Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



NEK9 Gene

protein-coding   GIFtS: 55

GC14M055716
NIMA (never in mitosis gene a)- related kinase 9
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
NIMA (never in mitosis gene a)- related kinase 91 2     Never in mitosis A-related kinase 92 3
NERCC1 2 3     NERCC12 5
Nek81 2 3     MGC1383062
DKFZp434D09351 2     NIMA-related kinase Nek82
MGC167141 2     serine/threonine-protein kinase Nek92
NimA-related kinase 82 3     KIAA19953
NimA-related protein kinase 92 3     NEK83
Nercc1 kinase2 3     EC 2.7.11.13

External Ids:    HGNC: 185911   Entrez Gene: 917542   Ensembl: ENSG000001196387   UniProtKB: Q8TD193   

Export aliases for NEK9 gene to outside databases

Previous GC identifers: GC14M073077 GC14M069365 GC14M073538 GC14M073541 GC14M074618 GC14M075548


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome
separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3
on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase
progression

Gene Wiki entry for NEK9

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NEK9 gene promoter:
         c-Myb   MRF-2   Bach1   FOXD1   SRY   ER-alpha   PPAR-gamma2   PPAR-gamma1   RORalpha1   COUP-TF1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for NEK9

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NEK9 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q24.3   Ensembl cytogenetic band:  14q24.3   HGNC cytogenetic band: 14q24.2

NEK9 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NEK9 gene location

GeneLoc gene densities for chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M055716:  view genomic region     (about GC identifiers)

Start:
55,716,982 bp from pter
End:
55,761,929 bp from pter
Size:
44,948 bases
Orientation:
minus strand

1 alternative location:
Chr14- 75,548,819-75,593,778     
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19 (See protein sequence)
Recommended Name: Serine/threonine-protein kinase Nek9  
Size: 979 amino acids; 107168 Da
Cofactor: Magnesium
Subunit: Homodimer. Binds to Ran GTPase. Has a greater affinity for Ran-GDP over Ran-GTP. Interacts with NEK6, NEK7 and
BICD2. Interacts with SSRP1 and SUPT16H, the 2 subunits of the FACT complex
Subcellular location: Cytoplasm. Nucleus
Developmental stage: Expression varied mildly across the cell cycle, with highest expression observed in G1 and
stationary-phase cells
Sequence caution: Sequence=AAD31936.1; Type=Erroneous gene model prediction; Sequence=BAC02704.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q52LK6 Q8NCN0 Q8TCY4 Q9UPI4 Q9Y6S4 Q9Y6S5 Q9Y6S6

Explore the universe of human proteins at neXtProt for NEK9: NX_Q8TD19 

Post-translational modifications:

  • Autophosphorylated on serine and threonine residues. When complexed with FACT, exhibits markedly elevated
  • phosphorylation on Thr-210. During mitosis, not phosphorylated on Thr-210. Phosphorylated by CDK1 in vitro1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_149107.4  

    ENSEMBL proteins: 
    ENSP00000238616 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NEK9
    OriGene Protein Over-expression Lysate: NEK9
    GenScript Custom Purified and Recombinant Proteins Services for NEK9 
    Novus Biologicals Proteins for NEK9
    Novus Biologicals Lysates for NEK9
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005739 mitochondrion IDA18029348
    About this table

    NEK9 for ontologies           About GeneDecksing



    Antibodies for NEK9: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for NEK9
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for NEK9 
    Novus Biologicals Antibodies for NEK9
    Browse antibodies at Epitomics

    Assays for NEK9: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NEK9 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for NEK9 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NEK9 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS
     IPR009091 Reg_csome_cond/b-lactamase_inh
     IPR000719 Prot_kinase_cat_dom

    Graphical View of Domain Structure for InterPro Entry Q8TD19

    ProtoNet protein and cluster: Q8TD19

    UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
    Domain: Dimerizes through its coiled-coil domain
    Similarity: Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily
    Similarity: Contains 1 protein kinase domain
    Similarity: Contains 6 RCC1 repeats


