Aliases &
Descriptions
for NSUN7 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| NOP2/Sun domain family, member 71 2 | | NOL1/NOP2/Sun domain family, member 71 2 | | FLJ140011 2 | | NOL1/NOP2/Sun domain family member 72 3 | | putative methyltransferase NSUN72 | | EC 2.1.1.-3 |
Export aliases for NSUN7 gene to outside databasesPrevious GC identifers: GC04P040446 GC04P040751 |
Summaries
for NSUN7 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: NSUN7_HUMAN, Q8NE18Function: May have S-adenosyl-L-methionine-dependent methyl-transferase activity (Potential)
|
Genomic Views
for NSUN7 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NSUN7 gene promoter:
ITF-2 Tal-1beta E47 Tal-1 RORalpha1 oct-B3 POU2F2B POU2F2 (Oct-2.1) POU2F2 POU2F1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NSUN7
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NSUN7  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p14 Ensembl cytogenetic band: 4p14 HGNC cytogenetic band: 4p14NSUN7 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P040073: view genomic region
(about GC identifiers)
Start:
|
40,073,760 bp from pter |
End:
|
40,133,961 bp from pter |
Size:
|
60,202 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr4+ 40,751,914-40,812,002 |
RefSeq DNA sequence:- NC_000004.11 NT_006238.11
|
Proteins
for NSUN7 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NSUN7_HUMAN, Q8NE18 (See
protein sequence)Recommended Name: Putative methyltransferase NSUN7 Size: 718 amino acids; 81039 Da
Sequence caution: Sequence=BAC04325.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: Q8N9K8 Q9H815Alternative splicing: 3 isoforms: Q8NE18-1 Q8NE18-2 Q8NE18-3 Explore the universe of human proteins at neXtProt for NSUN7: NX_Q8NE18
REFSEQ proteins: NP_078953.3
ENSEMBL proteins: ENSP00000371201 ENSP00000334980 ENSP00000319127
Human Recombinant Proteins
Antibodies for NSUN7:
Assays for NSUN7: |
Protein
Domains/
Families
for NSUN7 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NSUN7 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8NE18ProtoNet protein and cluster: Q8NE18 UniProtKB/Swiss-Prot: NSUN7_HUMAN, Q8NE18Similarity: Belongs to the methyltransferase superfamily. RsmB/NOP family |
Gene Function
for NSUN7 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NSUN7_HUMAN, Q8NE18Function: May have S-adenosyl-L-methionine-dependent methyl-transferase activity (Potential)Enzyme Number (IUBMB): EC 2.1.1.-
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008168 | methyltransferase activity |
IEA | -- | | GO:0016740 | transferase activity |
IEA | -- |
About this table
NSUN7 for ontologies About GeneDecksing
Animal Models: 1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Nsun7):
NSUN7 for phenotypes About GeneDecksing
|
Pathways & Interactions
for NSUN7 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for NSUN7
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NSUN7
|
Drugs & Compounds
for NSUN7 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NSUN7
|
Transcripts
for NSUN7 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NSUN7 gene: NM_024677.4 Additional cDNA sequence: AK024063.1 AK094298.1 AK130348.1 AK304048.1 BC036568.2 BC042401.1 5 DOTS entries: DT.306651 DT.104578 DT.95192925 DT.100748519 DT.91734382 24/55 AceView cDNA sequences (see all 55): AI275210 AA233610 BE550959 BM781928 AU143669 BC042401 AI216832 AK094298 BE042919 BX503583 BE222110 BQ023150 AI538394 AI961502 AA448524 AA988790 NM_024677 AK024063 BX113523 AA055869 BM844846 BI463713 AI221215 BC036568
 highest scoring ESTs for NSUN7:N52898 AA249173 AA557734 AI538394 AI916398 AI961502 AK094298 AW366714 AW973793 BE041423 Unigene Cluster for NSUN7: NOP2/Sun domain family, member 7 Hs.570821 [show with all ESTs]Unigene Representative Sequence: BC042401
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for NSUN7
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 |
|---|
|
| SP1: | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NSUN7
8 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000478857 ENST00000381782(uc003gvj.3 uc003gvi.3) ENST00000463952
ENST00000423784 ENST00000333934 ENST00000316607 ENST00000473399(uc003gvh.2)
ENST00000469033
|
Expression
for NSUN7 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NSUN7 expression in normal and diseased human tissues
1 / 2 / 3 6 probe-sets matching NSUN7 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 54335_at2, 3
|
U95-C |
1 |
0.88 |
1.00 |
0.84 |
0.71 |
T84489 |
0.80 |
1.00 |
0.91 |
1 |
| 46431_at2, 3
|
U95-B |
1 |
0.56 |
1.00 |
0.85 |
1.37 |
N52898 |
1.00 |
1.00 |
1.00 |
1 |
| 238983_at2, 3
|
U133-B |
1 |
0.64 |
1.00 |
-- |
-- |
AI538394 |
0.80 |
1.00 |
0.91 |
1 |
| 220194_at2, 3
|
U133-A |
1 |
0.46 |
1.00 |
-- |
-- |
NM_024677 |
0.60 |
1.00 |
0.82 |
1 |
| 238983_at2
|
U133Plus2 |
1 |
0.64 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 220194_at2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NSUN7 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GCAACAGAAA
SOURCE GeneReport for Unigene cluster: Hs.570821
SABiosciences Custom PCR Arrays for NSUN7
|
Orthologs
for NSUN7 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NSUN7 gene from 5/7 species (see all 7)
About this table Species with no ortholog for NSUN7
ENSEMBL Gene Tree for NSUN7 (if available) |
Paralogs
for NSUN7 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NSUN7 gene
- NSUN52
NSUN7 for paralogs About GeneDecksing
|
Genomic Variants
for NSUN7 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 4 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NSUN7 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for NSUN7
1 CNV: 31169 | | QIAGEN SeqTarget long-range PCR primers for resequencing NSUN7 |
|
Disorders & Mutations
for NSUN7 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for NSUN7 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NSUN7 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
6 PubMed articles for NSUN7 gene integrated from 7 sources:
(articles sorted by number of sources associating them with NSUN7)- Sperm motility defects and infertility in male mice with a mutation in Nsun7, a member of the Sun domain-containing family of putative RNA methyltransferases. (PubMed id 17442852)1, 3 Harris T....Schimenti J. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
|
External Searches for NSUN7 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NSUN7 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NSUN7 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NSUN7 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NSUN7 gene:
Search GeneIP for patents involving NSUN7
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NSUN7 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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