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OPN1LW Gene

protein-coding GIFtS: 49

GC0XP142061

opsin 1 (cone pigments), long-wave-sensitive
(Previous names: color blindness, protan, red cone photoreceptor pigment )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: CBBM, RCP, CBP)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
opsin 1 (cone pigments), long-wave-sensitive¹ ²		color blindness, protan¹
Red cone photoreceptor pigment¹ ² ³		CBP²
COD5¹ ²		long-wave-sensitive opsin 1²
Red-sensitive opsin² ³		cone dystrophy 5 (X-linked)²
ROP² ³		CBBM²
RCP² ³

External Ids:	HGNC: 9936¹	Entrez Gene: 5956²	Ensembl: ENSG00000102076⁷	UniProtKB: P04000³

Export aliases for OPN1LW gene to outside databases

Previous GC identifers: GC0XP147547 GC0XP149864 GC0XP150995 GC0XP151916 GC0XP151877 GC0XP152930 GC0XP153062 GC0XP153409

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OPN1LW:

This gene encodes for a light absorbing visual pigment of the opsin gene family. The encoded protein is called red cone

photopigment or long-wavelength sensitive opsin. Opsins are G-protein coupled receptors with seven transmembrane

domains, an N-terminal extracellular domain, and a C-terminal cytoplasmic domain. This gene and the medium-wavelength

opsin gene are tandemly arrayed on the X chromosome and frequent unequal recombination and gene conversion may occur

between these sequences. X chromosomes may have fusions of the medium- and long-wavelength opsin genes or may have

more than one copy of these genes. Defects in this gene are the cause of partial, protanopic colorblindness. (provided

by RefSeq)

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000

Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin,

covalently linked to cis-retinal

Gene Wiki entry for OPN1LW

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OPN1LW gene promoter:
         GATA-1   C/EBPalpha   SRF   FOXO4   STAT1alpha   STAT1beta   IRF-1   STAT1   Sp1   p300
         Other transcription factors

Search SABiosciences Chromatin IP Primers for OPN1LW

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28

OPN1LW Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OPN1LW gene location

GeneLoc gene densities for chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XP142061: view genomic region (about GC identifiers)

Start:	142,061,320 bp from pter
End:	142,074,959 bp from pter
Size:	13,640 bases
Orientation:	plus strand

1 alternative location:

ChrX+ 153,409,698-153,424,507

RefSeq DNA sequence:

NC_000023.10 NT_167198.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000 (See protein sequence)

Recommended Name: Long-wave-sensitive opsin 1

Size: 364 amino acids; 40572 Da

Subcellular location: Membrane; Multi-pass membrane protein

PDB structures from and Proteopedia :

1KPX (3D)

Explore the universe of human proteins at neXtProt for OPN1LW: NX_P04000

Post-translational modifications:

Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region¹

REFSEQ proteins: NP_064445.1

ENSEMBL proteins:

ENSP00000358967 ENSP00000402493

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	Browse ProSpec Recombinant Proteins

4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0005887	integral to plasma membrane	TAS	9860863
GO:0016020	membrane	--	--
GO:0016021	integral to membrane	--	--

About this table

OPN1LW for ontologies About GeneDecksing

Antibodies for OPN1LW:

	Millipore Mono- and Polyclonal Antibodies for the study of OPN1LW
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	Browse antibodies at Epitomics

Assays for OPN1LW:

	Browse Kits and Assays available from Millipore
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	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for OPN1LW
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for OPN1LW

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OPN1LW for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_supfam

IPR001760 Opsin

IPR000378 Opsin_red/grn

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry P04000

ProtoNet protein and cluster: P04000

2 Blocks protein families:

IPB000378 Red/green-sensitive opsin signature

IPB001760 Opsin

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000

Similarity: Belongs to the G-protein coupled receptor 1 family. Opsin subfamily

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000

Function: Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin,

covalently linked to cis-retinal

Biophysicochemical properties: Absorption: Abs(max)=560 nm;

