Aliases &
Descriptions
for NEO1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| neogenin 11 2 | | HsT175341 | | NGN1 2 3 5 | | DKFZp547A0662 | | IGDCC21 2 3 | | neogenin2 | | Immunoglobulin superfamily DCC subclass member 22 3 | | neogenin homolog 12 | | neogenin (chicken) homolog 11 | | DKFZp547B1462 |
Export aliases for NEO1 gene to outside databasesPrevious GC identifers: GC15P069350 GC15P066449 GC15P070920 GC15P071060 GC15P071131 GC15P073346 |
Summaries
for NEO1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NEO1:
This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded proteinconsists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain anda C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may beinvolved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cellproliferation in certain cancers. Alternate splicing results in multiple transcript variants. (provided by RefSeq)
UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859Function: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to theirdifferentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues
Gene Wiki entry for NEO1 |
Genomic Views
for NEO1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NEO1 gene promoter:
p53 MZF-1 STAT1beta STAT1alpha STAT1 Tal-1beta E47 Bach1 Nkx3-1 v4 Nkx3-1 v2
Other transcription factors
Search SABiosciences Chromatin IP Primers for NEO1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NEO1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.3-q23 Ensembl cytogenetic band: 15q24.1 HGNC cytogenetic band: 15q22.3-q23NEO1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15P050240: view genomic region
(about GC identifiers)
Start:
|
50,240,408 bp from pter |
End:
|
50,428,957 bp from pter |
Size:
|
188,550 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr15+ 73,344,875-73,597,546 |
RefSeq DNA sequence:- NC_000015.9 NT_010194.17
|
Proteins
for NEO1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859 (See
protein sequence)Recommended Name: Neogenin precursor Size: 1461 amino acids; 160017 Da
Subunit: Interacts with RGMA (By similarity)
Subcellular location: Cell membrane; Single-pass type I membrane protein
PDB structures from  and Proteopedia  :1X5F (3D)
1X5G (3D)
1X5H (3D)
1X5I (3D)
1X5J (3D)
1X5K (3D)
Secondary accessions: O00340 Q17RX1Alternative splicing: 2 isoforms: Q92859-1 Q92859-2 (Additional isoforms seem to exist)Explore the universe of human proteins at neXtProt for NEO1: NX_Q92859
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (3 alternative transcripts):
NP_001166094.1 NP_001166095.1 NP_002490.2
ENSEMBL proteins: ENSP00000341198 ENSP00000261908 ENSP00000369171
Human Recombinant Proteins
5/7 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 7): About this table
NEO1 for ontologies About GeneDecksing
Antibodies for NEO1:
Assays for NEO1: |
Protein
Domains/
Families
for NEO1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NEO1 for domains About GeneDecksing
5/8 InterPro domains/families (see all 8):Graphical View of Domain Structure for InterPro Entry Q92859ProtoNet protein and cluster: Q92859 3 Blocks protein families: IPB003598 Immunoglobulin C-2 type IPB003962 Fibronectin type III repeat signature IPB010560 Neogenin
UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859Similarity: Belongs to the immunoglobulin superfamily. DCC familySimilarity: Contains 6 fibronectin type-III domainsSimilarity: Contains 4 Ig-like C2-type (immunoglobulin-like) domains |
Gene Function
for NEO1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859Function: May be involved as a regulatory protein in the transition of undifferentiated proliferating cells to theirdifferentiated state. May also function as a cell adhesion molecule in a broad spectrum of embryonic and adult tissues
Genatlas biochemistry entry for NEO1:neogenin,cell surface protein,DCC related member of the Ig superfamily,expressed in nervous system of embryo3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- | | GO:0030528 | transcription regulator activity |
IEA | -- | | GO:0045296 | cadherin binding |
IEA | -- |
About this table
NEO1 for ontologies About GeneDecksing
Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Neo1):
NEO1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NEO1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
NEO1 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for NEO1):
SABiosciences Custom Pathway-Focused PCR Arrays for NEO1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NEO1
1 Interacting protein for NEO1 (ENSP000002619083) via UniProtKB, MINT, and/or STRINGAbout this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
NEO1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NEO1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NEO1
|
Transcripts
