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NPAS2 Gene

protein-coding GIFtS: 60

GC02P095284

neuronal PAS domain protein 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
neuronal PAS domain protein 2¹ ²		Basic-helix-loop-helix-PAS protein MOP4² ³
MOP4¹ ² ³ ⁵		PAS domain-containing protein 4² ³
PASD4¹ ² ³		MGC71151²
bHLHe9¹ ² ³		neuronal PAS domain-containing protein 2²
Class E basic helix-loop-helix protein 9² ³		FLJ23138²
Member of PAS protein 4² ³		member of PAS superfamily 4²
Neuronal PAS2² ³		BHLHE9³

External Ids:	HGNC: 7895¹	Entrez Gene: 4862²	Ensembl: ENSG00000170485⁷	UniProtKB: Q99743³

Export aliases for NPAS2 gene to outside databases

Previous GC identifers: GC02P099300 GC02P099889 GC02P101041 GC02P101058 GC02P100895 GC02P100803 GC02P101436

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NPAS2:

The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors.

A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may

function as a part of a molecular clock operative in the mammalian forebrain. (provided by RefSeq)

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743

Function: BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the

circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)

Gene Wiki entry for NPAS2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NPAS2 gene promoter:
         SRF   RORalpha2   POU2F2 (Oct-2.1)   POU2F2   Oct-B1   POU2F2C   POU2F1   oct-B3   oct-B2   POU2F2B
         Other transcription factors

Search SABiosciences Chromatin IP Primers for NPAS2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NPAS2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q11.2 Ensembl cytogenetic band: 2q11.2 HGNC cytogenetic band: 2q11.2

NPAS2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NPAS2 gene location

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P095284: view genomic region (about GC identifiers)

Start:	95,284,890 bp from pter
End:	95,377,330 bp from pter
Size:	92,441 bases
Orientation:	plus strand

1 alternative location:

Chr2+ 101,436,614-101,613,291

RefSeq DNA sequence:

NC_000002.11 NT_022171.15

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743 (See protein sequence)

Recommended Name: Neuronal PAS domain-containing protein 2

Size: 824 amino acids; 91791 Da

Subunit: Component of the circadian clock oscillator which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2,

CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Efficient DNA binding requires dimerization with another bHLH

protein. Heterodimerization with CLOCK or NPAS2 is required for E-box-dependent transactivation

Subcellular location: Nucleus (By similarity)

Secondary accessions: Q4ZFV9 Q53SQ3 Q86V96 Q99629

Explore the universe of human proteins at neXtProt for NPAS2: NX_Q99743

REFSEQ proteins: NP_002509.2

ENSEMBL proteins:

ENSP00000397595 ENSP00000338283 ENSP00000393396 ENSP00000395265 ENSP00000388528 ENSP00000392125

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for NPAS2
	Novus Biologicals Proteins for NPAS2
	Novus Biologicals Lysate for NPAS2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005667	transcription factor complex	IPI	9576906

About this table

NPAS2 for ontologies About GeneDecksing

Antibodies for NPAS2:

	Millipore Mono- and Polyclonal Antibodies for the study of NPAS2
	Sigma-Aldrich Antibodies for NPAS2
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for NPAS2
	Novus Biologicals Antibodies for NPAS2
	Epitomics antibodies for NPAS2

Assays for NPAS2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NPAS2
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NPAS2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NPAS2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR001092 HLH_DNA-bd_dom

IPR013655 PAS_fold_3

IPR001610 PAC

IPR013767 PAS_fold

IPR000014 PAS

Graphical View of Domain Structure for InterPro Entry Q99743

ProtoNet protein and cluster: Q99743

5 Blocks protein families:

IPB000014 PAS domain

IPB001067 Nuclear translocator signature

IPB001092 Basic helix-loop-helix dimerization domain bHLH

IPB001610 PAC motif

IPB013655 PAS fold-3

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743

Similarity: Contains 1 basic helix-loop-helix (bHLH) domain

Similarity: Contains 1 PAC (PAS-associated C-terminal) domain

Similarity: Contains 2 PAS (PER-ARNT-SIM) domains

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743

Function: BMAL1-NPAS2 heterodimers activate E-box element (3'-CACGTG-5') transcription of a number of proteins of the

