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NR4A2 Gene

protein-coding   GIFtS: 62

GC02M149066
nuclear receptor subfamily 4, group A, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: NURR1)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
nuclear receptor subfamily 4, group A, member 21 2     OTTHUMP000002094452
NOT1 2 3 5     T-cell nuclear receptor NOT2
TINUR1 2 3 5     NGFI-B/nur77 beta-type transcription factor homolog2
NURR12 3 5     nuclear receptor subfamily 4 group A member 22
RNR11 2     intermediate-early receptor protein2
HZF-31 2     OTTHUMP000002094572
Orphan nuclear receptor NURR12 3     nur related protein-1, human homolog of2
Transcriptionally-inducible nuclear receptor2 3     orphan nuclear receptor NR4A22
Immediate-early response protein NOT2 3     OTTHUMP000002044512
OTTHUMP000002094592     OTTHUMP000002094472
transcriptionally inducible nuclear receptor related 12     

External Ids:    HGNC: 79811   Entrez Gene: 49292   Ensembl: ENSG000001532347   UniProtKB: P433543   

Export aliases for NR4A2 gene to outside databases

Previous GC identifers: GC02M155112 GC02M155709 GC02M157144 GC02M157383 GC02M157006 GC02M156889


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NR4A2:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as
a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic
dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be
associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their
biological validity has not been determined. (provided by RefSeq)

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
Function: Probable nuclear receptor. May function as a general coactivator of gene transcription. Detection of the
protein in the brain, indicates that it is not mandatorily associated with cell cycle progression

Gene Wiki entry for NR4A2 (Nuclear receptor related 1 protein)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the NR4A2 gene promoter:
         Egr-1   AhR   C/EBPalpha   CREB   CUTL1   deltaCREB   ATF-2   Nkx2-2   Egr-2   IRF-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for NR4A2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NR4A2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q22-q23   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q22-q23

NR4A2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NR4A2 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M149066:  view genomic region     (about GC identifiers)

Start:
149,066,205 bp from pter
End:
149,074,545 bp from pter
Size:
8,341 bases
Orientation:
minus strand

1 alternative location:
Chr2- 157,180,944-157,198,860     
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354 (See protein sequence)
Recommended Name: Nuclear receptor subfamily 4 group A member 2  
Size: 598 amino acids; 66591 Da
Subcellular location: Nucleus (Probable)
Developmental stage: Rapidly and only very transiently expressed after cell activation, during the G0-G1 transition of
the cell cycle
PDB structures from and Proteopedia :
1OVL (3D)    
Secondary accessions: Q16311 Q53RZ2

Explore the universe of human proteins at neXtProt for NR4A2: NX_P43354 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006177.1  

    ENSEMBL proteins: 
    ENSP00000386993 ENSP00000388120 ENSP00000394671 ENSP00000389986 ENSP00000406808 ENSP00000410952 
    ENSP00000386747 ENSP00000385379 ENSP00000415632 ENSP00000344479 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: NR4A2
    OriGene Protein Over-expression Lysate (see all 2): NR4A2
    GenScript Custom Purified and Recombinant Proteins Services for NR4A2 
    Novus Biologicals Protein for NR4A2
    Novus Biologicals Lysates for NR4A2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005654 nucleoplasm TAS--
    GO:0005737 cytoplasm IEA--
    About this table

    NR4A2 for ontologies           About GeneDecksing



    Antibodies for NR4A2: 
    Millipore Mono- and Polyclonal Antibodies for the study of NR4A2
    Sigma-Aldrich Antibodies for NR4A2
    R&D Systems Antibodies for NR4A2 (Nurr1/NGFI-B beta/NR4A2)
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for NR4A2 
    Novus Biologicals Antibodies for NR4A2
    Browse antibodies at Epitomics

    Assays for NR4A2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for NR4A2 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    NR4A2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR008946 Nucl_hormone_rcpt_ligand-bd
     IPR001723 Str_hrmn_rcpt
     IPR003073 NURR_rcpt
     IPR013088 Znf_NHR/GATA
     IPR000536 Nucl_hrmn_rcpt_lig-bd_core

