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NR4A2 Gene

protein-coding GIFtS: 62

GC02M149066

nuclear receptor subfamily 4, group A, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NURR1)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
nuclear receptor subfamily 4, group A, member 2¹ ²		OTTHUMP00000209445²
NOT¹ ² ³ ⁵		T-cell nuclear receptor NOT²
TINUR¹ ² ³ ⁵		NGFI-B/nur77 beta-type transcription factor homolog²
NURR1² ³ ⁵		nuclear receptor subfamily 4 group A member 2²
RNR1¹ ²		intermediate-early receptor protein²
HZF-3¹ ²		OTTHUMP00000209457²
Orphan nuclear receptor NURR1² ³		nur related protein-1, human homolog of²
Transcriptionally-inducible nuclear receptor² ³		orphan nuclear receptor NR4A2²
Immediate-early response protein NOT² ³		OTTHUMP00000204451²
OTTHUMP00000209459²		OTTHUMP00000209447²
transcriptionally inducible nuclear receptor related 1²

External Ids:	HGNC: 7981¹	Entrez Gene: 4929²	Ensembl: ENSG00000153234⁷	UniProtKB: P43354³

Export aliases for NR4A2 gene to outside databases

Previous GC identifers: GC02M155112 GC02M155709 GC02M157144 GC02M157383 GC02M157006 GC02M156889

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR4A2:

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as

a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic

dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be

associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their

biological validity has not been determined. (provided by RefSeq)

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354

Function: Probable nuclear receptor. May function as a general coactivator of gene transcription. Detection of the

protein in the brain, indicates that it is not mandatorily associated with cell cycle progression

Gene Wiki entry for NR4A2 (Nuclear receptor related 1 protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NR4A2 gene promoter:
         Egr-1   AhR   C/EBPalpha   CREB   CUTL1   deltaCREB   ATF-2   Nkx2-2   Egr-2   IRF-1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for NR4A2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NR4A2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22-q23 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q22-q23

NR4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR4A2 gene location

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M149066: view genomic region (about GC identifiers)

Start:	149,066,205 bp from pter
End:	149,074,545 bp from pter
Size:	8,341 bases
Orientation:	minus strand

1 alternative location:

Chr2- 157,180,944-157,198,860

RefSeq DNA sequence:

NC_000002.11 NT_005403.17

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354 (See protein sequence)

Recommended Name: Nuclear receptor subfamily 4 group A member 2

Size: 598 amino acids; 66591 Da

Subcellular location: Nucleus (Probable)

Developmental stage: Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of

the cell cycle

PDB structures from and Proteopedia :

1OVL (3D)

Secondary accessions: Q16311 Q53RZ2

Explore the universe of human proteins at neXtProt for NR4A2: NX_P43354

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006177.1

ENSEMBL proteins:

ENSP00000386993 ENSP00000388120 ENSP00000394671 ENSP00000389986 ENSP00000406808 ENSP00000410952

ENSP00000386747 ENSP00000385379 ENSP00000415632 ENSP00000344479

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NR4A2 OriGene Protein Over-expression Lysate (see all 2): NR4A2
	GenScript Custom Purified and Recombinant Proteins Services for NR4A2
	Novus Biologicals Protein for NR4A2
	Novus Biologicals Lysates for NR4A2
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005654	nucleoplasm	TAS	--
GO:0005737	cytoplasm	IEA	--

About this table

NR4A2 for ontologies About GeneDecksing

Antibodies for NR4A2:

	Millipore Mono- and Polyclonal Antibodies for the study of NR4A2
	Sigma-Aldrich Antibodies for NR4A2
	R&D Systems Antibodies for NR4A2 (Nurr1/NGFI-B beta/NR4A2)
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for NR4A2
	Novus Biologicals Antibodies for NR4A2
	Browse antibodies at Epitomics

Assays for NR4A2:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NR4A2
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NR4A2 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR008946 Nucl_hormone_rcpt_ligand-bd