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
    Function: Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome
    separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3
    on serine and threonine residues and beta-casein on serine residues. Important for G1/S transition and S phase
    progression
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated during mitosis by intramolecular autophosphorylation. Activity and autophosphorylation is
    activated by manganese >> magnesium ions. Sensitive to increasing concentration of detergents. It is not cell-cycle
    regulated but activity is higher in G0-arrested cells
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for NEK9
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NEK9
    Sigma-Aldrich shRNA Panels and shRNA for NEK9
    OriGene 29mer shRNA kits in GFP-retroviral vector: NEK9
    OriGene shRNA RFP: NEK9
    OriGene basic RS shRNA: NEK9
    OriGene siRNA: NEK9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NEK9 
    miRNA:Sigma-Aldrich microRNA Mimics for NEK9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NEK9 
    2 SABiosciences Assays for microRNAs that regulate NEK9:
    hsa-miR-483-3p hsa-miR-595

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: NEK9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NEK9
    OriGene untagged cDNA clones in CMV expression vector (see all 2): NEK9
    OriGene 3'-UTR clone: NEK9 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NEK9 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for NEK9 

    5/8 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity IEA--
    GO:0005515 protein binding IPI17353931
    GO:0005524 ATP binding IEA--
    About this table

    NEK9 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for NEK9 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NEK9

    3 Interacting proteins for NEK9 (Q8TD191, 2 ENSP000002386163) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NEK6Q9HC981, ENSP000003627023EBI-1044009,EBI-740364 STRING: ENSP00000362702
    SSRP1Q089452, ENSP000002784123MINT-2984265 STRING: ENSP00000278412
    GABARAPL2P605201EBI-1044009,EBI-720116
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation IEA--
    GO:0007049 cell cycle IEA--
    GO:0007067 mitosis IEA--
    GO:0051301 cell division IEA--
    About this table

    NEK9 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NEK9


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for NEK9
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NEK9
    Sigma-Aldrich shRNA Panels and shRNA for NEK9
    OriGene 29mer shRNA kits in GFP-retroviral vector: NEK9
    OriGene shRNA RFP: NEK9
    OriGene basic RS shRNA: NEK9
    OriGene siRNA: NEK9
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NEK9 
    miRNA: Sigma-Aldrich microRNA Mimics for NEK9
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NEK9 
    2 SABiosciences Assays for microRNAs that regulate NEK9:
    hsa-miR-483-3p hsa-miR-595
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: NEK9
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NEK9
    OriGene untagged cDNA clones in CMV expression vector (see all 2): NEK9
    OriGene 3'-UTR Clone: NEK9 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NEK9 
    Primers: OriGene genome-wide validated SYBR primer pairs: NEK9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NEK9: PPH07488A

    REFSEQ mRNAs for NEK9 gene: 

    NM_033116.4  

    Additional cDNA sequence: 

    AB082526.1 AK128693.1 AL117502.1 AL832633.2 AL833036.1 AY048580.1 AY080896.1 BC001714.1 
    BC009336.2 BC062742.1 BC093881.1 BC112101.1 CR612206.1 L40402.1 

    17 DOTS entries:

    DT.100795741  DT.97800508  DT.219045  DT.40107140  DT.120791357  DT.91756610  DT.91638460  DT.100029539 
    DT.100795744  DT.100795742  DT.102822232  DT.40126940  DT.95177241  DT.95310804  DT.99959625  DT.120791347 
    DT.120791516 

    11 AceView cDNA sequences:

    AI884951 BE327500 AI859026 AA827006 AI950160 AI972045 AI199074 AW339836 
    AW195739 AA625810 AA528182 

    highest scoring ESTs for NEK9:

    AB082526 AI077817 AI298668 AI799812 AI961740 AW016183 AW578773 AW578778 AY048580 AY080896 

    Unigene Cluster for NEK9:

    NIMA (never in mitosis gene a)- related kinase 9
    Hs.728169  [show with all ESTs]
    Unigene Representative Sequence: NM_033116