    Graphical View of Domain Structure for InterPro Entry P43354

    ProtoNet protein and cluster: P43354

    3 Blocks protein families:
    IPB001723 Steroid hormone receptor signature
    IPB003070 Orphan nuclear receptor (4A nuclear receptor) family signature
    IPB003073 Orphan nuclear receptor NURR signature


    UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
    Similarity: Belongs to the nuclear hormone receptor family. NR4 subfamily
    Similarity: Contains 1 nuclear receptor DNA-binding domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
    Function: Probable nuclear receptor. May function as a general coactivator of gene transcription. Detection of the
    protein in the brain, indicates that it is not mandatorily associated with cell cycle progression

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NR4A2
    Sigma-Aldrich shRNA Panels and shRNA for NR4A2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): NR4A2
    OriGene shRNA RFP (see all 4): NR4A2
    OriGene basic RS shRNA (see all 4): NR4A2
    OriGene siRNA (see all 4): NR4A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NR4A2 
    miRNA:Sigma-Aldrich microRNA Mimics for NR4A2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NR4A2 
    8/39 SABiosciences Assays for microRNAs that regulate NR4A2 (see all 39):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-1224-3p hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-30a hsa-miR-372

    Gene
    Editing:
    Sigma-Aldrich CompoZr Knockout ZFN for NR4A2 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NR4A2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NR4A2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): NR4A2
    OriGene 3'-UTR clone: NR4A2 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NR4A2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for NR4A2 

    Genatlas biochemistry entry for NR4A2:
    nuclear receptor subfamily 4,group A,member 2,steroid/thyroid receptor superfamily,rapidly and transiently expressed
    after cell activation,exclusively in the brain,likely functioning as a general coactivation of gene
    transcription,NGF1-B/nur 77

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003700 sequence-specific DNA binding transcription factor activity IEA--
    GO:0003707 steroid hormone receptor activity IEA--
    GO:0004879 ligand-dependent nuclear receptor activity TAS7877627
    GO:0005515 protein binding IPI--
    GO:0008270 zinc ion binding IEA--
    About this table

    NR4A2 for ontologies           About GeneDecksing

    Animal Models: 7 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Nr4a2):

    behavior/neurologicalcellulargrowth/sizehomeostasis/metabolismlethality-postnatal
    lethality-prenatal/perinatalnervous system

    NR4A2 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    NR4A2 for pathways           About GeneDecksing

    1 Millipore Pathway for NR4A2
        Selected targets of CREB1

        SABiosciences Pathway-Focused PCR Arrays including NR4A2: PAHS-059A PAHS-066A 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for NR4A2

    5/30 Interacting proteins for NR4A2 (P433541 ENSP000003444793) via UniProtKB, MINT, and/or STRING (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FDX1P101091EBI-2681738,EBI-2694652
    TCEAL5Q5H9L21EBI-2681738,EBI-2681773
    NCOR1ENSP000002687123STRING: ENSP00000268712
    NCOR2ENSP000003485513STRING: ENSP00000348551
    NR0B1ENSP000003682533STRING: ENSP00000368253
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006355 regulation of transcription, DNA-dependent IEA--
    GO:0007165 signal transduction NAS7877627
    GO:0010035 response to inorganic substance IEA--
    GO:0010467 gene expression TAS--
    GO:0017085 response to insecticide IEA--
    About this table