IPR001723 Str_hrmn_rcpt

IPR003073 NURR_rcpt

IPR013088 Znf_NHR/GATA

IPR000536 Nucl_hrmn_rcpt_lig-bd_core

Graphical View of Domain Structure for InterPro Entry P43354

ProtoNet protein and cluster: P43354

3 Blocks protein families:

IPB001723 Steroid hormone receptor signature

IPB003070 Orphan nuclear receptor (4A nuclear receptor) family signature

IPB003073 Orphan nuclear receptor NURR signature

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354

Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily

Similarity: Contains 1 nuclear receptor DNA-binding domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354

Function: Probable nuclear receptor. May function as a general coactivator of gene transcription. Detection of the

protein in the brain, indicates that it is not mandatorily associated with cell cycle progression

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NR4A2 Sigma-Aldrich shRNA Panels and shRNA for NR4A2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): NR4A2 OriGene shRNA RFP (see all 4): NR4A2 OriGene basic RS shRNA (see all 4): NR4A2 OriGene siRNA (see all 4): NR4A2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NR4A2

miRNA:		Sigma-Aldrich microRNA Mimics for NR4A2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NR4A2
		8/39 SABiosciences Assays for microRNAs that regulate NR4A2 (see all 39):
		hsa-miR-323-3p hsa-miR-520e hsa-miR-1224-3p hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-30a hsa-miR-372

Gene
Editing:

Sigma-Aldrich CompoZr Knockout ZFN for NR4A2

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NR4A2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NR4A2 OriGene untagged cDNA clones in CMV expression vector (see all 2): NR4A2 OriGene 3'-UTR clone: NR4A2 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for NR4A2
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for NR4A2

Genatlas biochemistry entry for NR4A2:

nuclear receptor subfamily 4,group A,member 2,steroid/thyroid receptor superfamily,rapidly and transiently expressed

after cell activation,exclusively in the brain,likely functioning as a general coactivation of gene

transcription,NGF1-B/nur 77

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003700	sequence-specific DNA binding transcription factor activity	IEA	--
GO:0003707	steroid hormone receptor activity	IEA	--
GO:0004879	ligand-dependent nuclear receptor activity	TAS	7877627
GO:0005515	protein binding	IPI	--
GO:0008270	zinc ion binding	IEA	--

About this table

NR4A2 for ontologies About GeneDecksing

Animal Models: 7 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Nr4a2):

behavior/neurological	cellular	growth/size	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	nervous system

NR4A2 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

NR4A2 for pathways About GeneDecksing

1 Millipore Pathway for NR4A2

Selected targets of CREB1

SABiosciences Pathway-Focused PCR Arrays including NR4A2: PAHS-059A PAHS-066A

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NR4A2

5/30 Interacting proteins for NR4A2 (P43354¹ ENSP00000344479³) via UniProtKB, MINT, and/or STRING (see all 30)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
FDX1	P10109¹	EBI-2681738,EBI-2694652
TCEAL5	Q5H9L2¹	EBI-2681738,EBI-2681773
NCOR1	ENSP00000268712³	STRING: ENSP00000268712
NCOR2	ENSP00000348551³	STRING: ENSP00000348551
NR0B1	ENSP00000368253³	STRING: ENSP00000368253

About this table

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006355	regulation of transcription, DNA-dependent	IEA	--
GO:0007165	signal transduction	NAS	7877627
GO:0010035	response to inorganic substance	IEA	--
GO:0010467	gene expression	TAS	--
GO:0017085	response to insecticide	IEA	--

