Aliases &
Descriptions
for NT5C1B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| 5'-nucleotidase, cytosolic IB1 2 | | CN1B2 | | AIRP1 2 3 | | cytosolic 5'-nucleotidase 1B2 | | CN-IB1 2 | | cN-IB3 | | Autoimmune infertility-related protein2 3 | | cN1B3 | | OTTHUMP000002203602 | | EC 3.1.3.53 | | MGC266402 | | Cytosolic 5'-nucleotidase IB3 | | OTTHUMP000002004972 | | |
Export aliases for NT5C1B gene to outside databasesPrevious GC identifers: GC02M018630 GC02M018711 GC02M018728 GC02M018657 GC02M018665 GC02M018599 |
Summaries
for NT5C1B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NT5C1B:
Cytosolic 5-prime nucleotidases, such as NT5C1B, catalyze production of adenosine, which regulates diverse physiologicprocesses (Sala-Newby and Newby, 2001 (PubMed 11690631)).(supplied by OMIM)
UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (Bysimilarity)
|
Genomic Views
for NT5C1B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NT5C1B gene promoter:
STAT5A CUTL1 deltaCREB FOXJ2 (long isoform) CREB FOXD3 TBP TFIID FOXC1 GCNF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NT5C1B
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NT5C1B  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p24.2 Ensembl cytogenetic band: 2p24.2 HGNC cytogenetic band: 2p24.2NT5C1B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M018607: view genomic region
(about GC identifiers)
Start:
|
18,519,305 bp from pter |
End:
|
18,546,004 bp from pter |
Size:
|
26,700 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr2- 18,736,811-18,770,838 |
RefSeq DNA sequence:- NC_000002.11 NT_015926.15
|
Proteins
for NT5C1B gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26 (See
protein sequence)Recommended Name: Cytosolic 5'-nucleotidase 1B Size: 610 amino acids; 68804 Da
Cofactor: Magnesium (By similarity)
Subcellular location: Cytoplasm (By similarity)
Sequence caution: Sequence=AAK39108.1; Type=Erroneous initiation; Sequence=AAK83285.1; Type=Frameshift; Positions=320;Sequence=BAC04103.1; Type=Erroneous initiation; Sequence=CAC44363.1; Type=Erroneous initiation;
Secondary accessions: B5MCR0 B7ZVX7 Q53RX2 Q8N9W3 Q8NA26 Q96DU5 Q96KE6 Q96M25 Q96SA3Alternative splicing: 4 isoforms: Q96P26-1 Q96P26-2 Q96P26-3 Q96P26-4 Explore the universe of human proteins at neXtProt for NT5C1B: NX_Q96P26
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (5 alternative transcripts):
NP_001002006.1 NP_001186015.1 NP_001186016.1 NP_001186017.1 NP_150278.2
ENSEMBL proteins: ENSP00000384831 ENSP00000390811 ENSP00000383905 ENSP00000305979 ENSP00000401656 ENSP00000400724 ENSP00000389750 ENSP00000352904
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
NT5C1B for ontologies About GeneDecksing
Antibodies for NT5C1B:
Assays for NT5C1B: |
Protein
Domains/
Families
for NT5C1B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NT5C1B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96P26ProtoNet protein and cluster: Q96P26 1 Blocks protein family: IPB010394 5-nucleotidase
UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26Similarity: Belongs to the 5'-nucleotidase type 3 family |
Gene Function
for NT5C1B gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26Function: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (Bysimilarity)Catalytic activity: A 5'-ribonucleotide + H(2)O = a ribonucleoside + phosphateEnzyme regulation: Activated by ADP (By similarity)Enzyme Number (IUBMB): EC 3.1.3.5
4 Gene Ontology (GO) molecular function terms (GO ID links to tree view): About this table
NT5C1B for ontologies About GeneDecksing
|
Pathways & Interactions
for NT5C1B gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
NT5C1B for pathways About GeneDecksing
2  Millipore Pathways for NT5C1B
3  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for NT5C1B
4  Kegg Pathways (Kegg details for NT5C1B):
SABiosciences Custom Pathway-Focused PCR Arrays for NT5C1B
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for NT5C1B
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NT5C1B
5/73 Interacting proteins for NT5C1B (ENSP000003529043) via UniProtKB, MINT, and/or STRING (see all 73)About this table
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0006144 | purine base metabolic process |
TAS | -- | | GO:0006195 | purine nucleotide catabolic process |
TAS | -- | | GO:0009117 | nucleotide metabolic process |
IEA | -- | | GO:0055086 | nucleobase, nucleoside and nucleotide metabolic process |
TAS | -- |
About this table
NT5C1B for ontologies About GeneDecksing
|
Drugs & Compounds
for NT5C1B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NT5C1B
|
Transcripts
