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NTF3 Gene

protein-coding GIFtS: 64

GC12P005473

neurotrophin 3
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
neurotrophin 3¹ ²		NGF-2² ³
NGF2¹ ²		NT-3² ³
Nerve growth factor 2² ³		NT3²
Neurotrophic factor² ³		neurotrophin-3²
HDNF² ³		MGC129711²

External Ids:	HGNC: 8023¹	Entrez Gene: 4908²	Ensembl: ENSG00000185652⁷	UniProtKB: P20783³

Export aliases for NTF3 gene to outside databases

Previous GC identifers: GC12U990064 GC12P005487 GC12P005420

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NTF3:

The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of

mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor.

It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo

when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement

defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig,

rat and mouse. (provided by RefSeq)

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Function: Seems to promotes the survival of visceral and proprioceptive sensory neurons

Gene Wiki entry for NTF3 (Neurotrophin-3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NTF3 gene promoter:
         AP-1   CREB   deltaCREB   c-Fos   c-Jun   SRF   FOXJ2 (long isoform)   FOXC1   RORalpha1   SRY
         Other transcription factors

Search SABiosciences Chromatin IP Primers for NTF3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for NTF3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12p13 Ensembl cytogenetic band: 12p13.31 HGNC cytogenetic band: 12p13

NTF3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NTF3 gene location

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P005473: view genomic region (about GC identifiers)

Start:	5,455,606 bp from pter
End:	5,458,036 bp from pter
Size:	2,431 bases
Orientation:	plus strand

1 alternative location:

Chr12+ 5,541,280-5,604,464

RefSeq DNA sequence:

NC_000012.11 NT_009759.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783 (See protein sequence)

Recommended Name: Neurotrophin-3 precursor

Size: 257 amino acids; 29355 Da

Subcellular location: Secreted

PDB structures from and Proteopedia :

1B8K (3D)

1BND (3D)

1NT3 (3D)

3BUK (3D)

Secondary accessions: Q6FH50

Explore the universe of human proteins at neXtProt for NTF3: NX_P20783

REFSEQ proteins (2 alternative transcripts):

NP_001096124.1 NP_002518.1

ENSEMBL proteins:

ENSP00000397297 ENSP00000328738

Human Recombinant Proteins

	Millipore Purified and/or Recombinant NTF3 Protein
	Sigma-Aldrich Proteins for NTF3
	R&D Systems Recombinant & Natural Proteins for NTF3 (NT-3)
	Enzo Life Sciences proteins for NTF3
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate (see all 2): NTF3
	GenScript Custom Purified and Recombinant Proteins Services for NTF3
	Novus Biologicals Proteins for NTF3
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for NTF3

3 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0016023	cytoplasmic membrane-bounded vesicle	IEA	--

About this table

NTF3 for ontologies About GeneDecksing

Antibodies for NTF3:

	Millipore Mono- and Polyclonal Antibodies for the study of NTF3
	Sigma-Aldrich Antibodies for NTF3
	R&D Systems Antibodies for NTF3 (NT-3)
	Cell Signaling Technology (CST) Antibodies for NTF3 (Neurotrophin-3)
	OriGene Antibodies (see all 4): NTF3
	GenScript Custom Superior Antibodies Services for NTF3
	Novus Biologicals Antibodies for NTF3
	Browse antibodies at Epitomics

Assays for NTF3:

	Millipore Kits and Assays for the Analysis of NTF3
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	R&D Systems ELISAs for NTF3 (NT-3)
	GenScript Custom Assay Services for NTF3
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NTF3 for domains About GeneDecksing

4 InterPro domains/families:

IPR002072 Nerve_growth_factor-rel

IPR019846 Nerve_growth_factor_CS

IPR020408 Nerve_growth_factor-like

IPR015578 Neurotrophin-3

Graphical View of Domain Structure for InterPro Entry P20783

ProtoNet protein and cluster: P20783

2 Blocks protein families:

IPB002072 Nerve growth factor

IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Similarity: Belongs to the NGF-beta family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Function: Seems to promotes the survival of visceral and proprioceptive sensory neurons

