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NKIRAS2 Gene

protein-coding GIFtS: 48

GC17P035934

NFKB inhibitor interacting Ras-like 2
(Previous name: NFKB inhibitor interacting Ras-like protein 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
NFKB inhibitor interacting Ras-like 2¹ ²		DKFZP434N1526¹
KBRAS2¹ ² ³		DKFZp434N1526²
kappaB-Ras2¹ ²		NF-kappa-B inhibitor-interacting Ras-like protein 2²
NFKB inhibitor interacting Ras-like protein 2¹ ²		MGC74742²
Kappa B-Ras protein 2² ³		KappaB-Ras2³
I-kappa-B-interacting Ras-like protein 2² ³

External Ids:	HGNC: 17898¹	Entrez Gene: 28511²	Ensembl: ENSG00000168256⁷	UniProtKB: Q9NYR9³

Export aliases for NKIRAS2 gene to outside databases

Previous GC identifers: GC17P040546 GC17P037422 GC17P040170

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9

Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the

degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to

degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It

is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NKIRAS2 gene promoter:
         GR-beta   GR-alpha   STAT1beta   STAT1   STAT2   STAT3   STAT1alpha   STAT6   STAT5B   STAT5A
         Other transcription factors

Search SABiosciences Chromatin IP Primers for NKIRAS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NKIRAS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.2 Ensembl cytogenetic band: 17q21.2 HGNC cytogenetic band: 17q21.31

NKIRAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NKIRAS2 gene location

GeneLoc gene densities for chromosome 17 GeneLoc Exon Structure

GeneLoc location for GC17P035934: view genomic region (about GC identifiers)

Start:	35,934,823 bp from pter
End:	35,942,887 bp from pter
Size:	8,065 bases
Orientation:	plus strand

1 alternative location:

Chr17+ 40,169,038-40,177,659

RefSeq DNA sequence:

NC_000017.10 NT_010783.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9 (See protein sequence)

Recommended Name: NF-kappa-B inhibitor-interacting Ras-like protein 2

Size: 191 amino acids; 21508 Da

Subunit: Interacts with both NF-kappa-B inhibitor alpha (NFKBIA) and beta (NFKBIB) in vitro. However, it probably only

interacts with NFKBIB in vivo

Subcellular location: Cytoplasm (By similarity)

Sequence caution: Sequence=BAB55006.1; Type=Miscellaneous discrepancy; Note=Absence of residues from position 133

within an exon that change the frame which is not the result of an alternative splicing;

Secondary accessions: A6NCZ5 B3KNN0 Q6PK52 Q96KC7 Q9NSX1

Alternative splicing: 2 isoforms: Q9NYR9-1 Q9NYR9-2

Explore the universe of human proteins at neXtProt for NKIRAS2: NX_Q9NYR9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (5 alternative transcripts):

NP_001001349.1 NP_001138399.1 NP_001138400.1 NP_001138401.1 NP_060065.2

ENSEMBL proteins:

ENSP00000312773 ENSP00000377462 ENSP00000377463 ENSP00000419929 ENSP00000303580 ENSP00000377458

ENSP00000377459 ENSP00000401976

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NKIRAS2 OriGene Protein Over-expression Lysate: NKIRAS2
	GenScript Custom Purified and Recombinant Proteins Services for NKIRAS2
	Novus Biologicals Protein for NKIRAS2
	Novus Biologicals Lysate for NKIRAS2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005622	intracellular	--	--
GO:0005737	cytoplasm	IEA	--

About this table

NKIRAS2 for ontologies About GeneDecksing

Antibodies for NKIRAS2:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NKIRAS2
	Browse R&D Systems for Antibodies
	OriGene Antibodies: NKIRAS2
	GenScript Custom Superior Antibodies Services for NKIRAS2
	Novus Biologicals Antibodies for NKIRAS2
	Epitomics antibodies for NKIRAS2

Assays for NKIRAS2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NKIRAS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NKIRAS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NKIRAS2 for domains About GeneDecksing

