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NPAS2 Gene

protein-coding   GIFtS: 60

GC02P095284
neuronal PAS domain protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
neuronal PAS domain protein 21 2     Basic-helix-loop-helix-PAS protein MOP42 3
MOP41 2 3 5     PAS domain-containing protein 42 3
PASD41 2 3     MGC711512
bHLHe91 2 3     neuronal PAS domain-containing protein 22
Class E basic helix-loop-helix protein 92 3     FLJ231382
Member of PAS protein 42 3     member of PAS superfamily 42
Neuronal PAS22 3     BHLHE93

External Ids:    HGNC: 78951   Entrez Gene: 48622   Ensembl: ENSG000001704857   UniProtKB: Q997433   

Export aliases for NPAS2 gene to outside databases

Previous GC identifers: GC02P099300 GC02P099889 GC02P101041 GC02P101058 GC02P100895 GC02P100803 GC02P101436


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPAS2:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors.
A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may
function as a part of a molecular clock operative in the mammalian forebrain. (provided by RefSeq)

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743
Function: BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the
circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)

Gene Wiki entry for NPAS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NPAS2 gene promoter:
         SRF   RORalpha2   POU2F2 (Oct-2.1)   POU2F2   Oct-B1   POU2F2C   POU2F1   oct-B3   oct-B2   POU2F2B   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for NPAS2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NPAS2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2   Ensembl cytogenetic band:  2q11.2   HGNC cytogenetic band: 2q11.2

NPAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPAS2 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P095284:  view genomic region     (about GC identifiers)

Start:
95,284,890 bp from pter
End:
95,377,330 bp from pter
Size:
92,441 bases
Orientation:
plus strand

1 alternative location:
Chr2+ 101,436,614-101,613,291     
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743 (See protein sequence)
Recommended Name: Neuronal PAS domain-containing protein 2  
Size: 824 amino acids; 91791 Da
Subunit: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2,
CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH
protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation
Subcellular location: Nucleus (By similarity)
Secondary accessions: Q4ZFV9 Q53SQ3 Q86V96 Q99629

Explore the universe of human proteins at neXtProt for NPAS2: NX_Q99743 

REFSEQ proteins: NP_002509.2  

ENSEMBL proteins: 
ENSP00000397595 ENSP00000338283 ENSP00000393396 ENSP00000395265 ENSP00000388528 ENSP00000392125 


Human Recombinant Proteins 
Browse Purified and Recombinant Proteins at Millipore
Browse Human Recombinant Proteins at Sigma-Aldrich
Browse R&D Systems for human recombinant proteins
Browse recombinant and purified proteins available from Enzo Life Sciences
Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
Browse OriGene Protein Over-expression Lysates
GenScript Custom Purified and Recombinant Proteins Services for NPAS2 
Novus Biologicals Proteins for NPAS2
Novus Biologicals Lysate for NPAS2
Browse Sino Biological Recombinant Proteins
Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005634 nucleus IEA--
GO:0005667 transcription factor complex IPI9576906
About this table

NPAS2 for ontologies           About GeneDecksing



Antibodies for NPAS2: 
Millipore Mono- and Polyclonal Antibodies for the study of NPAS2
Sigma-Aldrich Antibodies for NPAS2
Browse R&D Systems for Antibodies
Browse OriGene Antibodies
GenScript Custom Superior Antibodies Services for NPAS2 
Novus Biologicals Antibodies for NPAS2
Epitomics antibodies for NPAS2

Assays for NPAS2: 
Browse Kits and Assays available from Millipore
Browse ELISAs at Sigma-Aldrich
OriGene Custom Immunoassay Development 
Browse OriGene Fluorogenic Cell Assay Kits 
Browse R&D Systems for biochemical assays
GenScript Custom Assay Services for NPAS2 
Browse Enzo Life Sciences for kits & assays
Uscn ELISAs and CLIAs for NPAS2 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NPAS2 for domains           About GeneDecksing

5/7 InterPro domains/families (see all 7):
 IPR001092 HLH_DNA-bd_dom
 IPR013655 PAS_fold_3
 IPR001610 PAC
 IPR013767 PAS_fold
 IPR000014 PAS

