OR6B2 Gene
protein-coding GIFtS : 40
GC02M240968
olfactory receptor, family 6, subfamily B, member 2 (Previous names: olfactory receptor, family 6, subfamily B, member 2 pseudogene )Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database (Previous symbol: OR6B2P )
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Aliases & Descriptionsfor OR6B2 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section Aliases & Descriptions olfactory receptor, family 6, subfamily B, member 21 2 OTTHUMP000002016002 olfactory receptor, family 6, subfamily B, member 2 pseudogene1 2 OR2-12 Olfactory receptor OR2-12 3 olfactory receptor 6B22 OR6B2P2 3
Export aliases for OR6B2 gene to outside databases Previous GC identifers: GC02U900763 GC02M240690 GC02M240617
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Summariesfor OR6B2 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for OR6B2 : Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq) UniProtKB/Swiss-Prot: OR6B2_HUMAN, Q6IFH4 Function : Odorant receptor (Potential)
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Genomic Viewsfor OR6B2 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60) ,
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences )About This Section Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the OR6B2 gene promoter: c-Rel AhR ATF-2 c-Jun CREB deltaCREB LCR-F1 CUTL1 NF-E2 NF-E2 p45 Other transcription factors Search SABiosciences Chromatin IP Primers for OR6B2 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for OR6B2
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2q37.3 OR6B2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M240968: view genomic region
(about GC identifiers )
Start:
240,968,911 bp from pter
End:
240,969,846 bp from pter
Size:
936 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000002.11 NT_005416.13
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Proteinsfor OR6B2 gene
(According to
1 UniProtKB ,
neXtProt ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological , and/or
ProSpec ,
Biochemical Assays by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene ,
Antibodies by
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals , and/or
Epitomics )
About This Section UniProtKB/Swiss-Prot: OR6B2_HUMAN, Q6IFH4 (See
protein sequence )Recommended Name: Olfactory receptor 6B2 Size : 312 amino acids; 35029 Da
Subcellular location : Cell membrane; Multi-pass membrane protein
Sequence caution : Sequence=DAA04686.1; Type=Erroneous initiation;
Secondary accessions : B2RPR3 Q8NGW0Explore the universe of human proteins at neXtProt for OR6B2: NX_Q6IFH4
REFSEQ proteins: NP_001005853.1 ENSEMBL proteins: ENSP00000328013 ENSP00000384563 Human Recombinant Proteins 2 Gene Ontology (GO) cellular component terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005886 plasma membrane
TAS -- GO:0016021 integral to membrane
IEA --
About this table
OR6B2 for ontologies About GeneDecksing Antibodies for OR6B2: Assays for OR6B2:
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Protein
Domains/ Familiesfor OR6B2 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
OR6B2 for domains About GeneDecksing 4 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q6IFH4 ProtoNet protein and cluster: Q6IFH4
1 Blocks protein family : IPB000725 Olfactory receptor signature UniProtKB/Swiss-Prot: OR6B2_HUMAN, Q6IFH4 Similarity : Belongs to the G-protein coupled receptor 1 family
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Gene Functionfor OR6B2 gene
(According to UniProtKB ,
IUBMB ,and/or
Genatlas , Animal models from MGI Dec 24 2010,
shRNA from
OriGene ,
Sigma-Aldrich ,
RNAi from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Clones from Millipore ,
Sigma-Aldrich ,
OriGene ,
GenScript ,
Sino Biological ,
Cell Lines from GenScript ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene .)
About This Section UniProtKB/Swiss-Prot: OR6B2_HUMAN, Q6IFH4 Function : Odorant receptor (Potential)
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0004872 receptor activity
IEA -- GO:0004984 olfactory receptor activity
IEA --
About this table
OR6B2 for ontologies About GeneDecksing
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Pathways & Interactionsfor OR6B2 gene
(Pathways according to
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
PCR Arrays from
SABiosciences ,
Proteins Network according to
SABiosciences ,
Sigma-Aldrich ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene) .
