Aliases &
Descriptions
for NRN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| neuritin 11 2 | | NRN1 2 3 5 | | neuritin2 | | dJ380B8.22 | | MGC448112 |
Export aliases for NRN1 gene to outside databasesPrevious GC identifers: GC06M005983 GC06M005943 |
Summaries
for NRN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NRN1:
This gene is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronalstructures associated with plasticity in the adult. The expression of this gene can be induced by neural activity andneurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol(GPI)-anchored proteins. In vitro assays demonstrated that this protein promotes neurite outgrowth and arborization,suggesting its role in promoting neuritogenesis. (provided by RefSeq)
UniProtKB/Swiss-Prot: NRN1_HUMAN, Q9NPD7Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and corticalcells (By similarity)
|
Genomic Views
for NRN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NRN1 gene promoter:
MyoD C/EBPalpha CUTL1 Cart-1 FOXJ2 (long isoform)
Other transcription factors
Search SABiosciences Chromatin IP Primers for NRN1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NRN1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p25.1 Ensembl cytogenetic band: 6p25.1 HGNC cytogenetic band: 6p25.1NRN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M005873: view genomic region
(about GC identifiers)
Start:
|
5,873,923 bp from pter |
End:
|
5,883,325 bp from pter |
Size:
|
9,403 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr6- 5,998,232-6,007,200 |
RefSeq DNA sequence:- NC_000006.11 NT_007592.15
|
Proteins
for NRN1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NRN1_HUMAN, Q9NPD7 (See
protein sequence)Recommended Name: Neuritin precursor Size: 142 amino acids; 15333 Da
Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor (Potential)
Secondary accessions: B2RA93 Q7Z4Y1Explore the universe of human proteins at neXtProt for NRN1: NX_Q9NPD7
REFSEQ proteins: NP_057672.1
ENSEMBL proteins: ENSP00000244766
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
IEA | -- | | GO:0031225 | anchored to membrane |
IEA | -- |
About this table
NRN1 for ontologies About GeneDecksing
Antibodies for NRN1:
Assays for NRN1: |
Protein
Domains/
Families
for NRN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9NPD7 UniProtKB/Swiss-Prot: NRN1_HUMAN, Q9NPD7Similarity: Belongs to the neuritin family |
Gene Function
for NRN1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NRN1_HUMAN, Q9NPD7Function: Promotes neurite outgrowth and especially branching of neuritic processes in primary hippocampal and corticalcells (By similarity)
|
Pathways & Interactions
for NRN1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for NRN1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NRN1
|
Drugs & Compounds
for NRN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NRN1
|
Transcripts
for NRN1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NRN1 gene: NM_016588.2 Additional cDNA sequence: AF114833.1 AF136631.1 AJ420483.1 AK093824.1 AK314095.1 BC002683.2 BC042019.1 CR591192.1 CR610397.1 CR610504.1 CR613189.1 CR614740.1 CR615533.1 CR620311.1 CR624108.1 10 DOTS entries: DT.445436 DT.100792356 DT.121355089 DT.97762304 DT.100792349 DT.100792353 DT.91928122 DT.100029054 DT.100792345 DT.95175068 24/200 AceView cDNA sequences (see all 200): BU633513 AI919239 BQ774533 CR591192 CR615533 CR614740 BU150419 CR610504 BU173962 AA054618 CD519184 BG057912 AF136631 AI190645 AA551666 BU177968 BU185614 CR620311 BX279990 W74094 CR624108 BU190549 BM704247 BQ720570
 highest scoring ESTs for NRN1:AF114833 AF136631 AI765692 AJ420483 AL541038 AV684909 AV694499 AV698002 BC002683 BC042019 Unigene Cluster for NRN1: Neuritin 1 Hs.103291 [show with all ESTs]Unigene Representative Sequence: BC042019
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for NRN1
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c |
|---|
|
| SP1: | | | - | | | | - | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | | | - | | | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NRN1
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000495850 ENST00000244766(uc003mwt.2 uc003mwu.2)
|
Expression
for NRN1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NRN1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching NRN1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 48038_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AI765692 |
0.80 |
1.00 |
0.91 |
1 |
| 218625_at2, 3
|
U133-A |
1 |
0.91 |
1.00 |
-- |
-- |
NM_016588 |
0.60 |
1.00 |
0.82 |
1 |
| 218625_at2
|
U133Plus2 |
1 |
0.91 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NRN1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTGCTATGGT
SOURCE GeneReport for Unigene cluster: Hs.103291
SABiosciences Custom PCR Arrays for NRN1
|
Orthologs
for NRN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NRN1 gene from 5/8 species (see all 8)
About this table Species with no ortholog for NRN1
ENSEMBL Gene Tree for NRN1 (if available) |
Paralogs
for NRN1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NRN1 gene
- NRN1L2
NRN1 for paralogs About GeneDecksing
|
Genomic Variants
for NRN1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 6 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NRN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NRN1
1 CNV: 0072 | | QIAGEN SeqTarget long-range PCR primers for resequencing NRN1 |
|
Disorders & Mutations
for NRN1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NRN1 for disorders About GeneDecksing
OMIM: 607409
1  Novoseek disease relationship for NRN1 gene
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0 |
2 |
16723126 (1) |
About this table
1 PharmGKB disease relationship for NRN1 geneAbout this table
Export disorders and mutations for NRN1 gene to outside databases
|
Medical News
for NRN1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NRN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/16 PubMed articles for NRN1 gene, integrated from 7 sources (see all 16):
(articles sorted by number of sources associating them with NRN1)- Neuritin: a gene induced by neural activity and neurotrophins that promotes neuritogenesis. (PubMed id 9122250)1, 2, 3, 7 Naeve G.S....Theill L.E. (1997)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Characterization of the expression of the hypoxia-induced genes neuritin, TXNIP and IGFBP3 in cancer. (PubMed id 16723126)1, 7 Le Jan S....Germain S. (2006)
- cpg15 and cpg15-2 constitute a family of activity-regulated ligands expressed differentially in the nervous system to promote neurite growth and neuronal survival. (PubMed id 18265009)1, 7 Fujino T....Nedivi E. (2008)
- Classification of pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12730115)5 Ross M.E....Downing J.R. (2003)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Neuritin (cpg15) enhances the differentiating effect of NGF on neuronal PC12 cells. (PubMed id 17335086)7 Cappelletti G....Poletti A. (2007)
- Impact of Neuritin 1 (NRN1) polymorphisms on fluid in telligence in schizophrenia. (PubMed id 19569075)7 Chandler D....Jablensky A. (2010)
|
External Searches for NRN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NRN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NRN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NRN1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NRN1 gene:
Search GeneIP for patents involving NRN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NRN1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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 |  |  |  | |
| |  | Search Tocris compounds for NRN1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for NRN1 |
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