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OR10P1 Gene

protein-coding GIFtS: 40

GC12P056030

olfactory receptor, family 10, subfamily P, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbols: OR10P1P, OR10P2P, OR10P3P)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 10, subfamily P, member 1¹ ²		OR10P1P² ³
OST701¹ ²		olfactory receptor, family 10, subfamily P, member 1 pseudogene²
Olfactory receptor 10P3² ³		OR12-7²
Olfactory receptor 10P2² ³		olfactory receptor, family 10, subfamily P, member 2 pseudogene²
Olfactory receptor OR12-7² ³		seven transmembrane helix receptor²
OR10P2P² ³		olfactory receptor 10P1²
OR10P3P² ³		olfactory receptor, family 10, subfamily P, member 3 pseudogene²

External Ids:	HGNC: 15378¹	Entrez Gene: 121130²	Ensembl: ENSG00000175398⁷	UniProtKB: Q8NGE3³

Export aliases for OR10P1 gene to outside databases

Previous GC identifers: GC12P054317 GC12P054318

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR10P1:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: O10P1_HUMAN, Q8NGE3

Function: Odorant receptor (Potential)

Gene Wiki entry for OR10P1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR10P1 gene promoter:
         Tal-1beta   ITF-2   YY1   Tal-1   E47   NF-1   SREBP-1a   SREBP-1b   SREBP-1c   Pax-6
         Other transcription factors

Search SABiosciences Chromatin IP Primers for OR10P1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.2 Ensembl cytogenetic band: 12q13.2 HGNC cytogenetic band: 12q13.13

OR10P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR10P1 gene location

GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure

GeneLoc location for GC12P056030: view genomic region (about GC identifiers)

Start:	56,030,676 bp from pter
End:	56,031,614 bp from pter
Size:	939 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000012.11 NT_029419.12

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: O10P1_HUMAN, Q8NGE3 (See protein sequence)

Recommended Name: Olfactory receptor 10P1

Size: 313 amino acids; 34741 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: B9EGY4

Explore the universe of human proteins at neXtProt for OR10P1: NX_Q8NGE3

REFSEQ proteins: NP_996782.1

ENSEMBL proteins:

ENSP00000308082

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

About this table

OR10P1 for ontologies About GeneDecksing

Antibodies for OR10P1:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR10P1 for domains About GeneDecksing

4 InterPro domains/families:

IPR015540 Olfact_rcpt_MOR269

IPR017452 GPCR_Rhodpsn_supfam

IPR000725 Olfact_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGE3

ProtoNet protein and cluster: Q8NGE3

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: O10P1_HUMAN, Q8NGE3

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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UniProtKB/Swiss-Prot: O10P1_HUMAN, Q8NGE3

Function: Odorant receptor (Potential)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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Gene
Editing:

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Cell
Lines:

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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

About this table

OR10P1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

OR10P1 for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for OR10P1):

hsa04740 Olfactory transduction

SABiosciences Custom Pathway-Focused PCR Arrays for OR10P1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR10P1

5/191 Interacting proteins for OR10P1 (ENSP00000308082³) via UniProtKB, MINT, and/or STRING (see all 191)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OR10G4	ENSP00000325076³	STRING: ENSP00000364161 STRING: ENSP00000325076
ENSG00000204702	ENSP00000366376³	STRING: ENSP00000366376
ENSG00000229412	ENSP00000366343³	STRING: ENSP00000366343
GNAL	ENSP00000334051³	STRING: ENSP00000334051
GNB1	ENSP00000367872³	STRING: ENSP00000367872

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

About this table

OR10P1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR10P1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): OR10P1 OriGene shRNA RFP (see all 2): OR10P1 OriGene basic RS shRNA (see all 2): OR10P1 OriGene siRNA (see all 2): OR10P1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR10P1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR10P1
		Search SABiosciences for Assays for microRNAs that regulate OR10P1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: OR10P1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR10P1 OriGene untagged cDNA clones in CMV expression vector: OR10P1 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: OR10P1

Primers:		OriGene genome-wide validated SYBR primer pairs: OR10P1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR10P1: PPH60330A

