Home
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

NEK9 Gene

protein-coding GIFtS: 55

GC14M055716

NIMA (never in mitosis gene a)- related kinase 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
NIMA (never in mitosis gene a)- related kinase 9¹ ²		Never in mitosis A-related kinase 9² ³
NERCC¹ ² ³		NERCC1² ⁵
Nek8¹ ² ³		MGC138306²
DKFZp434D0935¹ ²		NIMA-related kinase Nek8²
MGC16714¹ ²		serine/threonine-protein kinase Nek9²
NimA-related kinase 8² ³		KIAA1995³
NimA-related protein kinase 9² ³		NEK8³
Nercc1 kinase² ³		EC 2.7.11.1³

External Ids:	HGNC: 18591¹	Entrez Gene: 91754²	Ensembl: ENSG00000119638⁷	UniProtKB: Q8TD19³

Export aliases for NEK9 gene to outside databases

Previous GC identifers: GC14M073077 GC14M069365 GC14M073538 GC14M073541 GC14M074618 GC14M075548

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19

Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome

separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3

on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase

progression

Gene Wiki entry for NEK9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NEK9 gene promoter:
         c-Myb   MRF-2   Bach1   FOXD1   SRY   ER-alpha   PPAR-gamma2   PPAR-gamma1   RORalpha1   COUP-TF1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for NEK9

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NEK9

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3 Ensembl cytogenetic band: 14q24.3 HGNC cytogenetic band: 14q24.2

NEK9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK9 gene location

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M055716: view genomic region (about GC identifiers)

Start:	55,716,982 bp from pter
End:	55,761,929 bp from pter
Size:	44,948 bases
Orientation:	minus strand

1 alternative location:

Chr14- 75,548,819-75,593,778

RefSeq DNA sequence:

NC_000014.8 NT_026437.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19 (See protein sequence)

Recommended Name: Serine/threonine-protein kinase Nek9

Size: 979 amino acids; 107168 Da

Cofactor: Magnesium

Subunit: Homodimer. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with NEK6, NEK7 and

BICD2. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex

Subcellular location: Cytoplasm. Nucleus

Developmental stage: Expression varied mildly across the cell cycle, with highest expression observed in G1 and

stationary-phase cells

Sequence caution: Sequence=AAD31936.1; Type=Erroneous gene model prediction; Sequence=BAC02704.1; Type=Erroneous

initiation; Note=Translation N-terminally shortened;

Secondary accessions: Q52LK6 Q8NCN0 Q8TCY4 Q9UPI4 Q9Y6S4 Q9Y6S5 Q9Y6S6

Explore the universe of human proteins at neXtProt for NEK9: NX_Q8TD19

Post-translational modifications:

Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated

phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_149107.4

ENSEMBL proteins:

ENSP00000238616

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NEK9 OriGene Protein Over-expression Lysate: NEK9
	GenScript Custom Purified and Recombinant Proteins Services for NEK9
	Novus Biologicals Proteins for NEK9
	Novus Biologicals Lysates for NEK9
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005739	mitochondrion	IDA	18029348

About this table

NEK9 for ontologies About GeneDecksing

Antibodies for NEK9:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NEK9
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for NEK9
	Novus Biologicals Antibodies for NEK9
	Browse antibodies at Epitomics

Assays for NEK9:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NEK9
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NEK9

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NEK9 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR002290 Ser/Thr_prot_kinase_dom

IPR011009 Kinase-like_dom

IPR008271 Ser/Thr_prot_kinase_AS

IPR009091 Reg_csome_cond/b-lactamase_inh

IPR000719 Prot_kinase_cat_dom

Graphical View of Domain Structure for InterPro Entry Q8TD19

ProtoNet protein and cluster: Q8TD19

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19

Domain: Dimerizes through its coiled-coil domain

Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily

Similarity: Contains 1 protein kinase domain

Similarity: Contains 6 RCC1 repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19

Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome

separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3

on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase

progression

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is

activated by manganese >> magnesium ions. Sensitive to increasing concentration of detergents. It is not cell-cycle

regulated but activity is higher in G0-arrested cells

Enzyme Number (IUBMB): EC 2.7.11.1

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for NEK9 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NEK9 Sigma-Aldrich shRNA Panels and shRNA for NEK9
		OriGene 29mer shRNA kits in GFP-retroviral vector: NEK9 OriGene shRNA RFP: NEK9 OriGene basic RS shRNA: NEK9 OriGene siRNA: NEK9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NEK9

miRNA:		Sigma-Aldrich microRNA Mimics for NEK9 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NEK9
		2 SABiosciences Assays for microRNAs that regulate NEK9:
		hsa-miR-483-3p hsa-miR-595