Graphical View of Domain Structure for InterPro Entry Q99743

ProtoNet protein and cluster: Q99743

5 Blocks protein families:
IPB000014 PAS domain
IPB001067 Nuclear translocator signature
IPB001092 Basic helix-loop-helix dimerization domain bHLH
IPB001610 PAC motif
IPB013655 PAS fold-3


UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743
Similarity: Contains 1 basic helix-loop-helix (bHLH) domain
Similarity: Contains 1 PAC (PAS-associated C-terminal) domain
Similarity: Contains 2 PAS (PER-ARNT-SIM) domains


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743
Function: BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the
circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for NPAS2
Sigma-Aldrich shRNA for NPAS2
OriGene 29mer shRNA kits in GFP-retroviral vector: NPAS2
OriGene shRNA RFP: NPAS2
OriGene basic RS shRNA: NPAS2
OriGene siRNA: NPAS2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NPAS2 
miRNA:Sigma-Aldrich microRNA Mimics for NPAS2
Sigma-Aldrich microRNA target validation systems for NPAS2 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NPAS2 
8/25 SABiosciences Assays for microRNAs that regulate NPAS2 (see all 25):
hsa-miR-320a hsa-miR-520d-5p hsa-miR-106a hsa-miR-216b hsa-miR-320c hsa-miR-218 hsa-miR-519a hsa-miR-103

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: NPAS2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NPAS2
OriGene untagged cDNA clones in CMV expression vector: NPAS2
OriGene 3'-UTR clone: NPAS2 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: NPAS2 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for NPAS2 

Genatlas biochemistry entry for NPAS2:
neuronal PAS domain protein 2,expressed in the central nervous system

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO IDQualified GO termEvidencePubMed IDs
GO:0003677 DNA binding IPI9576906
GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
GO:0004871 signal transducer activity IEA--
GO:0005515 protein binding IEA--
GO:0030528 transcription regulator activity IEA--
About this table

NPAS2 for ontologies           About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Npas2):

behavior/neurologicalcardiovascular systemhomeostasis/metabolismnervous system

NPAS2 for phenotypes           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


NPAS2 for pathways           About GeneDecksing

1 Kegg Pathway  (Kegg details for NPAS2):
    hsa04710 Circadian rhythm - mammal

    SABiosciences Custom Pathway-Focused PCR Arrays for NPAS2 

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NPAS2

5/10 Interacting proteins for NPAS2 (ENSP000003382833) via UniProtKB, MINT, and/or STRING (see all 10)
InteractantInteraction Details
GeneCardExternal ID(s)
CLOCKENSP000003707233STRING: ENSP00000370723
NR1D1ENSP000002466723STRING: ENSP00000246672
TIMELESSENSP000002292013STRING: ENSP00000229201
ARNTLENSP000002561723STRING: ENSP00000256172
CSNK1DENSP000003244643STRING: ENSP00000324464
About this table

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO IDQualified GO termEvidencePubMed IDs
GO:0006355 regulation of transcription, DNA-dependent IEA--
GO:0007165 signal transduction ----
GO:0007417 central nervous system development TAS9012850
GO:0042745 circadian sleep/wake cycle IEA--
GO:0045449 regulation of transcription ----
About this table

NPAS2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NPAS2


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for NPAS2
Sigma-Aldrich shRNA for NPAS2
OriGene 29mer shRNA kits in GFP-retroviral vector: NPAS2
OriGene shRNA RFP: NPAS2
OriGene basic RS shRNA: NPAS2
OriGene siRNA: NPAS2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NPAS2 
miRNA: Sigma-Aldrich microRNA Mimics for NPAS2
Sigma-Aldrich microRNA target validation systems for NPAS2 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NPAS2 
8/25 SABiosciences Assays for microRNAs that regulate NPAS2 (see all 25):
hsa-miR-320a hsa-miR-520d-5p hsa-miR-106a hsa-miR-216b hsa-miR-320c hsa-miR-218 hsa-miR-519a hsa-miR-103
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: NPAS2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NPAS2
OriGene untagged cDNA clones in CMV expression vector: NPAS2
OriGene 3'-UTR Clone: NPAS2 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: NPAS2 
Primers: OriGene genome-wide validated SYBR primer pairs: NPAS2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for NPAS2: PPH06232A

REFSEQ mRNAs for NPAS2 gene: 

