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OR10G4 Gene

protein-coding   GIFtS: 42

GC11P123886
olfactory receptor, family 10, subfamily G, member 4
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
olfactory receptor, family 10, subfamily G, member 41 2
Olfactory receptor OR11-2782 3
OR11-2782
olfactory receptor 10G42

External Ids:    HGNC: 148091   Entrez Gene: 3902642   Ensembl: ENSG000002345607   UniProtKB: Q8NGN33   

Export aliases for OR10G4 gene to outside databases

Previous GC identifers: GC11U990358 GC11P123424 GC11P123391


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR10G4:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: O10G4_HUMAN, Q8NGN3
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10G4

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR10G4 gene promoter:
         IRF-1   Max1   c-Myc   Hlf   AREB6   FOXD1   GR-beta   GR-alpha   Lmo2   SRF   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for OR10G4

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1   Ensembl cytogenetic band:  11q24.1   HGNC cytogenetic band: 11q24.1

OR10G4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10G4 gene location

GeneLoc gene densities for chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P123886:  view genomic region     (about GC identifiers)

Start:
123,886,282 bp from pter
End:
123,887,214 bp from pter
Size:
933 bases
Orientation:
plus strand

1 alternative location:
Chr11+ 119,827,061-119,827,996     
RefSeq DNA sequence:
NC_000011.9  NT_033899.8  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: O10G4_HUMAN, Q8NGN3 (See protein sequence)
Recommended Name: Olfactory receptor 10G4  
Size: 311 amino acids; 34569 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: Q6IEW0

Explore the universe of human proteins at neXtProt for OR10G4: NX_Q8NGN3 

REFSEQ proteins: NP_001004462.1  

ENSEMBL proteins: 
ENSP00000389072 ENSP00000325076 ENSP00000364161 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS--
GO:0016021 integral to membrane IEA--
About this table

OR10G4 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR10G4 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR000725 Olfact_rcpt
 IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGN3

ProtoNet protein and cluster: Q8NGN3

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O10G4_HUMAN, Q8NGN3
Similarity: Belongs to the G-protein coupled receptor 1 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: O10G4_HUMAN, Q8NGN3
Function: Odorant receptor (Potential)

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich siRNA for OR10G4
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR10G4 
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Gene
Editing:
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Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene GFP tagged cDNA clones in CMV expression vector: OR10G4
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR10G4
OriGene untagged cDNA clones in CMV expression vector: OR10G4
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Cell
Lines:
  
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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004984 olfactory receptor activity IEA--
About this table

OR10G4 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


OR10G4 for pathways           About GeneDecksing

1 Kegg Pathway  (Kegg details for OR10G4):
    hsa04740 Olfactory transduction

    SABiosciences Custom Pathway-Focused PCR Arrays for OR10G4 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR10G4

1 Interacting protein for OR10G4 (ENSP000003641613) via UniProtKB, MINT, and/or STRING
InteractantInteraction Details
GeneCardExternal ID(s)
--ensp: ENSP000003250763STRING: ensp: ENSP00000325076
About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007186 G-protein coupled receptor protein signaling pathway ----
GO:0007608 sensory perception of smell IEA--
GO:0050896 response to stimulus IEA--
About this table

OR10G4 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR10G4


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for OR10G4
Browse shRNA at Sigma-Aldrich
OriGene 29mer shRNA kits in GFP-retroviral vector: OR10G4
OriGene shRNA RFP: OR10G4
OriGene basic RS shRNA: OR10G4
OriGene siRNA: OR10G4
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR10G4 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR10G4 
Search SABiosciences for Assays for microRNAs that regulate OR10G4
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: OR10G4
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR10G4
OriGene untagged cDNA clones in CMV expression vector: OR10G4
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: OR10G4 
Primers: OriGene genome-wide validated SYBR primer pairs: OR10G4
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for OR10G4: PPH60322A

REFSEQ mRNAs for OR10G4 gene: 

NM_001004462.1  

1 AceView cDNA sequence:

NM_001004462 

highest scoring ESTs for OR10G4:

NM_001004462 

Unigene Cluster for OR10G4:

Olfactory receptor, family 10, subfamily G, member 4
Hs.553760
Unigene Representative Sequence: NM_001004462


GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000431524(uc001pzp.1) ENST00000320891(uc010sac.1) ENST00000375021


(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR10G4 expression in normal and diseased human tissues

1 Data from GNF BioGPS
    About these images

OR10G4 gene expression
OR10G4 gene electronic northern expression
OR10G4 gene sage expression
About these images

CGAP SAGE TAG: GATGGAGTTG

SOURCE GeneReport for Unigene cluster: Hs.553760
Primers: OriGene genome-wide validated SYBR primer pairs: OR10G4
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for OR10G4: PPH60322A
    SABiosciences Custom PCR Arrays for OR10G4 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR10G4 gene from 2 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
rat
(Rattus norvegicus)
Olr13351   -- olfactory receptor 1335 83.76(n)
84.52(a)
300635  NM_001000479.1  NP_001000479.1 
mouse
(Mus musculus)
Olfr9801 , 5 9 (21.29 cM)5
olfactory receptor 9801, 5 84.95(n)1
85.48(a)1
2591101  NM_147106.11  NP_667317.11 
 AY0729805  AY3181745  (see all 7)
About this table        Species with no ortholog for OR10G4

ENSEMBL Gene Tree for OR10G4 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for OR10G4 gene
OR10G22  OR10G5P2  OR10S12  OR10G92  OR10G62  OR10G32  OR10D4P2  OR10D32  
OR10G72  

OR10G4 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/54 NCBI SNPs in OR10G4 are shown (see all 54)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 11 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs5032231,2
F,A123886717(+) CCACCC/TGCACT 3 R G C mis1 ref14Minor allele frequency- T:0.09MN NS 608
rs5175981,2
C,H123887314(-) AATAAT/AGTTTA 1 -- ng314Minor allele frequency- A:0.00NA 8
rs5470681,2
C,F,123886352(-) AGAGGA/GGGGCG 2 P L mis1 ref13Minor allele frequency- G:0.14MN NA 188
rs5478701,2
H123886290(-) CTGGCG/CTTGGA 2 /N /K ref1 mis15Minor allele frequency- C:0.00MN NS EA 600
rs5487031,2
--123886225(-) ATTTAC/GCACTT 1 -- ng510--------
rs18937641,2
C,F,A,H123886822(-) GGGCGG/ATGCGT 2 /P /S ref1 mis15Minor allele frequency- A:0.06MN NS EA 604
rs18937661,2
C,A,H123886681(-) CATCAT/CGCTGG 2 /M /V ref1 mis12Minor allele frequency- C:0.13MN NA 186
rs30177621,2
C,H123886698(+) AGCAGA/GTGTGC 2 R syn1 ref10--------
rs30177631,2
--123886809(+) CACTAC/TTTCTG 2 Y ref1 syn10--------
rs30177641,2
--123886812(+) TACTTC/GTGTGA 2 F L ref1 mis10--------
About this table

HapMap Linkage Disequilibrium images for OR10G4 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OR10G4
     1 CNV: 101364

QIAGEN SeqTarget long-range PCR primers for resequencing OR10G4 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OR10G4 for disorders           About GeneDecksing

Human Genome Epidemiology (HuGE) Navigator: OR10G4 (1 document)

Export disorders and mutations for OR10G4 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

3 PubMed articles for OR10G4 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR10G4)
  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
  3. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 390264 HGNC: 14809 AceView: OR10G4 Ensembl:ENSG00000234560 euGenes: HUgn390264
ECgene: OR10G4 Kegg: 390264 H-InvDB: OR10G4

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
HORDE entry for OR10G4 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for OR10G4 gene:
Search GeneIP for patents involving OR10G4

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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 SeqTarget long-range PCR primers for resequencing OR10G4
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR10G4
 GenScript Custom Purified and Recombinant Proteins Services for OR10G4 GenScript cDNA clones with any tag delivered in your preferred vector for OR10G4
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