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for OPN1LW Sigma-Aldrich shRNA Panels and shRNA for OPN1LW
		OriGene 29mer shRNA kits in GFP-retroviral vector: OPN1LW OriGene shRNA RFP: OPN1LW OriGene basic RS shRNA: OPN1LW OriGene siRNA: OPN1LW
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OPN1LW

miRNA:		Sigma-Aldrich microRNA Mimics for OPN1LW Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OPN1LW
		Search SABiosciences for Assays for microRNAs that regulate OPN1LW

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: OPN1LW OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OPN1LW OriGene untagged cDNA clones in CMV expression vector: OPN1LW Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for OPN1LW
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for OPN1LW

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0009881	photoreceptor activity	IEA	--

About this table

OPN1LW for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

OPN1LW for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for OPN1LW

Phototransduction Pathway

SABiosciences Custom Pathway-Focused PCR Arrays for OPN1LW

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for OPN1LW

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for OPN1LW

5/6 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 6):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	TAS	2937147
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--
GO:0007601	visual perception	IEA	--
GO:0007602	phototransduction	IEA	--
GO:0018298	protein-chromophore linkage	IEA	--

About this table

OPN1LW for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

OPN1LW for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OPN1LW
2 Novoseek chemical compound relationships for OPN1LW gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
choline	35.6	2	15895092 (2)
calcium	0	2	2029536 (1), 11574661 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA Panels and esiRNA and siRNA for OPN1LW Sigma-Aldrich shRNA Panels and shRNA for OPN1LW
		OriGene 29mer shRNA kits in GFP-retroviral vector: OPN1LW OriGene shRNA RFP: OPN1LW OriGene basic RS shRNA: OPN1LW OriGene siRNA: OPN1LW
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OPN1LW

miRNA:		Sigma-Aldrich microRNA Mimics for OPN1LW Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OPN1LW
		Search SABiosciences for Assays for microRNAs that regulate OPN1LW

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: OPN1LW OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OPN1LW OriGene untagged cDNA clones in CMV expression vector: OPN1LW Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for OPN1LW

Primers:		OriGene genome-wide validated SYBR primer pairs: OPN1LW Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OPN1LW: PPH24186A

REFSEQ mRNAs for OPN1LW gene:

NM_020061.4

Additional cDNA sequence: CR749814.1

1 DOTS entry:

DT.436489

24/28 AceView cDNA sequences (see all 28):

BQ637240 NM_020061 BQ638605 BV181234 BV167401 BV167405 BV183299 BQ639996

AW950066 BV181233 BV181076 BV183301 BV167403 BV167402 BV183302 T27896

BV182704 BV182703 BQ638223 BV183303 BV183300 BV167404 BM704021 CR749814

highest scoring ESTs for OPN1LW:

AW950066 BM688032 BM704021 CR749814 NM_020061 T27896 BQ637240 DN693335 BM695482 W21948

Unigene Cluster for OPN1LW:

Opsin 1 (cone pigments), long-wave-sensitive

Hs.592247 [show with all ESTs]

Unigene Representative Sequence: CR749814

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000369951(uc004fjz.3) ENST00000463296 ENST00000442922

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OPN1LW expression in normal and diseased human tissues

¹ / ² / ³

2 probe-sets matching OPN1LW gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
221327_s_at²^{, 3}	U133-A	3	1.00	0.46	--	--	NM_000513	0.20	0.33	0.27	2
221327_s_at²	U133Plus2	3	1.00	0.46	--	--	--	--	--	--	--

About this table
Data from Genenote (Publications) and GNF BioGPS
About these images

OPN1LW gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.592247

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000

Tissue specificity: The three color pigments are found in the cone photoreceptor cells

Primers:		OriGene genome-wide validated SYBR primer pairs: OPN1LW Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OPN1LW: PPH24186A

