221002 | | Never in mitosis A-related kinase 62 3 | | OTTHUMP000000220982 | | Protein kinase SID6-15122 3 | | OTTHUMP000000220942 | | NimA-related protein kinase 62 3 | | serine/threonine-protein kinase Nek62 | | OTTHUMP000000220992 | | EC 2.7.11.13 | | putative serine-threonine protein kinase2 | | |
Export aliases for NEK6 gene to outside databasesPrevious GC identifers: GC09P118134 GC09P118666 GC09P120473 GC09P122395 GC09P122396 GC09P124099 GC09P126059 GC09P127019 |
Summaries
for NEK6 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NEK6:
The Aspergillus nidulans 'never in mitosis A' (NIMA) gene encodes a serine/threonine kinase that controls initiation ofmitosis. NIMA-related kinases (NEKs) are a group of protein kinases that are homologous to NIMA. Evidence suggeststhat NEKs perform functions similar to those of NIMA.(supplied by OMIM)
UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98Function: Activated during M phase. Required for chromosome segregation at metaphase-anaphase transition and thereforefor mitotic progression. Inhibition of activity results in apoptosis. Phosphorylates KIF11 to promote mitotic spindleformation
Gene Wiki entry for NEK6 |
Genomic Views
for NEK6 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NEK6 gene promoter:
MEF-2A AhR COUP-TF1 HNF-4alpha2 POU3F1 RSRFC4 HSF2 ISGF-3 STAT2 STAT5A
Other transcription factors
Search SABiosciences Chromatin IP Primers for NEK6
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 9q33.3-q34.11 Ensembl cytogenetic band: 9q33.3 HGNC cytogenetic band: 9q33.3-q34.11NEK6 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure GeneLoc location for GC09P096633: view genomic region
(about GC identifiers)
Start:
|
96,633,275 bp from pter |
End:
|
96,727,666 bp from pter |
Size:
|
94,392 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr9+ 127,019,885-127,115,586 |
RefSeq DNA sequence:- NC_000009.11 NT_008470.19
|
Proteins
for NEK6 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98 (See
protein sequence)Recommended Name: Serine/threonine-protein kinase Nek6 Size: 313 amino acids; 35714 Da
Cofactor: Magnesium
Subunit: Interacts with NEK9, predominantly in mitosis. Interacts with KIF11 (via C-terminus)
Subcellular location: Cytoplasm. Nucleus
Sequence caution: Sequence=AAG13417.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;Sequence=BAA85045.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAH70247.1;Type=Erroneous gene model prediction; Sequence=CAI10876.1; Type=Erroneous gene model prediction; Sequence=EAW87581.1;Type=Erroneous gene model prediction;
Secondary accessions: Q5TBG3 Q5TBG9 Q6FG86 Q6IAR3 Q96E83 Q9ULX2Explore the universe of human proteins at neXtProt for NEK6: NX_Q9HC98
Post-translational modifications:
Autophosphorylated1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (7 alternative transcripts):
NP_001138473.1 NP_001159639.1 NP_001159640.1 NP_001159641.1 NP_001159642.1 NP_001159643.1 NP_055212.2
ENSEMBL proteins: ENSP00000377749 ENSP00000389517 ENSP00000405215 ENSP00000403087 ENSP00000411401 ENSP00000362702 ENSP00000362705 ENSP00000362703 ENSP00000399847 ENSP00000319734 ENSP00000362698 ENSP00000403414
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
NEK6 for ontologies About GeneDecksing
Antibodies for NEK6:
Assays for NEK6: |
Protein
Domains/
Families
for NEK6 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NEK6 for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q9HC98ProtoNet protein and cluster: Q9HC98 UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamilySimilarity: Contains 1 protein kinase domain |
Gene Function
for NEK6 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98Function: Activated during M phase. Required for chromosome segregation at metaphase-anaphase transition and thereforefor mitotic progression. Inhibition of activity results in apoptosis. Phosphorylates KIF11 to promote mitotic spindleformationCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1
5/10 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 10): About this table
NEK6 for ontologies About GeneDecksing
Animal Models: 1 MGI phenotypic allele  for Nek6 (no phenotypes)
NEK6 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NEK6 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including NEK6: PAHS-085A
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEK6
5/24 Interacting proteins for NEK6 (ENSP000003627023 Q9HC981) via UniProtKB, MINT, and/or STRING (see all 24)About this table
5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9): About this table
NEK6 for ontologies About GeneDecksing
|
Drugs & Compounds
for NEK6 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NEK6
|
Transcripts
for NEK6 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NEK6 gene (7 alternative transcripts): NM_001145001.2 NM_001166167.1 NM_001166168.1 NM_001166169.1 NM_001166170.1 NM_001166171.1 NM_014397.5 Additional cDNA sequence: AB026289.1 AF087909.1 AJ420460.1 AK294614.1 AK313071.1 AL832574.2 AY567967.1 BC000101.2 BC004174.2 BC004209.2 BC012761.2 CR457091.1 CR542222.1 CR608265.1 CR611916.1 CR614269.1 CR619855.1 22 DOTS entries: DT.85105540 DT.451785 DT.100793525 DT.99938623 DT.100793524 DT.100793530 DT.99934741 DT.404604 DT.100793528 DT.121148913 DT.121148643 DT.121148918 DT.99944232 DT.121148712 DT.86857274 DT.100793523 DT.100805605 DT.121148931 DT.121148940 DT.86851328 DT.95338501 DT.97845843 24/341 AceView cDNA sequences (see all 341): CA423501 BU501296 BQ941244 BQ375243 AI984544 AA451721 AA600235 AA969269 BM765808 BQ028289 AW188433 AA291952 CR611916 CR608265 AA463188 BU728776 CA418621 BE326807 AI673193 CB159544 CR619855 T11445 BQ772826 BU527818