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: NEK9 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NEK9 OriGene untagged cDNA clones in CMV expression vector (see all 2): NEK9 OriGene 3'-UTR clone: NEK9 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for NEK9
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for NEK9

5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005515	protein binding	IPI	17353931
GO:0005524	ATP binding	IEA	--

About this table

NEK9 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for NEK9

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NEK9

3 Interacting proteins for NEK9 (Q8TD19^{1, 2} ENSP00000238616³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NEK6	Q9HC98¹, ENSP00000362702³	EBI-1044009,EBI-740364 STRING: ENSP00000362702
SSRP1	Q08945², ENSP00000278412³	MINT-2984265 STRING: ENSP00000278412
GABARAPL2	P60520¹	EBI-1044009,EBI-720116

About this table

4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IEA	--
GO:0007049	cell cycle	IEA	--
GO:0007067	mitosis	IEA	--
GO:0051301	cell division	IEA	--

About this table

NEK9 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NEK9

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for NEK9 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NEK9 Sigma-Aldrich shRNA Panels and shRNA for NEK9
		OriGene 29mer shRNA kits in GFP-retroviral vector: NEK9 OriGene shRNA RFP: NEK9 OriGene basic RS shRNA: NEK9 OriGene siRNA: NEK9
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NEK9

miRNA:		Sigma-Aldrich microRNA Mimics for NEK9 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NEK9
		2 SABiosciences Assays for microRNAs that regulate NEK9:
		hsa-miR-483-3p hsa-miR-595

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: NEK9 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NEK9 OriGene untagged cDNA clones in CMV expression vector (see all 2): NEK9 OriGene 3'-UTR Clone: NEK9 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for NEK9

Primers:		OriGene genome-wide validated SYBR primer pairs: NEK9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NEK9: PPH07488A

REFSEQ mRNAs for NEK9 gene:

NM_033116.4

Additional cDNA sequence:

AB082526.1 AK128693.1 AL117502.1 AL832633.2 AL833036.1 AY048580.1 AY080896.1 BC001714.1

BC009336.2 BC062742.1 BC093881.1 BC112101.1 CR612206.1 L40402.1

17 DOTS entries:

DT.100795741 DT.97800508 DT.219045 DT.40107140 DT.120791357 DT.91756610 DT.91638460 DT.100029539

DT.100795744 DT.100795742 DT.102822232 DT.40126940 DT.95177241 DT.95310804 DT.99959625 DT.120791347

DT.120791516

11 AceView cDNA sequences:

AI884951 BE327500 AI859026 AA827006 AI950160 AI972045 AI199074 AW339836

AW195739 AA625810 AA528182

highest scoring ESTs for NEK9:

AB082526 AI077817 AI298668 AI799812 AI961740 AW016183 AW578773 AW578778 AY048580 AY080896

Unigene Cluster for NEK9:

NIMA (never in mitosis gene a)- related kinase 9

Hs.728169 [show with all ESTs]

Unigene Representative Sequence: NM_033116

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NEK9 (see all 10)

ExUns:	1	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^
SP1:															-																										-
SP2:									-						-
SP3:											-				-
SP4:
SP5:

ExUns:	18a	·	18b	^	19	^	20a	·	20b	·	20c	^	21	^	22	^	23	^	24a	·	24b
SP1:			-				-										-
SP2:
SP3:
SP4:																	-
SP5:

About this scheme

ECgene alternative splicing isoforms for NEK9
1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000238616(uc001xrj.2 uc001xrk.2 uc001xrl.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NEK9 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching NEK9 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35843_at²^{, 3}	U95-A	1	0.56	1.00	0.73	0.78	L40402	0.80	1.00	0.91	1
63729_f_at²	U95-C	1589	0.56	0.00	0.81	1.22	--	--	--	--	--
214738_s_at²^{, 3}	U133-A	1	0.73	1.00	--	--	BE792298	0.60	1.00	0.82	1
212299_at²^{, 3}	U133-A	1	0.64	1.00	--	--	AL117502	0.40	1.00	0.76	1
214738_s_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
212299_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--