SABiosciences Custom PCR Arrays for OPN1LW

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OPN1LW gene from 5/9 species (see all 9)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OPN1LW¹	--	opsin 1 (cone pigments), long-wave-sensitive	88.55(n) 89.29(a)	403778 XM_538203.2 XP_538203.2
chimpanzee (Pan troglodytes)	OPN1LW¹	--	opsin 1 (cone pigments), long-wave-sensitive	98.9(n) 98.63(a)	741998 XM_001144896.1 XP_001144896.1
cow (Bos taurus)	OPN1LW¹	--	opsin 1 (cone pigments), long-wave-sensitive	88.1(n) 89.29(a)	282293 NM_174566.1 NP_776991.1
rat (Rattus norvegicus)	Opn1mw¹	--	opsin 1 (cone pigments), medium-wave-sensitive	85.99(n) 89.08(a)	89810 NM_053548.1 NP_446000.1
mouse (Mus musculus)	Opn1lw⁵ Opn1mw¹	X⁵	opsin 1 (cone pigments), long-wave-sensitive⁵ opsin 1 (cone pigments), medium-wave-sensitive (color more¹	86.65(n)¹ 88.24(a)¹	14539¹ NM_008106.2¹ NP_032132.1¹ AF121351⁵

About this table Species with no ortholog for OPN1LW

ENSEMBL Gene Tree for OPN1LW (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OPN1LW gene

OPN3² OPN1MW² OPN1SW² RGR² RHO² OPN1MW2²

OPN1LW for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr X pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs949431^1,2	C,F	153418541(+)	`TCTGGG/TCTGCT`	2	A S	mis¹ ref¹		2		MN NA	186
rs1065422^1,2	F	153416362(+)	`GGTCTC/ATGGCT`	2	/Y /S	mis¹ ref¹ ese³		1		MN	184
rs1065439^1,2	C,F,O	153421912(+)	`CCTGGT/CTACGC`	2	/G	syn¹ ref¹		3		NA	109
rs1065440^1,2	--	153421916(+)	`GTTACC/GCCTTC`	2	P A	mis¹ ref¹ ese³		0	--	--	--	--
rs1573656^1,2	C,F,A	153408884(+)	`GGCCCG/ATTGGT`	1	--	ng5¹		5		NS EA NA	411
rs2314756^1,2	--	153413702(+)	`gggtgA/Ccagag`	1	--	int¹		0	--	--	--	--
rs2315122^1,2	C	153421844(+)	`TGATGA/GTCTTT`	2	I V	ref¹ mis¹ ese³		4		NS EA	400
rs2315123^1,2	C	153421847(+)	`TGATCC/TTTGCG`	2	L F	mis¹ ref¹ ese³		0	--	--	--	--
rs2315124^1,2	--	153421849(+)	`ATCTTG/TGCGTA`	2	L F	mis¹ ref¹ ese³		0	--	--	--	--
rs2315125^1,2	C	153421852(+)	`TTTGCA/GTACTG`	2	A	syn¹ ref¹ ese³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for OPN1LW (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for OPN1LW
3 CNVs: 97108 83868 74085

QIAGEN SeqTarget long-range PCR primers for resequencing OPN1LW

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OPN1LW for disorders About GeneDecksing

OMIM: 300822

UniProtKB/Swiss-Prot: OPSR_HUMAN, P04000

Defects in OPN1LW are the cause of partial colorblindness protan series (CBP) [MIM:303900]; also known as

protanopia

GeneTests: OPN1LW

Red-Green Color Vision Defects

Locus Specific Mutation Databases (LSDB): OPN1LW
Human Gene Mutation Database (HGMD): OPN1LW
Human Genome Epidemiology (HuGE) Navigator: OPN1LW (3 documents)

Export disorders and mutations for OPN1LW gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/47 PubMed articles for OPN1LW gene, integrated from 7 sources (see all 47):
(articles sorted by number of sources associating them with OPN1LW)

