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OR2AG2 Gene

protein-coding GIFtS: 41

GC11M006745

olfactory receptor, family 2, subfamily AG, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: OR2AG2P)

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 2, subfamily AG, member 2¹ ²
OR2AG2P² ³
olfactory receptor OR11-76 pseudogene²
OR11-76²
olfactory receptor 2AG2²
olfactory receptor, family 2, subfamily AG, member 2 pseudogene²

External Ids:	HGNC: 15143¹	Entrez Gene: 338755²	Ensembl: ENSG00000188124⁷	UniProtKB: A6NM03³

Export aliases for OR2AG2 gene to outside databases

Previous GC identifer: GC11M006754

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR2AG2:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: O2AG2_HUMAN, A6NM03

Function: Odorant receptor (Potential)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR2AG2 gene promoter:
         Meis-1   HOXA9B   RP58   CHOP-10   C/EBPalpha   Elk-1   FOXI1   E47   Tal-1beta   FOXJ2 (long isoform)
         Other transcription factors

Search SABiosciences Chromatin IP Primers for OR2AG2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11p15.4 Ensembl cytogenetic band: 11p15.4 HGNC cytogenetic band: 11p15.4

OR2AG2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR2AG2 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M006745: view genomic region (about GC identifiers)

Start:	6,789,241 bp from pter
End:	6,790,188 bp from pter
Size:	948 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.9 NT_009237.18

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: O2AG2_HUMAN, A6NM03 (See protein sequence)

Recommended Name: Olfactory receptor 2AG2

Size: 316 amino acids; 35270 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Explore the universe of human proteins at neXtProt for OR2AG2: NX_A6NM03

REFSEQ proteins: NP_001004490.1

ENSEMBL proteins:

ENSP00000342697

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

About this table

OR2AG2 for ontologies About GeneDecksing

Antibodies for OR2AG2:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR2AG2 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_supfam

IPR000725 Olfact_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry A6NM03

ProtoNet protein and cluster: A6NM03

UniProtKB/Swiss-Prot: O2AG2_HUMAN, A6NM03

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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UniProtKB/Swiss-Prot: O2AG2_HUMAN, A6NM03

Function: Odorant receptor (Potential)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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Gene
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		GenScript cDNA clone with any tag delivered in your preferred vector: OR2AG2
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Cell
Lines:

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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

About this table

OR2AG2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

OR2AG2 for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for OR2AG2):

hsa04740 Olfactory transduction

SABiosciences Custom Pathway-Focused PCR Arrays for OR2AG2

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR2AG2

5/191 Interacting proteins for OR2AG2 (ENSP00000342697³) via UniProtKB, MINT, and/or STRING (see all 191)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
OR10G4	ENSP00000325076³	STRING: ENSP00000364161 STRING: ENSP00000325076
ENSG00000204702	ENSP00000366376³	STRING: ENSP00000366376
ENSG00000229412	ENSP00000366343³	STRING: ENSP00000366343
GNAL	ENSP00000334051³	STRING: ENSP00000334051
GNB1	ENSP00000367872³	STRING: ENSP00000367872

About this table

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

About this table

OR2AG2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR2AG2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR2AG2
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Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: OR2AG2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR2AG2 OriGene untagged cDNA clones in CMV expression vector: OR2AG2 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: OR2AG2

Primers:		OriGene genome-wide validated SYBR primer pairs: OR2AG2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR2AG2: PPH57874A

REFSEQ mRNAs for OR2AG2 gene:

NM_001004490.1

Additional cDNA sequence: BC140734.1

1 DOTS entry:

DT.91849298

1 AceView cDNA sequence:

NM_001004490

highest scoring ESTs for OR2AG2:

EG357714 NM_001004490 BE897401

Unigene Cluster for OR2AG2:

Olfactory receptor, family 2, subfamily AG, member 2

Hs.534614

Unigene Representative Sequence: BC140734

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000338569(uc001meq.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR2AG2 expression in normal and diseased human tissues

