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OR6B2 Gene

protein-coding   GIFtS: 40

GC02M240968
olfactory receptor, family 6, subfamily B, member 2
(Previous names: olfactory receptor, family 6, subfamily B, member 2 pseudogene )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: OR6B2P)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 6, subfamily B, member 21 2     OTTHUMP000002016002
olfactory receptor, family 6, subfamily B, member 2 pseudogene1 2     OR2-12
Olfactory receptor OR2-12 3     olfactory receptor 6B22
OR6B2P2 3     

External Ids:    HGNC: 150411   Entrez Gene: 3890902   Ensembl: ENSG000001820837   UniProtKB: Q6IFH43   

Export aliases for OR6B2 gene to outside databases

Previous GC identifers: GC02U900763 GC02M240690 GC02M240617


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR6B2:
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the
perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors
(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many
neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of
odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the
olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: OR6B2_HUMAN, Q6IFH4
Function: Odorant receptor (Potential)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the OR6B2 gene promoter:
         c-Rel   AhR   ATF-2   c-Jun   CREB   deltaCREB   LCR-F1   CUTL1   NF-E2   NF-E2 p45   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for OR6B2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for OR6B2 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q37.3   Ensembl cytogenetic band:  2q37.3   HGNC cytogenetic band: 2q37.3

OR6B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6B2 gene location

GeneLoc gene densities for chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M240968:  view genomic region     (about GC identifiers)

Start:
240,968,911 bp from pter
End:
240,969,846 bp from pter
Size:
936 bases
Orientation:
minus strand
RefSeq DNA sequence:
NC_000002.11  NT_005416.13  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: OR6B2_HUMAN, Q6IFH4 (See protein sequence)
Recommended Name: Olfactory receptor 6B2  
Size: 312 amino acids; 35029 Da
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=DAA04686.1; Type=Erroneous initiation;
Secondary accessions: B2RPR3 Q8NGW0

Explore the universe of human proteins at neXtProt for OR6B2: NX_Q6IFH4 

REFSEQ proteins: NP_001005853.1  

ENSEMBL proteins: 
ENSP00000328013 ENSP00000384563 


Human Recombinant Proteins 
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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0005886 plasma membrane TAS--
GO:0016021 integral to membrane IEA--
About this table

OR6B2 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR6B2 for domains           About GeneDecksing

4 InterPro domains/families:
 IPR017452 GPCR_Rhodpsn_supfam
 IPR015539 Olfact_rcpt_MOR103
 IPR000725 Olfact_rcpt
 IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q6IFH4

ProtoNet protein and cluster: Q6IFH4

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR6B2_HUMAN, Q6IFH4
Similarity: Belongs to the G-protein coupled receptor 1 family


(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: OR6B2_HUMAN, Q6IFH4
Function: Odorant receptor (Potential)

Inhib.
RNA:
    
Browse for Gene Knock-down Tools from Millipore
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miRNA:Browse microRNA Mimics at Sigma-Aldrich
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QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR6B2 
Search SABiosciences for Assays for microRNAs that regulate OR6B2

Gene
Editing:
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Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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OriGene GFP tagged cDNA clones in CMV expression vector: OR6B2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR6B2
OriGene untagged cDNA clones in CMV expression vector: OR6B2
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Cell
Lines:
  
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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0004872 receptor activity IEA--
GO:0004984 olfactory receptor activity IEA--
About this table

OR6B2 for ontologies           About GeneDecksing


(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section


OR6B2 for pathways           About GeneDecksing

1 Kegg Pathway  (Kegg details for OR6B2):
    hsa04740 Olfactory transduction

    SABiosciences Custom Pathway-Focused PCR Arrays for OR6B2 

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR6B2

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO IDQualified GO termEvidencePubMed IDs
GO:0007186 G-protein coupled receptor protein signaling pathway ----
GO:0007608 sensory perception of smell IEA--
GO:0050896 response to stimulus IEA--
About this table

OR6B2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section
Browse Small Molecules at Sigma-Aldrich
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR6B2


(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib.
RNA:
     
Browse for Gene Knock-down Tools from Millipore
Browse Nano Scale siRNA at Sigma-Aldrich
Sigma-Aldrich esiRNA and siRNA for OR6B2
Browse shRNA at Sigma-Aldrich
OriGene 29mer shRNA kits in GFP-retroviral vector: OR6B2
OriGene shRNA RFP: OR6B2
OriGene basic RS shRNA: OR6B2
OriGene siRNA: OR6B2
QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR6B2 
miRNA: Browse microRNA Mimics at Sigma-Aldrich
Browse microRNA target validation systems at Sigma-Aldrich 
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR6B2 
Search SABiosciences for Assays for microRNAs that regulate OR6B2
Clones: Browse FLAG tag genes at Sigma-Aldrich
OriGene GFP tagged cDNA clones in CMV expression vector: OR6B2
OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR6B2
OriGene untagged cDNA clones in CMV expression vector: OR6B2
Browse 3'-UTR reporter clones for miRNA target validation 
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GenScript cDNA clone with any tag delivered in your preferred vector: OR6B2 
Primers: OriGene genome-wide validated SYBR primer pairs: OR6B2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for OR6B2: PPH24380A

REFSEQ mRNAs for OR6B2 gene: 

NM_001005853.1  

Additional cDNA sequence: 