    NR4A2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    NR4A2 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for NR4A2
    10/21 Novoseek chemical compound relationships for NR4A2 gene (see all 21)
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    nor 1 91.4 17 14525795 (2), 18945812 (2), 12351928 (2), 12770726 (1) (see all 13)
    dopamine 69.8 104 20049900 (7), 12915123 (7), 19522012 (5), 15340833 (4) (see all 39)
    tyrosine 56.4 28 17184956 (2), 12496759 (1), 14659823 (1), 17890097 (1) (see all 24)
    retinoic acid 42.2 7 9636132 (1), 12130634 (1), 11602619 (1), 20195526 (1) (see all 6)
    retinoid 38.7 8 7705655 (1), 9636132 (1), 12122012 (1), 15635645 (1)
    forskolin 35.1 5 15106839 (3), 9931442 (1)
    steroid 33 8 7706727 (1), 10601324 (1), 10216261 (1), 11803525 (1) (see all 7)
    pd 98,059 26.4 4 15106839 (1), 17890097 (1)
    3beta-hydroxysteroid 24.2 1 15666793 (1)
    6 mercaptopurine 22.5 7 12709433 (3)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for NR4A2
    Sigma-Aldrich shRNA Panels and shRNA for NR4A2
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 4): NR4A2
    OriGene shRNA RFP (see all 4): NR4A2
    OriGene basic RS shRNA (see all 4): NR4A2
    OriGene siRNA (see all 4): NR4A2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NR4A2 
    miRNA: Sigma-Aldrich microRNA Mimics for NR4A2
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NR4A2 
    8/39 SABiosciences Assays for microRNAs that regulate NR4A2 (see all 39):
    hsa-miR-323-3p hsa-miR-520e hsa-miR-1224-3p hsa-miR-106a hsa-miR-30d hsa-miR-449a hsa-miR-30a hsa-miR-372
    Clones: Sigma-Aldrich FLAG tag genes for NR4A2
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 4): NR4A2
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 4): NR4A2
    OriGene untagged cDNA clones in CMV expression vector (see all 2): NR4A2
    OriGene 3'-UTR Clone: NR4A2 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for NR4A2 
    Primers: OriGene genome-wide validated SYBR primer pairs: NR4A2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NR4A2: PPH02082A

    REFSEQ mRNAs for NR4A2 gene: 

    NM_006186.3  

    Additional cDNA sequence: 

    AK223625.1 AK291456.1 AK299439.1 AK309786.1 BC009288.2 BC066890.1 FJ643484.1 FJ643485.1 
    S77154.1 X75918.1 

    13 DOTS entries:

    DT.415336  DT.95375793  DT.100026308  DT.95351510  DT.40280240  DT.120951451  DT.415337  DT.86997413 
    DT.100026305  DT.120951440  DT.120951461  DT.91760528  DT.95375796 

    24/126 AceView cDNA sequences (see all 126):

    AW450714 AA454469 BE047656 CA393074 NM_173171 AA481451 AW170067 NM_173173 
    NM_173172 BE047651 AA481687 CB850547 AW044464 CD722676 AA235472 CD245602 
    CD515223 AI978937 AI887924 AW469461 AI280196 BE645908 F10268 CA396488 

    highest scoring ESTs for NR4A2:

    S77154 X75918 AL138201 AU279831 BC009288 BC066890 BG718296 BI909615 BM922519 AA292516 

    Unigene Cluster for NR4A2:

    Nuclear receptor subfamily 4, group A, member 2
    Hs.563344  [show with all ESTs]
    Unigene Representative Sequence: NM_006186


    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for NR4A2 (see all 9)

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g · 5h ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10
    SP1:              -     -                                                                                                   
    SP2:              -     -           -     -                                                                                 
    SP3:                                                                                                        -               
    SP4:              -     -           -                                                                                       
    SP5:                    -                                                                                                   

    About this scheme

    ECgene alternative splicing isoforms for NR4A2
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000409108 ENST00000421709 ENST00000417972 ENST00000426264 ENST00000424077
    ENST00000429376 ENST00000409572 ENST00000406048 ENST00000417764 ENST00000339562(uc002tyz.3 uc002tyx.3 uc010zcf.1 uc010zcg.1)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    NR4A2 expression in normal and diseased human tissues

    1  / 2  / 3

    8 probe-sets matching NR4A2 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    547_s_at2, 3 U95-A 1 1.00 1.00 0.97 0.86 S77154 1.00 1.00 1.00 1
    37623_at2, 3 U95-A 1 1.00 1.00 0.96 1.16 X75918 1.00 1.00 1.00 1
    216248_s_at2, 3 U133-A 1 1.00 1.00 -- -- S77154 1.00 1.00 1.00 1
    204621_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI935096 0.60 1.00 0.82 1
    204622_x_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006186 0.60 1.00 0.82 1
    216248_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    204621_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    204622_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    About this table

