Home
GeneCards Guide
Suite
- GeneALaCart
- GeneDecks
- GeneIP
- GeneNote
- GeneAnnot
- GeneLoc
- GeneTide
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

NMNAT3 Gene

protein-coding GIFtS: 49

GC03M136654

nicotinamide nucleotide adenylyltransferase 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
nicotinamide nucleotide adenylyltransferase 3¹ ²		NMN adenylyltransferase 3² ³
PNAT3¹ ² ⁵		nicotinamide mononucleotide adenylyltransferase 3²
Pyridine nucleotide adenylyltransferase 3² ³		PNAT-3³
Nicotinate-nucleotide adenylyltransferase 3² ³		EC 2.7.7.18³
NaMN adenylyltransferase 3² ³		EC 2.7.7.1³

External Ids:	HGNC: 20989¹	Entrez Gene: 349565²	Ensembl: ENSG00000163864⁷	UniProtKB: Q96T66³

Export aliases for NMNAT3 gene to outside databases

Previous GC identifers: GC03U900263 GC03M140599 GC03M140761 GC03M139279

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NMNAT3:

The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein

ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT (EC 2.7.7.1) is a central enzyme

in NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide

(NaMN) with the AMP moiety of ATP to form NAD or NaAD (Zhang et al., 2003 (PubMed 12574164)).(supplied by OMIM)

UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66

Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated

form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate

(TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the

pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic

acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave

phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NMNAT3 gene promoter:
         GCNF-2   GCNF-1   HNF-1A   Cdc5   FAC1   GATA-1   Chx10   Meis-1   HOXA9B   SRF
         Other transcription factors

Search SABiosciences Chromatin IP Primers for NMNAT3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NMNAT3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q23 Ensembl cytogenetic band: 3q23 HGNC cytogenetic band: 3q23

NMNAT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NMNAT3 gene location

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M136654: view genomic region (about GC identifiers)

Start:	136,654,478 bp from pter
End:	136,772,283 bp from pter
Size:	117,806 bases
Orientation:	minus strand

1 alternative location:

Chr3- 139,279,022-139,396,859

RefSeq DNA sequence:

NC_000003.11 NT_005612.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66 (See protein sequence)

Recommended Name: Nicotinamide mononucleotide adenylyltransferase 3

Size: 252 amino acids; 28322 Da

Cofactor: Divalent metal cations. Magnesium confers the highest activity

Subunit: Homotetramer

Subcellular location: Mitochondrion

PDB structures from and Proteopedia :

1NUP (3D)

1NUQ (3D)

1NUR (3D)

1NUS (3D)

1NUT (3D)

1NUU (3D)

Secondary accessions: Q8N4G1

Alternative splicing: 2 isoforms: Q96T66-1 Q96T66-2

Explore the universe of human proteins at neXtProt for NMNAT3: NX_Q96T66

REFSEQ proteins: NP_835471.1

ENSEMBL proteins:

ENSP00000384319 ENSP00000426357 ENSP00000427634 ENSP00000340523 ENSP00000384684 ENSP00000426375

ENSP00000425041 ENSP00000296202 ENSP00000423335 ENSP00000412953

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Enzo Life Sciences proteins for NMNAT3
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for NMNAT3
	Novus Biologicals Proteins for NMNAT3
	Novus Biologicals Lysate for NMNAT3
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IDA	16118205
GO:0005829	cytosol	TAS	--

About this table

NMNAT3 for ontologies About GeneDecksing

Antibodies for NMNAT3:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for NMNAT3
	Novus Biologicals Antibodies for NMNAT3
	Browse antibodies at Epitomics

Assays for NMNAT3:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NMNAT3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NMNAT3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NMNAT3 for domains About GeneDecksing

3 InterPro domains/families:

IPR005248 NAMN_adtrnsfrase

IPR014729 Rossmann-like_a/b/a_fold

IPR004820 Cytidylyltransf

Graphical View of Domain Structure for InterPro Entry Q96T66

ProtoNet protein and cluster: Q96T66

1 Blocks protein family: IPB004820 Cytidylyltransferase

UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66

Similarity: Belongs to the eukaryotic NMN adenylyltransferase family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66

