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NUDT12 Gene

protein-coding GIFtS: 55

GC05M098066

nudix (nucleoside diphosphate linked moiety X)-type motif 12
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
nudix (nucleoside diphosphate linked moiety X)-type motif 12¹ ²		OTTHUMP00000222655²
Nudix motif 12² ³		peroxisomal NADH pyrophosphatase NUDT12²
Nucleoside diphosphate-linked moiety X motif 12² ³		nucleoside diphosphate linked moiety X-type motif 12²
DKFZP761I172¹		EC 3.6.1.22³
DKFZp761I172²

External Ids:	HGNC: 18826¹	Entrez Gene: 83594²	Ensembl: ENSG00000112874⁷	UniProtKB: Q9BQG2³

Export aliases for NUDT12 gene to outside databases

Previous GC identifers: GC05M102544 GC05M103315 GC05M102915 GC05M102960 GC05M102912

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for NUDT12:

Nucleotides are involved in numerous biochemical reactions and pathways within the cell as substrates, cofactors, and

effectors. Nudix hydrolases, such as NUDT12, regulate the concentrations of individual nucleotides and of nucleotide

ratios in response to changing circumstances (Abdelraheim et al., 2003 (PubMed 12790796)).(supplied by OMIM)

UniProtKB/Swiss-Prot: NUD12_HUMAN, Q9BQG2

Function: Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards

NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide

nucleotide cofactors required for oxidative metabolism in this organelle

Gene Wiki entry for NUDT12

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the NUDT12 gene promoter:
         LCR-F1   PPAR-gamma1   PPAR-gamma2   Elk-1   TBP   TFIID   SRF   FOXO3b   FOXO3a   HNF-4alpha2
         Other transcription factors

Search SABiosciences Chromatin IP Primers for NUDT12

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q21.2 Ensembl cytogenetic band: 5q21.2 HGNC cytogenetic band: 5q15

NUDT12 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
NUDT12 gene location

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M098066: view genomic region (about GC identifiers)

Start:	98,066,154 bp from pter
End:	98,080,094 bp from pter
Size:	13,941 bases
Orientation:	minus strand

1 alternative location:

Chr5- 102,884,556-102,898,494

RefSeq DNA sequence:

NC_000005.9 NT_034772.6

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: NUD12_HUMAN, Q9BQG2 (See protein sequence)

Recommended Name: Peroxisomal NADH pyrophosphatase NUDT12

Size: 462 amino acids; 52076 Da

Cofactor: Magnesium or manganese (By similarity)

Subcellular location: Peroxisome

Secondary accessions: B3KUW2 Q8TAL7

Explore the universe of human proteins at neXtProt for NUDT12: NX_Q9BQG2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_113626.1

ENSEMBL proteins:

ENSP00000230792 ENSP00000424521

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: NUDT12 OriGene Protein Over-expression Lysate: NUDT12
	GenScript Custom Purified and Recombinant Proteins Services for NUDT12
	Novus Biologicals Protein for NUDT12
	Novus Biologicals Lysates for NUDT12
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	11256614
GO:0005777	peroxisome	IEA	--

About this table

NUDT12 for ontologies About GeneDecksing

Antibodies for NUDT12:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for NUDT12
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	Novus Biologicals Antibodies for NUDT12
	Browse antibodies at Epitomics

Assays for NUDT12:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for NUDT12
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for NUDT12

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

NUDT12 for domains About GeneDecksing

5/7 InterPro domains/families (see all 7):

IPR015797 NUDIX_hydrolase_dom-like

IPR002110 Ankyrin_rpt

IPR015376 Znr_NADH_PPase

IPR020084 NUDIX_hydrolase_CS

IPR020683 Ankyrin_rpt-contain_dom

Graphical View of Domain Structure for InterPro Entry Q9BQG2

ProtoNet protein and cluster: Q9BQG2

2 Blocks protein families:

IPB000086 NUDIX hydrolase

IPB002110 Ankyrin repeat signature

UniProtKB/Swiss-Prot: NUD12_HUMAN, Q9BQG2

Similarity: Belongs to the Nudix hydrolase family. NudC subfamily

Similarity: Contains 3 ANK repeats

Similarity: Contains 1 nudix hydrolase domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: NUD12_HUMAN, Q9BQG2

