Aliases &
Descriptions
for NOBOX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| NOBOX oogenesis homeobox1 2 | | TCAG_120422 | | OG21 2 | | OG2X2 | | POF52 5 | | homeobox protein NOBOX2 | | Og2x1 | | OG-22 | | OTTHUMP000002125882 | | newborn ovary homeobox-encoding2 |
Export aliases for NOBOX gene to outside databasesPrevious GC identifers: GC07M143533 GC07M143726 GC07M144094 |
Summaries
for NOBOX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NOBOX:
NOBOX is a homeobox gene that is preferentially expressed in oocytes. In mice, it is essential for folliculogenesis andregulation of oocyte-specific genes (Huntriss et al., 2006 (PubMed 16597639)).(supplied by OMIM)
UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393Function: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3' (By similarity)
|
Genomic Views
for NOBOX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NOBOX gene promoter:
CUTL1 GATA-1 MEF-2A Lmo2 Pbx1a E47 Tal-1 Max1 FOXF2 Tal-1beta
Other transcription factors
Search SABiosciences Chromatin IP Primers for NOBOX
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q35 Ensembl cytogenetic band: 7q35 HGNC cytogenetic band: 7q35NOBOX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M138173: view genomic region
(about GC identifiers)
Start:
|
138,172,481 bp from pter |
End:
|
138,178,827 bp from pter |
Size:
|
6,347 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr7- 144,094,333-144,107,320 |
RefSeq DNA sequence:- NC_000007.13 NT_007914.15 NT_079596.2
|
Proteins
for NOBOX gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393 (See
protein sequence)Recommended Name: Homeobox protein NOBOX Size: 691 amino acids; 73906 Da
Subcellular location: Nucleus (By similarity)
Sequence caution: Sequence=AAC12957.1; Type=Erroneous gene model prediction;
Secondary accessions: A6NCD3 A8MZN5Alternative splicing: 2 isoforms: O60393-1 O60393-2 Explore the universe of human proteins at neXtProt for NOBOX: NX_O60393
REFSEQ proteins: NP_001073882.2
ENSEMBL proteins: ENSP00000223140 ENSP00000419457 ENSP00000419565
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
NOBOX for ontologies About GeneDecksing
Antibodies for NOBOX:
Assays for NOBOX: |
Protein
Domains/
Families
for NOBOX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NOBOX for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O60393ProtoNet protein and cluster: O60393 UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393Similarity: Contains 1 homeobox DNA-binding domain |
Gene Function
for NOBOX gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393Function: Transcription factor which may play a role in oogenesis. Binds preferentially to the DNA sequences5'-TAATTG-3', 5'-TAGTTG-3' and 5'-TAATTA-3' (By similarity)
3 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
-- | -- | | GO:0003700 | sequence-specific DNA binding transcription factor activity |
IEA | -- | | GO:0043565 | sequence-specific DNA binding |
IEA | -- |
About this table
NOBOX for ontologies About GeneDecksing
Animal Models: 2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Nobox):
NOBOX for phenotypes About GeneDecksing
|
Pathways & Interactions
for NOBOX gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for NOBOX
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NOBOX
5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001541 | ovarian follicle development |
IEA | -- | | GO:0006355 | regulation of transcription, DNA-dependent |
IEA | -- | | GO:0007275 | multicellular organismal development |
IEA | -- | | GO:0030154 | cell differentiation |
IEA | -- | | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter |
IEA | -- |
About this table
NOBOX for ontologies About GeneDecksing
|
Drugs & Compounds
for NOBOX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NOBOX
|
Transcripts
for NOBOX gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NOBOX gene: NM_001080413.2 2 DOTS entries: DT.121116057 DT.121116056
 highest scoring ESTs for NOBOX:EG328625 EG328624 NM_001080413 Unigene Cluster for NOBOX: NOBOX oogenesis homeobox Hs.558628 [show with all ESTs]Unigene Representative Sequence: NM_001080413
GeneLoc Exon Structure
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000223140(uc011kue.1) ENST00000467773 ENST00000483238
|
Expression
for NOBOX gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NOBOX expression in normal and diseased human tissues
1 / 2 2 probe-sets matching NOBOX gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 234519_at2
|
U133-B |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 234519_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTGCTGACTT
SOURCE GeneReport for Unigene cluster: Hs.558628
UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393Tissue specificity: Expressed in ovaries, testes and pancreas. Expressed within all stages of the adult femalegermline, from primordial follicles through to MII oocytes
SABiosciences Custom PCR Arrays for NOBOX
|
Orthologs
for NOBOX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NOBOX gene from 5 species
About this table Species with no ortholog for NOBOX
ENSEMBL Gene Tree for NOBOX (if available) |
Paralogs
for NOBOX gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for NOBOX gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 7 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NOBOX (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NOBOX
2 CNVs: 4573 3708
1 Inversion: 37284 | | QIAGEN SeqTarget long-range PCR primers for resequencing NOBOX |
|
Disorders & Mutations
for NOBOX gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NOBOX for disorders About GeneDecksing
OMIM: 610934 disorders: 611548 UniProtKB/Swiss-Prot: NOBOX_HUMAN, O60393
Defects in NOBOX are the cause of premature ovarian failure type 5 (POF5) [MIM:611548]. An ovarian disorderdefined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea oramenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiolHuman Gene Mutation Database (HGMD): NOBOX
Human Genome Epidemiology (HuGE) Navigator: NOBOX (2 documents)
Export disorders and mutations for NOBOX gene to outside databases
|
Medical News
for NOBOX gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NOBOX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/13 PubMed articles for NOBOX gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with NOBOX)- cDNA cloning and expression of the human NOBOX gene in oocytes and ovarian follicles. (PubMed id 16597639)1, 2, 3 Huntriss J.... Picton H.M. (2006)
- NOBOX homeobox mutation causes premature ovarian failure. (PubMed id 17701902)1, 2 Qin Y.... Rajkovic A. (2007)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (2003)
- Nobox is a homeobox-encoding gene preferentially expressed in primordial and growing oocytes. (PubMed id 11804785)1, 3 Suzumori N....Rajkovic A. (2002)
- Clinical, biological and genetic analysis of prepuber tal isolated ovarian cyst in 11 girls. (PubMed id 20593028)1 Brauner R....McElreavey K. (2010)
- Premature ovarian failure and gene polymorphisms. (PubMed id 19610175)1 van Dooren M.F....Oldenburg R.A. (2009)
- A genome-wide linkage scan in a Dutch family identifi es a premature ovarian failure susceptibility locus. (PubMed id 18689850)1 Oldenburg R.A....Bertoli-Avella A.M. (2008)
- A 12Mb deletion at 7q33-q35 associated with autism sp ectrum disorders and primary amenorrhea. (PubMed id 18675947)1 Rossi E....Zuffardi O. (2008)
- Mutation analysis of NOBOX homeodomain in chinese women with premature ovarian failure. (PubMed id 18930203)1 Qin Y....Chen Z.J. (2008)
- Mutational analysis of the homeobox region of the human NOBOX gene in Japanese women who exhibit premature ovarian failure. (PubMed id 15950662)1 Zhao X.X....Suzumori K. (2005)
|
External Searches for NOBOX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NOBOX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NOBOX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NOBOX gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NOBOX gene:
Search GeneIP for patents involving NOBOX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NOBOX gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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