About this table

NR4A2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

NR4A2 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NR4A2
10/21 Novoseek chemical compound relationships for NR4A2 gene (see all 21)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
nor 1	91.4	17	14525795 (2), 18945812 (2), 12351928 (2), 12770726 (1) (see all 13)
dopamine	69.8	104	20049900 (7), 12915123 (7), 19522012 (5), 15340833 (4) (see all 39)
tyrosine	56.4	28	17184956 (2), 12496759 (1), 14659823 (1), 17890097 (1) (see all 24)
retinoic acid	42.2	7	9636132 (1), 12130634 (1), 11602619 (1), 20195526 (1) (see all 6)
retinoid	38.7	8	7705655 (1), 9636132 (1), 12122012 (1), 15635645 (1)
forskolin	35.1	5	15106839 (3), 9931442 (1)
steroid	33	8	7706727 (1), 10601324 (1), 10216261 (1), 11803525 (1) (see all 7)
pd 98,059	26.4	4	15106839 (1), 17890097 (1)
3beta-hydroxysteroid	24.2	1	15666793 (1)
6 mercaptopurine	22.5	7	12709433 (3)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NR4A2 Sigma-Aldrich shRNA Panels and shRNA for NR4A2
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): NR4A2 OriGene shRNA RFP (see all 4): NR4A2 OriGene basic RS shRNA (see all 4): NR4A2 OriGene siRNA (see all 4): NR4A2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NR4A2

miRNA:		Sigma-Aldrich microRNA Mimics for NR4A2 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NR4A2
		8/39 SABiosciences Assays for microRNAs that regulate NR4A2 (see all 39):
		hsa-miR-323-3p hsa-miR-520e hsa-miR-1224-3p hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-30a hsa-miR-372

Clones:		Sigma-Aldrich FLAG tag genes for NR4A2
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NR4A2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NR4A2 OriGene untagged cDNA clones in CMV expression vector (see all 2): NR4A2 OriGene 3'-UTR Clone: NR4A2 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for NR4A2

Primers:		OriGene genome-wide validated SYBR primer pairs: NR4A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NR4A2: PPH02082A

REFSEQ mRNAs for NR4A2 gene:

NM_006186.3

Additional cDNA sequence:

AK223625.1 AK291456.1 AK299439.1 AK309786.1 BC009288.2 BC066890.1 FJ643484.1 FJ643485.1

S77154.1 X75918.1

13 DOTS entries:

DT.415336 DT.95375793 DT.100026308 DT.95351510 DT.40280240 DT.120951451 DT.415337 DT.86997413

DT.100026305 DT.120951440 DT.120951461 DT.91760528 DT.95375796

24/126 AceView cDNA sequences (see all 126):

AW450714 AA454469 BE047656 CA393074 NM_173171 AA481451 AW170067 NM_173173

NM_173172 BE047651 AA481687 CB850547 AW044464 CD722676 AA235472 CD245602

CD515223 AI978937 AI887924 AW469461 AI280196 BE645908 F10268 CA396488

highest scoring ESTs for NR4A2:

S77154 X75918 AL138201 AU279831 BC009288 BC066890 BG718296 BI909615 BM922519 AA292516

Unigene Cluster for NR4A2:

Nuclear receptor subfamily 4, group A, member 2

Hs.563344 [show with all ESTs]

Unigene Representative Sequence: NM_006186

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NR4A2 (see all 9)

ExUns:	1a	·	1b	^	2	^	3	^	4	^	5a	·	5b	·	5c	·	5d	·	5e	·	5f	·	5g	·	5h	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10
SP1:					-		-
SP2:					-		-				-		-
SP3:																																			-
SP4:					-		-				-
SP5:							-

About this scheme

ECgene alternative splicing isoforms for NR4A2
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000409108 ENST00000421709 ENST00000417972 ENST00000426264 ENST00000424077

ENST00000429376 ENST00000409572 ENST00000406048 ENST00000417764 ENST00000339562(uc002tyz.3 uc002tyx.3 uc010zcf.1 uc010zcg.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NR4A2 expression in normal and diseased human tissues

¹ / ² / ³

8 probe-sets matching NR4A2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
547_s_at²^{, 3}	U95-A	1	1.00	1.00	0.97	0.86	S77154	1.00	1.00	1.00	1
37623_at²^{, 3}	U95-A	1	1.00	1.00	0.96	1.16	X75918	1.00	1.00	1.00	1
216248_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	S77154	1.00	1.00	1.00	1
204621_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI935096	0.60	1.00	0.82	1
204622_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006186	0.60	1.00	0.82	1
216248_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204621_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
204622_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