BC065821.1 BC137561.1 BC137562.1 

1 DOTS entry:

DT.99965559 

highest scoring ESTs for OR6B2:

XM_371606 BC065821 BQ893658 NM_001005853 

Unigene Cluster for OR6B2:

Olfactory receptor, family 6, subfamily B, member 2
Hs.531343
Unigene Representative Sequence: BC065821


GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000329042(uc002vyr.2) ENST00000402971(uc010zoc.1)

(Experimental results according to 1GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR6B2 expression in normal and diseased human tissues

1 Data from GNF BioGPS
    About these images

OR6B2 gene expression
OR6B2 gene electronic northern expression
OR6B2 gene sage expression
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.531343
Primers: OriGene genome-wide validated SYBR primer pairs: OR6B2
Browse OriGene validated miRNA SYBR primer pairs 
SABiosciences RT2 qPCR Primer Assay for OR6B2: PPH24380A
    SABiosciences Custom PCR Arrays for OR6B2 


(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR6B2 gene from 5 species
Organism Gene Locus Description Human
Similarity
NCBI accessions
dog
(Canis familiaris)
LOC6082531   -- similar to olfactory receptor Olr1343 87.33(n)
83.33(a)
608253  XM_845221.1  XP_850314.1 
chimpanzee
(Pan troglodytes)
LOC4706981   -- similar to TPA_exp: olfactory receptor OR2-2 98.72(n)
97.76(a)
470698  XM_526081.2  XP_526081.2 
cow
(Bos taurus)
LOC6188171   -- similar to olfactory receptor 1416 89.11(n)
85.81(a)
618817  XM_871140.2  XP_876233.2 
rat
(Rattus norvegicus)
Olr13431   -- olfactory receptor 1343 86.26(n)
86.36(a)
405982  NM_001001088.1  NP_001001088.1 
mouse
(Mus musculus)
Olfr14161 , 5 1 (46.43 cM)5
olfactory receptor 14161, 5 86.56(n)1
86.45(a)1
2590401  NM_147038.11  NP_667249.11 
 AY0730505  AY3186335  (see all 7)
About this table        Species with no ortholog for OR6B2

ENSEMBL Gene Tree for OR6B2 (if available)

(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
Paralogs for OR6B2 gene
OR6B12  OR6Q12  OR6Y12  OR6B32  OR11L12  OR6A22  OR6P12  

OR6B2 for paralogs           About GeneDecksing



(SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

10/41 NCBI SNPs in OR6B2 are shown (see all 41)
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidChr 2 posSequenceRecsAA
Chg
TypeMoreRecsAllele
freq
PopTotal
sample
More
----------
rs8740601,2
C,F,A,240971450(+) agatcT/Ctccat 1 -- ng5119Minor allele frequency- C:0.45NS EA NA WA 1270
rs101875741,2
C,H,240969312(+) GTCACG/AGAAGA 2 /R /C mis1 ref1 ese31Minor allele frequency- A:0.50NA 2
rs101875851,2
C,A240969340(+) GAGCCA/GCAGAA 2 C syn1 ref1 ese30--------
rs109335511,2
C,F,A,H,240970382(+) GCTCTC/GGGGGA 1 -- ng518Minor allele frequency- G:0.46NA EA WA 222
rs109335521,2
C,F,A,240971519(+) attgaT/Cattgg 1 -- ng51 tfbs318Minor allele frequency- C:0.22NS EA NA WA 1476
rs118902831,2
C,F,H,240970402(+) CAGGTG/CGGGGA 1 -- ng51 trp31Minor allele frequency- C:0.50NA 4
rs118966821,2
C,F,A,H,240970422(+) TAGCCG/ACAGCC 1 -- ng512Minor allele frequency- A:0.50NA WA 6
rs130254771,2
C,F,240971822(+) AGAACG/AGATGT 1 -- ng5110Minor allele frequency- A:0.09NS EA NA 778
rs134095681,2
C,F,240968700(+) TGATCT/CGGGAG 1 -- ng314Minor allele frequency- C:0.17NA EA WA 164
rs346342691,2
--240971510(+) AGTAA-/GGGGAT 1 -- ng510--------
About this table

HapMap Linkage Disequilibrium images for OR6B2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for OR6B2
     1 CNV: 0031

Search QIAGEN SeqTarget long-range PCR primers for resequencing for OR6B2 

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(Possibly Related Articles in Doctor's Guide)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
About This Section

4 PubMed articles for OR6B2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR6B2)
  1. The human olfactory receptor gene family. (PubMed id 14983052)1, 2 Malnic B.... Buck L.B. (2004)
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  4. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 389090 HGNC: 15041 Ensembl:ENSG00000182083 euGenes: HUgn389090 ECgene: OR6B2 Kegg: 389090
H-InvDB: OR6B2

(According to HUGE)
About This Section
  --

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
HORDE entry for OR6B2 The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from XenneX, Inc.)
About This Section
Patent Information for OR6B2 gene:
Search GeneIP for patents involving OR6B2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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 QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR6B2
 Search QIAGEN SeqTarget long-range PCR primers for resequencing for OR6B2
 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for OR6B2
 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR6B2
 GenScript Custom Purified and Recombinant Proteins Services for OR6B2 GenScript cDNA clones with any tag delivered in your preferred vector for OR6B2
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 Regulatory tfbs in OR6B2 promoter
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