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NOP10 Gene

protein-coding   GIFtS: 51

GC15M011497
NOP10 ribonucleoprotein homolog (yeast)
(Previous names: nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NOLA3)
Products    

Aliases &
Descriptions
for NOP10 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases & Descriptions
NOP10 ribonucleoprotein homolog (yeast)1 2     Nucleolar protein family A member 32 3
NOLA32 3 5     Nucleolar protein 102 3
nucleolar protein family A, member 3 (H/ACA small nucleolar RNPs)1 2     snoRNP protein NOP102 3
NOP10P1 2     homolog of yeast Nop10p2
MGC706511 2     H/ACA ribonucleoprotein complex subunit 32

External Ids:    HGNC: 143781   Entrez Gene: 555052   Ensembl: ENSG000001821177   UniProtKB: Q9NPE33   

Export aliases for NOP10 gene to outside databases

Previous GC identifers: GC15M032422 GC15M034633


Summaries
for NOP10 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for NOP10:
This gene is a member of the H/ACA snoRNPs (small nucleolar ribonucleoproteins) gene family. snoRNPs are involved in
various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA. The
H/ACA snoRNPs also include the DKC1, NOLA1 and NOLA2 proteins. These four H/ACA snoRNP proteins localize to the dense
fibrillar components of nucleoli and to coiled (Cajal) bodies in the nucleus. Both 18S rRNA production and rRNA
pseudouridylation are impaired if any one of the four proteins is depleted. The four H/ACA snoRNP proteins are also
components of the telomerase complex. This gene encodes a protein related to Saccharomyces cerevisiae Nop10p.
(provided by RefSeq)

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3
Function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar
ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization
of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to
100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for
correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase
(TERT) holoenzyme


Genomic Views
for NOP10 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for NOP10
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for NOP10

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q14-q15   Ensembl cytogenetic band:  15q14   HGNC cytogenetic band: 15q14-q15

NOP10 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NOP10 gene location

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M011497:  view genomic region     (about GC identifiers)

Start:
 11,497,261 bp from pter
End:
 11,498,790 bp from pter
Size:
 1,530 bases
Orientation:
 minus strand

1 alternative location:
Chr15- 34,633,914-34,635,378     
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  

Proteins
for NOP10 gene

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section
UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3 (See protein sequence)
Recommended Name: H/ACA ribonucleoprotein complex subunit 3  
Size: 64 amino acids; 7706 Da
Subunit: Part of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which contains NHP2/NOLA2,
GAR1/NOLA1, NOP10/NOLA3, and DKC1/NOLA4, which is presumed to be the catalytic subunit. The complex contains a stable
core formed by binding of one or two NOP10-DKC1 heterodimers to NHP2; GAR1 subsequently binds to this core via DKC1.
The complex binds a box H/ACA small nucleolar RNA (snoRNA), which may target the specific site of modification within
the RNA substrate. During assembly, the complex contains NAF1 instead of GAR1/NOLA1. The complex also interacts with
TERC, which contains a 3'-terminal domain related to the box H/ACA snoRNAs. Specific interactions with snoRNAs or TERC
are mediated by GAR1 and NHP2. Associates with NOLC1/NOPP140. H/ACA snoRNPs interact with the SMN complex, consisting
of SMN1 or SMN2, SIP1/GEMIN2, DDX20/GEMIN3, and GEMIN4. This is mediated by interaction between GAR1 and SMN1 or SMN2.
The SMN complex may be required for correct assembly of the H/ACA snoRNP complex. Component of the telomerase
holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a
telomerase RNA template component (TERC)
Subcellular location: Nucleus, nucleolus. Nucleus, Cajal body. Note=Also localized to Cajal bodies (coiled bodies)

Explore the universe of human proteins at neXtProt for NOP10: NX_Q9NPE3 

REFSEQ proteins: NP_061118.1  

ENSEMBL proteins: 
ENSP00000332198 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
OriGene Protein Over-expression Lysate: NOP10
GenScript Custom Purified and Recombinant Proteins Services for NOP10 
Novus Biologicals Protein for NOP10
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005730 nucleolus IEA--
GO:0005732 small nucleolar ribonucleoprotein complex TAS9843512
GO:0015030 Cajal body IEA--
About this table

