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OR1L8 Gene

protein-coding GIFtS: 42

GC09M125329

olfactory receptor, family 1, subfamily L, member 8
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 1, subfamily L, member 8¹ ²
Olfactory receptor OR9-24² ³
OR9-24²
olfactory receptor 1L8²

External Ids:	HGNC: 15110¹	Entrez Gene: 138881²	Ensembl: ENSG00000171496⁷	UniProtKB: Q8NGR8³

Export aliases for OR1L8 gene to outside databases

Previous GC identifers: GC09U990175 GC09M120706 GC09M122409 GC09M124369

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR1L8:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: OR1L8_HUMAN, Q8NGR8

Function: Odorant receptor (Potential)

Gene Wiki entry for OR1L8

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR1L8 gene promoter:
         FOXC1   NF-kappaB2   NF-kappaB1   NF-kappaB   PPAR-gamma2   PPAR-gamma1   ATF   HNF-4alpha2   COUP-TF1   STAT3
         Other transcription factors

Search SABiosciences Chromatin IP Primers for OR1L8

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.2 Ensembl cytogenetic band: 9q33.2 HGNC chromosome: 9

OR1L8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR1L8 gene location

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M125329: view genomic region (about GC identifiers)

Start:	125,329,830 bp from pter
End:	125,330,756 bp from pter
Size:	927 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000009.11 NT_008470.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: OR1L8_HUMAN, Q8NGR8 (See protein sequence)

Recommended Name: Olfactory receptor 1L8

Size: 309 amino acids; 35083 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: A3KFM3 B9EIR6 Q6IF15 Q96R79

Explore the universe of human proteins at neXtProt for OR1L8: NX_Q8NGR8

REFSEQ proteins: NP_001004454.1

ENSEMBL proteins:

ENSP00000306607

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

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OR1L8 for ontologies About GeneDecksing

Antibodies for OR1L8:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR1L8 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_supfam

IPR000725 Olfact_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGR8

ProtoNet protein and cluster: Q8NGR8

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR1L8_HUMAN, Q8NGR8

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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UniProtKB/Swiss-Prot: OR1L8_HUMAN, Q8NGR8

Function: Odorant receptor (Potential)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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Gene
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Cell
Lines:

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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

About this table

OR1L8 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
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OR1L8 for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for OR1L8):

hsa04740 Olfactory transduction

SABiosciences Custom Pathway-Focused PCR Arrays for OR1L8

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR1L8

5/191 Interacting proteins for OR1L8 (ENSP00000306607³) via UniProtKB, MINT, and/or STRING (see all 191)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OR10G4	ENSP00000325076³	STRING: ENSP00000364161 STRING: ENSP00000325076
ENSG00000204702	ENSP00000366376³	STRING: ENSP00000366376
ENSG00000229412	ENSP00000366343³	STRING: ENSP00000366343
GNAL	ENSP00000334051³	STRING: ENSP00000334051
GNB1	ENSP00000367872³	STRING: ENSP00000367872

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

About this table

OR1L8 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

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Browse Tocris compounds for OR1L8

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): OR1L8 OriGene shRNA RFP (see all 2): OR1L8 OriGene basic RS shRNA (see all 2): OR1L8 OriGene siRNA (see all 2): OR1L8
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR1L8
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Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: OR1L8 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR1L8 OriGene untagged cDNA clones in CMV expression vector: OR1L8 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: OR1L8

Primers:		OriGene genome-wide validated SYBR primer pairs: OR1L8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR1L8: PPH60346A

REFSEQ mRNAs for OR1L8 gene:

NM_001004454.1

Additional cDNA sequence: BC140910.1

1 AceView cDNA sequence:

NM_001004454

highest scoring ESTs for OR1L8:

NM_001004454

Unigene Cluster for OR1L8:

Olfactory receptor, family 1, subfamily L, member 8

Hs.632695

Unigene Representative Sequence: BC140910

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000304865(uc004bmp.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR1L8 expression in normal and diseased human tissues