    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for NEK9 (see all 10)

    ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^
    SP1:                                            -                                                                             -                                 
    SP2:                          -                 -                                                                                                               
    SP3:                                -           -                                                                                                               
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 18a · 18b ^ 19 ^ 20a · 20b · 20c ^ 21 ^ 22 ^ 23 ^ 24a · 24b
    SP1:        -           -                             -               
    SP2:                                                                  
    SP3:                                                                  
    SP4:                                                  -               
    SP5:                                                                  

    About this scheme

    ECgene alternative splicing isoforms for NEK9
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000238616(uc001xrj.2 uc001xrk.2 uc001xrl.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    NEK9 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching NEK9 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    35843_at2, 3 U95-A 1 0.56 1.00 0.73 0.78 L40402 0.80 1.00 0.91 1
    63729_f_at2 U95-C 1589 0.56 0.00 0.81 1.22 -- -- -- -- --
    214738_s_at2, 3 U133-A 1 0.73 1.00 -- -- BE792298 0.60 1.00 0.82 1
    212299_at2, 3 U133-A 1 0.64 1.00 -- -- AL117502 0.40 1.00 0.76 1
    214738_s_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    212299_at2 U133Plus2 1 0.64 1.00 -- -- -- -- -- -- --
    About this table

    NEK9 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    NEK9 gene expression
    NEK9 gene electronic northern expression
    NEK9 gene sage expression
    About these images

    CGAP SAGE TAG: GAGCTGATGG

    SOURCE GeneReport for Unigene cluster: Hs.728169

    Expression variation in blood from EXPOLDB for NEK9

    UniProtKB/Swiss-Prot: NEK9_HUMAN, Q8TD19
    Tissue specificity: Most abundant in heart, liver, kidney and testis. Also expressed in smooth muscle cells and
    fibroblasts

    Primers: OriGene genome-wide validated SYBR primer pairs: NEK9
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NEK9: PPH07488A
        SABiosciences Custom PCR Arrays for NEK9 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for NEK9 gene from 5/8 species (see all 8)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NEK91   -- NIMA (never in mitosis gene a)- related kinase 9 93.53(n)
    95.89(a)
    490790  XM_547912.2  XP_547912.2 
    cow
    (Bos taurus)
    NEK91   -- NIMA (never in mitosis gene a)- related kinase 9 92.63(n)
    96.11(a)
    534652  XM_614489.3  XP_614489.3 
    mouse
    (Mus musculus)
    Nek91 , 5 12 (39.63 cM)5
    NIMA (never in mitosis gene a)-related expressed kinase more1, 5 90.24(n)1
    95.6(a)1
    2177181  NM_145138.11  NP_660120.11 
     AI4284215  AJ4898285  (see all 17)
    chicken
    (Gallus gallus)
    NEK91   -- NIMA (never in mitosis gene a)- related kinase 9 79.05(n)
    85.74(a)
    428891  XM_001235084.1  XP_001235085.1 
    fruit fly
    (Drosophila melanogaster)
    CG109513 96A23--24 protein amino acid phosphorylation receptor
    signaling more
    30(a)   --
    About this table        Species with no ortholog for NEK9

    ENSEMBL Gene Tree for NEK9 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for NEK9 gene
    NEK22  NEK102  NEK42  NEK62  NEK72  