NOP10 for ontologies           About GeneDecksing



Antibodies for NOP10: 
Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
Browse Antibodies at Sigma-Aldrich
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for NOP10 
Browse antibodies at Epitomics

Assays for NOP10: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for NOP10 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 

Protein Domains/
Families
for NOP10 gene

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
NOP10 for domains           About GeneDecksing

1 InterPro domain/family:
 IPR007264 H/ACA_rnp_Nop10

Graphical View of Domain Structure for InterPro Entry Q9NPE3

ProtoNet protein and cluster: Q9NPE3

1 Blocks protein family: IPB007264 Nucleolar RNA-binding protein Nop10p

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3
Similarity: Belongs to the NOP10 family


Gene Function
for NOP10 gene

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3
Function: Required for ribosome biogenesis and telomere maintenance. Part of the H/ACA small nucleolar
ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization
of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to
100 pseudouridine ("psi") residues, which may serve to stabilize the conformation of rRNAs. May also be required for
correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase
(TERT) holoenzyme

Inhib.
RNA:    		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for NOP10
Sigma-Aldrich shRNA for NOP10
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): NOP10
OriGene shRNA RFP (see all 2): NOP10
OriGene basic RS shRNA (see all 2): NOP10
OriGene siRNA (see all 2): NOP10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NOP10 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NOP10 
Search SABiosciences for Assays for microRNAs that regulate NOP10

Gene
Editing:		Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: NOP10
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NOP10
OriGene untagged cDNA clones in CMV expression vector: NOP10
OriGene 3'-UTR clone: NOP10 
Browse MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for NOP10 
Browse Sino Biological Human cDNA Clones

Cell
Lines:  		GenScript Custom overexpressing Cell Line Services for NOP10 

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005515 protein binding IPI16601202
About this table

NOP10 for ontologies           About GeneDecksing


Pathways & Interactions
for NOP10 gene

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


NOP10 for pathways           About GeneDecksing

1 Kegg Pathway  (Kegg details for NOP10):
    hsa03013 RNA transport

    SABiosciences Custom Pathway-Focused PCR Arrays for NOP10 

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NOP10

2 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0001522 pseudouridine synthesis NAS9843512
GO:0006364 rRNA processing IEA--
About this table

NOP10 for ontologies           About GeneDecksing



Drugs & Compounds
for NOP10 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

NOP10 for compounds           About GeneDecksing

Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NOP10
2 Novoseek chemical compound relationships for NOP10 gene
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
pseudouridine 86.1 4 17855403 (1), 17412831 (1), 16373493 (1), 19481523 (1)
uridine 67.9 1 19481523 (1)
About this table



Transcripts
for NOP10 gene

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section
Inhib.
RNA:     		Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for NOP10
Sigma-Aldrich shRNA for NOP10
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): NOP10
OriGene shRNA RFP (see all 2): NOP10
OriGene basic RS shRNA (see all 2): NOP10
OriGene siRNA (see all 2): NOP10
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NOP10 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NOP10 
Search SABiosciences for Assays for microRNAs that regulate NOP10
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: NOP10
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NOP10
OriGene untagged cDNA clones in CMV expression vector: NOP10
OriGene 3'-UTR Clone: NOP10 
Browse OriGene MicroRNA Expression Plasmids 
GenScript Custom cDNA clone Services for NOP10 
Primers: OriGene genome-wide validated SYBR primer pairs: NOP10
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for NOP10: PPH07981A

REFSEQ mRNAs for NOP10 gene: 

NM_018648.3  

Additional cDNA sequence: 

AB043104.1 BC008886.2 BC063023.1 CR612859.1 

9 DOTS entries:

DT.319408  DT.121064740  DT.91759139  DT.95273853  DT.86854773  DT.91759143  DT.92325594  DT.121064739 
DT.97867251 

24/335 AceView cDNA sequences (see all 335):

CR612859 H83558 AA156862 BU728962 AA934691 BM846103 CA453345 H78197 
W84570 BU541623 BP431793 AA083998 H78183 AI583242 AI695124 AA293783 
AI718796 AA035030 BE877608 AA398357 AA112121 BC008886 AA905911 BM826533 

Unigene Cluster for NOP10:

NOP10 ribonucleoprotein homolog (yeast)
Hs.14317  [show with all ESTs]
Unigene Representative Sequence: CF596384