About this table

NEK9 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

NEK9 gene electronic northern expression

About these images

CGAP SAGE TAG: GAGCTGATGG

SOURCE GeneReport for Unigene cluster: Hs.728169

Expression variation in blood from EXPOLDB for NEK9

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19

Tissue specificity: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and

fibroblasts

Primers:		OriGene genome-wide validated SYBR primer pairs: NEK9 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NEK9: PPH07488A

SABiosciences Custom PCR Arrays for NEK9

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NEK9 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NEK9¹	--	NIMA (never in mitosis gene a)- related kinase 9	93.53(n) 95.89(a)	490790 XM_547912.2 XP_547912.2
cow (Bos taurus)	NEK9¹	--	NIMA (never in mitosis gene a)- related kinase 9	92.63(n) 96.11(a)	534652 XM_614489.3 XP_614489.3
mouse (Mus musculus)	Nek9^{1 , 5}	12 (39.63 cM)⁵	NIMA (never in mitosis gene a)-related expressed kinase more^{1, 5}	90.24(n)¹ 95.6(a)¹	217718¹ NM_145138.1¹ NP_660120.1¹ AI428421⁵ AJ489828⁵ (see all 17)
chicken (Gallus gallus)	NEK9¹	--	NIMA (never in mitosis gene a)- related kinase 9	79.05(n) 85.74(a)	428891 XM_001235084.1 XP_001235085.1
fruit fly (Drosophila melanogaster)	CG10951³	96A23--24	protein amino acid phosphorylation receptor signaling more	30(a)	--

About this table Species with no ortholog for NEK9

ENSEMBL Gene Tree for NEK9 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NEK9 gene

NEK2² NEK10² NEK4² NEK6² NEK7²

NEK9 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs9672^1,2	F,H	75548967(+)	`CAAAAG/ACAATM`	1	--	ut3¹		5		MN NS EA	602
rs10707^1,2	--	75549009(+)	`ATAAAG/AAAAAA`	1	--	ut3¹ trp³		1		MN	184
rs11866^1,2	--	75549158(+)	`GTCCCA/GGGCAC`	1	--	ut3¹		0	--	--	--	--
rs96358^1,2	C,F,A,	75572265(+)	`ATCTGG/ATGGTC`	1	--	int¹		15		NS EA NA	2286
rs119076^1,2	C,F,O,A,	75572419(+)	`AGTAAG/TATGTG`	1	--	int¹		19		NS EA NA WA	2124
rs119077^1,2	C,F,H,	75572559(+)	`ATAAAC/TACCTT`	1	--	int¹		12		NS EA NA WA	486
rs175447^1,2	C,F,H,	75591401(+)	`TAAGAA/GAAGTC`	1	--	int¹		11		NS EA NA WA	422
rs175448^1,2	C,F,A,H,	75591071(+)	`TTAAAG/AGTTAT`	1	--	int¹		10		NS EA NA WA	600
rs175449^1,2	C,F,O,A,H,	75590846(-)	`GAGATA/TGTTAT`	2	I	syn¹ ref¹		98		NS MN EA PA EU CA WA NA	5206
rs175450^1,2	C,F,O,A,	75590340(+)	`TCTTTG/AGACCA`	1	--	int¹		13		NS EA NA WA	770

About this table

HapMap Linkage Disequilibrium images for NEK9 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NEK9: --

Search QIAGEN SeqTarget long-range PCR primers for resequencing for NEK9

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NEK9 for disorders About GeneDecksing

OMIM: 609798

1 PharmGKB disease relationship for NEK9 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

Export disorders and mutations for NEK9 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/28 PubMed articles for NEK9 gene, integrated from 7 sources (see all 28):
(articles sorted by number of sources associating them with NEK9)

Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2. (PubMed id 11864968)^{1, 2, 3, 7} Holland P.M.... Virca G.D. (2002)
The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)^{1, 2} Rapley J....Roig J. (2008)
Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)^{1, 2} Wissing J.... Daub H. (2007)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Nek9, a novel FACT-associated protein, modulates interphase progression. (PubMed id 14660563)^{1, 2} Tan B.C.-M. and Lee S.-C. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{1, 2} Heilig R.... Weissenbach J. (2003)
Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. (PubMed id 12101123)^{1, 2} Roig J.... Avruch J. (2002)
Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)^{1, 2} Ohara O.... Koseki H. (2002)
An autoinhibitory tyrosine motif in the cell-cycle-re gulated Nek7 kinase is released through binding of Nek9. (PubMed id 19941817)^{1, 7} Richards M.W....Bayliss R. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 91754	HGNC: 18591	AceView: NEK9.1	Ensembl:ENSG00000119638	euGenes: HUgn91754
ECgene: NEK9	H-InvDB: NEK9