Function: Hydrolyzes NAD(P)H to NMNH and AMP (2',5'-ADP), and diadenosine diphosphate to AMP. Has also activity towards

NAD(P)(+), ADP-ribose and diadenosine triphosphate. May act to regulate the concentration of peroxisomal nicotinamide

nucleotide cofactors required for oxidative metabolism in this organelle

Catalytic activity: NAD(+) + H(2)O = AMP + NMN

Biophysicochemical properties: Kinetic parameters: KM=11 uM for NADH; KM=16 uM for NADPH; KM=190 uM for NAD; pH

dependence: Optimum pH is 8-9;

Enzyme Number (IUBMB): EC 3.6.1.22

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NUDT12 Sigma-Aldrich shRNA for NUDT12
		OriGene 29mer shRNA kits in GFP-retroviral vector: NUDT12 OriGene shRNA RFP: NUDT12 OriGene basic RS shRNA: NUDT12 OriGene siRNA: NUDT12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NUDT12

miRNA:		Sigma-Aldrich microRNA Mimics for NUDT12 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NUDT12
		5 SABiosciences Assays for microRNAs that regulate NUDT12:
		hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-664 hsa-miR-181b

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: NUDT12 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NUDT12 OriGene untagged cDNA clones in CMV expression vector (see all 2): NUDT12 OriGene 3'-UTR clone: NUDT12 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: NUDT12
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for NUDT12

4 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000210	NAD+ diphosphatase activity	IEA	--
GO:0005515	protein binding	IEA	--
GO:0016787	hydrolase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

NUDT12 for ontologies About GeneDecksing

Animal Models: 1 MGI phenotypic allele for Nudt12 (no phenotypes)

NUDT12 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

NUDT12 for pathways About GeneDecksing

1 Millipore Pathway for NUDT12

NAD metabolism

2 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathways for NUDT12

	Biosynthesis of Steroids
	Nicotinate and Nicotinamide Metabolism

2 Kegg Pathways (Kegg details for NUDT12):

	hsa00760 Nicotinate and nicotinamide metabolism
	hsa04146 Peroxisome

SABiosciences Custom Pathway-Focused PCR Arrays for NUDT12

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for NUDT12

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for NUDT12

5/18 Interacting proteins for NUDT12 (ENSP00000230792³) via UniProtKB, MINT, and/or STRING (see all 18)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NT5E	ENSP00000257770³	STRING: ENSP00000257770
BST1	ENSP00000371783³	STRING: ENSP00000371783
C9orf95	ENSP00000366007³	STRING: ENSP00000366007
CD38	ENSP00000226279³	STRING: ENSP00000226279
NADK	ENSP00000367890³	STRING: ENSP00000367890

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for NUDT12

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for NUDT12 Sigma-Aldrich shRNA for NUDT12
		OriGene 29mer shRNA kits in GFP-retroviral vector: NUDT12 OriGene shRNA RFP: NUDT12 OriGene basic RS shRNA: NUDT12 OriGene siRNA: NUDT12
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NUDT12

miRNA:		Sigma-Aldrich microRNA Mimics for NUDT12 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NUDT12
		5 SABiosciences Assays for microRNAs that regulate NUDT12:
		hsa-miR-181c hsa-miR-181a hsa-miR-181d hsa-miR-664 hsa-miR-181b

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: NUDT12 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: NUDT12 OriGene untagged cDNA clones in CMV expression vector (see all 2): NUDT12 OriGene 3'-UTR Clone: NUDT12 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: NUDT12

