Aliases &
Descriptions
for NUP35 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| nucleoporin 35kDa1 2 | | 35 kDa nucleoporin2 3 | | MP441 2 3 | | NUP532 3 | | Nuclear pore complex protein Nup532 3 | | NP442 5 | | Nucleoporin Nup352 3 | | OTTHUMP000002053692 | | Mitotic phosphoprotein 442 3 | | nucleoporin NUP532 | | MP-442 3 | | |
Export aliases for NUP35 gene to outside databasesPrevious GC identifers: GC02P184192 GC02P183814 GC02P183697 GC02P183982 |
Summaries
for NUP35 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for NUP35:
This gene encodes a member of the nucleoporin family. The protein is localized to the nuclear rim and is part of thenuclear pore complex (NPC). All molecules entering or leaving the nucleus either diffuse through or are activelytransported by the NPC. (provided by RefSeq)
UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to asnucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners fortransiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC
Gene Wiki entry for NUP35 |
Genomic Views
for NUP35 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the NUP35 gene promoter:
C/EBPbeta Hlf CUTL1 LCR-F1 Cart-1 C/EBPalpha Arnt Chx10 Pbx1a AP-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for NUP35
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q32.1 Ensembl cytogenetic band: 2q32.1 HGNC cytogenetic band: 2q32NUP35 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P175847: view genomic region
(about GC identifiers)
Start:
|
175,847,884 bp from pter |
End:
|
175,885,184 bp from pter |
Size:
|
37,301 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr2+ 183,982,242-184,026,408 |
RefSeq DNA sequence:- NC_000002.11 NT_005403.17
|
Proteins
for NUP35 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5 (See
protein sequence)Recommended Name: Nucleoporin NUP53 Size: 326 amino acids; 34774 Da
Subunit: Interacts with TMEM48/NDC1, lamin B, NUP93, NUP155 and NUP205
Subcellular location: Nucleus, nuclear pore complex. Note=Tightly associated with the nuclear membrane and lamina
Secondary accessions: Q4ZFZ9 Q53S95 Q8TDJ1Explore the universe of human proteins at neXtProt for NUP35: NX_Q8NFH5
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_612142.2
ENSEMBL proteins: ENSP00000412554 ENSP00000295119 ENSP00000387305 ENSP00000364066 ENSP00000412311 ENSP00000403819 ENSP00000393130
Human Recombinant Proteins
5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8): About this table
NUP35 for ontologies About GeneDecksing
Antibodies for NUP35:
Assays for NUP35: |
Protein
Domains/
Families
for NUP35 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
NUP35 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8NFH5ProtoNet protein and cluster: Q8NFH5 UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5Similarity: Belongs to the Nup53 familySimilarity: Contains 1 RRM Nup35-type domain |
Gene Function
for NUP35 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: NUP53_HUMAN, Q8NFH5Function: Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to asnucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners fortransiently associated nuclear transport factors. May play a role in the association of MAD1 with the NPC
|
Pathways & Interactions
for NUP35 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
NUP35 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for NUP35):
SABiosciences Custom Pathway-Focused PCR Arrays for NUP35
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for NUP35
5/27 Interacting proteins for NUP35 (ENSP000002951193) via UniProtKB, MINT, and/or STRING (see all 27)About this table
5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8): About this table
NUP35 for ontologies About GeneDecksing
|
Drugs & Compounds
for NUP35 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for NUP35
|
Transcripts
for NUP35 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for NUP35 gene: NM_138285.3 Additional cDNA sequence: AF411516.1 AF514993.1 AK289601.1 AK290760.1 AK298199.1 AK302350.1 BC022333.1 BC035597.1 BC047029.1 BC061698.1 BC111016.1 CR615924.1 CR619859.1 CR624044.1 7 DOTS entries: DT.415692 DT.92439428 DT.92439430 DT.86858290 DT.102827351 DT.120944993 DT.95271139 24/149 AceView cDNA sequences (see all 149): CR615924 BU945472 BC035597 BC061698 BQ435302 T16472 Z43996 BG503466 F11883 BC047029 F09530 CR624044 BQ002933 BC022333 CR619859 AA805736 AA805768 BE855908 BI756639 N59330 BE552422 N77138 F03229 F13074
 highest scoring ESTs for NUP35:AA843681 AA521252 AA570560 AA805736 AA805768 AF411516 AF514993 AI024131 AI205823 AI240085 Unigene Cluster for NUP35: Nucleoporin 35kDa Hs.180591 [show with all ESTs]Unigene Representative Sequence: BC111016
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for NUP35 (see all 7)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | · | 1g | ^ | 2a | · | 2b | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | - | | | | - | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | - | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for NUP35
10 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000446612 ENST00000472844 ENST00000497330 ENST00000295119(uc010zfs.1 uc002upf.2 uc010zft.1 uc002upg.2)
ENST00000409798 ENST00000479162 ENST00000374930 ENST00000452137 ENST00000442895
ENST00000455063
|
Expression
for NUP35 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| NUP35 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching NUP35 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 48572_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AA843681 |
1.00 |
1.00 |
1.00 |
1 |
| 225470_at2, 3
|
U133-B |
1 |
1.00 |
1.00 |
-- |
-- |
AL529634 |
0.60 |
1.00 |
0.82 |
1 |
| 225470_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
NUP35 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: AAGGGGAACT
SOURCE GeneReport for Unigene cluster: Hs.180591
SABiosciences Custom PCR Arrays for NUP35
|
Orthologs
for NUP35 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for NUP35 gene from 5/11 species (see all 11)
About this table Species with no ortholog for NUP35
ENSEMBL Gene Tree for NUP35 (if available) |
Paralogs
for NUP35 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| -- |
Genomic Variants
for NUP35 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for NUP35 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 4 variations for NUP35
4 Indels: 78895 78894 63250 90168 | | QIAGEN SeqTarget long-range PCR primers for resequencing NUP35 |
|
Disorders & Mutations
for NUP35 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
NUP35 for disorders About GeneDecksing
OMIM: 608140
Human Genome Epidemiology (HuGE) Navigator: NUP35 (1 document)
Export disorders and mutations for NUP35 gene to outside databases
|
Medical News
for NUP35 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for NUP35 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/18 PubMed articles for NUP35 gene, integrated from 7 sources (see all 18):
(articles sorted by number of sources associating them with NUP35)- A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- The conserved transmembrane nucleoporin NDC1 is required for nuclear pore complex assembly in vertebrate cells. (PubMed id 16600873)1, 2 Mansfeld J.... Antonin W. (2006)
- Vertebrate Nup53 interacts with the nuclear lamina and is required for the assembly of a Nup93-containing complex. (PubMed id 15703211)1, 2 Hawryluk-Gara L.A.... Wozniak R.W. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Proteomic analysis of the mammalian nuclear pore complex. (PubMed id 12196509)1, 2 Cronshaw J.M.... Matunis M.J. (2002)
- Replication of previous genome-wide association studi es of bone mineral density in premenopausal American women. (PubMed id 20200978)1 Ichikawa S....Econs M.J. (2010)
- Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
- Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)2 Mayya V.... Han D.K. (2009)
|
External Searches for NUP35 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing NUP35 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing NUP35 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing NUP35 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for NUP35 gene:
Search GeneIP for patents involving NUP35
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for NUP35 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
 | |
 |
| | | |
 |
 |
| | |
 |  |  |  | |
| |  | Search Tocris compounds for NUP35 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for NUP35 |
| |
|
|