¹ Data from GNF BioGPS
About these images

OR2AG2 gene electronic northern expression

About these images

CGAP SAGE TAG: CGGGCCTTGA

SOURCE GeneReport for Unigene cluster: Hs.534614

Primers:		OriGene genome-wide validated SYBR primer pairs: OR2AG2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR2AG2: PPH57874A

SABiosciences Custom PCR Arrays for OR2AG2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR2AG2 gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC466416¹	--	similar to olfactory receptor, family 2, subfamily AG, member 2 less	98.63(n) 98.1(a)	466416 XM_521815.2 XP_521815.2
cow (Bos taurus)	LOC528111¹	--	similar to olfactory receptor	84.84(n) 80.32(a)	528111 XM_606523.3 XP_606523.3
rat (Rattus norvegicus)	Olr218¹	--	olfactory receptor 218	81.54(n) 80.06(a)	365340 NM_001000551.1 NP_001000551.1
mouse (Mus musculus)	Olfr706^{1 , 5}	7 (56.10 cM)⁵	olfactory receptor 706^{1, 5}	82.07(n)¹ 82.28(a)¹	258350¹ NM_146353.1¹ NP_666465.1¹ AY073740⁵ AY317827⁵ (see all 6)

About this table Species with no ortholog for OR2AG2

ENSEMBL Gene Tree for OR2AG2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OR2AG2 gene

OR2T35² OR2T4² OR2T7² OR2T11² OR2T34² OR2T29² OR2T6² OR2T1²

OR2T2² OR2AG1² OR2T5² OR2T3² OR2T10²

OR2AG2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs530667^1,2	F,O	6791894(-)	`TTTGGA/GCTTGT`	1	--	ng5¹		1		MN	184
rs670151^1,2	C,F,O,A,H,	6791151(-)	`AAAGCA/GAGCCA`	1	--	ng5¹		21		MN NA NS EA WA	1324
rs7102536^1,2	C,F,H,	6790106(+)	`TAGCAC/TAGAGC`	2	Y C	ref¹ mis¹		19		EA NA NS WA	1070
rs7103980^1,2	--	6791393(+)	`tcaatA/Caatat`	1	--	ng5¹ tfbs³		0	--	--	--	--
rs7924459^1,2	C,A	6789294(+)	`GGCCCC/GCATGA`	2	R G	ref¹ mis¹ ese³		4		NA WA	8
rs7936463^1,2	C,A,	6788779(+)	`CCTCTA/GTTAGT`	1	--	ng3¹		6		NA EA WA	216
rs10839616^1,2	C,F,A,H,	6790028(+)	`GGAGCC/GGGGCT`	2	P R	mis¹ ref¹ ese³		12		NA NS EA WA	572
rs11041009^1,2	C,F,	6792058(+)	`TCAAAA/GAGAAG`	1	--	ng5¹ trp³		31		NS EA NA WA	3368
rs11443145^1,2	--	6791634(+)	`ATTAA-/AAAAAA`	1	--	ng5¹ trp³		0	--	--	--	--
rs11825348^1,2	C,F,A,H,	6792036(+)	`CACCAC/GATGTT`	1	--	ng5¹		11		EA NA WA	434

About this table

HapMap Linkage Disequilibrium images for OR2AG2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR2AG2: --

QIAGEN SeqTarget long-range PCR primers for resequencing OR2AG2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

4 PubMed articles for OR2AG2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR2AG2)

Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
The human olfactory receptor gene family. (PubMed id 14983052)¹ Malnic B.... Buck L.B. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)¹ Fuchs T.... Shamir R. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 338755	HGNC: 15143	AceView: OR2AG2	Ensembl:ENSG00000188124	euGenes: HUgn338755
ECgene: OR2AG2	Kegg: 338755	H-InvDB: OR2AG2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
HORDE entry for OR2AG2	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR2AG2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for OR2AG2 gene:
Search GeneIP for patents involving OR2AG2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR2AG2
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	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR2AG2

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OR2AG2 Gene

protein-coding GIFtS: 41

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OR2AG2 Gene

protein-coding GIFtS: 41

Aliases & Descriptionsfor OR2AG2 gene

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