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NTF3 Sigma-Aldrich shRNA for NTF3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): NTF3 OriGene shRNA RFP (see all 2): NTF3 OriGene basic RS shRNA (see all 2): NTF3 OriGene siRNA (see all 2): NTF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NTF3

miRNA:		Sigma-Aldrich microRNA Mimics for NTF3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NTF3
		8/17 SABiosciences Assays for microRNAs that regulate NTF3 (see all 17):
		hsa-miR-548j hsa-miR-448 hsa-miR-429 hsa-miR-548i hsa-miR-374a hsa-miR-221 hsa-miR-1183 hsa-miR-548a-5p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NTF3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NTF3 OriGene untagged cDNA clones in CMV expression vector (see all 2): NTF3 Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for NTF3
		Sino Biological Human cDNA Clone for NTF3

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for NTF3

Genatlas biochemistry entry for NTF3:

neurotrophic factor (neurotrophin) 3,29.3kDa,ligand for NTRK3 (TRKC),expressed in retina and the anterior segment of

the developing eye

5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005102	receptor binding	TAS	2236018
GO:0005165	neurotrophin receptor binding	IEA	--
GO:0005515	protein binding	IPI	7703225
GO:0008083	growth factor activity	IEA	--
GO:0048406	nerve growth factor binding	IEA	--

About this table

NTF3 for ontologies About GeneDecksing

Animal Models: 13 MGI mutant phenotypes (inferred from 8 alleles) (MGI details for Ntf3):

behavior/neurological	cardiovascular system	growth/size	homeostasis/metabolism	lethality-postnatal
lethality-prenatal/perinatal	life span-post-weaning/aging	muscle	nervous system	normal
reproductive system	respiratory system	vision/eye

NTF3 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

NTF3 for pathways About GeneDecksing

2 Millipore Pathways for NTF3

	Development Neurotrophin family signaling
	Development MAG-dependent inhibition of neurite outgrowth

4 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for NTF3

	Thyroid Cancer Signaling
	Human Embryonic Stem Cell Pluripotency
	Neurotrophin/TRK Signaling
	Axonal Guidance Signaling

2 Kegg Pathways (Kegg details for NTF3):

	hsa04010 MAPK signaling pathway
	hsa04722 Neurotrophin signaling pathway

SABiosciences Pathway-Focused PCR Arrays including NTF3 (see all 3): PAHS-031A PAHS-041A

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for NTF3

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for NTF3

5/12 Interacting proteins for NTF3 (ENSP00000328738³ P20783^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 12)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BDNF	P23560¹^,²	STRING: ENSP00000320002 EBI-1025994,EBI-1026003 MINT-24751
NTRK3	ENSP00000354207³	STRING: ENSP00000354207
CREB1	ENSP00000236996³	STRING: ENSP00000236996
HRAS	ENSP00000373382³	STRING: ENSP00000373382
MCF2L	ENSP00000364758³	STRING: ENSP00000364758

About this table

5/20 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 20):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	2236018
GO:0007267	cell-cell signaling	TAS	2236018
GO:0007274	neuromuscular synaptic transmission	IEA	--
GO:0007399	nervous system development	TAS	1542658
GO:0007403	glial cell fate determination	IEA	--

About this table

NTF3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

NTF3 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NTF3
10/74 Novoseek chemical compound relationships for NTF3 gene (see all 74)

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
k252a	77.7	14	9065506 (2), 9689129 (2), 10595705 (2), 19783665 (1) (see all 6)
tyrosine	69.8	126	8106527 (4), 1649702 (3), 1645620 (2), 15770067 (2) (see all 76)
ly294002	29.7	4	15797869 (1), 8756297 (1), 11238738 (1)
choline	27.4	7	9476208 (1), 7867750 (1), 11988020 (1), 11779407 (1) (see all 5)
retinoic acid	24.9	33	10051769 (5), 11520943 (4), 19428697 (3), 15869429 (1) (see all 9)
glutamate	20.5	10	11117506 (2), 12666655 (2), 9707630 (1), 10391433 (1) (see all 7)
anisomycin	20.1	1	19158291 (1)
quinolinic acid	13.3	3	10964490 (2), 8692996 (1)
2 chloroadenosine	12.5	1	7545019 (1)
bromodeoxyuridine	10.5	1	19796180 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NTF3 Sigma-Aldrich shRNA for NTF3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): NTF3 OriGene shRNA RFP (see all 2): NTF3 OriGene basic RS shRNA (see all 2): NTF3 OriGene siRNA (see all 2): NTF3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NTF3

miRNA:		Sigma-Aldrich microRNA Mimics for NTF3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NTF3
		8/17 SABiosciences Assays for microRNAs that regulate NTF3 (see all 17):
		hsa-miR-548j hsa-miR-448 hsa-miR-429 hsa-miR-548i hsa-miR-374a hsa-miR-221 hsa-miR-1183 hsa-miR-548a-5p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NTF3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NTF3 OriGene untagged cDNA clones in CMV expression vector (see all 2): NTF3 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for NTF3