¹ Data from GNF BioGPS
About these images

OR1L8 gene electronic northern expression

About these images

CGAP SAGE TAG: CTCAATCCTT

SOURCE GeneReport for Unigene cluster: Hs.632695

Primers:		OriGene genome-wide validated SYBR primer pairs: OR1L8 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR1L8: PPH60346A

SABiosciences Custom PCR Arrays for OR1L8

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR1L8 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	OR04C10¹	--	olfactory receptor	86.01(n) 80.98(a)	491350 XM_548471.2 XP_548471.2
chimpanzee (Pan troglodytes)	LOC473044¹	--	similar to seven transmembrane helix receptor	97.95(n) 95.47(a)	473044 XM_528414.2 XP_528414.2
cow (Bos taurus)	LOC531878¹	--	similar to olfactory receptor 355	87.61(n) 84.54(a)	531878 XM_610381.3 XP_610381.3
rat (Rattus norvegicus)	Olr418¹	--	olfactory receptor 418	83.33(n) 84.09(a)	405114 NM_001000825.1 NP_001000825.1
mouse (Mus musculus)	Olfr355^{1 , 5}	2 (24.19 cM)⁵	olfactory receptor 355^{1, 5}	83.23(n)¹ 85.06(a)¹	258618¹ NM_146625.1¹ NP_666836.1¹ AY073472⁵ AY317451⁵

About this table Species with no ortholog for OR1L8

ENSEMBL Gene Tree for OR1L8 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OR1L8 gene

OR1L1² OR1Q1² OR1K1² OR1L6² OR1L4² OR1L3²

OR1L8 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs1411265^1,2	C,F,A,H,	125331205(+)	`taaaaC/Tagtat`	1	--	ng5¹		10		NS EA NA WA	512
rs1831365^1,2	C,F,A,	125330957(+)	`GGGCAT/ATATAT`	1	--	ng5¹		9		NA EA WA	354
rs1831366^1,2	C,F,A,	125330984(+)	`AGAGGA/GAGAGT`	1	--	ng5¹ trp³		10		NS EA NA WA	586
rs1831367^1,2	C,F,A,	125331047(+)	`CCTATC/TCTGTG`	1	--	ng5¹		19		NS EA NA WA	1476
rs1934924^1,2	C,F,A,H,	125331386(-)	`CAACAT/GTCGTC`	1	--	ng5¹		24		NS EA NA WA	1542
rs1999182^1,2	C,F,O,A,	125330739(+)	`CTGGTA/GTGGTT`	2	H	ref¹ syn¹ ese³		12		NA NS EA WA	634
rs1999183^1,2	C,F,O,A,	125330859(+)	`GTTTGG/ATCACA`	1	--	ng5¹		15		NA NS EA WA	1110
rs4120968^1,2	H	125331510(-)	`AAACAA/TTTTAC`	1	--	ng5¹		4		NS EA	420
rs6151167^1,2	--	125331957(+)	`ttatt-/TTATTTT ATTTTATTTTattat`	1	--	ng5¹		0	--	--	--	--
rs10739614^1,2	C,F,A,H,	125330125(+)	`GAAAAG/CGAGTC`	2	/P /R	mis¹ ref¹ ese³		21		NA NS EA WA	1296

About this table

HapMap Linkage Disequilibrium images for OR1L8 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR1L8: --

QIAGEN SeqTarget long-range PCR primers for resequencing OR1L8

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

6 PubMed articles for OR1L8 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR1L8)

The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)^{1, 2} Fuchs T.... Shamir R. (2002)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)² Humphray S.J.... Dunham I. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 138881	HGNC: 15110	AceView: OR1L8	Ensembl:ENSG00000171496	euGenes: HUgn138881
ECgene: OR1L8	Kegg: 138881	H-InvDB: OR1L8

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
HORDE entry for OR1L8	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR1L8 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for OR1L8 gene:
Search GeneIP for patents involving OR1L8

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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OR1L8 Gene

protein-coding GIFtS: 42

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OR1L8 Gene

protein-coding GIFtS: 42

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