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OPN1LW Gene

protein-coding   GIFtS: 49

GC0XP142061
opsin 1 (cone pigments), long-wave-sensitive
(Previous names: color blindness, protan, red cone photoreceptor pigment )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CBBM, RCP, CBP)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
opsin 1 (cone pigments), long-wave-sensitive1 2     color blindness, protan1
Red cone photoreceptor pigment1 2 3     CBP2
COD51 2     long-wave-sensitive opsin 12
Red-sensitive opsin2 3     cone dystrophy 5 (X-linked)2
ROP2 3     CBBM2
RCP2 3     

External Ids:    HGNC: 99361   Entrez Gene: 59562   Ensembl: ENSG000001020767   UniProtKB: P040003   

Export aliases for OPN1LW gene to outside databases

Previous GC identifers: GC0XP147547 GC0XP149864 GC0XP150995 GC0XP151916 GC0XP151877 GC0XP152930 GC0XP153062 GC0XP153409


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OPN1LW:
This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone
photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane
domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength
opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur
between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have
more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. (provided
by RefSeq)

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin,
covalently linked to cis-retinal

Gene Wiki entry for OPN1LW

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OPN1LW gene promoter:
         GATA-1   C/EBPalpha   SRF   FOXO4   STAT1alpha   STAT1beta   IRF-1   STAT1   Sp1   p300   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for OPN1LW

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28   Ensembl cytogenetic band:  Xq28   HGNC cytogenetic band: Xq28

OPN1LW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPN1LW gene location

GeneLoc gene densities for chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP142061:  view genomic region     (about GC identifiers)

Start:
142,061,320 bp from pter
End:
142,074,959 bp from pter
Size:
13,640 bases
Orientation:
plus strand

1 alternative location:
ChrX+ 153,409,698-153,424,507     
RefSeq DNA sequence:
NC_000023.10  NT_167198.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000 (See protein sequence)
Recommended Name: Long-wave-sensitive opsin 1  
Size: 364 amino acids; 40572 Da
Subcellular location: Membrane; Multi-pass membrane protein
PDB structures from and Proteopedia :
1KPX (3D)    

Explore the universe of human proteins at neXtProt for OPN1LW: NX_P04000 

Post-translational modifications:

  • Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region1


  • REFSEQ proteins: NP_064445.1  

    ENSEMBL proteins: 
    ENSP00000358967 ENSP00000402493 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for OPN1LW 
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886 plasma membrane TAS--
    GO:0005887 integral to plasma membrane TAS9860863
    GO:0016020 membrane ----
    GO:0016021 integral to membrane ----
    About this table

    OPN1LW for ontologies           About GeneDecksing



    Antibodies for OPN1LW: 
    Millipore Mono- and Polyclonal Antibodies for the study of OPN1LW
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    Browse antibodies at Epitomics

    Assays for OPN1LW: 
    Browse Kits and Assays available from Millipore
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    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for OPN1LW 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for OPN1LW 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    OPN1LW for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017452 GPCR_Rhodpsn_supfam
     IPR001760 Opsin
     IPR000378 Opsin_red/grn
     IPR000276 7TM_GPCR_Rhodpsn

    Graphical View of Domain Structure for InterPro Entry P04000

    ProtoNet protein and cluster: P04000

    2 Blocks protein families:
    IPB000378 Red/green-sensitive opsin signature
    IPB001760 Opsin


    UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
    Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
    Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin,
    covalently linked to cis-retinal
    Biophysicochemical properties: Absorption: Abs(max)=560 nm;

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for OPN1LW
    Sigma-Aldrich shRNA Panels and shRNA for OPN1LW
    OriGene 29mer shRNA kits in GFP-retroviral vector: OPN1LW
    OriGene shRNA RFP: OPN1LW
    OriGene basic RS shRNA: OPN1LW
    OriGene siRNA: OPN1LW
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OPN1LW 
    miRNA:Sigma-Aldrich microRNA Mimics for OPN1LW
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OPN1LW 
    Search SABiosciences for Assays for microRNAs that regulate OPN1LW

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: OPN1LW
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OPN1LW
    OriGene untagged cDNA clones in CMV expression vector: OPN1LW
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for OPN1LW 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for OPN1LW 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930 G-protein coupled receptor activity IEA--
    GO:0009881 photoreceptor activity IEA--
    About this table

    OPN1LW for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    OPN1LW for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  OPN1LW
        Phototransduction Pathway

        SABiosciences Custom Pathway-Focused PCR Arrays for OPN1LW 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for OPN1LW
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for OPN1LW