Primers:		OriGene genome-wide validated SYBR primer pairs: NUDT12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NUDT12: PPH20313A

REFSEQ mRNAs for NUDT12 gene:

NM_031438.2

Additional cDNA sequence:

AK098066.1 AK304010.1 AK309942.1 AL136592.1 BC026748.1 BC041099.1

4 DOTS entries:

DT.70104078 DT.423151 DT.91837033 DT.95303722

24/61 AceView cDNA sequences (see all 61):

CA411882 CB131118 NM_031438 BC026748 BX281841 AI207545 BF033178 BG400646

BU930336 AI765426 CA446689 CA394947 BF513640 BC041099 AA329654 BM856229

BE327894 BQ428185 BI850602 BG545936 AW361036 AI635320 BM979756 AI520819

highest scoring ESTs for NUDT12:

AI635320 AK098066 AL136592 BC041099 BE384043 BI602095 BM451172 BQ221135 BQ428185 BX281841

Unigene Cluster for NUDT12:

Nudix (nucleoside diphosphate linked moiety X)-type motif 12

Hs.434289 [show with all ESTs]

Unigene Representative Sequence: NM_031438

GeneLoc Exon Structure

5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUDT12 (see all 7)

ExUns:	1a	·	1b	^	2	^	3a	·	3b	·	3c	·	3d	·	3e	^	4a	·	4b	·	4c	^	5a	·	5b	^	6a	·	6b	^	7	^	8
SP1:					-								-		-														-
SP2:					-								-		-
SP3:					-						-		-		-
SP4:					-
SP5:					-

About this scheme

ECgene alternative splicing isoforms for NUDT12
4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000230792(uc003koi.2 uc011cvb.1) ENST00000515407 ENST00000507423

ENST00000508889(uc010jbq.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

NUDT12 expression in normal and diseased human tissues

¹ / ² / ³

4 probe-sets matching NUDT12 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
92016_at²^{, 3}	U95-D	1	1.00	1.00	1.00	1.00	AI635320	0.80	1.00	0.91	1
223535_at²^{, 3}	U133-B	1	0.82	1.00	--	--	AL136592	0.80	1.00	0.91	1
223535_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
1562775_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

NUDT12 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

NUDT12 gene electronic northern expression

About these images

CGAP SAGE TAG: GAAGGAGAAA

SOURCE GeneReport for Unigene cluster: Hs.434289

Primers:		OriGene genome-wide validated SYBR primer pairs: NUDT12 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for NUDT12: PPH20313A

SABiosciences Custom PCR Arrays for NUDT12

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for NUDT12 gene from 5/13 species (see all 13)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	NUDT12¹	--	nudix (nucleoside diphosphate linked moiety X)-type more	92.25(n) 91.96(a)	488881 XM_545998.2 XP_545998.2
chimpanzee (Pan troglodytes)	NUDT12¹	--	nudix (nucleoside diphosphate linked moiety X)-type more	99.4(n) 99.55(a)	461977 XM_517859.2 XP_517859.2
cow (Bos taurus)	NUDT12¹	--	nudix (nucleoside diphosphate linked moiety X)-type more	92.57(n) 93.92(a)	617720 NM_001046608.1 NP_001040073.1
rat (Rattus norvegicus)	Nudt12¹	--	nudix (nucleoside diphosphate linked moiety X)-type more	80.71(n) 81.52(a)	367323 XM_346080.3 XP_346081.3
mouse (Mus musculus)	Nudt12^{1 , 5}	17 (30.64 cM)⁵	nudix (nucleoside diphosphate linked moiety X)-type more^{1, 5}	84.13(n)¹ 87.88(a)¹	67993¹ NM_026497.2¹ NP_080773.1¹ AA796863⁵ AI323961⁵ (see all 11)

About this table Species with no ortholog for NUDT12

ENSEMBL Gene Tree for NUDT12 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for NUDT12 gene

