Aliases &
Descriptions
for OR2T1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
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|
| Aliases & Descriptions |
|---|
| olfactory receptor, family 2, subfamily T, member 11 2 | | OR1-251 2 3 | | Olfactory receptor 1-252 3 | | Olfactory receptor OR1-612 3 | | olfactory receptor 2T12 | | OTTHUMP000000382682 |
Export aliases for OR2T1 gene to outside databasesPrevious GC identifers: GC01U990267 GC01M243796 GC01P244617 GC01P245467 GC01P244876 GC01P246635 |
Summaries
for OR2T1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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|
Entrez Gene summary for OR2T1:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers theperception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with manyneurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction ofodorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to theolfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)
UniProtKB/Swiss-Prot: OR2T1_HUMAN, O43869Function: Odorant receptor (Potential)
Gene Wiki entry for OR2T1 |
Genomic Views
for OR2T1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the OR2T1 gene promoter:
GR-alpha TBP PPAR-gamma2 PPAR-gamma1 MEF-2A Tal-1beta ITF-2 TFIID Pax-2 SRF
Other transcription factors
Search SABiosciences Chromatin IP Primers for OR2T1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q44 Ensembl cytogenetic band: 1q44 HGNC cytogenetic band: 1q44OR2T1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P248569: view genomic region
(about GC identifiers)
Start:
|
248,569,449 bp from pter |
End:
|
248,570,402 bp from pter |
Size:
|
954 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000001.10 NT_167186.1
|
Proteins
for OR2T1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: OR2T1_HUMAN, O43869 (See
protein sequence)Recommended Name: Olfactory receptor 2T1 Size: 369 amino acids; 41996 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Caution: It is uncertain whether Met-1 or Met-52 is the initiator
Secondary accessions: Q6IEZ9Explore the universe of human proteins at neXtProt for OR2T1: NX_O43869
REFSEQ proteins: NP_112166.1
ENSEMBL proteins: ENSP00000355430 ENSP00000308089
Human Recombinant Proteins
2 Gene Ontology (GO) cellular component terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005886 | plasma membrane |
TAS | -- | | GO:0016021 | integral to membrane |
IEA | -- |
About this table
OR2T1 for ontologies About GeneDecksing
Antibodies for OR2T1:
Assays for OR2T1: |
Protein
Domains/
Families
for OR2T1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OR2T1 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry O43869ProtoNet protein and cluster: O43869 1 Blocks protein family: IPB000725 Olfactory receptor signature
UniProtKB/Swiss-Prot: OR2T1_HUMAN, O43869Similarity: Belongs to the G-protein coupled receptor 1 family |
Gene Function
for OR2T1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: OR2T1_HUMAN, O43869Function: Odorant receptor (Potential)
Genatlas biochemistry entry for OR2T1:olfactory receptor,family 2,subfamily T,member 1,G protein coupled receptor superfamily2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004872 | receptor activity |
IEA | -- | | GO:0004984 | olfactory receptor activity |
IEA | -- |
About this table
OR2T1 for ontologies About GeneDecksing
|
Pathways & Interactions
for OR2T1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
OR2T1 for pathways About GeneDecksing
1  Kegg Pathway (Kegg details for OR2T1):
SABiosciences Custom Pathway-Focused PCR Arrays for OR2T1
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR2T1
5/191 Interacting proteins for OR2T1 (ENSP000003554303) via UniProtKB, MINT, and/or STRING (see all 191)About this table
3 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007186 | G-protein coupled receptor protein signaling pathway |
-- | -- | | GO:0007608 | sensory perception of smell |
IEA | -- | | GO:0050896 | response to stimulus |
IEA | -- |
About this table
OR2T1 for ontologies About GeneDecksing
|
Drugs & Compounds
for OR2T1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for OR2T1
|
Transcripts
for OR2T1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for OR2T1 gene: NM_030904.1
 highest scoring ESTs for OR2T1:NM_030904 NM_001005471 Unigene Cluster for OR2T1: Olfactory receptor, family 2, subfamily T, member 1 Hs.626885 Unigene Representative Sequence: NM_030904
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000366474(uc010pzm.1) ENST00000310206
|
Expression
for OR2T1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| OR2T1 expression in normal and diseased human tissues
1 Data from GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.626885
SABiosciences Custom PCR Arrays for OR2T1
|
Orthologs
for OR2T1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OR2T1 gene from 5 species
About this table Species with no ortholog for OR2T1
ENSEMBL Gene Tree for OR2T1 (if available) |
Paralogs
for OR2T1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for OR2T1 gene
- OR2T352 OR2T42 OR2T72 OR2T112 OR2T342 OR2T292 OR2T62 OR2T22
- OR2AG22 OR2T52 OR2AG12 OR2T32 OR2T102
OR2T1 for paralogs About GeneDecksing
|
Genomic Variants
for OR2T1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 1 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for OR2T1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 14 variations for OR2T1
14 CNVs: 34797 84991 8935 34795 84988 74991 34796 84993 8355 74993 74990 3340 8354 84992 | | QIAGEN SeqTarget long-range PCR primers for resequencing OR2T1 |
|
Disorders & Mutations
for OR2T1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for OR2T1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for OR2T1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
4 PubMed articles for OR2T1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR2T1)- Distribution of olfactory receptor genes in the human genome. (PubMed id 9500546)1, 2, 3 Rouquier S.... Giorgi D. (1998)
- The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
- DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)1, 2 Fuchs T.... Shamir R. (2002)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
|
External Searches for OR2T1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing OR2T1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OR2T1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OR2T1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| HORDE entry for OR2T1 | The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science |
|
| | |
About This Section
| Patent Information for OR2T1 gene:
Search GeneIP for patents involving OR2T1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OR2T1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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