    NR4A2 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    NR4A2 gene expression
    NR4A2 gene electronic northern expression
    NR4A2 gene sage expression
    About these images

    CGAP SAGE TAG: TAAATGAAAA

    SOURCE GeneReport for Unigene cluster: Hs.563344

    Expression variation in blood from EXPOLDB for NR4A2

    UniProtKB/Swiss-Prot: NR4A2_HUMAN, P43354
    Tissue specificity: Expressed in a number of cell lines of T-cell, B-cell and fibroblast origin. Strong expression in
    brain tissue

    Primers: OriGene genome-wide validated SYBR primer pairs: NR4A2
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for NR4A2: PPH02082A
        SABiosciences Expression via Pathway-Focused PCR Arrays including NR4A2: PAHS-059A PAHS-066A 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for NR4A2 gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    NR4A21   -- nuclear receptor subfamily 4, group A, member 2 96.99(n)
    99.83(a)
    478754  XM_535920.2  XP_535920.2 
    chimpanzee
    (Pan troglodytes)
    NR4A21   -- nuclear receptor subfamily 4, group A, member 2 99.78(n)
    100(a)
    459669  XM_001142735.1  XP_001142735.1 
    cow
    (Bos taurus)
    NR4A21   -- nuclear receptor subfamily 4, group A, member 2 96.21(n)
    99.83(a)
    540245  NM_001076208.1  NP_001069676.1 
    rat
    (Rattus norvegicus)
    Nr4a21   -- nuclear receptor subfamily 4, group A, member 2 93.59(n)
    99.67(a)
    54278  NM_019328.3  NP_062201.2 
    mouse
    (Mus musculus)
    Nr4a21 , 5 2 (31.66 cM)5
    nuclear receptor subfamily 4, group A, member 21, 5 93.59(n)1
    99.5(a)1
    182271  NM_013613.11  NP_038641.11 
     AB0148895  AK0874955  (see all 16)
    About this table        Species with no ortholog for NR4A2

    ENSEMBL Gene Tree for NR4A2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for NR4A2 gene
    RORC2  NR4A32  NR1D22  RORA2  NR4A12  RORB2  NR1D12  

    NR4A2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/97 NCBI SNPs in NR4A2 are shown (see all 97)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 2 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs128031,2
    C,F,157181925(-) TATAAT/GGTATA 1 -- ut31 ese322Minor allele frequency- G:0.41MN EA NA NS WA 2498
    rs7071291,2
    C,F,A,157190398(+) TGGCTC/GTGGGA 1 -- ng5110Minor allele frequency- G:0.47EA NA 310
    rs8348341,2
    C,F,O,A,157183635(+) AATTGT/CCATTT 1 -- int112Minor allele frequency- C:0.50MN NS EA NA WA 820
    rs8348351,2
    C,F,O,A,H,157188145(+) CCTAGT/CAATTT 1 -- int117Minor allele frequency- C:0.50EA NA NS WA 2044
    rs8348361,2
    C,F,H,157189011(+) CGTCTC/GTCTTC 1 -- ut51 ese316Minor allele frequency- G:0.01MN NS EA NA WA 756
    rs10577271,2
    F157185208(-) gaaaaG/Aaaaga 1 -- int11Minor allele frequency- A:0.04MN 184
    rs10577281,2
    --157185204(-) agaaaG/Aaaaga 1 -- int11Minor allele frequency- A:0.00MN 184
    rs11501471,2
    C,F,A,157180785(+) ATCTGG/CATAAT 1 -- ng319Minor allele frequency- C:0.49EA NA WA 962
    rs15284591,2
    --157185706(+) CGGCGG/CACCCC 1 -- int13Minor allele frequency- C:0.00EA NA 60
    rs18525361,2
    --157189095(+) TGGGCA/GGAGGG 1 -- ut510--------
    About this table