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000328848(uc001zie.1)

Expression
for NOP10 gene

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NOP10 expression in normal and diseased human tissues

1  / 2

4 probe-sets matching NOP10 gene

Affymetrix
probe-set		 Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
74609_at2 U95-D 2 0.88 0.96 0.96 1.03 -- -- -- -- --
91722_at2 U95-E 2 0.69 0.95 0.94 0.97 -- -- -- -- --
217962_at2 U133-A 1 0.91 1.00 -- -- -- -- -- -- --
217962_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
About this table

NOP10 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
NOP10 gene expression
NOP10 gene electronic northern expression
NOP10 gene sage expression
About these images

CGAP SAGE TAG: GTGGCATCAC

SOURCE GeneReport for Unigene cluster: Hs.14317
Primers: OriGene genome-wide validated SYBR primer pairs: NOP10
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for NOP10: PPH07981A
    SABiosciences Custom PCR Arrays for NOP10 


Orthologs
for NOP10 gene

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section
Orthologs for NOP10 gene from 5/12 species (see all 12)
Organism Gene Locus Description Human
Similarity		 NCBI accessions
dog
(Canis familiaris)		 NOP101   -- NOP10 ribonucleoprotein homolog (yeast) 90.1(n)
96.87(a)		 607299  XM_843924.1  XP_849017.1 
chimpanzee
(Pan troglodytes)		 NOP101   -- NOP10 ribonucleoprotein homolog (yeast) 99.48(n)
100(a)		 746535  XM_001165865.1  XP_001165865.1 
cow
(Bos taurus)		 NOP101   -- NOP10 ribonucleoprotein homolog (yeast) 91.67(n)
95.31(a)		 616675  XM_868763.2  XP_873856.1 
rat
(Rattus norvegicus)		 Nola31   -- nucleolar protein family A, member 3 94.79(n)
100(a)		 691534  XM_001078710.1  XP_001078710.1 
mouse
(Mus musculus)		 Nop101 , 5 2 (56.99 cM)5
 NOP10 ribonucleoprotein homolog (yeast)1, 5 94.27(n)1
100(a)1		 661811  NM_025403.21  NP_079679.11 
 AK0041205  AK0128755  (see all 7)
About this table        Species with no ortholog for NOP10

ENSEMBL Gene Tree for NOP10 (if available)

Paralogs
for NOP10 gene

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for NOP10 gene
LOC1002891432  

NOP10 for paralogs           About GeneDecksing


Pseudogenes
1 related pseudogene



Genomic Variants
for NOP10 gene

(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/49 NCBI SNPs in NOP10 are shown (see all 49)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 15 posSequenceRecsAA
Chg		TypeMoreRecsAllele
freq		PopTotal
sample		More
----------
rs30621,2
C34634050(+) CGAGAA/GACTGG 1 -- ut31 ese30--------
rs30631,2
C,A,34634033(+) AGCATA/G/TATCAA 1 -- ut3110MN NS EA NA WA 706
rs71731,2
C,F,34634020(+) ATTGCC/TTCACA 1 -- ut31 ese35Minor allele frequency- T:0.04MN NA 262
rs128181,2
C34634019(+) GATTGC/TCTCAC 1 -- ut31 ese31Minor allele frequency- T:0.00MN 184
rs151171,2
F34634012(+) CCACCA/TTGATT 1 -- ut311Minor allele frequency- T:0.05MN 184
rs1932271,2
C34634310(+) AATTTC/TTGCTC 1 -- int1 spl33Minor allele frequency- T:0.00NA EA 252
rs3478381,2
C,F,A,H,34633611(+) TGTCTG/ATAATA 1 -- ng319Minor allele frequency- A:0.34EA NA WA 366
rs4223881,2
C,F,A,34634324(-) ATTCTG/CTGTTC 1 -- int110Minor allele frequency- C:0.45NS EA NA WA 628
rs4288111,2
--34633458(-) tttttC/Tttttt 1 -- ng310--------
rs10451941,2
C,F,A,34634139(-) CTGCCA/GCCTGT 1 -- ut31 ese32Minor allele frequency- G:0.01MN WA 234
About this table

HapMap Linkage Disequilibrium images for NOP10 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NOP10
     4 CNVs: 0783 0187 3957 7058