Primers:		OriGene genome-wide validated SYBR primer pairs: NTF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NTF3: PPH00687A

REFSEQ mRNAs for NTF3 gene (2 alternative transcripts):

NM_001102654.1 NM_002527.4

Additional cDNA sequence:

AK293895.1 BC069773.1 BC107075.1 CR541906.1 X53655.1

3 DOTS entries:

DT.308620 DT.102821597 DT.99982565

5 AceView cDNA sequences:

AL552418 X53655 BU939830 AL575726 BX386364

highest scoring ESTs for NTF3:

AA448311 AW190653 BC069773 BE938782 BF446664 BF732411 BF857345 BX386363 X53655 AL575726

Unigene Cluster for NTF3:

Neurotrophin 3

Hs.99171 [show with all ESTs]

Unigene Representative Sequence: NM_001102654

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000423158(uc001qnk.3 uc001qnl.3) ENST00000331010

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NTF3 expression in normal and diseased human tissues

¹ / ² / ³

3 probe-sets matching NTF3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
35041_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X53655	0.80	1.00	0.91	1
206706_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002527	0.60	1.00	0.82	1
206706_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

About this table

NTF3 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

NTF3 gene electronic northern expression

About these images

CGAP SAGE TAG: ACTGTTGTTT

SOURCE GeneReport for Unigene cluster: Hs.99171

Expression variation in blood from EXPOLDB for NTF3

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Tissue specificity: Brain and peripheral tissues

Primers:		OriGene genome-wide validated SYBR primer pairs: NTF3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NTF3: PPH00687A

SABiosciences Expression via Pathway-Focused PCR Arrays including NTF3 (see all 3): PAHS-031A PAHS-041A

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NTF3 gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NTF3¹	--	neurotrophin 3	91.83(n) 96.11(a)	486731 XM_543858.2 XP_543858.2
chimpanzee (Pan troglodytes)	NTF3¹	--	neurotrophin 3	98.7(n) 98.83(a)	466931 XM_522331.2 XP_522331.2
cow (Bos taurus)	NTF3¹	--	neurotrophin 3	89.1(n) 95.11(a)	532393 XM_001255023.1 XP_001255024.1
rat (Rattus norvegicus)	Ntf3¹	--	neurotrophin 3	90.14(n) 95.72(a)	81737 NM_031073.2 NP_112335.2
mouse (Mus musculus)	Ntf3^{1 , 5}	6 (60.45 cM)⁵	neurotrophin 3^{1, 5}	89.62(n)¹ 96.11(a)¹	18205¹ NM_008742.2¹ NP_032768.1¹ AA198264⁵ AI316846⁵ (see all 11)

About this table Species with no ortholog for NTF3

ENSEMBL Gene Tree for NTF3 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NTF3 gene

NTF6B² NTF4² BDNF² NGF²

NTF3 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

UniProtKB/Swiss-Prot: NTF3_HUMAN, P20783

Polymorphism: Variant Glu-76 (frequently reported as Glu-63) was thought to be associated with severe forms of

schizophrenia. This does not seem to be the case

SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs6332^1,2	C,F,A,H,	5603632(+)	`CAGCCG/AGTGAT`	2	/P	syn¹ ref¹ ese³		23		MN EA NA NS WA	1558
rs918177^1,2	C,F,A,H,	5553061(-)	`TCTCTC/TGCCTC`	1	--	int¹		7		NA WA	134
rs1549035^1,2	C,F,H,	5560898(-)	`gtctaG/Caagac`	1	--	int¹		16		NS EA NA WA	910
rs1549036^1,2	C,F,H,	5559380(-)	`CAAACT/CGTGTT`	1	--	int¹		13		MN NS EA NA WA	666
rs1800598^1,2	--	5539746(+)	`CCCCCA/GGACTC`	1	--	ng5¹		0	--	--	--	--
rs1800599^1,2	C,F,	5540045(+)	`AAGGGA/CTGAGG`	1	--	ng5¹		2		WA	52
rs1805149^1,2	C,F,A,	5603607(+)	`GGGAGG/AGCCCG`	2	/E /G	mis¹ ref¹ ese³		10		NS EA NA WA	956
rs1805150^1,2	C,	5603989(+)	`AAAAAC/TGGTTG`	2	N	ref¹ syn¹		1		EA	88
rs1861836^1,2	C,F,A,H,	5570255(-)	`TAGTTC/TTCCCT`	1	--	int¹		8		NS EA NA WA	624
rs1978390^1,2	C,F,H,	5559894(-)	`gtttcA/Cgttgc`	1	--	int¹		11		NS EA NA WA	432