(According to HUGE)
About This Section

HUGE: KIAA1995

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for NEK9 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for NEK9 gene:
Search GeneIP for patents involving NEK9

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NEK9		Antibodies for NEK9
	Super-pooled esiRNAs for NEK9		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NEK9		microRNA Mimics for NEK9
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Nano Scale siRNA for NEK9
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NEK9
	Search QIAGEN SeqTarget long-range PCR primers for resequencing for NEK9
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NEK9
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NEK9

	GenScript Custom Purified and Recombinant Proteins Services for NEK9		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NEK9
	GenScript Custom Assay Services for NEK9		GenScript Custom Superior Antibodies Services for NEK9
	GenScript Custom overexpressing Cell Line Services for NEK9		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NEK9 promoter
	Search Chromatin IP Primers for NEK9
	RT² qPCR Primer Assay for NEK9
	GNC Network for NEK9
	Assays for microRNAs that regulate NEK9
	SABiosciences Custom PCR Arrays for NEK9

Search Tocris compounds for NEK9

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for NEK9
	Proteins for NEK9
	Lysates for NEK9

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for NEK9

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

View Random Gene

Category
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

NEK9 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

Advanced Search

Export list of displayed genes

NEK9 Gene

protein-coding GIFtS: 55

Aliases &
Descriptions
for NEK9 gene

Summaries
for NEK9 gene

Genomic Views
for NEK9 gene

Proteins
for NEK9 gene

Protein Domains/
Families
for NEK9 gene

Gene Function
for NEK9 gene

Pathways & Interactions
for NEK9 gene

Drugs & Compounds
for NEK9 gene

Transcripts
for NEK9 gene

Expression
for NEK9 gene

Orthologs
for NEK9 gene

Paralogs
for NEK9 gene

Genomic Variants
for NEK9 gene

Disorders & Mutations
for NEK9 gene

Medical News
for NEK9 gene

Publications
for NEK9 gene

External Searches for NEK9 gene

Genome Databases showing NEK9 gene

Other Databases showing NEK9 gene

Specialized Databases showing NEK9 gene

Intellectual Property
for NEK9 gene

Products
for NEK9 gene

View Random Gene

Advanced Search

Export list of displayed genes

NEK9 Gene

protein-coding GIFtS: 55

Aliases & Descriptionsfor NEK9 gene

Summariesfor NEK9 gene

Genomic Viewsfor NEK9 gene

Proteinsfor NEK9 gene

Protein Domains/Familiesfor NEK9 gene

Gene Functionfor NEK9 gene

Pathways & Interactionsfor NEK9 gene

Drugs & Compoundsfor NEK9 gene

Transcriptsfor NEK9 gene

Expression for NEK9 gene

Orthologsfor NEK9 gene

Paralogsfor NEK9 gene

Genomic Variantsfor NEK9 gene

Disorders & Mutationsfor NEK9 gene

Medical Newsfor NEK9 gene

Publicationsfor NEK9 gene

External Searches for NEK9 gene

Genome Databases showing NEK9 gene

Other Databases showing NEK9 gene

Specialized Databases showing NEK9 gene

Intellectual Propertyfor NEK9 gene

Productsfor NEK9 gene

View Random Gene

Aliases &
Descriptions
for NEK9 gene

Summaries
for NEK9 gene

Genomic Views
for NEK9 gene

Proteins
for NEK9 gene

Protein Domains/
Families
for NEK9 gene

Gene Function
for NEK9 gene

Pathways & Interactions
for NEK9 gene

Drugs & Compounds
for NEK9 gene

Transcripts
for NEK9 gene

Expression
for NEK9 gene

Orthologs
for NEK9 gene

Paralogs
for NEK9 gene

Genomic Variants
for NEK9 gene

Disorders & Mutations
for NEK9 gene

Medical News
for NEK9 gene

Publications
for NEK9 gene

Intellectual Property
for NEK9 gene

Products
for NEK9 gene