    HapMap Linkage Disequilibrium images for NR4A2 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for NR4A2: --

    QIAGEN SeqTarget long-range PCR primers for resequencing NR4A2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    NR4A2 for disorders           About GeneDecksing

    OMIM: 601828

    10/20 Novoseek disease relationships for NR4A2 gene (see all 20)

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    parkinson disease 75.2 52 12496759 (4), 18463503 (3), 16532445 (2), 17890097 (2) (see all 25)
    inflammatory joint disease 53.8 5 15972692 (3)
    carcinoma adrenocortical 36.4 1 15292355 (1)
    schizophrenia 31.4 29 16631355 (4), 12627459 (3), 15211629 (2), 11803525 (2) (see all 10)
    neurodegeneration 24.8 3 12401563 (1), 19821032 (1)
    adenoma 17.3 4 16293616 (1), 15292355 (1), 15666793 (1)
    arthritis psoriatic 15 1 15972692 (1)
    genetic susceptibility 14 3 16690213 (1), 11840500 (1)
    bipolar disorder 13.5 9 16631355 (3), 11121187 (2), 15635645 (1)
    neurological disorders 5.36 1 18684475 (1)
    About this table

    GeneTests: NR4A2
    Parkinson Disease

    Human Gene Mutation Database (HGMD): NR4A2
    Genetic Association Database (GAD): NR4A2
    Human Genome Epidemiology (HuGE) Navigator: NR4A2 (31 documents)

    Export disorders and mutations for NR4A2 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/240 PubMed articles for NR4A2 gene, integrated from 7 sources (see all 240):
    (articles sorted by number of sources associating them with NR4A2)
    1. cDNA cloning of a NGFI-B/nur77-related transcription factor from an apoptotic human T cell line. (PubMed id 7706727)1, 2, 3, 7 Okabe T.... Watanabe T. (1995)
    2. Organization of the human orphan nuclear receptor Nurr1 gene. (PubMed id 10216261)1, 2, 7 Torii T.... Kawakami H. (1999)
    3. Mutations in NR4A2 associated with familial Parkinson disease. (PubMed id 12496759)1, 4, 7 Le W.D....Vassilatis D.K. (2003)
    4. Genetic analysis of Nurr1 haplotypes in Parkinson's disease. (PubMed id 12875905)1, 4, 7 Tan E.K....Wong M.C. (2003)
    5. Distribution of haplotypes derived from three common variants of the NR4A2 gene in Japanese patients with schizophrenia. (PubMed id 12627459)1, 4, 7 Iwayama-Shigeno Y....Yoshikawa T. (2003)
    6. Association of homozygous 7048G7049 variant in the intron six of Nurr1 gene with Parkinson's disease. (PubMed id 11914402)1, 4, 7 Xu P.Y....Le W.D. (2002)
    7. Evaluation of the role of Nurr1 in a large sample of familial Parkinson's disease. (PubMed id 15197702)1, 4, 7 Nichols W.C....Foroud T. (2004)
    8. NR4A2 and schizophrenia: lack of association in a Portuguese/Brazilian study. (PubMed id 15211629)1, 4, 7 Ruano D....Palha J.A. (2004)
    9. NURR1 promoter polymorphisms: Parkinson's disease, schizophrenia, and personality traits. (PubMed id 12815740)1, 4, 7 Carmine A....Olson L. (2003)
    10. Mutation analysis of the human NR4A2 gene, an essential gene for midbrain dopaminergic neurogenesis, in schizophrenic patients. (PubMed id 11803525)1, 4, 7 Chen Y.H....Chen C.H. (2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
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      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 4929 HGNC: 7981 AceView: NR4A2 Ensembl:ENSG00000153234 euGenes: HUgn4929
    ECgene: NR4A2 H-InvDB: NR4A2

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NR4A2

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for NR4A2 gene:
    Search GeneIP for patents involving NR4A2

    Licensable Technologies for NR4A2 gene:
     Salk Institute: Regulation of Tyrosine Hydroxylase Expression
    GeneCards and IP:
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