NUDT13²

NUDT12 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs169800^1,2	C,	102884487(+)	`AACGAT/CTGAAA`	1	--	ng3¹		7	NA EA WA	218
rs294043^1,2		102888874(+)	`acttaT/Aaataa`	1	--	int¹		3	NA EA	252
rs294044^1,2	C,O,A,	102888453(+)	`GTATAC/TATTGT`	1	--	int¹		7	NA EA WA	218
rs294045^1,2	C,A,H,	102887434(+)	`TTTTAA/GAAAGT`	1	--	int¹		5	NA EA WA	214
rs294046^1,2	C,F,A,	102887111(+)	`cgcccC/TgccTC`	1	--	int¹		1	WA	50
rs294047^1,2	C,F,	102885981(+)	`TTAGAC/TGAGTG`	1	--	ut3¹ ese³		5	NS EA WA	446
rs294048^1,2	C,A,	102884700(+)	`GAGTTC/GTTATT`	1	--	ut3¹		4	NA EA WA	164
rs365321^1,2	C,	102893959(+)	`ATcaaG/Acccta`	1	--	int¹		4	NS EA WA	342
rs443022^1,2	C,F,A,H,	102891490(+)	`AAAGTA/GTGTAA`	1	--	int¹		8	NA EA WA	220
rs645188^1,2	C,F,	102892390(+)	`TAAATC/ATTAAA`	1	--	int¹		9	EA NA NS WA	620

About this table

HapMap Linkage Disequilibrium images for NUDT12 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for NUDT12: --

QIAGEN SeqTarget long-range PCR primers for resequencing NUDT12

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

NUDT12 for disorders About GeneDecksing

OMIM: 609232

Human Genome Epidemiology (HuGE) Navigator: NUDT12 (1 document)

Export disorders and mutations for NUDT12 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/11 PubMed articles for NUDT12 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with NUDT12)

Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)^{1, 2, 3} Wiemann S.... Poustka A. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein. (PubMed id 12790796)^{1, 2} Abdelraheim S.R.... McLennan A.G. (2003)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. (PubMed id 16712791)¹ Wang A.G....Kim N.S. (2006)
The LIFEdb database in 2006. (PubMed id 16381901)¹ Mehrle A....Wiemann S. (2006)
From ORFeome to biology: a functional genomics pipeline. (PubMed id 15489336)¹ Wiemann S....Poustka A. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)¹ Simpson J.C.... Wiemann S. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 83594	HGNC: 18826	AceView: NUDT12	Ensembl:ENSG00000112874	euGenes: HUgn83594
ECgene: NUDT12	Kegg: 83594	H-InvDB: NUDT12

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for NUDT12 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for NUDT12 gene:
Search GeneIP for patents involving NUDT12

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for NUDT12		Antibodies for NUDT12
	Super-pooled esiRNAs for NUDT12		Browse proteins at Sigma-Aldrich
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	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of NUDT12
	SeqTarget long-range PCR primers for resequencing NUDT12
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of NUDT12

	GenScript Custom Purified and Recombinant Proteins Services for NUDT12		GenScript cDNA clones with any tag delivered in your preferred vector for NUDT12
	GenScript Custom Assay Services for NUDT12		GenScript Custom Superior Antibodies Services for NUDT12
	GenScript Custom overexpressing Cell Line Services for NUDT12		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Search for Antibodies & Assays

	Regulatory tfbs in NUDT12 promoter
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Browse antibodies at Epitomics

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ELISAs and CLIAs for NUDT12

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

NUDT12 gene at Home site.

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NUDT12 Gene

protein-coding GIFtS: 55

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NUDT12 Gene

protein-coding GIFtS: 55

Aliases & Descriptionsfor NUDT12 gene

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for NUDT12 gene

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for NUDT12 gene

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for NUDT12 gene

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for NUDT12 gene

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for NUDT12 gene

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for NUDT12 gene

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for NUDT12 gene

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for NUDT12 gene

Expression
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