Function: Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated

form; nicotinic acid mononucleotide (NaMN) as substrate with the same efficiency. Can use triazofurin monophosphate

(TrMP) as substrate. Can also use GTP and ITP as nucleotide donors. Also catalyzes the reverse reaction, i.e. the

pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity, can use NAD (+), NADH, NAAD, nicotinic

acid adenine dinucleotide phosphate (NHD), nicotinamide guanine dinucleotide (NGD) as substrates. Fails to cleave

phosphorylated dinucleotides NADP(+), NADPH and NAADP(+). Protects against axonal degeneration following injury

Catalytic activity: ATP + nicotinamide ribonucleotide = diphosphate + NAD(+)

Catalytic activity: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD(+)

Enzyme regulation: Activity is strongly inhibited by galotannin. Inhibited by

P1-(adenosine-5')-P4-(nicotinic-acid-riboside-5')-tetraphosphate (Nap4AD)

Biophysicochemical properties: Kinetic parameters: KM=209 uM for NMN; KM=130 uM for NAD(+); KM=29 uM for ATP; KM=390 uM

for PPi; KM=276 uM for GTP; KM=350 uM for ITP; KM=111 uM for NaMN; KM=130 uM for NMNH; KM=2.01 uM for triazofurin

monophosphate; Vmax=3.6 umol/min/mg enzyme for NAD synthesis; Vmax=12.8 umol/min/mg enzyme for pyrophosphorolytic

NAD(+) cleavage; Vmax=2.9 umol/min/mg enzyme for pyrophosphorolytic NADH cleavage;

Enzyme Numbers (IUBMB): EC 2.7.7.18 EC 2.7.7.1

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NMNAT3 Sigma-Aldrich shRNA for NMNAT3
		OriGene 29mer shRNA kits in GFP-retroviral vector: NMNAT3 OriGene shRNA RFP: NMNAT3 OriGene basic RS shRNA: NMNAT3 OriGene siRNA: NMNAT3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NMNAT3

miRNA:		Sigma-Aldrich microRNA Mimics for NMNAT3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NMNAT3
		2 SABiosciences Assays for microRNAs that regulate NMNAT3:
		hsa-miR-188-5p hsa-miR-1236

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: NMNAT3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NMNAT3 OriGene untagged cDNA clones in CMV expression vector: NMNAT3 OriGene 3'-UTR clone: NMNAT3 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: NMNAT3
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for NMNAT3

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0000309	nicotinamide-nucleotide adenylyltransferase activity	TAS	--
GO:0004515	nicotinate-nucleotide adenylyltransferase activity	IDA	16118205
GO:0005524	ATP binding	IEA	--
GO:0016740	transferase activity	IEA	--

About this table

NMNAT3 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

NMNAT3 for pathways About GeneDecksing

1 Millipore Pathway for NMNAT3

NAD metabolism

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for NMNAT3

Nicotinate and Nicotinamide Metabolism

2 Kegg Pathways (Kegg details for NMNAT3):

	hsa00760 Nicotinate and nicotinamide metabolism
	hsa01100 Metabolic pathways

UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66

Pathway: Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide D-ribonucleotide: step 1/1

    SABiosciences Custom Pathway-Focused PCR Arrays for NMNAT3

  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for NMNAT3
  Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NMNAT3

5/20 Interacting proteins for NMNAT3 (ENSP00000296202³) via UniProtKB, MINT, and/or STRING (see all 20)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NADK	ENSP00000367890³	STRING: ENSP00000367890
QPRT	ENSP00000219771³	STRING: ENSP00000219771
BST1	ENSP00000371783³	STRING: ENSP00000371783
C9orf95	ENSP00000366007³	STRING: ENSP00000366007
CD38	ENSP00000226279³	STRING: ENSP00000226279

About this table

5/7 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006766	vitamin metabolic process	TAS	--
GO:0006767	water-soluble vitamin metabolic process	TAS	--
GO:0009058	biosynthetic process	IEA	--
GO:0009435	NAD biosynthetic process	IC	16118205
GO:0019363	pyridine nucleotide biosynthetic process	IEA	--

