Aliases &
Descriptions
for NMI gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| N-myc (and STAT) interactor1 2 | | N-myc interactor2 | | N-myc-interactor2 | | N-myc and STAT interactor3 | | Nmi3 |
Export aliases for NMI gene to outside databasesPrevious GC identifers: GC02M149820 GC02M150656 GC02M152091 GC02M152329 GC02M151952 GC02M151835 GC02M152126 |
Summaries
for NMI gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NMI:
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), andother transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATsexcept STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has lowexpression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cellline-myeloid leukemias. (provided by RefSeq)
UniProtKB/Swiss-Prot: NMI_HUMAN, Q13287Function: May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcriptionfactors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 andSTAT5
Gene Wiki entry for NMI |
Genomic Views
for NMI gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NMI gene promoter:
POU2F1 STAT5A GATA-1 STAT5B C/EBPalpha NF-AT3 NF-AT2 NF-AT1 NF-AT4 Bach1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NMI
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NMI  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q23 Ensembl cytogenetic band: 2q23.3 HGNC cytogenetic band: 2q23NMI Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M144023: view genomic region
(about GC identifiers)
Start:
|
144,023,466 bp from pter |
End:
|
144,042,922 bp from pter |
Size:
|
19,457 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr2- 152,126,979-152,146,571 |
RefSeq DNA sequence:- NC_000002.11 NT_005403.17
|
Proteins
for NMI gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NMI_HUMAN, Q13287 (See
protein sequence)Recommended Name: N-myc-interactor Size: 307 amino acids; 35057 Da
Subunit: Interacts with MYCN and MYC, as well as with other transcription factors with a Zip, HLH or a HLH-Zip motif.Interacts with all STAT proteins except STAT2
Subcellular location: Cytoplasm
Secondary accessions: B5BU69 Q53TI8 Q9BVE5Explore the universe of human proteins at neXtProt for NMI: NX_Q13287
REFSEQ proteins: NP_004679.2
ENSEMBL proteins: ENSP00000387373 ENSP00000243346
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
NMI for ontologies About GeneDecksing
Antibodies for NMI:
Assays for NMI: |
Protein
Domains/
Families
for NMI gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NMI for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q13287ProtoNet protein and cluster: Q13287 1 Blocks protein family: IPB009909 Nmi/IFP 35
UniProtKB/Swiss-Prot: NMI_HUMAN, Q13287Similarity: Belongs to the NMI family |
Gene Function
for NMI gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NMI_HUMAN, Q13287Function: May be involved in augmenting coactivator protein recruitment to a group of sequence-specific transcriptionfactors. Augments cytokine-mediated STAT transcription. Enhances CBP/p300 coactivator protein recruitment to STAT1 andSTAT5Induction: By IL2/interleukin-2 and IFNG/IFN-gamma
Genatlas biochemistry entry for NMI:N-myc interactor,also interacting with c-myc,Max and STATs (except STAT2) transcription factors carrying leucine zipperwith/without helix-loop-helix,expressed at low levels in all fetal and adult tissues,except brain,increasing STAmediated transcription in response to IL2 and IFNG3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
NMI for ontologies About GeneDecksing
|
Pathways & Interactions
for NMI gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
NMI for pathways About GeneDecksing
1  Millipore Pathway for NMI
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for NMI
SABiosciences Pathway-Focused PCR Arrays including NMI: PAHS-016A PAHS-3803A
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for NMI
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NMI
5/14 Interacting proteins for NMI (ENSP000002433463 Q132871) via UniProtKB, MINT, and/or STRING (see all 14)About this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
NMI for ontologies About GeneDecksing
|
Drugs & Compounds
for NMI gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NMI
|
Transcripts
for NMI gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NMI gene: NM_004688.2 Additional cDNA sequence: AB451305.1 AB451436.1 AK124323.1 AK291548.1 AK298754.1 BC001268.1 BC021987.2 CR604696.1 EF036506.1 U32849.1 8 DOTS entries: DT.413087 DT.95161340 DT.95329069 DT.101969708 DT.92026026 DT.100682669 DT.75183576 DT.95348488 24/136 AceView cDNA sequences (see all 136): AA352450 BI334466 BX279948 CA429809 AL548649 BU508494 AA173501 BC001268 BU615284 BX113977 CA429966 AI758449 CB160217 CB151555 CD366054 CR604696 BQ775677 CA444717 BF197582 AK124323 BC021987 AU135484 CD370310 BU164561