4 InterPro domains/families:

IPR001806 Ras_GTPase

IPR005225 Small_GTP-bd

IPR020851 Small_GTPase

IPR013753 Ras

Graphical View of Domain Structure for InterPro Entry Q9NYR9

ProtoNet protein and cluster: Q9NYR9

2 Blocks protein families:

IPB001806 Transforming protein P21 RAS signature

IPB013684 Miro-like

UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9

Domain: In contrast to other members of the Ras family, the members of the KappaB-Ras subfamily do not contain the

conserved Gly and Gln residues in positions 13 and 65, which are replaced by Ala and Leu residues, respectively, and

are therefore similar to the constitutively active forms of oncogenic forms of Ras. This suggests that members of this

family are clearly different from other small GTPases proteins

Similarity: Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9

Function: Atypical Ras-like protein that acts as a potent regulator of NF-kappa-B activity by preventing the

degradation of NF-kappa-B inhibitor beta (NFKBIB) by most signals, explaining why NFKBIB is more resistant to

degradation. May act by blocking phosphorylation of NFKBIB and nuclear localization of p65/RELA NF-kappa-B subunit. It

is unclear whether it acts as a GTPase. Both GTP- and GDP-bound forms block phosphorylation of NFKBIB (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NKIRAS2 Sigma-Aldrich shRNA for NKIRAS2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): NKIRAS2 OriGene shRNA RFP (see all 5): NKIRAS2 OriGene basic RS shRNA (see all 5): NKIRAS2 OriGene siRNA (see all 5): NKIRAS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NKIRAS2

miRNA:		Sigma-Aldrich microRNA Mimics for NKIRAS2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NKIRAS2
		2 SABiosciences Assays for microRNAs that regulate NKIRAS2:
		hsa-miR-324-3p hsa-miR-599

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NKIRAS2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NKIRAS2 OriGene untagged cDNA clones in CMV expression vector (see all 3): NKIRAS2 OriGene 3'-UTR clone (see all 5): NKIRAS2 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for NKIRAS2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for NKIRAS2

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0003924	GTPase activity	NAS	10657303
GO:0005525	GTP binding	IEA	--

About this table

NKIRAS2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for NKIRAS2

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NKIRAS2

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007249	I-kappaB kinase/NF-kappaB cascade	NAS	10657303
GO:0007264	small GTPase mediated signal transduction	IEA	--
GO:0015031	protein transport	--	--

About this table

NKIRAS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NKIRAS2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NKIRAS2 Sigma-Aldrich shRNA for NKIRAS2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 5): NKIRAS2 OriGene shRNA RFP (see all 5): NKIRAS2 OriGene basic RS shRNA (see all 5): NKIRAS2 OriGene siRNA (see all 5): NKIRAS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NKIRAS2

miRNA:		Sigma-Aldrich microRNA Mimics for NKIRAS2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NKIRAS2
		2 SABiosciences Assays for microRNAs that regulate NKIRAS2:
		hsa-miR-324-3p hsa-miR-599

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): NKIRAS2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): NKIRAS2 OriGene untagged cDNA clones in CMV expression vector (see all 3): NKIRAS2 OriGene 3'-UTR Clone (see all 5): NKIRAS2 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for NKIRAS2

Primers:		OriGene genome-wide validated SYBR primer pairs: NKIRAS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NKIRAS2: PPH22730A

REFSEQ mRNAs for NKIRAS2 gene (5 alternative transcripts):

NM_001001349.2 NM_001144927.1 NM_001144928.1 NM_001144929.1 NM_017595.5

Additional cDNA sequence:

AF229840.1 AK027265.1 AK054571.1 AK297975.1 BC007316.2 BC007450.2 BC009059.1 BC047369.1

BC063498.1 CR595468.1 CR598071.1 CR618051.1

24/27 DOTS entries (see all 27):

DT.100791038 DT.100791034 DT.101961705 DT.95143112 DT.100791037 DT.120967382 DT.100791033 DT.446442

DT.120967366 DT.95143111 DT.95211743 DT.40300640 DT.92451426 DT.100815292 DT.100705586 DT.100638705

DT.97859316 DT.120967431 DT.120967457 DT.100032622 DT.100033703 DT.100791032 DT.100791043 DT.120967528

24/324 AceView cDNA sequences (see all 324):

AA865300 BE905141 BQ956332 AL543340 BM556086 AI754801 BU520932 AL560957

BE261602 AK054571 T17464 BG987733 BU931632 BM697900 AU280166 BU787576

BU194047 BI754729 BQ883174 BM811395 BE047113 AA149586 BM468757 AA356283

highest scoring ESTs for NKIRAS2:

AA843965 AI754801 AA088819 AA149586 AA308366 AA349382 AA361212 AA403155 AA403244 AA443872

Unigene Cluster for NKIRAS2:

NFKB inhibitor interacting Ras-like 2

Hs.632252 [show with all ESTs]

Unigene Representative Sequence: BC063498

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for NKIRAS2 (see all 11)

ExUns:	1	^	2a	·	2b	·	2c	·	2d	·	2e	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	·	6g	·	6h
SP1:											-		-				-		-
SP2:											-		-				-		-
SP3:			-		-		-		-		-		-				-		-
SP4:											-		-				-		-
SP5:											-						-		-

About this scheme

ECgene alternative splicing isoforms for NKIRAS2
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000316082 ENST00000393884(uc010wgd.1 uc002hyr.2 uc002hys.2 uc010wge.1 uc002hyt.2)

ENST00000393885 ENST00000462043 ENST00000491638 ENST00000307641(uc002hyq.2)

ENST00000479407 ENST00000393879 ENST00000393880 ENST00000393881 ENST00000449471

ENST00000485789

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NKIRAS2 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching NKIRAS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
56329_at²^{, 3}	U95-B	1	1.00	1.00	0.96	0.95	AA843965	1.00	1.00	1.00	1
90254_at²^{, 3}	U95-E	1	1.00	1.00	0.89	1.05	AI754801	1.00	1.00	1.00	1
218240_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_017595	0.60	1.00	0.82	1
222105_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AA452565	0.40	1.00	0.76	1
218240_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
222105_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

NKIRAS2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

NKIRAS2 gene electronic northern expression

About these images

CGAP SAGE TAG: GTGAAGGCTG

SOURCE GeneReport for Unigene cluster: Hs.632252

UniProtKB/Swiss-Prot: KBRS2_HUMAN, Q9NYR9

Tissue specificity: Widely expressed

Primers:		OriGene genome-wide validated SYBR primer pairs: NKIRAS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NKIRAS2: PPH22730A

SABiosciences Custom PCR Arrays for NKIRAS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NKIRAS2 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NKIRAS2¹	--	NFKB inhibitor interacting Ras-like 2	92.67(n) 100(a)	480518 XM_537638.2 XP_537638.1
chimpanzee (Pan troglodytes)	NKIRAS2¹	--	NFKB inhibitor interacting Ras-like 2	92.71(n) 91.26(a)	454675 XM_511498.2 XP_511498.2
cow (Bos taurus)	NKIRAS2¹	--	NFKB inhibitor interacting Ras-like 2	93.19(n) 100(a)	509053 NM_001075387.1 NP_001068855.1
rat (Rattus norvegicus)	Nkiras2¹	--	NFKB inhibitor interacting Ras-like 2	90.75(n) 98.95(a)	287707 XM_213462.4 XP_213462.1
mouse (Mus musculus)	Nkiras2^{1 , 5}	11 (63.47 cM)⁵	NFKB inhibitor interacting Ras-like protein 2^{1, 5}	90.92(n)¹ 98.95(a)¹	71966¹ NM_028024.2¹ NP_082300.1¹ AA031156⁵ AI596353⁵ (see all 18)

About this table Species with no ortholog for NKIRAS2

ENSEMBL Gene Tree for NKIRAS2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NKIRAS2 gene

NKIRAS1²

NKIRAS2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 17 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1128719^1,2	--	40177464(+)	`TGCTTC/TTAAGG`	5	--	ut3¹		0	--	--	--	--
rs1141073^1,2	--	40174433(+)	`ATCGAG/TACGCA`	10	E D	ref¹ mis¹		0	--	--	--	--
rs4796759^1,2	C,F,A,H,	40174841(+)	`TCAACC/AAAAGA`	5	--	int¹		28		NS EA NA WA	1726
rs5022678^1,2	C,F	40176617(+)	`gaaacC/Gccatc`	5	--	ut3¹		2		NS	94
rs8082153^1,2	C,F,A,	40172467(+)	`AGTGAT/CCTATC`	5	--	int¹		5		NA WA	264
rs9894001^1,2	C,F,A,H,	40173851(+)	`CAAATC/ACGGAG`	5	--	int¹		16		NS EA NA WA	730
rs11540536^1,2	--	40176591(+)	`TTCACG/TACCAG`	5	--	ut3¹		0	--	--	--	--
rs11540538^1,2	C,F,	40176129(+)	`TCCCCA/CTCCCA`	5	--	ut3¹		2		NS	94
rs11540539^1,2	--	40177297(-)	`GAGGAC/GCACCT`	5	--	ut3¹		0	--	--	--	--
rs11655320^1,2	H	40174029(+)	`tcgagA/Cccagc`	5	--	int¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for NKIRAS2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NKIRAS2: --