NM_002518.3  

Additional cDNA sequence: 

AK091665.1 BC035412.1 

15 DOTS entries:

DT.436335  DT.100026680  DT.85102881  DT.95277739  DT.100786389  DT.40214010  DT.92431921  DT.121029483 
DT.92431922  DT.121029652  DT.121029381  DT.65285512  DT.95221441  DT.95277736  DT.95277740 

1 AceView cDNA sequence:

BC035412 

highest scoring ESTs for NPAS2:

AI743090 U77970 AA247562 AA361974 AA401966 AA402086 AA402173 AA411982 AA455445 AA455967 

Unigene Clusters for NPAS2:

Neuronal PAS domain protein 2
Hs.156832  [show with all ESTs], Hs.705895  [show with all ESTs]
Unigene Representative Sequences: NM_002518, BC035412


GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NPAS2 (see all 6)

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b · 18c ^ 19 ^
SP1:                                -                                               -                                                     -                     
SP2:                                                                                                                                -     -     -     -     -   
SP3:                                                                                                                                                            
SP4:                                                                                                                                                            
SP5:                                                                                                                                                            

ExUns: 20 ^ 21a · 21b
SP1:                  
SP2:                  
SP3:                  
SP4:                  
SP5:        -         

About this scheme

ECgene alternative splicing isoforms for NPAS2
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000427413 ENST00000335681(uc002tap.1 uc010yvt.1 uc010fit.1)
ENST00000492373 ENST00000433408 ENST00000451740 ENST00000474550 ENST00000448812
ENST00000471974 ENST00000486017 ENST00000495559 ENST00000490052 ENST00000450763


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NPAS2 expression in normal and diseased human tissues

1  / 2  / 3

12 probe-sets matching NPAS2 gene

Affymetrix
probe-set
Array  GeneAnnot data GeneNote data GeneTide data
# genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
39548_at2, 3 U133-A 1 0.75 1.00 0.91 1.01 U77970 1.00 1.00 1.00 1
39549_at2, 3 U133-A 1 0.62 1.00 0.99 1.01 AI743090 1.00 1.00 1.00 1
205460_at2, 3 U133-A 1 1.00 1.00 -- -- NM_002518 0.60 1.00 0.82 1
39548_at2, 3 U133-A 1 0.75 1.00 -- -- U77970 1.00 1.00 1.00 1
213462_at2, 3 U133-A 1 0.73 1.00 -- -- AW000928 0.80 1.00 0.91 1
205459_s_at2, 3 U133-A 1 0.73 1.00 -- -- NM_002518 0.60 1.00 0.82 1
39549_at2, 3 U133-A 1 0.62 1.00 -- -- AI743090 1.00 1.00 1.00 1
205460_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
39548_at2 U133Plus2 1 0.75 1.00 -- -- -- -- -- -- --
213462_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
205459_s_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
39549_at2 U133Plus2 1 0.62 1.00 -- -- -- -- -- -- --
About this table

NPAS2 for expression           About GeneDecksing

Data from Genenote  (Publications) and GNF BioGPS
    About these images
NPAS2 gene expression
NPAS2 gene electronic northern expression
NPAS2 gene sage expression
About these images

CGAP SAGE TAG: AGAATACTGA

SOURCE GeneReport for Unigene clusters: Hs.156832 Hs.705895

Expression variation in blood from EXPOLDB for NPAS2

Primers: OriGene genome-wide validated SYBR primer pairs: NPAS2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for NPAS2: PPH06232A
    SABiosciences Custom PCR Arrays for NPAS2 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NPAS2 gene from 5/8 species (see all 8)
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
NPAS21   -- neuronal PAS domain protein 2 89.93(n)
90.95(a)
474552  XM_531781.2  XP_531781.2 
chimpanzee
(Pan troglodytes)
NPAS21   -- neuronal PAS domain protein 2 99.72(n)
99.76(a)
459449  XM_515656.2  XP_515656.2 
cow
(Bos taurus)
NPAS21   -- neuronal PAS domain protein 2 88.39(n)
90.42(a)
614049  XM_865373.2  XP_870466.2 
rat
(Rattus norvegicus)
Npas21   -- neuronal PAS domain protein 2 86.74(n)
88.42(a)
316351  XM_244089.3  XP_244089.3 
mouse
(Mus musculus)
Npas21 , 5 1 (17.98 cM)5
neuronal PAS domain protein 21, 5 86.86(n)1
88.42(a)1
181431  NM_008719.11  NP_032745.11 
 AK0758245  BB5247295  (see all 9)
About this table        Species with no ortholog for NPAS2