NR4A2 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

NR4A2 gene electronic northern expression

About these images

CGAP SAGE TAG: TAAATGAAAA

SOURCE GeneReport for Unigene cluster: Hs.563344

Expression variation in blood from EXPOLDB for NR4A2

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354

Tissue specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in

brain tissue

Primers:		OriGene genome-wide validated SYBR primer pairs: NR4A2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NR4A2: PPH02082A

SABiosciences Expression via Pathway-Focused PCR Arrays including NR4A2: PAHS-059A PAHS-066A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NR4A2 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NR4A2¹	--	nuclear receptor subfamily 4, group A, member 2	96.99(n) 99.83(a)	478754 XM_535920.2 XP_535920.2
chimpanzee (Pan troglodytes)	NR4A2¹	--	nuclear receptor subfamily 4, group A, member 2	99.78(n) 100(a)	459669 XM_001142735.1 XP_001142735.1
cow (Bos taurus)	NR4A2¹	--	nuclear receptor subfamily 4, group A, member 2	96.21(n) 99.83(a)	540245 NM_001076208.1 NP_001069676.1
rat (Rattus norvegicus)	Nr4a2¹	--	nuclear receptor subfamily 4, group A, member 2	93.59(n) 99.67(a)	54278 NM_019328.3 NP_062201.2
mouse (Mus musculus)	Nr4a2^{1 , 5}	2 (31.66 cM)⁵	nuclear receptor subfamily 4, group A, member 2^{1, 5}	93.59(n)¹ 99.5(a)¹	18227¹ NM_013613.1¹ NP_038641.1¹ AB014889⁵ AK087495⁵ (see all 16)

About this table Species with no ortholog for NR4A2

ENSEMBL Gene Tree for NR4A2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NR4A2 gene

RORC² NR4A3² NR1D2² RORA² NR4A1² RORB² NR1D1²

NR4A2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs12803^1,2	C,F,	157181925(-)	`TATAAT/GGTATA`	1	--	ut3¹ ese³		22		MN EA NA NS WA	2498
rs707129^1,2	C,F,A,	157190398(+)	`TGGCTC/GTGGGA`	1	--	ng5¹		10		EA NA	310
rs834834^1,2	C,F,O,A,	157183635(+)	`AATTGT/CCATTT`	1	--	int¹		12		MN NS EA NA WA	820
rs834835^1,2	C,F,O,A,H,	157188145(+)	`CCTAGT/CAATTT`	1	--	int¹		17		EA NA NS WA	2044
rs834836^1,2	C,F,H,	157189011(+)	`CGTCTC/GTCTTC`	1	--	ut5¹ ese³		16		MN NS EA NA WA	756
rs1057727^1,2	F	157185208(-)	`gaaaaG/Aaaaga`	1	--	int¹		1		MN	184
rs1057728^1,2	--	157185204(-)	`agaaaG/Aaaaga`	1	--	int¹		1		MN	184
rs1150147^1,2	C,F,A,	157180785(+)	`ATCTGG/CATAAT`	1	--	ng3¹		9		EA NA WA	962
rs1528459^1,2	--	157185706(+)	`CGGCGG/CACCCC`	1	--	int¹		3		EA NA	60
rs1852536^1,2	--	157189095(+)	`TGGGCA/GGAGGG`	1	--	ut5¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for NR4A2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NR4A2: --

QIAGEN SeqTarget long-range PCR primers for resequencing NR4A2

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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NR4A2 for disorders About GeneDecksing