QIAGEN SeqTarget long-range PCR primers for resequencing NKIRAS2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NKIRAS2 for disorders About GeneDecksing

OMIM: 604497

Human Genome Epidemiology (HuGE) Navigator: NKIRAS2 (1 document)

Export disorders and mutations for NKIRAS2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

9 PubMed articles for NKIRAS2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with NKIRAS2)

A subclass of Ras proteins that regulate the degradation of IkappaB. (PubMed id 10657303)^{1, 2, 3} Fenwick C....Ghosh S. (2000)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
KappaB-Ras is a nuclear-cytoplasmic small GTPase that inhibits NF-kappaB activation through the suppression of transcriptional activ ation of p65/RelA. (PubMed id 20639196)¹ Tago K....Itoh H. (2010 Oct 1)
Genetic variation in the NF{kappa}B pathway in relation to susceptibility to rheumatoid arthritis. (PubMed id 18434448)¹ Dieguez-Gonzalez R....Gonzalez A. (2008)
The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PubMed id 16625196)² Zody M.C.... Nusbaum C. (2006)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 28511	HGNC: 17898	AceView: NKIRAS2	Ensembl:ENSG00000168256	euGenes: HUgn28511
ECgene: NKIRAS2	H-InvDB: NKIRAS2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for NKIRAS2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for NKIRAS2 gene:
Search GeneIP for patents involving NKIRAS2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Predesigned and custom siRNAs for NKIRAS2		Antibodies for NKIRAS2
	Super-pooled esiRNAs for NKIRAS2		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NKIRAS2		microRNA Mimics for NKIRAS2
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
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	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NKIRAS2
	SeqTarget long-range PCR primers for resequencing NKIRAS2
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NKIRAS2
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NKIRAS2

	GenScript Custom Purified and Recombinant Proteins Services for NKIRAS2		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NKIRAS2
	GenScript Custom Assay Services for NKIRAS2		GenScript Custom Superior Antibodies Services for NKIRAS2
	GenScript Custom overexpressing Cell Line Services for NKIRAS2		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NKIRAS2 promoter
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	RT² qPCR Primer Assay for NKIRAS2
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	Assays for microRNAs that regulate NKIRAS2
	SABiosciences Custom PCR Arrays for NKIRAS2

Search Tocris compounds for NKIRAS2

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Antibodies for NKIRAS2

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ELISAs and CLIAs for NKIRAS2

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

NKIRAS2 gene at Home site.

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NKIRAS2 Gene

protein-coding GIFtS: 48

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NKIRAS2 Gene

protein-coding GIFtS: 48

Aliases & Descriptionsfor NKIRAS2 gene

Summariesfor NKIRAS2 gene

Genomic Viewsfor NKIRAS2 gene

Proteinsfor NKIRAS2 gene

Protein Domains/Familiesfor NKIRAS2 gene

Gene Functionfor NKIRAS2 gene

Pathways & Interactionsfor NKIRAS2 gene

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Transcriptsfor NKIRAS2 gene

Expression for NKIRAS2 gene

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External Searches for NKIRAS2 gene

Genome Databases showing NKIRAS2 gene

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Specialized Databases showing NKIRAS2 gene

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Aliases &
Descriptions
for NKIRAS2 gene

Summaries
for NKIRAS2 gene

Genomic Views
for NKIRAS2 gene

Proteins
for NKIRAS2 gene

Protein Domains/
Families
for NKIRAS2 gene

Gene Function
for NKIRAS2 gene

Pathways & Interactions
for NKIRAS2 gene

Drugs & Compounds
for NKIRAS2 gene

Transcripts
for NKIRAS2 gene

Expression
for NKIRAS2 gene

Orthologs
for NKIRAS2 gene

Paralogs
for NKIRAS2 gene

Genomic Variants
for NKIRAS2 gene

Disorders & Mutations
for NKIRAS2 gene

Medical News
for NKIRAS2 gene

Publications
for NKIRAS2 gene

Intellectual Property
for NKIRAS2 gene

Products
for NKIRAS2 gene