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OR10P1 Gene

protein-coding   GIFtS: 40

GC12P056030
olfactory receptor, family 10, subfamily P, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: OR10P1P, OR10P2P, OR10P3P)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 10, subfamily P, member 11 2     OR10P1P2 3
OST7011 2     olfactory receptor, family 10, subfamily P, member 1 pseudogene2
Olfactory receptor 10P32 3     OR12-72
Olfactory receptor 10P22 3     olfactory receptor, family 10, subfamily P, member 2 pseudogene2
Olfactory receptor OR12-72 3     seven transmembrane helix receptor2
OR10P2P2 3     olfactory receptor 10P12
OR10P3P2 3     olfactory receptor, family 10, subfamily P, member 3 pseudogene2

External Ids:    HGNC: 153781   Entrez Gene: 1211302   Ensembl: ENSG000001753987   UniProtKB: Q8NGE33   

Export aliases for OR10P1 gene to outside databases

Previous GC identifers: GC12P054317 GC12P054318


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR10P1:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: O10P1_HUMAN, Q8NGE3
Function: Odorant receptor (Potential)

Gene Wiki entry for OR10P1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR10P1 gene promoter:
         Tal-1beta   ITF-2   YY1   Tal-1   E47   NF-1   SREBP-1a   SREBP-1b   SREBP-1c   Pax-6   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for OR10P1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2   Ensembl cytogenetic band:  12q13.2   HGNC cytogenetic band: 12q13.13

OR10P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10P1 gene location

GeneLoc gene densities for chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P056030:  view genomic region     (about GC identifiers)

Start:
56,030,676 bp from pter
End:
56,031,614 bp from pter
Size:
939 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000012.11  NT_029419.12  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: O10P1_HUMAN, Q8NGE3 (See protein sequence)
Recommended Name: Olfactory receptor 10P1  
Size: 313 amino acids; 34741 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Secondary accessions: B9EGY4

Explore the universe of human proteins at neXtProt for OR10P1: NX_Q8NGE3 

REFSEQ proteins: NP_996782.1  

ENSEMBL proteins: 
ENSP00000308082 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS--
GO:0016021 integral to membrane IEA--
About this table

OR10P1 for ontologies           About GeneDecksing



Antibodies for OR10P1: 
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Assays for OR10P1: 
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GenScript Custom Assay Services for OR10P1 
Browse Enzo Life Sciences for kits & assays
Browse ELISAs and CLIAs at Uscn 


(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR10P1 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR015540 Olfact_rcpt_MOR269
 IPR017452 GPCR_Rhodpsn_supfam
 IPR000725 Olfact_rcpt
 IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGE3

ProtoNet protein and cluster: Q8NGE3

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O10P1_HUMAN, Q8NGE3
Similarity: Belongs to the G-protein coupled receptor 1 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: O10P1_HUMAN, Q8NGE3
Function: Odorant receptor (Potential)

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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Sigma-Aldrich siRNA for OR10P1
Browse shRNA at Sigma-Aldrich
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): OR10P1
OriGene shRNA RFP (see all 2): OR10P1
OriGene basic RS shRNA (see all 2): OR10P1
OriGene siRNA (see all 2): OR10P1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR10P1 
miRNA:Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR10P1 
Search SABiosciences for Assays for microRNAs that regulate OR10P1

Gene
Editing:
Browse CompoZr Knockout ZFN at Sigma-Aldrich 

Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
Browse iPSC Reprogramming Factors at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: OR10P1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR10P1
OriGene untagged cDNA clones in CMV expression vector: OR10P1
Browse 3'-UTR reporter clones for miRNA target validation 
Browse MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: OR10P1 
Browse Sino Biological Human cDNA Clones

Cell
Lines:
  
GenScript Custom overexpressing Cell Line Services for OR10P1 

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004984 olfactory receptor activity IEA--
About this table

OR10P1 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


OR10P1 for pathways           About GeneDecksing

1 Kegg Pathway  (Kegg details for OR10P1):
    hsa04740 Olfactory transduction

    SABiosciences Custom Pathway-Focused PCR Arrays for OR10P1 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR10P1

5/191 Interacting proteins for OR10P1 (ENSP000003080823) via UniProtKB, MINT, and/or STRING (see all 191)
InteractantInteraction Details
GeneCardExternal ID(s)
OR10G4ENSP000003250763STRING: ENSP00000364161 STRING: ENSP00000325076
ENSG00000204702ENSP000003663763STRING: ENSP00000366376
ENSG00000229412ENSP000003663433STRING: ENSP00000366343
GNALENSP000003340513STRING: ENSP00000334051
GNB1ENSP000003678723STRING: ENSP00000367872
About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007186 G-protein coupled receptor protein signaling pathway ----
GO:0007608 sensory perception of smell IEA--
GO:0050896 response to stimulus IEA--
About this table