About this table

NMNAT3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NMNAT3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NMNAT3 Sigma-Aldrich shRNA for NMNAT3
		OriGene 29mer shRNA kits in GFP-retroviral vector: NMNAT3 OriGene shRNA RFP: NMNAT3 OriGene basic RS shRNA: NMNAT3 OriGene siRNA: NMNAT3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NMNAT3

miRNA:		Sigma-Aldrich microRNA Mimics for NMNAT3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NMNAT3
		2 SABiosciences Assays for microRNAs that regulate NMNAT3:
		hsa-miR-188-5p hsa-miR-1236

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: NMNAT3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NMNAT3 OriGene untagged cDNA clones in CMV expression vector: NMNAT3 OriGene 3'-UTR Clone: NMNAT3 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: NMNAT3

Primers:		OriGene genome-wide validated SYBR primer pairs: NMNAT3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NMNAT3: PPH07995A

REFSEQ mRNAs for NMNAT3 gene:

NM_178177.2

Additional cDNA sequence:

AF345564.1 AK123208.1 AK127477.1 BC034374.1 BC036218.1 BX649063.1

8 DOTS entries:

DT.101983519 DT.213011 DT.75176519 DT.75199714 DT.92416392 DT.97854978 DT.40126591 DT.40298207

24/63 AceView cDNA sequences (see all 63):

AF345564 AI142380 BU192858 BC036218 BX088743 T79582 BM931466 AA809713

BF507839 BX649063 AA917773 BM980641 BF197923 BI964038 AA514053 AA676739

CB069824 BI908510 AK127477 BI758722 T79660 BM019115 AW249913 AI913815

highest scoring ESTs for NMNAT3:

AA243119 AA833694 AW009234 CK903720 AA232215 AA514053 AA662455 AA676739 AA703131 AA703143

Unigene Cluster for NMNAT3:

Nicotinamide nucleotide adenylyltransferase 3

Hs.208673 [show with all ESTs]

Unigene Representative Sequence: AK127477

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NMNAT3 (see all 6)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5a	·	5b	^	6	^	7a	·	7b	·	7c	·	7d
SP1:													-
SP2:									-				-		-
SP3:											-		-		-		-
SP4:							-		-				-		-
SP5:													-		-		-

About this scheme

ECgene alternative splicing isoforms for NMNAT3
16 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000406164 ENST00000512391 ENST00000505779 ENST00000511003 ENST00000509291

ENST00000339837 ENST00000406824 ENST00000509447 ENST00000509737 ENST00000514703

ENST00000509034 ENST00000511444 ENST00000507242 ENST00000296202 ENST00000506254(uc003etj.2 uc003etk.2 uc003etl.2 uc010hul.2)

ENST00000413939

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NMNAT3 expression in normal and diseased human tissues

¹ / ² / ³

6 probe-sets matching NMNAT3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
58237_at²^{, 3}	U95-B	1	0.88	1.00	0.97	0.83	AW009234	0.80	1.00	0.91	1
77748_at²^{, 3}	U95-D	1	0.44	1.00	0.86	1.17	AA833694	0.80	1.00	0.91	1
228090_at²^{, 3}	U133-B	1	0.91	1.00	--	--	AW249913	0.60	1.00	0.82	1
243738_at²^{, 3}	U133-B	1	0.55	1.00	--	--	AW172570	0.60	1.00	0.82	1
228090_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
243738_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--

About this table

NMNAT3 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

NMNAT3 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.208673

UniProtKB/Swiss-Prot: NMNA3_HUMAN, Q96T66

Tissue specificity: Expressed in lung and spleen with lower levels in placenta and kidney

Primers:		OriGene genome-wide validated SYBR primer pairs: NMNAT3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NMNAT3: PPH07995A

SABiosciences Custom PCR Arrays for NMNAT3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NMNAT3 gene from 5/11 species (see all 11)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NMNAT3¹	--	nicotinamide nucleotide adenylyltransferase 3	83.72(n) 76.74(a)	477091 XM_534286.2 XP_534286.2
chimpanzee (Pan troglodytes)	NMNAT3¹	--	nicotinamide nucleotide adenylyltransferase 3	98.91(n) 99.07(a)	460735 XM_001158899.1 XP_001158899.1
cow (Bos taurus)	NMNAT3¹	--	nicotinamide nucleotide adenylyltransferase 3	82.5(n) 76.5(a)	518138 XM_596322.3 XP_596322.3
mouse (Mus musculus)	Nmnat3^{1 , 5}	9 (51.35 cM)⁵	nicotinamide nucleotide adenylyltransferase 3^{1, 5}	83.74(n)¹ 81.28(a)¹	74080¹ NM_144533.2¹ NP_653116.1¹ AK016744⁵ AK040783⁵ (see all 10)
chicken (Gallus gallus)	NMNAT3¹	--	nicotinamide nucleotide adenylyltransferase 3	61.11(n) 60.78(a)	424820 XM_422634.2 XP_422634.2