 highest scoring ESTs for NEK6:AA461376 AA031793 AA037273 AA147758 AA157070 AA263061 AA291952 AA360254 AA379372 AA424134 Unigene Cluster for NEK6: NIMA (never in mitosis gene a)-related kinase 6 Hs.197071 [show with all ESTs]Unigene Representative Sequence: AL832574
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for NEK6 (see all 8)
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | · | 16c |
|---|
|
| SP1: | | | | | - | | - | | - | | - | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NEK6
12 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000394199 ENST00000444973 ENST00000454453 ENST00000425237 ENST00000422297
ENST00000373600(uc004boh.2 uc004bog.2 uc010mwj.2) ENST00000373603(uc004bof.2 uc010mwk.2 uc004boi.2)
ENST00000373601 ENST00000423785 ENST00000320246 ENST00000373596 ENST00000447379
|
Expression
for NEK6 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NEK6 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching NEK6 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 58695_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AA461376 |
1.00 |
1.00 |
1.00 |
1 |
| 223158_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BE616825 |
0.80 |
1.00 |
0.91 |
1 |
| 223159_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BC000101 |
0.80 |
0.88 |
0.84 |
1 |
| 223158_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 223159_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NEK6 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TCACTGATGG
SOURCE GeneReport for Unigene cluster: Hs.197071
UniProtKB/Swiss-Prot: NEK6_HUMAN, Q9HC98Tissue specificity: Ubiquitous, with highest expression in heart and skeletal muscle
SABiosciences Expression via Pathway-Focused PCR Array including NEK6: PAHS-085A
|
Orthologs
for NEK6 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NEK6 gene from 5/8 species (see all 8)
About this table Species with no ortholog for NEK6
ENSEMBL Gene Tree for NEK6 (if available) |
Paralogs
for NEK6 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NEK6 gene
- NEK22 NEK102 NEK42 NEK92 NEK72
NEK6 for paralogs About GeneDecksing
|
Genomic Variants
for NEK6 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 9 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NEK6 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NEK6
4 CNVs: 30333 30334 52708 30332 | | QIAGEN SeqTarget long-range PCR primers for resequencing NEK6 |
|
Disorders & Mutations
for NEK6 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NEK6 for disorders About GeneDecksing
OMIM: 604884
Human Genome Epidemiology (HuGE) Navigator: NEK6 (2 documents)
Export disorders and mutations for NEK6 gene to outside databases
|
Medical News
for NEK6 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NEK6 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/33 PubMed articles for NEK6 gene, integrated from 7 sources (see all 33):
(articles sorted by number of sources associating them with NEK6)- Assignment of NEK6, a NIMA-related gene, to human chromosome 9q33. 3-->q34.11 by radiation hybrid mapping. (PubMed id 10702691)1, 2, 3 Li M.Z.... Zhao S.Y. (1999)
- The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. (PubMed id 14563848)1, 2, 7 Yin M.J.... Jallal B. (2003)
- The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)1, 2 Rapley J....Roig J. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Identification and characterization of Nek6 protein kinase, a potential human homolog of NIMA histone H3 kinase. (PubMed id 12054534)1, 2 Hashimoto Y.... Nakanishi M. (2002)
- Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo. (PubMed id 12023960)1, 7 Lizcano J.M....Alessi D.R. (2002)
- Human NIMA-related kinase 6 is one of the Fe65 WW domain binding proteins. (PubMed id 17512906)1, 7 Lee E.J....Kang S.S. (2007)
- Interaction of Pin1 with Nek6 and characterization of their expression correlation in Chinese hepatocellular carcinoma patients. (PubMed id 16476580)1, 7 Chen J....Yu L. (2006)
- Identification and assignment of the human NIMA-related protein kinase 7 gene (NEK7) to human chromosome 1q31.3. (PubMed id 11701951)1, 7 Kimura M. and Okano Y. (2001)
- Role of NEK6 in tumor promoter-induced transformation in JB6 C141 mouse skin epidermal cells. (PubMed id 20595392)1 Jeon Y.J....Dong Z. (2010 Sep 3)
|
External Searches for NEK6 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NEK6 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NEK6 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NEK6 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NEK6 gene:
Search GeneIP for patents involving NEK6
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NEK6 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for NEK6 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for NEK6 |
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