QIAGEN SeqTarget long-range PCR primers for resequencing NOP10 

Disorders & Mutations
for NOP10 gene

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
NOP10 for disorders           About GeneDecksing

OMIM: 606471   disorders: 224230  

UniProtKB/Swiss-Prot: NOP10_HUMAN, Q9NPE3

  • Defects in NOP10 are a cause of dyskeratosis congenita autosomal recessive (ARDKC) [MIM:224230]. ARDKC is a
    • rare, progressive bone marrow failure syndrome characterized by the triad of reticulated skin hyperpigmentation, nail
    dystrophy, and mucosal leukoplakia. Early mortality is often associated with bone marrow failure, infections, fatal
    pulmonary complications, or malignancy

    1 Novoseek disease relationship for NOP10 gene

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    dyskeratosis congenita 94.9 4 18239083 (1), 18989882 (1), 20008900 (1), 18252230 (1)
    About this table

    Locus Specific Mutation Databases (LSDB): NOP10
    Human Gene Mutation Database (HGMD): NOP10
    Human Genome Epidemiology (HuGE) Navigator: NOP10 (3 documents)

    Export disorders and mutations for NOP10 gene to outside databases

    Medical News
    for NOP10 gene

    (Possibly Related Articles in Doctor's Guide)
    About This Section
    		   --

    Publications
    for NOP10 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/35 PubMed articles for NOP10 gene, integrated from 7 sources (see all 35):
    (articles sorted by number of sources associating them with NOP10)
    1. Human H/ACA small nucleolar RNPs and telomerase share evolutionarily conserved proteins NHP2 and NOP10. (PubMed id 11074001)1, 2, 3, 7 Pogacic V.... Filipowicz W. (2000)
    2. Genetic heterogeneity in autosomal recessive dyskeratosis congenita with one subtype due to mutations in the telomerase-associated protein NOP10. (PubMed id 17507419)1, 2, 7 Walne A.J....Dokal I. (2007)
    3. hNaf1 is required for accumulation of human box H/ACA snoRNPs, scaRNPs, and telomerase. (PubMed id 16601202)1, 2 Hoareau-Aveilla C....Henry Y. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    5. Architecture and assembly of mammalian H/ACA small nucleolar and telomerase ribonucleoproteins. (PubMed id 15044956)1, 2 Wang C. and Meier U.T. (2004)
    6. Nhp2p and Nop10p are essential for the function of H/ACA snoRNPs. (PubMed id 9843512)1, 3 Henras A....Caizergues-Ferrer M. (1998)
    7. Effects of dyskeratosis congenita mutations in dysker in, NHP2 and NOP10 on assembly of H/ACA pre-RNPs. (PubMed id 20008900)1, 7 Trahan C....Dragon F. (2010)
    8. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. (PubMed id 15814878)1, 7 Yamaguchi H.... Young N.S. (2005)
    9. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. (PubMed id 19179534)2 Venteicher A.S.... Artandi S.E. (2009)
    10. Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)

    External Searches for NOP10 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing NOP10 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 55505 HGNC: 14378 AceView: NOLA3 Ensembl:ENSG00000182117 euGenes: HUgn55505
    ECgene: NOP10 Kegg: 55505 H-InvDB: NOP10

    Other Databases showing NOP10 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing NOP10 gene

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    		   --

    Intellectual Property
    for NOP10 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    		Patent Information for NOP10 gene:
    Search GeneIP for patents involving NOP10

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for NOP10 gene

    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for NOP10 Browse antibodies at Sigma-Aldrich
     Super-pooled esiRNAs for NOP10 Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for NOP10 Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NOP10
     SeqTarget long-range PCR primers for resequencing NOP10
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NOP10
     GenScript Custom Purified and Recombinant Proteins Services for NOP10 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for NOP10
     GenScript Custom Assay Services for NOP10 GenScript Custom Superior Antibodies Services for NOP10
     GenScript Custom overexpressing Cell Line Services for NOP10 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for NOP10
     Search Chromatin IP Primers for NOP10
     RT2 qPCR Primer Assay for NOP10
     GNC Network for NOP10
     Search for Assays for microRNAs that regulate NOP10
     SABiosciences Custom PCR Arrays for NOP10
     Search Tocris compounds for NOP10
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Proteins for NOP10
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     Browse ELISAs and CLIAs at Uscn
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
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