About This Section
OR6B2 for pathways About GeneDecksing 1 Kegg Pathway (Kegg details for OR6B2) : SABiosciences Custom Pathway-Focused PCR Arrays for OR6B2 Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OR6B2 3 Gene Ontology (GO) biological process terms (GO ID links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007186 G-protein coupled receptor protein signaling pathway
-- -- GO:0007608 sensory perception of smell
IEA -- GO:0050896 response to stimulus
IEA --
About this table
OR6B2 for ontologies About GeneDecksing
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Drugs & Compoundsfor OR6B2 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
About This Section Browse Tocris compounds for OR6B2
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Transcriptsfor OR6B2 gene (GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
Millipore ,
siRNAs from
Sigma-Aldrich ,
OriGene ,
Qiagen ,
Super-pooled esiRNAs from Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
microRNA from Sigma-Aldrich ,
Qiagen ,
SABiosciences ,
Tagged/untagged cDNA clones from
OriGene ,
Sigma-Aldrich ,
GenScript ,
Primers from
OriGene and/or
SABiosciences )About This Section REFSEQ mRNAs for OR6B2 gene: NM_001005853.1
Additional cDNA sequence: BC065821.1 BC137561.1 BC137562.1
1 DOTS entry : DT.99965559
highest scoring ESTs for OR6B2 :XM_371606 BC065821 BQ893658 NM_001005853 Unigene Cluster for OR6B2:
Olfactory receptor, family 6, subfamily B, member 2 Hs.531343 Unigene Representative Sequence: BC065821 GeneLoc Exon Structure 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000329042 (uc002vyr.2 ) ENST00000402971 (uc010zoc.1 )
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Expression for OR6B2 gene
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Primers from
OriGene and/or
SABiosciences
)
About This Section OR6B2 expression in normal and diseased human tissues 1 Data from GNF BioGPS About these images
About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.531343 SABiosciences Custom PCR Arrays for OR6B2
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Orthologsfor OR6B2 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
About This Section
Orthologs for OR6B2 gene from 5 species
About this table Species with no ortholog for OR6B2 ENSEMBL Gene Tree for OR6B2 (if available)
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Paralogsfor OR6B2 gene (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section Paralogs for OR6B2 gene OR6B1 2 OR6Q1 2 OR6Y1 2 OR6B3 2 OR11L1 2 OR6A2 2 OR6P1 2
OR6B2 for paralogs About GeneDecksing
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Genomic Variantsfor OR6B2 gene (SNPs according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Resequencing Primers from Qiagen )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Chr 2 pos Sequence Recs AA Chg Type More Recs Allele freq Pop Total sample More
About this table HapMap Linkage Disequilibrium images for OR6B2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for OR6B2 1 CNV : 0031
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Disorders & Mutationsfor OR6B2 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
LSDB, HGMD, GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section --
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Medical Newsfor OR6B2 gene (Possibly Related Articles in
Doctor's Guide )
About This Section --
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Publicationsfor OR6B2 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 UniProtKB/TrEMBL , and/or
7 Novoseek )
About This Section 4 PubMed articles for OR6B2 gene integrated from 7 sources : (articles sorted by number of sources associating them with OR6B2) The human olfactory receptor gene family. (PubMed id 14983052) 1 , 2 Malnic B.... Buck L.B. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000)
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External Searches for OR6B2 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing OR6B2 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing OR6B2 gene
(According to HUGE )
About This Section --
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Specialized Databases showing OR6B2 gene (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
HORDE entry for OR6B2 The H uman O lfactory R eceptor D ata E xplorer at the Weizmann Institute of Science
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About This Section Patent Information for OR6B2 gene: Search GeneIP for patents involving OR6B2 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor OR6B2 gene (Antibodies, recombinant proteins, and assays by Millipore , Sigma-Aldrich , R&D Systems , Qiagen , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Epitomics , ProSpec , Uscn , Clones available from Millipore , Sigma-Aldrich , OriGene , GenScript , Sino Biological , PCR Arrays from SABiosciences , Drugs and/or compounds by Sigma-Aldrich , Tocris Bioscience , and/or
Enzo Life Sciences )About This Section
Search Tocris compounds for OR6B2
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