REFSEQ mRNAs for OR10P1 gene:

NM_206899.1

Additional cDNA sequence: BC136914.1

highest scoring ESTs for OR10P1:

NM_206899

Unigene Cluster for OR10P1:

Olfactory receptor, family 10, subfamily P, member 1

Hs.554551

Unigene Representative Sequence: BC136914

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000309675(uc010spq.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR10P1 expression in normal and diseased human tissues

¹ Data from GNF BioGPS
About these images

OR10P1 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.554551

Primers:		OriGene genome-wide validated SYBR primer pairs: OR10P1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR10P1: PPH60330A

SABiosciences Custom PCR Arrays for OR10P1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR10P1 gene from 3 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
cow (Bos taurus)	LOC520305¹	--	similar to Olfactory receptor 10P1 (Olfactory receptor more	87.18(n) 85.9(a)	520305 XM_598543.2 XP_598543.2
rat (Rattus norvegicus)	Olr1016¹	--	olfactory receptor 1016	80.87(n) 81.64(a)	288858 NM_001000070.1 NP_001000070.1
mouse (Mus musculus)	Olfr796^{1 , 5}	10 (77.42 cM)⁵	olfactory receptor 796^{1, 5}	82.9(n)¹ 84.84(a)¹	258933¹ NM_146931.1¹ NP_667142.1¹ AY073157⁵ AY317971⁵

About this table Species with no ortholog for OR10P1

ENSEMBL Gene Tree for OR10P1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OR10P1 gene

OR10AG1²

OR10P1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 12 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1474447^1,2	C,F,O,H,	56029584(+)	`AGGACC/AAAAGG`	1	--	ng5¹		24	NS EA NA WA	1624
rs2550671^1,2	C,F,O,	56030092(-)	`CTGTGA/CTCAGC`	1	--	ng5¹		16	NS EA NA WA	1162
rs2555035^1,2	C,F,A,H,	56031704(+)	`AATCAC/TGCAGC`	1	--	ng3¹		13	NS EA NA WA	604
rs2555036^1,2	C,F,A,H,	56031992(+)	`AAGTGA/GCCCAC`	1	--	ng3¹		10	NS EA NA WA	510
rs7305623^1,2	C,F,	56030921(+)	`ACCCTG/AGCCAA`	2	/L	syn¹ ref¹ ese³		5	NS EA WA	470
rs7309433^1,2	C,F,A,H,	56031837(+)	`GAATGA/GAAGTG`	1	--	ng3¹		18	NA NS EA WA	1198
rs7970885^1,2	C,F,A,H,	56031273(+)	`TCTCCG/ATGATG`	2	/M /V	mis¹ ref¹ ese³		17	NS EA NA	1344
rs7977603^1,2	C,H	56029175(+)	`gcgccC/TggccT`	1	--	ng5¹		6	NA WA	12
rs10876838^1,2	C,F,A,H,	56030938(+)	`CTCCCC/TGCATC`	2	P L	ref¹ mis¹ ese³		14	NS EA NA	1010
rs10876839^1,2	C,F,A,H,	56031863(+)	`AAAGGA/GCATTT`	1	--	ng3¹		13	NS EA NA WA	754

About this table

HapMap Linkage Disequilibrium images for OR10P1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR10P1: --

QIAGEN SeqTarget long-range PCR primers for resequencing OR10P1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

6 PubMed articles for OR10P1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR10P1)

The finished DNA sequence of human chromosome 12. (PubMed id 16541075)^{1, 2} Scherer S.E.... Gibbs R.A. (2006)
The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)¹ Fuchs T.... Shamir R. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 121130	HGNC: 15378	Ensembl:ENSG00000175398	euGenes: HUgn121130	ECgene: OR10P1	Kegg: 121130
H-InvDB: OR10P1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
HORDE entry for OR10P1	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR10P1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for OR10P1 gene:
Search GeneIP for patents involving OR10P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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OR10P1 Gene

protein-coding GIFtS: 40

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OR10P1 Gene

protein-coding GIFtS: 40

Aliases & Descriptionsfor OR10P1 gene

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