OMIM: 601828

10/20 Novoseek disease relationships for NR4A2 gene (see all 20)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
parkinson disease	75.2	52	12496759 (4), 18463503 (3), 16532445 (2), 17890097 (2) (see all 25)
inflammatory joint disease	53.8	5	15972692 (3)
carcinoma adrenocortical	36.4	1	15292355 (1)
schizophrenia	31.4	29	16631355 (4), 12627459 (3), 15211629 (2), 11803525 (2) (see all 10)
neurodegeneration	24.8	3	12401563 (1), 19821032 (1)
adenoma	17.3	4	16293616 (1), 15292355 (1), 15666793 (1)
arthritis psoriatic	15	1	15972692 (1)
genetic susceptibility	14	3	16690213 (1), 11840500 (1)
bipolar disorder	13.5	9	16631355 (3), 11121187 (2), 15635645 (1)
neurological disorders	5.36	1	18684475 (1)

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GeneTests: NR4A2

Parkinson Disease

Human Gene Mutation Database (HGMD): NR4A2
Genetic Association Database (GAD): NR4A2
Human Genome Epidemiology (HuGE) Navigator: NR4A2 (31 documents)

Export disorders and mutations for NR4A2 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/240 PubMed articles for NR4A2 gene, integrated from 7 sources (see all 240):
(articles sorted by number of sources associating them with NR4A2)

cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. (PubMed id 7706727)^{1, 2, 3, 7} Okabe T.... Watanabe T. (1995)
Organization of the human orphan nuclear receptor Nurr1 gene. (PubMed id 10216261)^{1, 2, 7} Torii T.... Kawakami H. (1999)
Mutations in NR4A2 associated with familial Parkinson disease. (PubMed id 12496759)^{1, 4, 7} Le W.D....Vassilatis D.K. (2003)
Genetic analysis of Nurr1 haplotypes in Parkinson's disease. (PubMed id 12875905)^{1, 4, 7} Tan E.K....Wong M.C. (2003)
Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia. (PubMed id 12627459)^{1, 4, 7} Iwayama-Shigeno Y....Yoshikawa T. (2003)
Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. (PubMed id 11914402)^{1, 4, 7} Xu P.Y....Le W.D. (2002)
Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease. (PubMed id 15197702)^{1, 4, 7} Nichols W.C....Foroud T. (2004)
NR4A2 and schizophrenia: lack of association in a Portuguese/Brazilian study. (PubMed id 15211629)^{1, 4, 7} Ruano D....Palha J.A. (2004)
NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. (PubMed id 12815740)^{1, 4, 7} Carmine A....Olson L. (2003)
Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients. (PubMed id 11803525)^{1, 4, 7} Chen Y.H....Chen C.H. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
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Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4929	HGNC: 7981	AceView: NR4A2	Ensembl:ENSG00000153234	euGenes: HUgn4929
ECgene: NR4A2	H-InvDB: NR4A2

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NR4A2

Intellectual Property for NR4A2 gene
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NR4A2 Gene

protein-coding GIFtS: 62

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NR4A2 (Gene Symbol)
nuclear receptor subfamily 4, group A, member 2
NOT
TINUR
NURR1
RNR1
HZF-3
Orphan nuclear receptor NURR1
Transcriptionally-inducible nuclear receptor
Immediate-early response protein NOT
OTTHUMP00000209459
transcriptionally inducible nuclear receptor related 1
OTTHUMP00000209445
T-cell nuclear receptor NOT
NGFI-B/nur77 beta-type transcription factor homolog
nuclear receptor subfamily 4 group A member 2
intermediate-early receptor protein
OTTHUMP00000209457
nur related protein-1, human homolog of
orphan nuclear receptor NR4A2
OTTHUMP00000204451
OTTHUMP00000209447

Carcinoma Adrenocortical
Arthritis Psoriatic
Neurological Disorders
Parkinson Disease
Genetic Susceptibility
inflammatory joint disease
Adenoma
Inflammation
Leukemia
Alzheimers Disease
Bipolar Disorder
Rheumatoid Arthritis
neurodegeneration
Tumors
Alcoholism
Schizophrenia
Necrosis
Cancer
Arthritis
Parkinsonism

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NR4A2 Gene

protein-coding GIFtS: 62

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