circadian clock. This transcription is inhibited in a feedback loop by PER, and also by CRY proteins (By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NPAS2 Sigma-Aldrich shRNA for NPAS2
		OriGene 29mer shRNA kits in GFP-retroviral vector: NPAS2 OriGene shRNA RFP: NPAS2 OriGene basic RS shRNA: NPAS2 OriGene siRNA: NPAS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NPAS2

miRNA:		Sigma-Aldrich microRNA Mimics for NPAS2 Sigma-Aldrich microRNA target validation systems for NPAS2
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NPAS2
		8/25 SABiosciences Assays for microRNAs that regulate NPAS2 (see all 25):
		hsa-miR-320a hsa-miR-520d-5p hsa-miR-106a hsa-miR-216b hsa-miR-320c hsa-miR-218 hsa-miR-519a hsa-miR-103

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: NPAS2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NPAS2 OriGene untagged cDNA clones in CMV expression vector: NPAS2 OriGene 3'-UTR clone: NPAS2 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: NPAS2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for NPAS2

Genatlas biochemistry entry for NPAS2:

neuronal PAS domain protein 2,expressed in the central nervous system

5/6 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IPI	9576906
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0004871	signal transducer activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0030528	transcription regulator activity	IEA	--

About this table

NPAS2 for ontologies About GeneDecksing

Animal Models: 4 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Npas2):

behavior/neurological

cardiovascular system

homeostasis/metabolism

nervous system

NPAS2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

NPAS2 for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for NPAS2):

hsa04710 Circadian rhythm - mammal

SABiosciences Custom Pathway-Focused PCR Arrays for NPAS2

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NPAS2

5/10 Interacting proteins for NPAS2 (ENSP00000338283³) via UniProtKB, MINT, and/or STRING (see all 10)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CLOCK	ENSP00000370723³	STRING: ENSP00000370723
NR1D1	ENSP00000246672³	STRING: ENSP00000246672
TIMELESS	ENSP00000229201³	STRING: ENSP00000229201
ARNTL	ENSP00000256172³	STRING: ENSP00000256172
CSNK1D	ENSP00000324464³	STRING: ENSP00000324464

About this table

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007165	signal transduction	--	--
GO:0007417	central nervous system development	TAS	9012850
GO:0042745	circadian sleep/wake cycle	IEA	--
GO:0045449	regulation of transcription	--	--

About this table

NPAS2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NPAS2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NPAS2 Sigma-Aldrich shRNA for NPAS2
		OriGene 29mer shRNA kits in GFP-retroviral vector: NPAS2 OriGene shRNA RFP: NPAS2 OriGene basic RS shRNA: NPAS2 OriGene siRNA: NPAS2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NPAS2

miRNA:		Sigma-Aldrich microRNA Mimics for NPAS2 Sigma-Aldrich microRNA target validation systems for NPAS2
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NPAS2
		8/25 SABiosciences Assays for microRNAs that regulate NPAS2 (see all 25):
		hsa-miR-320a hsa-miR-520d-5p hsa-miR-106a hsa-miR-216b hsa-miR-320c hsa-miR-218 hsa-miR-519a hsa-miR-103

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: NPAS2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NPAS2 OriGene untagged cDNA clones in CMV expression vector: NPAS2 OriGene 3'-UTR Clone: NPAS2 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: NPAS2

Primers:		OriGene genome-wide validated SYBR primer pairs: NPAS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NPAS2: PPH06232A

REFSEQ mRNAs for NPAS2 gene:

NM_002518.3

Additional cDNA sequence:

AK091665.1 BC035412.1

15 DOTS entries:

DT.436335 DT.100026680 DT.85102881 DT.95277739 DT.100786389 DT.40214010 DT.92431921 DT.121029483

DT.92431922 DT.121029652 DT.121029381 DT.65285512 DT.95221441 DT.95277736 DT.95277740

1 AceView cDNA sequence:

BC035412

highest scoring ESTs for NPAS2:

AI743090 U77970 AA247562 AA361974 AA401966 AA402086 AA402173 AA411982 AA455445 AA455967

Unigene Clusters for NPAS2:

Neuronal PAS domain protein 2

Hs.156832 [show with all ESTs], Hs.705895 [show with all ESTs]

Unigene Representative Sequences: NM_002518, BC035412

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for NPAS2 (see all 6)

ExUns:	1	^	2a	·	2b	^	3	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12a	·	12b	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17	^	18a	·	18b	·	18c	^	19	^
SP1:											-																-																		-
SP2:																																											-		-		-		-		-
SP3:
SP4:
SP5:

ExUns:	20	^	21a	·	21b
SP1:
SP2:
SP3:
SP4:
SP5:			-

About this scheme

ECgene alternative splicing isoforms for NPAS2
12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000427413 ENST00000335681(uc002tap.1 uc010yvt.1 uc010fit.1)

ENST00000492373 ENST00000433408 ENST00000451740 ENST00000474550 ENST00000448812

ENST00000471974 ENST00000486017 ENST00000495559 ENST00000490052 ENST00000450763

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NPAS2 expression in normal and diseased human tissues

¹ / ² / ³

12 probe-sets matching NPAS2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39548_at²^{, 3}	U133-A	1	0.75	1.00	0.91	1.01	U77970	1.00	1.00	1.00	1
39549_at²^{, 3}	U133-A	1	0.62	1.00	0.99	1.01	AI743090	1.00	1.00	1.00	1
205460_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002518	0.60	1.00	0.82	1
39548_at²^{, 3}	U133-A	1	0.75	1.00	--	--	U77970	1.00	1.00	1.00	1
213462_at²^{, 3}	U133-A	1	0.73	1.00	--	--	AW000928	0.80	1.00	0.91	1
205459_s_at²^{, 3}	U133-A	1	0.73	1.00	--	--	NM_002518	0.60	1.00	0.82	1
39549_at²^{, 3}	U133-A	1	0.62	1.00	--	--	AI743090	1.00	1.00	1.00	1
205460_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
39548_at²	U133Plus2	1	0.75	1.00	--	--	--	--	--	--	--
213462_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
205459_s_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
39549_at²	U133Plus2	1	0.62	1.00	--	--	--	--	--	--	--

About this table

NPAS2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

NPAS2 gene electronic northern expression

About these images

CGAP SAGE TAG: AGAATACTGA

SOURCE GeneReport for Unigene clusters: Hs.156832 Hs.705895

Expression variation in blood from EXPOLDB for NPAS2

Primers:		OriGene genome-wide validated SYBR primer pairs: NPAS2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NPAS2: PPH06232A

SABiosciences Custom PCR Arrays for NPAS2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NPAS2 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NPAS2¹	--	neuronal PAS domain protein 2	89.93(n) 90.95(a)	474552 XM_531781.2 XP_531781.2
chimpanzee (Pan troglodytes)	NPAS2¹	--	neuronal PAS domain protein 2	99.72(n) 99.76(a)	459449 XM_515656.2 XP_515656.2
cow (Bos taurus)	NPAS2¹	--	neuronal PAS domain protein 2	88.39(n) 90.42(a)	614049 XM_865373.2 XP_870466.2
rat (Rattus norvegicus)	Npas2¹	--	neuronal PAS domain protein 2	86.74(n) 88.42(a)	316351 XM_244089.3 XP_244089.3
mouse (Mus musculus)	Npas2^{1 , 5}	1 (17.98 cM)⁵	neuronal PAS domain protein 2^{1, 5}	86.86(n)¹ 88.42(a)¹	18143¹ NM_008719.1¹ NP_032745.1¹ AK075824⁵ BB524729⁵ (see all 9)

About this table Species with no ortholog for NPAS2

ENSEMBL Gene Tree for NPAS2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NPAS2 gene