 highest scoring ESTs for NMI:U32849 AA100101 AA352450 AI298625 AU135484 BC001268 BG167440 BG257330 BG494790 BG503460 Unigene Cluster for NMI: N-myc (and STAT) interactor Hs.54483 [show with all ESTs]Unigene Representative Sequence: AK124323
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NMI
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 |
|---|
|
| SP1: | | | | | - | | | | - | | | | | | - | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | | | | | | | | | | | |
| SP5: | | | | | - | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NMI
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000414946 ENST00000477072 ENST00000243346(uc002txi.2 uc010zbx.1)
ENST00000491771(uc002txj.2)
|
Expression
for NMI gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NMI expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching NMI gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 36472_at2, 3
|
U95-A |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
U32849 |
1.00 |
1.00 |
1.00 |
1 |
| 203964_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_004688 |
0.60 |
1.00 |
0.82 |
1 |
| 203964_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NMI for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTTTCAACTA
SOURCE GeneReport for Unigene cluster: Hs.54483
Expression variation in blood from EXPOLDB for NMI UniProtKB/Swiss-Prot: NMI_HUMAN, Q13287Tissue specificity: Expressed in all adult and fetal tissues except brain and skin. More abundant in fetal tissuesespecially liver
SABiosciences Expression via Pathway-Focused PCR Arrays including NMI: PAHS-016A PAHS-3803A
|
Orthologs
for NMI gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NMI gene from 5/6 species (see all 6)
About this table Species with no ortholog for NMI
ENSEMBL Gene Tree for NMI (if available) |
Paralogs
for NMI gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NMI gene
- IFI352
NMI for paralogs About GeneDecksing
|
Genomic Variants
for NMI gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NMI (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for NMI
2 CNVs: 90079 8961 | | QIAGEN SeqTarget long-range PCR primers for resequencing NMI |
|
Disorders & Mutations
for NMI gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NMI for disorders About GeneDecksing
OMIM: 603525
1  Novoseek disease relationship for NMI gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cancer |
0 |
2 |
14647428 (1), 8668343 (1) |
About this table
Human Genome Epidemiology (HuGE) Navigator: NMI (8 documents)
Export disorders and mutations for NMI gene to outside databases
|
Medical News
for NMI gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NMI gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/32 PubMed articles for NMI gene, integrated from 7 sources (see all 32):
(articles sorted by number of sources associating them with NMI)- Isolation and characterization of Nmi, a novel partner of Myc proteins. (PubMed id 8668343)1, 2, 3, 7 Bao J. and Zervos A.S. (1996)
- Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. (PubMed id 9989503)1, 2, 3 Zhu M.-H.... Leonard W.J. (1999)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Nmi (N-Myc interactor) inhibits Wnt/beta-catenin sign aling and retards tumor growth. (PubMed id 19358268)1, 7 Fillmore R.A....Samant R.S. (2009)
- The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling. (PubMed id 17197158)1, 7 Zhang L.... He F. (2007)
- The high-mobility group transcription factor Sox10 interacts with the N-myc-interacting protein Nmi. (PubMed id 16214168)1, 7 Schlierf B....Wegner M. (2005)
- STAT1 and Nmi are downstream targets of Ets-1 transcription factor in MCF-7 human breast cancer cell. (PubMed id 15996661)1, 7 Jung H.H....Im Y.H. (2005)
- Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35. (PubMed id 10779520)1, 7 Zhou X....Omary M.B. (2000)
- Intracellular redistribution of interferon-inducible proteins Nmi and IFP 35 in apoptotic cells. (PubMed id 11911807)1, 7 Chen J. and Naumovski L. (2002)
|
External Searches for NMI gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NMI gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NMI gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NMI gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NMI gene:
Search GeneIP for patents involving NMI
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NMI gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for NMI |
| |  |  |  |  | | | | | Antibodies for NMI |
| |
 | | | ELISAs and CLIAs for NMI |
| |
|
|
