Aliases &
Descriptions
for NMRAL1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| NmrA-like family domain containing 11 2 | | HSCARG1 2 3 | | SDR48A11 2 | | FLJ259181 2 | | nmrA-like family domain-containing protein 12 | | short chain dehydrogenase/reductase family 48A, member 12 |
Export aliases for NMRAL1 gene to outside databases |
Summaries
for NMRAL1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NMRL1_HUMAN, Q9HBL8Function: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes inintracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and bindsargininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs itsactivity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPHconcentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one moleculeof NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer
|
Genomic Views
for NMRAL1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NMRAL1 gene promoter:
MEF-2A C/EBPalpha CHOP-10 POU2F1 CUTL1 AREB6 PPAR-gamma1 PPAR-gamma2 CREB Pax-5
Other transcription factors
Search SABiosciences Chromatin IP Primers for NMRAL1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NMRAL1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16p13.3 Ensembl cytogenetic band: 16p13.3 HGNC cytogenetic band: 16p13.3NMRAL1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M004452: view genomic region
(about GC identifiers)
Start:
|
4,479,007 bp from pter |
End:
|
4,492,208 bp from pter |
Size:
|
13,202 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr16- 4,511,695-4,524,896 |
RefSeq DNA sequence:- NC_000016.9 NT_010393.16
|
Proteins
for NMRAL1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NMRL1_HUMAN, Q9HBL8 (See
protein sequence)Recommended Name: NmrA-like family domain-containing protein 1 Size: 299 amino acids; 33344 Da
Subunit: Homodimer. Interacts with ASS1. Interaction is enhanced by low NADPH/NADP(+) ratios, which results ininhibition of ASS1 activity
Subcellular location: Cytoplasm. Cytoplasm, perinuclear region. Nucleus. Note=Under normal redox growth conditionslocalizes in the cytoplasm and perinuclear region. Nuclear localization is promoted by increased intracellular nitricoxide and reduced NADPH/NADP(+) ratios
Miscellaneous: Reduced levels of NMRAL1 by RNAi increases nitric oxide production and reduces cell viability.Overexpression of NMRAL1 increases cell viability
Caution: Lacks the conserved Tyr residue in the active site triad of Ser-Tyr-Lys necessary for dehydrogenase activity,suggesting that it has no oxidoreductase activity
PDB structures from  and Proteopedia  :2EXX (3D)
2WM3 (3D)
2WMD (3D)
3DXF (3D)
3E5M (3D)
Explore the universe of human proteins at neXtProt for NMRAL1: NX_Q9HBL8
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_065728.1
ENSEMBL proteins: ENSP00000283429 ENSP00000383962
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
NMRAL1 for ontologies About GeneDecksing
Antibodies for NMRAL1:
Assays for NMRAL1: |
Protein
Domains/
Families
for NMRAL1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NMRAL1 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9HBL8ProtoNet protein and cluster: Q9HBL8 UniProtKB/Swiss-Prot: NMRL1_HUMAN, Q9HBL8Similarity: Belongs to the NmrA-type oxidoreductase family |
Gene Function
for NMRAL1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NMRL1_HUMAN, Q9HBL8Function: Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes inintracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and bindsargininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs itsactivity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPHconcentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one moleculeof NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimerInduction: By nitric oxide, cGMP and proinflammatory cytokines
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
NMRAL1 for ontologies About GeneDecksing
|
Pathways & Interactions
for NMRAL1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for NMRAL1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NMRAL1
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006813 | potassium ion transport |
-- | -- |
About this table
NMRAL1 for ontologies About GeneDecksing
|
Drugs & Compounds
for NMRAL1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NMRAL1
|
Transcripts
for NMRAL1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NMRAL1 gene: NM_020677.3 Additional cDNA sequence: AF225419.1 AK098784.1 BC002927.2 BC007364.2 CR606906.1 CR608452.1 CR622057.1 17 DOTS entries: DT.75105422 DT.100816267 DT.100677718 DT.95312856 DT.446751 DT.100816264 DT.100737452 DT.120676666 DT.95215789 DT.120676645 DT.100702406 DT.100816265 DT.95215803 DT.97814356 DT.100036355 DT.40125288 DT.95073778 24/217 AceView cDNA sequences (see all 217): CR608452 BC007364 AI783775 AL528210 BX115709 CD676285 BI793072 BU944032 CB053984 CA430801 CR606906 CB142918 CR622057 BG222843 CA488996 BQ221699 BU634439 CB529496 BM912560 BE886955 BC002927 T08490 AI937269 CK820999