OR10P1 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR10P1


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich siRNA for OR10P1
Browse shRNA at Sigma-Aldrich
OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): OR10P1
OriGene shRNA RFP (see all 2): OR10P1
OriGene basic RS shRNA (see all 2): OR10P1
OriGene siRNA (see all 2): OR10P1
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR10P1 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR10P1 
Search SABiosciences for Assays for microRNAs that regulate OR10P1
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: OR10P1
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR10P1
OriGene untagged cDNA clones in CMV expression vector: OR10P1
Browse 3'-UTR reporter clones for miRNA target validation 
Browse OriGene MicroRNA Expression Plasmids 
GenScript cDNA clone with any tag delivered in your preferred vector: OR10P1 
Primers: OriGene genome-wide validated SYBR primer pairs: OR10P1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for OR10P1: PPH60330A

REFSEQ mRNAs for OR10P1 gene: 

NM_206899.1  

Additional cDNA sequence: BC136914.1 

highest scoring ESTs for OR10P1:

NM_206899 

Unigene Cluster for OR10P1:

Olfactory receptor, family 10, subfamily P, member 1
Hs.554551
Unigene Representative Sequence: BC136914


GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000309675(uc010spq.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR10P1 expression in normal and diseased human tissues

1 Data from GNF BioGPS
    About these images

OR10P1 gene expression
OR10P1 gene electronic northern expression
OR10P1 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.554551
Primers: OriGene genome-wide validated SYBR primer pairs: OR10P1
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for OR10P1: PPH60330A
    SABiosciences Custom PCR Arrays for OR10P1 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR10P1 gene from 3 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
cow
(Bos taurus)
LOC5203051   -- similar to Olfactory receptor 10P1 (Olfactory receptor more 87.18(n)
85.9(a)
520305  XM_598543.2  XP_598543.2 
rat
(Rattus norvegicus)
Olr10161   -- olfactory receptor 1016 80.87(n)
81.64(a)
288858  NM_001000070.1  NP_001000070.1 
mouse
(Mus musculus)
Olfr7961 , 5 10 (77.42 cM)5
olfactory receptor 7961, 5 82.9(n)1
84.84(a)1
2589331  NM_146931.11  NP_667142.11 
 AY0731575  AY3179715 
About this table        Species with no ortholog for OR10P1

ENSEMBL Gene Tree for OR10P1 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for OR10P1 gene
OR10AG12  

OR10P1 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/53 NCBI SNPs in OR10P1 are shown (see all 53)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 12 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs14744471,2
C,F,O,H,56029584(+) AGGACC/AAAAGG 1 -- ng5124Minor allele frequency- A:0.23NS EA NA WA 1624
rs25506711,2
C,F,O,56030092(-) CTGTGA/CTCAGC 1 -- ng5116Minor allele frequency- C:0.16NS EA NA WA 1162
rs25550351,2
C,F,A,H,56031704(+) AATCAC/TGCAGC 1 -- ng3113Minor allele frequency- T:0.27NS EA NA WA 604
rs25550361,2
C,F,A,H,56031992(+) AAGTGA/GCCCAC 1 -- ng3110Minor allele frequency- G:0.45NS EA NA WA 510
rs73056231,2
C,F,56030921(+) ACCCTG/AGCCAA 2 /L syn1 ref1 ese35Minor allele frequency- A:0.02NS EA WA 470
rs73094331,2
C,F,A,H,56031837(+) GAATGA/GAAGTG 1 -- ng3118Minor allele frequency- G:0.21NA NS EA WA 1198
rs79708851,2
C,F,A,H,56031273(+) TCTCCG/ATGATG 2 /M /V mis1 ref1 ese317Minor allele frequency- A:0.26NS EA NA 1344
rs79776031,2
C,H56029175(+) gcgccC/TggccT 1 -- ng516Minor allele frequency- T:0.00NA WA 12
rs108768381,2
C,F,A,H,56030938(+) CTCCCC/TGCATC 2 P L ref1 mis1 ese314Minor allele frequency- T:0.27NS EA NA 1010
rs108768391,2
C,F,A,H,56031863(+) AAAGGA/GCATTT 1 -- ng3113Minor allele frequency- G:0.31NS EA NA WA 754
About this table

HapMap Linkage Disequilibrium images for OR10P1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for OR10P1: --

QIAGEN SeqTarget long-range PCR primers for resequencing OR10P1 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

6 PubMed articles for OR10P1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR10P1)
  1. The finished DNA sequence of human chromosome 12. (PubMed id 16541075)1, 2 Scherer S.E.... Gibbs R.A. (2006)
  2. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1 Fuchs T.... Shamir R. (2002)
  6. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 121130 HGNC: 15378 Ensembl:ENSG00000175398 euGenes: HUgn121130 ECgene: OR10P1 Kegg: 121130
H-InvDB: OR10P1

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
HORDE entry for OR10P1 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for OR10P1 gene:
Search GeneIP for patents involving OR10P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR10P1
 SeqTarget long-range PCR primers for resequencing OR10P1
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR10P1
 GenScript Custom Purified and Recombinant Proteins Services for OR10P1 GenScript cDNA clones with any tag delivered in your preferred vector for OR10P1
 GenScript Custom Assay Services for OR10P1 GenScript Custom Superior Antibodies Services for OR10P1
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 Regulatory tfbs in OR10P1 promoter
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 Browse ELISAs and CLIAs at Uscn
       

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