About this table

HapMap Linkage Disequilibrium images for NTF3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NTF3
2 CNVs: 86156 75911
2 Indels: 101411 86157

QIAGEN SeqTarget long-range PCR primers for resequencing NTF3

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NTF3 for disorders About GeneDecksing

OMIM: 162660

10/64 Novoseek disease relationships for NTF3 gene (see all 64)

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
sensory neuropathy	50.1	1	8599726 (1)
diabetic neuropathies	49.9	17	9728960 (5), 12677448 (1), 12805110 (1), 8580713 (1) (see all 8)
neurodegenerative diseases	43.7	6	10961440 (1), 9639663 (1), 8819011 (1), 9836577 (1)
neuroaxonal dystrophies	38.3	2	10973596 (1), 11245210 (1)
diabetic polyneuropathy	37.1	2	9728960 (1)
neurodegeneration	36.2	5	10867782 (1), 8780007 (1), 10023126 (1), 10527802 (1)
medulloblastoma	29.2	6	9560008 (3), 11379821 (1), 15994942 (1)
neurological disorders	28.6	3	12753507 (1), 10391433 (1), 7838303 (1)
motor neuron disease	28.4	2	9212104 (1), 8752586 (1)
alzheimers disease	26.2	15	11156744 (2), 9116211 (2), 10867782 (1), 7955419 (1) (see all 8)

About this table

Human Gene Mutation Database (HGMD): NTF3
Genetic Association Database (GAD): NTF3
Human Genome Epidemiology (HuGE) Navigator: NTF3 (13 documents)

Export disorders and mutations for NTF3 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/680 PubMed articles for NTF3 gene, integrated from 7 sources (see all 680):
(articles sorted by number of sources associating them with NTF3)

Human and rat brain-derived neurotrophic factor and neurotrophin-3: gene structures, distributions, and chromosomal localizations. (PubMed id 1889806)^{1, 2, 3, 7} Maisonpierre P.C....Yancopoulos G.D. (1991)
Association of neurotrophin-3 gene variant with severe forms of schizophrenia. (PubMed id 7733919)^{1, 2, 4, 7} Hattori M. and Nanko S. (1995)
Structure of the brain-derived neurotrophic factor/neurotrophin 3 heterodimer. (PubMed id 7703225)^{1, 2, 7} Robinson R.C.... Jones E.Y. (1995)
Analysis of enhancer activity of a dinucleotide repeat polymorphism in the neurotrophin-3 gene and its association with bipolar disorder. (PubMed id 15365216)^{1, 4, 7} Tadokoro K....Kunugi H. (2004)
Cloning and expression of a cDNA encoding a novel human neurotrophic factor. (PubMed id 2365067)^{1, 2, 7} Kaisho Y.... Nakahama K. (1990)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Novel polymorphisms in the promoter region of the neurotrophin-3 gene and their associations with schizophrenia. (PubMed id 11920853)^{1, 4} Hattori M....Nanko S. (2002)
Failure to find associations of the CA repeat polymorphism in the first intron and the Gly-63/Glu-63 polymorphism of the neurotrophin-3 gene with schizophrenia. (PubMed id 8925252)^{1, 2} Arinami T.... Toru M. (1996)
Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. (PubMed id 2025430)^{1, 2} Hallboeoek F.... Persson H. (1991)
Primary structure and biological activity of a novel human neurotrophic factor. (PubMed id 2344409)^{1, 2} Rosenthal A.... Winslow J.W. (1990)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 4908	HGNC: 8023	AceView: NTF3	Ensembl:ENSG00000185652	euGenes: HUgn4908
ECgene: NTF3	Kegg: 4908	H-InvDB: NTF3

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Intellectual Property for NTF3 gene
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Patent Information for NTF3 gene:
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Antibodies & Assays for NTF3 (Neurotrophin-3)

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