ENSEMBL Gene Tree for NPAS2 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for NPAS2 gene
ARNT22  CLOCK2  ARNT2  ARNTL2  ARNTL22  

NPAS2 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743
Polymorphism: Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIM:608516]. SAD is a
depressive condition resulting from seasonal changes, and with diurnal preference


10/1842 NCBI SNPs in NPAS2 are shown (see all 1842)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs92231,2
C,F,H,101609827(+) CAGACC/TGTGTT 2 T ref1 syn119Minor allele frequency- T:0.24NS EA NA MN 1514
rs741061,2
C,F,A,H,101545555(-) accccA/Gtcttc 1 -- int14Minor allele frequency- G:0.25NA WA 12
rs1848171,2
C,F,O,A,H,101547756(-) ATGAGT/CCTTTG 1 -- int117Minor allele frequency- C:0.11NS EA NA WA 1062
rs3566411,2
C,F,A,101538194(+) ttcaAC/TGGCTA 1 -- int17Minor allele frequency- T:0.38NS EA NA 746
rs3566421,2
C,F,O,H,101537438(+) GGAACG/ACAAAC 1 -- int115Minor allele frequency- A:0.10NS EA NA WA 646
rs3566431,2
C,F,A,101536192(+) CTCCAA/GTTGAG 1 -- int118Minor allele frequency- G:0.48NS EA NA WA 1368
rs3566441,2
C,F,A,101535756(+) gcataC/Tcttta 1 -- int111Minor allele frequency- T:0.44NS EA NA WA 636
rs3566451,2
C,A101548209(-) cagcaC/Gtttgg 1 -- int15Minor allele frequency- G:0.20NA WA 10
rs3566461,2
C,F,O,A,H,101547630(-) AAACGA/TCCAGT 1 -- int119Minor allele frequency- T:0.22NS EA NA WA 1078
rs3566471,2
C,F,101547520(-) GGCAAG/AGAAGA 1 -- int1 trp37Minor allele frequency- A:0.11NS EA NA WA 624
About this table

HapMap Linkage Disequilibrium images for NPAS2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for NPAS2: --

QIAGEN SeqTarget long-range PCR primers for resequencing NPAS2 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NPAS2 for disorders           About GeneDecksing

OMIM: 603347

Human Gene Mutation Database (HGMD): NPAS2
Human Genome Epidemiology (HuGE) Navigator: NPAS2 (20 documents)

Export disorders and mutations for NPAS2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

10/43 PubMed articles for NPAS2 gene, integrated from 7 sources (see all 43):
(articles sorted by number of sources associating them with NPAS2)
  1. Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. (PubMed id 9012850)1, 2, 3 Zhou Y.-D.... McKnight S.L. (1997)
  2. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. (PubMed id 9079689)1, 2, 3 Hogenesch J.B.... Bradfield C.A. (1997)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  4. Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. (PubMed id 12655319)1, 2 Johansson C.... Partonen T. (2003)
  5. The circadian gene NPAS2 is a novel prognostic biomar ker for breast cancer. (PubMed id 19649706)1, 7 Yi C....Katsaro D. (2009)
  6. The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response. (PubMed id 18819933)1, 7 Hoffman A.E....Zhu Y. (2008)
  7. Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. (PubMed id 17453337)1, 7 Zhu Y....Zheng T. (2008)
  8. Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. (PubMed id 17096334)1, 7 Zhu Y....Zheng T. (2007)
  9. Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)1 Bhatti P....Sigurdson A.J. (2010)
  10. Systematic analysis of circadian genes in a populatio n-based sample reveals association of TIMELESS with depression and sleep distur bance. (PubMed id 20174623)1 Utge S.J....Paunio T. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4862 HGNC: 7895 AceView: NPAS2.1 Ensembl:ENSG00000170485 euGenes: HUgn4862
ECgene: NPAS2 Kegg: 4862 H-InvDB: NPAS2

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