    5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007165 signal transduction TAS2937147
    GO:0007186 G-protein coupled receptor protein signaling pathway ----
    GO:0007601 visual perception IEA--
    GO:0007602 phototransduction IEA--
    GO:0018298 protein-chromophore linkage IEA--
    About this table

    OPN1LW for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    OPN1LW for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for OPN1LW
    2 Novoseek chemical compound relationships for OPN1LW gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choline 35.6 2 15895092 (2)
    calcium 0 2 2029536 (1), 11574661 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for OPN1LW
    Sigma-Aldrich shRNA Panels and shRNA for OPN1LW
    OriGene 29mer shRNA kits in GFP-retroviral vector: OPN1LW
    OriGene shRNA RFP: OPN1LW
    OriGene basic RS shRNA: OPN1LW
    OriGene siRNA: OPN1LW
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OPN1LW 
    miRNA: Sigma-Aldrich microRNA Mimics for OPN1LW
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OPN1LW 
    Search SABiosciences for Assays for microRNAs that regulate OPN1LW
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: OPN1LW
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OPN1LW
    OriGene untagged cDNA clones in CMV expression vector: OPN1LW
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for OPN1LW 
    Primers: OriGene genome-wide validated SYBR primer pairs: OPN1LW
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for OPN1LW: PPH24186A

    REFSEQ mRNAs for OPN1LW gene: 

    NM_020061.4  

    Additional cDNA sequence: CR749814.1 

    1 DOTS entry:

    DT.436489 

    24/28 AceView cDNA sequences (see all 28):

    BQ637240 NM_020061 BQ638605 BV181234 BV167401 BV167405 BV183299 BQ639996 
    AW950066 BV181233 BV181076 BV183301 BV167403 BV167402 BV183302 T27896 
    BV182704 BV182703 BQ638223 BV183303 BV183300 BV167404 BM704021 CR749814 

    highest scoring ESTs for OPN1LW:

    AW950066 BM688032 BM704021 CR749814 NM_020061 T27896 BQ637240 DN693335 BM695482 W21948 

    Unigene Cluster for OPN1LW:

    Opsin 1 (cone pigments), long-wave-sensitive
    Hs.592247  [show with all ESTs]
    Unigene Representative Sequence: CR749814


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000369951(uc004fjz.3) ENST00000463296 ENST00000442922

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    OPN1LW expression in normal and diseased human tissues

    1  / 2  / 3

    2 probe-sets matching OPN1LW gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    221327_s_at2, 3 U133-A 3 1.00 0.46 -- -- NM_000513 0.20 0.33 0.27 2
    221327_s_at2 U133Plus2 3 1.00 0.46 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    OPN1LW gene expression
    OPN1LW gene electronic northern expression
    OPN1LW gene sage expression
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.592247

    UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
    Tissue specificity: The three color pigments are found in the cone photoreceptor cells

    Primers: OriGene genome-wide validated SYBR primer pairs: OPN1LW
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for OPN1LW: PPH24186A
        SABiosciences Custom PCR Arrays for OPN1LW 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for OPN1LW gene from 5/9 species (see all 9)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    OPN1LW1   -- opsin 1 (cone pigments), long-wave-sensitive 88.55(n)
    89.29(a)
    403778  XM_538203.2  XP_538203.2 
    chimpanzee
    (Pan troglodytes)
    OPN1LW1   -- opsin 1 (cone pigments), long-wave-sensitive 98.9(n)
    98.63(a)
    741998  XM_001144896.1  XP_001144896.1 
    cow
    (Bos taurus)
    OPN1LW1   -- opsin 1 (cone pigments), long-wave-sensitive 88.1(n)
    89.29(a)
    282293  NM_174566.1  NP_776991.1 
    rat
    (Rattus norvegicus)
    Opn1mw1   -- opsin 1 (cone pigments), medium-wave-sensitive 85.99(n)
    89.08(a)
    89810  NM_053548.1  NP_446000.1 
    mouse
    (Mus musculus)
    Opn1lw5
    Opn1mw1
    X5
    opsin 1 (cone pigments), long-wave-sensitive5
    opsin 1 (cone pigments), medium-wave-sensitive (color more1
    86.65(n)1
    88.24(a)1
    145391  NM_008106.21  NP_032132.11 
     AF1213515 
    About this table        Species with no ortholog for OPN1LW

    ENSEMBL Gene Tree for OPN1LW (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for OPN1LW gene
    OPN32  OPN1MW2  OPN1SW2  RGR2  RHO2  OPN1MW22  