for NT5C1B gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NT5C1B gene (5 alternative transcripts): NM_001002006.2 NM_001199086.1 NM_001199087.1 NM_001199088.1 NM_033253.3 Additional cDNA sequence: AF352326.1 AF356185.1 AF417165.1 AJ295254.1 AK093234.1 AK093464.1 AK097422.1 AK302084.1 AK302200.1 AK302795.1 AK307653.1 BC026076.2 BC136387.1 BC141842.1 BC171761.1 6 DOTS entries: DT.100020580 DT.100746307 DT.100020581 DT.120965561 DT.99930159 DT.99939458 24/136 AceView cDNA sequences (see all 136): AA774597 AI623153 AI910921 AL579184 AI261840 CR597110 AK057444 AK093234 BU838555 BC009830 AI954386 AI570292 CR619475 NM_001002006 AA864535 CR612704 AI041525 AF352326 BU076588 CR598421 N76631 CR598793 AA886674 AI952491
 highest scoring ESTs for NT5C1B:AA774429 AF356185 AF417165 AK093464 AK097422 BC026076 DB020679 DB021790 DB023088 DB023308 Unigene Cluster for NT5C1B: 5'-nucleotidase, cytosolic IB Hs.120319 [show with all ESTs]Unigene Representative Sequence: NM_001002006
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NT5C1B (see all 7)
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | - | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NT5C1B
10 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000403770(uc002rcy.2) ENST00000418427 ENST00000406971 ENST00000460052
ENST00000304081 ENST00000416783 ENST00000418007(uc010yju.1 uc002rda.2 uc010yjw.1)
ENST00000455492(uc002rcz.2 uc010yjv.1 uc010exs.2) ENST00000359846
ENST00000490687(uc002rdb.1)
|
Expression
for NT5C1B gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NT5C1B expression in normal and diseased human tissues
1 / 2 / 3 4 probe-sets matching NT5C1B gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 81455_at2, 3
|
U95-E |
1 |
1.00 |
1.00 |
1.00 |
1.00 |
AA774429 |
0.80 |
0.88 |
0.84 |
1 |
| 243100_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AA974253 |
0.60 |
0.83 |
0.73 |
1 |
| 243100_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1554368_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NT5C1B for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.120319
UniProtKB/Swiss-Prot: 5NT1B_HUMAN, Q96P26Tissue specificity: Highly expressed in testis, placenta and pancreas. Detected at lower levels in heart, kidney, liverand lung
SABiosciences Custom PCR Arrays for NT5C1B
|
Orthologs
for NT5C1B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NT5C1B gene from 2 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
mouse
(Mus musculus) |
Nt5c1b5 |
12 (5.27 cM) |
5'-nucleotidase, cytosolic IB |
-- |
BC060976 |
sea squirt
(Ciona intestinalis) |
Cin.123542 |
-- |
Ciona intestinalis cDNA, clonecieg023o01, full insert sequence. less |
71.88(n) |
AK114945.1 |
About this table Species with no ortholog for NT5C1B
ENSEMBL Gene Tree for NT5C1B (if available) |
Paralogs
for NT5C1B gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for NT5C1B gene
- ENSG000002507412 NT5C1A2
NT5C1B for paralogs About GeneDecksing
|
Genomic Variants
for NT5C1B gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NT5C1B (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for NT5C1B
2 CNVs: 89518 8365
1 Indel: 45914 | | QIAGEN SeqTarget long-range PCR primers for resequencing NT5C1B |
|
Disorders & Mutations
for NT5C1B gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NT5C1B for disorders About GeneDecksing
OMIM: 610526
Human Genome Epidemiology (HuGE) Navigator: NT5C1B (1 document)
Export disorders and mutations for NT5C1B gene to outside databases
|
Medical News
for NT5C1B gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NT5C1B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
9 PubMed articles for NT5C1B gene integrated from 7 sources:
(articles sorted by number of sources associating them with NT5C1B)- Cloning of a mouse cytosolic 5'-nucleotidase-I identifies a new gene related to human autoimmune infertility-related protein. (PubMed id 11690631)1, 2, 3 Sala-Newby G.B. and Newby A.C. (2001)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Common genetic variation and performance on standardi zed cognitive tests. (PubMed id 20125193)1 Cirulli E.T....Goldstein D.B. (2010)
- Contribution of adenosine related genes to the risk o f depression with disturbed sleep. (PubMed id 20392501)1 Gass N....Paunio T. (2010)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for NT5C1B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NT5C1B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NT5C1B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NT5C1B gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NT5C1B gene:
Search GeneIP for patents involving NT5C1B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NT5C1B gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| |  | Search Tocris compounds for NT5C1B |
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