About this table Species with no ortholog for NMNAT3

ENSEMBL Gene Tree for NMNAT3 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NMNAT3 gene

NMNAT2² NMNAT1²

NMNAT3 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs8309^1,2	F	139279149(+)	`AGTTCC/ATTTTT`	1	--	ut3¹		1		MN	184
rs47442^1,2	C,F,A,H,	139307160(-)	`GTGCTC/TGTCGT`	1	--	int¹		20		NS EA NA WA	1418
rs167189^1,2	C,F,A,	139295138(+)	`ATGCAA/GTTGGT`	1	--	int¹		20		NS EA NA WA	1196
rs169825^1,2	C,F,A,	139280685(+)	`TAGGAA/GCTAGT`	1	--	int¹		15		NS EA NA WA	1056
rs169826^1,2	C,F,H,	139282808(+)	`ATAAAG/ACTGAA`	1	--	int¹		17		NS EA NA WA	982
rs176991^1,2	--	139285731(+)	`ttccaA/Gttctg`	1	--	int¹		0	--	--	--	--
rs188417^1,2	C,F,	139308878(+)	`tgacaG/Atatag`	1	--	int¹		11		NS EA NA	918
rs188418^1,2	--	139310708(+)	`gatggA/Ggaaaa`	1	--	int¹ trp³		0	--	--	--	--
rs188423^1,2	C,F,A,	139290469(+)	`GGTAGC/TCCCTA`	1	--	int¹		9		NS EA NA	584
rs192689^1,2	C,F,	139290811(+)	`ATGCTA/GTCTCC`	1	--	int¹		9		NS EA NA	584

About this table

HapMap Linkage Disequilibrium images for NMNAT3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NMNAT3: --

QIAGEN SeqTarget long-range PCR primers for resequencing NMNAT3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NMNAT3 for disorders About GeneDecksing

OMIM: 608702

Export disorders and mutations for NMNAT3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10 PubMed articles for NMNAT3 gene integrated from 7 sources:
(articles sorted by number of sources associating them with NMNAT3)

Structural characterization of a human cytosolic NMN/NaMN adenylyltransferase and implication in human NAD biosynthesis. (PubMed id 12574164)^{1, 2, 3} Zhang X....Zhang H. (2003)
Initial-rate kinetics of human NMN-adenylyltransferases: substrate and metal ion specificity, inhibition by products and multisubstrate analogues, and isozyme contributions to NAD+ biosynthesis. (PubMed id 17402747)^{1, 2} Sorci L.... Magni G. (2007)
Subcellular compartmentation and differential catalytic properties of the three human nicotinamide mononucleotide adenylyltransferase isoforms. (PubMed id 16118205)^{1, 2} Berger F.... Ziegler M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Unique expression pattern of human nicotinamide monon ucleotide adenylyltransferase isozymes in red blood cells. (PubMed id 20457531)¹ Di Stefano M....Magni G. (2010)
Isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases. (PubMed id 20388704)¹ Lau C....Ziegler M. (2010)
Enzymology of NAD+ homeostasis in man. (PubMed id 14704851)¹ Magni G....Ruggieri S. (2004)
Structure of human nicotinamide/nicotinic acid mononucleotide adenylyltransferase. Basis for the dual substrate specificity and activation of the oncolytic agent tiazofurin. (PubMed id 11788603)¹ Zhou T.... Zhang H. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 349565	HGNC: 20989	AceView: NMNAT3	Ensembl:ENSG00000163864	euGenes: HUgn349565
ECgene: NMNAT3	Kegg: 349565	H-InvDB: NMNAT3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for NMNAT3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for NMNAT3 gene:
Search GeneIP for patents involving NMNAT3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NMNAT3		Browse antibodies at Sigma-Aldrich
	Super-pooled esiRNAs for NMNAT3		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for NMNAT3		microRNA Mimics for NMNAT3
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NMNAT3
	SeqTarget long-range PCR primers for resequencing NMNAT3
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NMNAT3
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NMNAT3