    OPN1LW for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/39 NCBI SNPs in OPN1LW are shown (see all 39)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr X posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs9494311,2
    C,F153418541(+) TCTGGG/TCTGCT 2 A S mis1 ref12Minor allele frequency- T:0.44MN NA 186
    rs10654221,2
    F153416362(+) GGTCTC/ATGGCT 2 /Y /S mis1 ref1 ese31Minor allele frequency- A:0.44MN 184
    rs10654391,2
    C,F,O153421912(+) CCTGGT/CTACGC 2 /G syn1 ref13Minor allele frequency- C:0.15NA 109
    rs10654401,2
    --153421916(+) GTTACC/GCCTTC 2 P A mis1 ref1 ese30--------
    rs15736561,2
    C,F,A153408884(+) GGCCCG/ATTGGT 1 -- ng515Minor allele frequency- A:0.32NS EA NA 411
    rs23147561,2
    --153413702(+) gggtgA/Ccagag 1 -- int10--------
    rs23151221,2
    C153421844(+) TGATGA/GTCTTT 2 I V ref1 mis1 ese34Minor allele frequency- G:0.00NS EA 400
    rs23151231,2
    C153421847(+) TGATCC/TTTGCG 2 L F mis1 ref1 ese30--------
    rs23151241,2
    --153421849(+) ATCTTG/TGCGTA 2 L F mis1 ref1 ese30--------
    rs23151251,2
    C153421852(+) TTTGCA/GTACTG 2 A syn1 ref1 ese30--------
    About this table

    HapMap Linkage Disequilibrium images for OPN1LW (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for OPN1LW
         3 CNVs: 97108 83868 74085

    QIAGEN SeqTarget long-range PCR primers for resequencing OPN1LW 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    OPN1LW for disorders           About GeneDecksing

    OMIM: 300822

    UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000
  • Defects in OPN1LW are the cause of partial colorblindness protan series (CBP) [MIM:303900]; also known as
  • protanopia

    GeneTests: OPN1LW

    Red-Green Color Vision Defects

    Locus Specific Mutation Databases (LSDB): OPN1LW
    Human Gene Mutation Database (HGMD): OPN1LW
    Human Genome Epidemiology (HuGE) Navigator: OPN1LW (3 documents)

    Export disorders and mutations for OPN1LW gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/47 PubMed articles for OPN1LW gene, integrated from 7 sources (see all 47):
    (articles sorted by number of sources associating them with OPN1LW)
    1. The DNA sequence of the human X chromosome. (PubMed id 15772651)1, 2 Ross M.T.... Bentley D.R. (2005)
    2. Genetic heterogeneity among blue-cone monochromats. (PubMed id 8213841)1, 2 Nathans J.... Heckenlively J.R. (1993)
    3. Polymorphism in red photopigment underlies variation in colour matching. (PubMed id 1557123)1, 2 Winderickx J....Deeb S.S. (1992)
    4. Molecular biology of the visual pigments. (PubMed id 3303660)1, 2 Applebury M.L. and Hargrave P.A. (1986)
    5. Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. (PubMed id 2937147)1, 2 Nathans J.... Hogness D.S. (1986)
    6. Signatures of selection and gene conversion associated with human color vision variation. (PubMed id 15252758)1, 7 Verrelli B.C. and Tishkoff S.A. (2004)
    7. Cyclooxygenase-2 gene promoter polymorphisms affect s usceptibility to hepatitis C virus infection and disease progression. (PubMed id 20880066)1 Sakaki M....Imawari M. (2010)
    8. Variable retinal phenotypes caused by mutations in th e X-linked photopigment gene array. (PubMed id 20220053)1 Mizrahi-Meissonnier L....Sharon D. (2010)
    9. Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip. (PubMed id 20801516)1 Booij J.C....Florijn R.J. (2010 Aug 27)
    10. X-linked cone dystrophy caused by mutation of the red and green cone opsins. (PubMed id 20579627)1 Gardner J.C....Hardcastle A.J. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5956 HGNC: 9936 AceView: OPN1LW Ensembl:ENSG00000102076 euGenes: HUgn5956
    ECgene: OPN1LW H-InvDB: OPN1LW

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    Mutations of the color pigment geneshttp://www.retina-international.com/sci-news/cppmut.htm
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/OPN1LW

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for OPN1LW gene:
    Search GeneIP for patents involving OPN1LW

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for OPN1LW Browse antibodies at Sigma-Aldrich
     Super-pooled esiRNAs for OPN1LW Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for OPN1LW microRNA Mimics for OPN1LW
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
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     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OPN1LW
     SeqTarget long-range PCR primers for resequencing OPN1LW
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
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     Regulatory tfbs in OPN1LW promoter
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     ELISAs and CLIAs for OPN1LW
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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