The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)
Genetic heterogeneity among blue-cone monochromats. (PubMed id 8213841)^{1, 2} Nathans J.... Heckenlively J.R. (1993)
Polymorphism in red photopigment underlies variation in colour matching. (PubMed id 1557123)^{1, 2} Winderickx J....Deeb S.S. (1992)
Molecular biology of the visual pigments. (PubMed id 3303660)^{1, 2} Applebury M.L. and Hargrave P.A. (1986)
Molecular genetics of human color vision: the genes encoding blue, green, and red pigments. (PubMed id 2937147)^{1, 2} Nathans J.... Hogness D.S. (1986)
Signatures of selection and gene conversion associated with human color vision variation. (PubMed id 15252758)^{1, 7} Verrelli B.C. and Tishkoff S.A. (2004)
Cyclooxygenase-2 gene promoter polymorphisms affect s usceptibility to hepatitis C virus infection and disease progression. (PubMed id 20880066)¹ Sakaki M....Imawari M. (2010)
Variable retinal phenotypes caused by mutations in th e X-linked photopigment gene array. (PubMed id 20220053)¹ Mizrahi-Meissonnier L....Sharon D. (2010)
Simultaneous Mutation Detection in 90 Retinal Disease Genes in Multiple Patients Using a Custom-designed 300-kb Retinal Resequencing Chip. (PubMed id 20801516)¹ Booij J.C....Florijn R.J. (2010 Aug 27)
X-linked cone dystrophy caused by mutation of the red and green cone opsins. (PubMed id 20579627)¹ Gardner J.C....Hardcastle A.J. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 5956	HGNC: 9936	AceView: OPN1LW	Ensembl:ENSG00000102076	euGenes: HUgn5956
ECgene: OPN1LW	H-InvDB: OPN1LW

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Mutations of the color pigment genes	http://www.retina-international.com/sci-news/cppmut.htm
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/OPN1LW

Intellectual Property for OPN1LW gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for OPN1LW gene:
Search GeneIP for patents involving OPN1LW

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for OPN1LW		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for OPN1LW		microRNA Mimics for OPN1LW
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

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	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OPN1LW
	SeqTarget long-range PCR primers for resequencing OPN1LW
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OPN1LW

	GenScript Custom Purified and Recombinant Proteins Services for OPN1LW		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for OPN1LW
	GenScript Custom Assay Services for OPN1LW		GenScript Custom Superior Antibodies Services for OPN1LW
	GenScript Custom overexpressing Cell Line Services for OPN1LW		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

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	GNC Network for OPN1LW
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	SABiosciences Custom PCR Arrays for OPN1LW

Search Tocris compounds for OPN1LW

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

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Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for OPN1LW

GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 10 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

OPN1LW gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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OPN1LW Gene

protein-coding GIFtS: 49

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Expression
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Export list of displayed genes

OPN1LW Gene

protein-coding GIFtS: 49

Aliases & Descriptionsfor OPN1LW gene

Summariesfor OPN1LW gene

Genomic Viewsfor OPN1LW gene

Proteinsfor OPN1LW gene

Protein Domains/Familiesfor OPN1LW gene

Gene Functionfor OPN1LW gene

Pathways & Interactionsfor OPN1LW gene

Drugs & Compoundsfor OPN1LW gene

Transcriptsfor OPN1LW gene

Expression for OPN1LW gene

Orthologsfor OPN1LW gene

Paralogsfor OPN1LW gene

Genomic Variantsfor OPN1LW gene

Disorders & Mutationsfor OPN1LW gene

Medical Newsfor OPN1LW gene

Publicationsfor OPN1LW gene

External Searches for OPN1LW gene

Genome Databases showing OPN1LW gene

Other Databases showing OPN1LW gene

Specialized Databases showing OPN1LW gene

Intellectual Propertyfor OPN1LW gene

Productsfor OPN1LW gene

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Aliases &
Descriptions
for OPN1LW gene

Summaries
for OPN1LW gene

Genomic Views
for OPN1LW gene

Proteins
for OPN1LW gene

Protein Domains/
Families
for OPN1LW gene

Gene Function
for OPN1LW gene

Pathways & Interactions
for OPN1LW gene

Drugs & Compounds
for OPN1LW gene

Transcripts
for OPN1LW gene

Expression
for OPN1LW gene

Orthologs
for OPN1LW gene

Paralogs
for OPN1LW gene

Genomic Variants
for OPN1LW gene

Disorders & Mutations
for OPN1LW gene

Medical News
for OPN1LW gene

Publications
for OPN1LW gene

Intellectual Property
for OPN1LW gene

Products
for OPN1LW gene