    NEK9 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/371 NCBI SNPs in NEK9 are shown (see all 371)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 14 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs96721,2
    F,H75548967(+) CAAAAG/ACAATM 1 -- ut315Minor allele frequency- A:0.02MN NS EA 602
    rs107071,2
    --75549009(+) ATAAAG/AAAAAA 1 -- ut31 trp31Minor allele frequency- A:0.00MN 184
    rs118661,2
    --75549158(+) GTCCCA/GGGCAC 1 -- ut310--------
    rs963581,2
    C,F,A,75572265(+) ATCTGG/ATGGTC 1 -- int115Minor allele frequency- A:0.19NS EA NA 2286
    rs1190761,2
    C,F,O,A,75572419(+) AGTAAG/TATGTG 1 -- int119Minor allele frequency- T:0.27NS EA NA WA 2124
    rs1190771,2
    C,F,H,75572559(+) ATAAAC/TACCTT 1 -- int112Minor allele frequency- T:0.03NS EA NA WA 486
    rs1754471,2
    C,F,H,75591401(+) TAAGAA/GAAGTC 1 -- int111Minor allele frequency- G:0.01NS EA NA WA 422
    rs1754481,2
    C,F,A,H,75591071(+) TTAAAG/AGTTAT 1 -- int110Minor allele frequency- A:0.39NS EA NA WA 600
    rs1754491,2
    C,F,O,A,H,75590846(-) GAGATA/TGTTAT 2 I syn1 ref198Minor allele frequency- T:0.34NS MN EA PA EU CA WA NA 5206
    rs1754501,2
    C,F,O,A,75590340(+) TCTTTG/AGACCA 1 -- int113Minor allele frequency- A:0.30NS EA NA WA 770
    About this table

    HapMap Linkage Disequilibrium images for NEK9 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NEK9: --

    Search QIAGEN SeqTarget long-range PCR primers for resequencing for NEK9 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NEK9 for disorders           About GeneDecksing

    OMIM: 609798

    1 PharmGKB disease relationship for NEK9 gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table


    Export disorders and mutations for NEK9 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/28 PubMed articles for NEK9 gene, integrated from 7 sources (see all 28):
    (articles sorted by number of sources associating them with NEK9)
    1. Purification, cloning, and characterization of Nek8, a novel NIMA- related kinase, and its candidate substrate Bicd2. (PubMed id 11864968)1, 2, 3, 7 Holland P.M.... Virca G.D. (2002)
    2. The NIMA-family kinase Nek6 phosphorylates the kinesin Eg5 at a novel site necessary for mitotic spindle formation. (PubMed id 19001501)1, 2 Rapley J....Roig J. (2008)
    3. Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. (PubMed id 17192257)1, 2 Wissing J.... Daub H. (2007)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    6. Nek9, a novel FACT-associated protein, modulates interphase progression. (PubMed id 14660563)1, 2 Tan B.C.-M. and Lee S.-C. (2004)
    7. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    8. Nercc1, a mammalian NIMA-family kinase, binds the Ran GTPase and regulates mitotic progression. (PubMed id 12101123)1, 2 Roig J.... Avruch J. (2002)
    9. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2 Ohara O.... Koseki H. (2002)
    10. An autoinhibitory tyrosine motif in the cell-cycle-re gulated Nek7 kinase is released through binding of Nek9. (PubMed id 19941817)1, 7 Richards M.W....Bayliss R. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 91754 HGNC: 18591 AceView: NEK9.1 Ensembl:ENSG00000119638 euGenes: HUgn91754
    ECgene: NEK9 H-InvDB: NEK9

    (According to HUGE)
    About This Section
    HUGE: KIAA1995

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for NEK9 gene:
    Search GeneIP for patents involving NEK9

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for NEK9 Antibodies for NEK9
     Super-pooled esiRNAs for NEK9 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NEK9 microRNA Mimics for NEK9
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Nano Scale siRNA for NEK9
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NEK9
     Search QIAGEN SeqTarget long-range PCR primers for resequencing for NEK9
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NEK9
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NEK9
     GenScript Custom Purified and Recombinant Proteins Services for NEK9 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NEK9
     GenScript Custom Assay Services for NEK9 GenScript Custom Superior Antibodies Services for NEK9
     GenScript Custom overexpressing Cell Line Services for NEK9 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in NEK9 promoter
     Search Chromatin IP Primers for NEK9
     RT2 qPCR Primer Assay for NEK9
     GNC Network for NEK9
     Assays for microRNAs that regulate NEK9
     SABiosciences Custom PCR Arrays for NEK9
     Search Tocris compounds for NEK9
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for NEK9
     Proteins for NEK9
     Lysates for NEK9
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     ELISAs and CLIAs for NEK9
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    NEK9 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4