ARNT2² CLOCK² ARNT² ARNTL² ARNTL2²

NPAS2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

UniProtKB/Swiss-Prot: NPAS2_HUMAN, Q99743

Polymorphism: Variants in NPAS2 show a susceptibility to seasonal affective disorder (SAD) [MIM:608516]. SAD is a

depressive condition resulting from seasonal changes, and with diurnal preference

SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs9223^1,2	C,F,H,	101609827(+)	`CAGACC/TGTGTT`	2	T	ref¹ syn¹		19	NS EA NA MN	1514
rs74106^1,2	C,F,A,H,	101545555(-)	`accccA/Gtcttc`	1	--	int¹		4	NA WA	12
rs184817^1,2	C,F,O,A,H,	101547756(-)	`ATGAGT/CCTTTG`	1	--	int¹		17	NS EA NA WA	1062
rs356641^1,2	C,F,A,	101538194(+)	`ttcaAC/TGGCTA`	1	--	int¹		7	NS EA NA	746
rs356642^1,2	C,F,O,H,	101537438(+)	`GGAACG/ACAAAC`	1	--	int¹		15	NS EA NA WA	646
rs356643^1,2	C,F,A,	101536192(+)	`CTCCAA/GTTGAG`	1	--	int¹		18	NS EA NA WA	1368
rs356644^1,2	C,F,A,	101535756(+)	`gcataC/Tcttta`	1	--	int¹		11	NS EA NA WA	636
rs356645^1,2	C,A	101548209(-)	`cagcaC/Gtttgg`	1	--	int¹		5	NA WA	10
rs356646^1,2	C,F,O,A,H,	101547630(-)	`AAACGA/TCCAGT`	1	--	int¹		19	NS EA NA WA	1078
rs356647^1,2	C,F,	101547520(-)	`GGCAAG/AGAAGA`	1	--	int¹ trp³		7	NS EA NA WA	624

About this table

HapMap Linkage Disequilibrium images for NPAS2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NPAS2: --

QIAGEN SeqTarget long-range PCR primers for resequencing NPAS2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NPAS2 for disorders About GeneDecksing

OMIM: 603347

Human Gene Mutation Database (HGMD): NPAS2
Human Genome Epidemiology (HuGE) Navigator: NPAS2 (20 documents)

Export disorders and mutations for NPAS2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/43 PubMed articles for NPAS2 gene, integrated from 7 sources (see all 43):
(articles sorted by number of sources associating them with NPAS2)

Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. (PubMed id 9012850)^{1, 2, 3} Zhou Y.-D.... McKnight S.L. (1997)
Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. (PubMed id 9079689)^{1, 2, 3} Hogenesch J.B.... Bradfield C.A. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference. (PubMed id 12655319)^{1, 2} Johansson C.... Partonen T. (2003)
The circadian gene NPAS2 is a novel prognostic biomar ker for breast cancer. (PubMed id 19649706)^{1, 7} Yi C....Katsaro D. (2009)
The circadian gene NPAS2, a putative tumor suppressor, is involved in DNA damage response. (PubMed id 18819933)^{1, 7} Hoffman A.E....Zhu Y. (2008)
Non-synonymous polymorphisms in the circadian gene NPAS2 and breast cancer risk. (PubMed id 17453337)^{1, 7} Zhu Y....Zheng T. (2008)
Ala394Thr polymorphism in the clock gene NPAS2: a circadian modifier for the risk of non-Hodgkin's lymphoma. (PubMed id 17096334)^{1, 7} Zhu Y....Zheng T. (2007)
Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists. (PubMed id 20095854)¹ Bhatti P....Sigurdson A.J. (2010)
Systematic analysis of circadian genes in a populatio n-based sample reveals association of TIMELESS with depression and sleep distur bance. (PubMed id 20174623)¹ Utge S.J....Paunio T. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4862	HGNC: 7895	AceView: NPAS2.1	Ensembl:ENSG00000170485	euGenes: HUgn4862
ECgene: NPAS2	Kegg: 4862	H-InvDB: NPAS2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Intellectual Property for NPAS2 gene
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Patent Information for NPAS2 gene:
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