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Aliases & Descriptionsfor NSUN3 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions NOP2/Sun domain family, member 31 2 FLJ221092 NOL1/NOP2/Sun domain family 31 2 putative methyltransferase NSUN32 FLJ226091 2 MST0772 NOL1/NOP2/Sun domain family, member 31 2 EC 2.1.1.-3 NOL1/NOP2/Sun domain family member 32 3
Export aliases for NSUN3 gene to outside databases Previous GC identifers: GC03P095264 GC03P093781
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Summariesfor NSUN3 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: NSUN3_HUMAN, Q9H649 Function : May have S-adenosyl-L-methionine-dependent methyl-transferase activity (Potential)
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Genomic Viewsfor NSUN3 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the NSUN3 gene promoter: IRF-7A C/EBPbeta Chx10 RREB-1 FOXJ2 (long isoform) Cdc5 AREB6 FOXD3 POU2F1 FOXL1 Other transcription factors Search SABiosciences Chromatin IP Primers for NSUN3 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NSUN3
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 3q11.1 Ensembl cytogenetic band: 3q11.1 HGNC cytogenetic band: 3q11.2 NSUN3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure
GeneLoc location for GC03P091144: view genomic region
(about GC identifiers )
Start:
91,144,472 bp from pter
End:
91,208,238 bp from pter
Size:
63,767 bases
Orientation:
plus strand
1 alternative location : Chr 3+ 93,781,760-93,847,389
RefSeq DNA sequence: NC_000003.11 NT_005612.16
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Proteinsfor NSUN3 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: NSUN3_HUMAN, Q9H649 (See
protein sequence )Recommended Name: Putative methyltransferase NSUN3 Size : 340 amino acids; 38244 Da
Sequence caution : Sequence=AAN76512.1; Type=Miscellaneous discrepancy; Note=Chimera; Sequence=AAQ13600.1;Type=Frameshift; Positions=98; Sequence=BAB15234.1; Type=Erroneous initiation;
Secondary accessions : Q6PG41 Q8IXG9 Q9H6M2Explore the universe of human proteins at neXtProt for NSUN3: NX_Q9H649
REFSEQ proteins: NP_071355.1 ENSEMBL proteins: ENSP00000318986 ENSP00000419297 Human Recombinant Proteins Antibodies for NSUN3: Assays for NSUN3:
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Protein
Domains/ Familiesfor NSUN3 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
NSUN3 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q9H649 ProtoNet protein and cluster: Q9H649
1 Blocks protein family : IPB001678 Bacterial Sun/eukaryotic nucleolar Nop1/Nop2 UniProtKB/Swiss-Prot: NSUN3_HUMAN, Q9H649 Similarity : Belongs to the methyltransferase superfamily. RsmB/NOP family
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Gene Functionfor NSUN3 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: NSUN3_HUMAN, Q9H649 Function : May have S-adenosyl-L-methionine-dependent methyl-transferase activity (Potential)Enzyme Number (IUBMB): EC 2.1.1.-
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0008168 methyltransferase activity
IEA -- GO:0016740 transferase activity
IEA --
About this table
NSUN3 for ontologies About GeneDecksing
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Pathways & Interactionsfor NSUN3 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section SABiosciences Custom Pathway-Focused PCR Arrays for NSUN3 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NSUN3
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Drugs & Compoundsfor NSUN3 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for NSUN3
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Transcriptsfor NSUN3 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for NSUN3 gene: NM_022072.3
Additional cDNA sequence: AF169972.1 AK026262.1 BC018432.1 BC020602.1 BC057238.1 CR594640.1
4 DOTS entries : DT.413029 DT.91793842 DT.120888284 DT.97839066
24/58 AceView cDNA sequences (see all 58 ):
AA416796 CR594640 BE891052 BM469478 AI702903 BC018432 AA807341 AA705035 AA736939 N62649 BU665363 BG502931 AA777523 AI332912 NM_022072 BC020602 BM477400 AA700816 AA694053 C00750 BC057238 BX090417 BG251198 BG528694
highest scoring ESTs for NSUN3 :AA700816 AA429938 AA682850 AA694053 AA736939 AF169972 AI332912 AI417596 AI586968 AI702903 Unigene Cluster for NSUN3:
NOP2/Sun domain family, member 3 Hs.448003 [show with all ESTs ] Unigene Representative Sequence: BC020602 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for NSUN3 ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 SP1 :     -   -               SP2 :       -               SP3 :                    
About this scheme ECgene alternative splicing isoforms for NSUN3 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000468555 ENST00000461625 ENST00000476588 ENST00000485793 ENST00000477077 (uc003drk.2 )ENST00000314622 (uc003drl.1 ) ENST00000483378
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Expression for NSUN3 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section NSUN3 expression in normal and diseased human tissues 1 / 2 / 3
6 probe-sets matching NSUN3 gene
Affymetrix probe-set
Array
GeneAnnot data
GeneNote data
GeneTide data
# genes
Sensitivity
Specificity
Correlation
Length
Gb_Accession
Consensus
Uniqueness
Score
Rank
59085_at2 , 3
U95-B
1
1.00
1.00
1.00
1.00
AA700816
1.00
1.00
1.00
1
219458_s_at2 , 3
U133-A
1
1.00
1.00
--
--
NM_022072
0.60
1.00
0.82
1
222886_at*2 , 3
U133-B
1
0.46
1.00
--
--
AK025762
0.60
1.00
0.82
1
219458_s_at2
U133Plus2
1
1.00
1.00
--
--
--
--
--
--
--
1568913_at2
U133Plus2
1
0.73
1.00
--
--
--
--
--
--
--
222886_at*2
U133Plus2
1
0.46
1.00
--
--
--
--
--
--
--
About this table
NSUN3 for expression About GeneDecksing Data from
Genenote  
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.448003 SABiosciences Custom PCR Arrays for NSUN3
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Orthologsfor NSUN3 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for NSUN3 gene from 5/6 species (see all 6 )
About this table Species with no ortholog for NSUN3 ENSEMBL Gene Tree for NSUN3 (if available)
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Paralogsfor NSUN3 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for NSUN3 gene NOP2 2 NSUN6 2 NSUN4 2
NSUN3 for paralogs About GeneDecksing
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Genomic Variantsfor NSUN3 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 3 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for NSUN3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for NSUN3: --
QIAGEN SeqTarget long-range PCR primers for resequencing NSUN3
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Disorders & Mutationsfor NSUN3 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
NSUN3 for disorders About GeneDecksing Human Genome Epidemiology (HuGE) Navigator: NSUN3 (1 document)Export disorders and mutations for NSUN3 gene to outside databases
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Medical Newsfor NSUN3 gene (Possibly Related Articles in
Doctor's Guide )
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Publicationsfor NSUN3 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 5 PubMed articles for NSUN3 gene integrated from 7 sources : (articles sorted by number of sources associating them with NSUN3) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 , 3 Strausberg R.L....Marra M.A. (2002) Coeliac disease associated risk variants in TNFAIP3 and REL implicate altered NF-{kappa}B signalling. (PubMed id 19240061) 1 Trynka G....Wijmenga C. (2009) hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965) 1 Lamesch P.... Vidal M. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004)
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External Searches for NSUN3 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing NSUN3 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing NSUN3 gene
(According to HUGE )
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Specialized Databases showing NSUN3 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for NSUN3 gene: Search GeneIP for patents involving NSUN3 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor NSUN3 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for NSUN3
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