 highest scoring ESTs for NMRAL1:AA315785 AA429231 AA534535 AF225419 AI612797 AK098784 BC007364 BE265612 BE733251 BE903204 Unigene Cluster for NMRAL1: NmrA-like family domain containing 1 Hs.288969 [show with all ESTs]Unigene Representative Sequence: BM458171
GeneLoc Exon Structure
5/12 Alternative Splicing Database (ASD) splice patterns (SP) for NMRAL1 (see all 12)
| ExUns: | 1 | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3a | · | 3b | · | 3c | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | · | 9c | ^ | 10a | · | 10b | · | 10c | ^ | 11 | ^ | 12a | · | 12b | · |
|---|
|
| SP1: | | | | | | | | | | | | | - | | - | | - | | - | | | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | - | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | - | | | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | - | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | | | | | - | | | | | | | | - | | | | | | - | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | | | | | - | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NMRAL1
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000283429(uc002cwo.2 uc002cwp.2) ENST00000404295(uc002cwm.2 uc002cwn.2)
|
Expression
for NMRAL1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NMRAL1 expression in normal and diseased human tissues
1 / 2 / 3 10 probe-sets matching NMRAL1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 73741_g_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
0.93 |
0.80 |
AA534535 |
0.80 |
1.00 |
0.91 |
1 |
| 73739_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
0.92 |
1.30 |
AA534535 |
0.80 |
1.00 |
0.91 |
1 |
| 64455_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.92 |
1.09 |
AI612797 |
0.80 |
1.00 |
0.91 |
1 |
| 50996_s_at2, 3
|
U95-C |
1 |
1.00 |
1.00 |
0.65 |
1.26 |
AI080701 |
0.60 |
1.00 |
0.82 |
1 |
| 81699_at2, 3
|
U95-E |
1 |
0.94 |
1.00 |
0.53 |
0.98 |
AA315785 |
1.00 |
1.00 |
1.00 |
1 |
| 79723_r_at*2, 3
|
U95-E |
1 |
-- |
-- |
0.21 |
0.58 |
R35842 |
0.40 |
1.00 |
0.76 |
1 |
| 223206_s_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
BC002927 |
0.60 |
1.00 |
0.82 |
1 |
| 231271_x_at2, 3
|
U133-B |
1 |
0.73 |
1.00 |
-- |
-- |
AI080701 |
0.60 |
1.00 |
0.82 |
1 |
| 223206_s_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 231271_x_at2
|
U133Plus2 |
1 |
0.73 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NMRAL1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TTCCGTTTCT
SOURCE GeneReport for Unigene cluster: Hs.288969
SABiosciences Custom PCR Arrays for NMRAL1
|
Orthologs
for NMRAL1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NMRAL1 gene from 5/8 species (see all 8)
About this table Species with no ortholog for NMRAL1
ENSEMBL Gene Tree for NMRAL1 (if available) |
Paralogs
for NMRAL1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for NMRAL1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 16 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NMRAL1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NMRAL1
1 CNV: 72438 |
Disorders & Mutations
for NMRAL1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for NMRAL1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NMRAL1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/12 PubMed articles for NMRAL1 gene, integrated from 7 sources (see all 12):
(articles sorted by number of sources associating them with NMRAL1)- The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative. (PubMed id 19027726)1, 3 Persson B.... Oppermann U. (2009)
- NADPH is an allosteric regulator of HSCARG. (PubMed id 19254724)1, 2 Dai X....Zheng X. (2009)
- An NADPH sensor protein (HSCARG) down-regulates nitric oxide synthesis by association with argininosuccinate synthetase and is essential for epithelial cell viability. (PubMed id 18263583)1, 2 Zhao Y.... Zheng X. (2008)
- Restructuring of the dinucleotide-binding fold in an NADP(H) sensor protein. (PubMed id 17496144)1, 2 Zheng X....Luo M. (2007)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)1, 2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- HSCARG inhibits activation of NF-kappaB by interactin g with IkappaB kinase-beta. (PubMed id 19843583)1 Gan Q....Zheng X. (2009)
- HSCARG regulates NF-kappaB activation by promoting th e ubiquitination of RelA or COMMD1. (PubMed id 19433587)1 Lian M. and Zheng X. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
|
External Searches for NMRAL1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NMRAL1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NMRAL1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NMRAL1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NMRAL1 gene:
Search GeneIP for patents involving NMRAL1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NMRAL1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for NMRAL1 |
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