for NEO1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NEO1 gene (3 alternative transcripts): NM_001172623.1 NM_001172624.1 NM_002499.3 Additional cDNA sequence: AB209412.1 AL355708.1 AL359597.1 AL390182.1 BC117161.1 BC143270.1 BC143271.1 BC143279.1 U61262.1 U72391.1 9 DOTS entries: DT.217276 DT.75122843 DT.100752161 DT.121019971 DT.40120627 DT.121019984 DT.121019999 DT.40118194 DT.95125422 24/284 AceView cDNA sequences (see all 284): AI097595 CD722663 AI418017 BF437670 CA843823 AW117483 BG149193 AI392826 BM666235 BQ917623 AA335289 AI393298 BQ000467 BU146322 BQ575097 CB069095 AA363681 AI739564 CB068937 U72391 AL355708 BE856703 BU160358 AI800118
 highest scoring ESTs for NEO1:U61262 AA233463 AA363681 AA666265 AA954219 AI126934 AI291020 AI381819 AI393785 AI745456 Unigene Cluster for NEO1: Neogenin 1 Hs.388613 [show with all ESTs]Unigene Representative Sequence: NM_002499
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for NEO1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | | |
| ExUns: | 24 | ^ | 25 | ^ | 26 | ^ | 27 | ^ | 28 | ^ | 29 |
|---|
|
| SP1: | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NEO1
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000339362(uc010uky.1) ENST00000261908(uc002avm.3 uc010ukx.1 uc010ukz.1)
ENST00000379842(uc002avn.3)
|
Expression
for NEO1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NEO1 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching NEO1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 91205_s_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
0.99 |
1.30 |
N20978 |
0.80 |
1.00 |
0.91 |
1 |
| 33169_at2, 3
|
U95-A |
1 |
0.88 |
1.00 |
0.97 |
0.70 |
U61262 |
1.00 |
1.00 |
1.00 |
1 |
| 204321_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_002499 |
0.60 |
1.00 |
0.82 |
1 |
| 225270_at2, 3
|
U133-B |
1 |
0.91 |
1.00 |
-- |
-- |
AL355708 |
0.60 |
1.00 |
0.82 |
1 |
| 204321_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 225270_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NEO1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.388613
Expression variation in blood from EXPOLDB for NEO1 UniProtKB/Swiss-Prot: NEO1_HUMAN, Q92859Tissue specificity: Widely expressed and also in cancer cell lines
SABiosciences Custom PCR Arrays for NEO1
|
Orthologs
for NEO1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NEO1 gene from 5/10 species (see all 10)
About this table Species with no ortholog for NEO1
ENSEMBL Gene Tree for NEO1 (if available) |
Paralogs
for NEO1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NEO1 gene
- DCC2 ROBO22 ROBO42 ROBO12 ROBO32
NEO1 for paralogs About GeneDecksing
|
Genomic Variants
for NEO1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 15 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NEO1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NEO1
3 Indels: 45365 87740 77001 | | QIAGEN SeqTarget long-range PCR primers for resequencing NEO1 |
|
Disorders & Mutations
for NEO1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NEO1 for disorders About GeneDecksing
OMIM: 601907
Human Genome Epidemiology (HuGE) Navigator: NEO1 (1 document)
Export disorders and mutations for NEO1 gene to outside databases
|
Medical News
for NEO1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NEO1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/25 PubMed articles for NEO1 gene, integrated from 7 sources (see all 25):
(articles sorted by number of sources associating them with NEO1)- Identification and characterization of neogenin, a DCC-related gene. (PubMed id 9121761)1, 2, 3, 7 Meyerhardt J.A.... Fearon E.R. (1997)
- Molecular characterization of human neogenin, a DCC-related protein, and the mapping of its gene (NEO1) to chromosomal position 15q22.3- q23. (PubMed id 9169140)1, 2, 7 Vielmetter J.... Dreyer W.J. (1997)
- Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. (PubMed id 16335952)1, 2 Liu T.... Smith R.D. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Characterization of the netrin/RGMa receptor neogenin in neurogenic regions of the mouse and human adult forebrain. (PubMed id 20575069)1 Bradford D....Cooper H.M. (2010 Aug 15)
- Hemojuvelin-neogenin interaction is required for bone morphogenic protein-4-induced hepcidin expression. (PubMed id 19564337)1 Zhang A.S....Enns C.A. (2009)
- Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)2 Wollscheid B.... Watts J.D. (2009)
- Neogenin regulates neuronal survival through DAP kinase. (PubMed id 18583991)1 Fujita Y....Yamashita T. (2008)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
|
External Searches for NEO1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NEO1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NEO1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NEO1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NEO1 gene:
Search GeneIP for patents involving NEO1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NEO1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for NEO1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for NEO1 |
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