	GenScript Custom Purified and Recombinant Proteins Services for NMNAT3		GenScript cDNA clones with any tag delivered in your preferred vector for NMNAT3
	GenScript Custom Assay Services for NMNAT3		GenScript Custom Superior Antibodies Services for NMNAT3
	GenScript Custom overexpressing Cell Line Services for NMNAT3		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in NMNAT3 promoter
	Search Chromatin IP Primers for NMNAT3
	RT² qPCR Primer Assay for NMNAT3
	Search GNC Networks for NMNAT3
	Assays for microRNAs that regulate NMNAT3
	SABiosciences Custom PCR Arrays for NMNAT3

Search Tocris compounds for NMNAT3

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

	Proteins for NMNAT3
	Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	Antibodies for NMNAT3
	Proteins for NMNAT3
	Lysates for NMNAT3

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for NMNAT3

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

View Random Gene

Category
GIFtS Group

The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

NMNAT3 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

Advanced Search

Export list of displayed genes

NMNAT3 Gene

protein-coding GIFtS: 49

Aliases &
Descriptions
for NMNAT3 gene

Summaries
for NMNAT3 gene

Genomic Views
for NMNAT3 gene

Proteins
for NMNAT3 gene

Protein Domains/
Families
for NMNAT3 gene

Gene Function
for NMNAT3 gene

Pathways & Interactions
for NMNAT3 gene

Drugs & Compounds
for NMNAT3 gene

Transcripts
for NMNAT3 gene

Expression
for NMNAT3 gene

Orthologs
for NMNAT3 gene

Paralogs
for NMNAT3 gene

Genomic Variants
for NMNAT3 gene

Disorders & Mutations
for NMNAT3 gene

Medical News
for NMNAT3 gene

Publications
for NMNAT3 gene

External Searches for NMNAT3 gene

Genome Databases showing NMNAT3 gene

Other Databases showing NMNAT3 gene

Specialized Databases showing NMNAT3 gene

Intellectual Property
for NMNAT3 gene

Products
for NMNAT3 gene

View Random Gene

Advanced Search

Export list of displayed genes

NMNAT3 Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor NMNAT3 gene

Summariesfor NMNAT3 gene

Genomic Viewsfor NMNAT3 gene

Proteinsfor NMNAT3 gene

Protein Domains/Familiesfor NMNAT3 gene

Gene Functionfor NMNAT3 gene

Pathways & Interactionsfor NMNAT3 gene

Drugs & Compoundsfor NMNAT3 gene

Transcriptsfor NMNAT3 gene

Expression for NMNAT3 gene

Orthologsfor NMNAT3 gene

Paralogsfor NMNAT3 gene

Genomic Variantsfor NMNAT3 gene

Disorders & Mutationsfor NMNAT3 gene

Medical Newsfor NMNAT3 gene

Publicationsfor NMNAT3 gene

External Searches for NMNAT3 gene

Genome Databases showing NMNAT3 gene

Other Databases showing NMNAT3 gene

Specialized Databases showing NMNAT3 gene

Intellectual Propertyfor NMNAT3 gene

Productsfor NMNAT3 gene

View Random Gene

Aliases &
Descriptions
for NMNAT3 gene

Summaries
for NMNAT3 gene

Genomic Views
for NMNAT3 gene

Proteins
for NMNAT3 gene

Protein Domains/
Families
for NMNAT3 gene

Gene Function
for NMNAT3 gene

Pathways & Interactions
for NMNAT3 gene

Drugs & Compounds
for NMNAT3 gene

Transcripts
for NMNAT3 gene

Expression
for NMNAT3 gene

Orthologs
for NMNAT3 gene

Paralogs
for NMNAT3 gene

Genomic Variants
for NMNAT3 gene

Disorders & Mutations
for NMNAT3 gene

Medical News
for NMNAT3 gene

Publications
for NMNAT3 gene

Intellectual Property
for NMNAT3 gene

Products
for NMNAT3 gene