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OR6P1 Gene

protein-coding GIFtS: 30

GC01M158532

olfactory receptor, family 6, subfamily P, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 6, subfamily P, member 1¹ ²
Olfactory receptor OR1-12² ³
olfactory receptor 6P1²
seven transmembrane helix receptor²

External Ids:	HGNC: 15036¹	Entrez Gene: 128366²	Ensembl: ENSG00000186440⁷	UniProtKB: Q8NGX9³

Export aliases for OR6P1 gene to outside databases

Previous GC identifers: GC01U990384 GC01M155750 GC01M155345 GC01M156799

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR6P1:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: OR6P1_HUMAN, Q8NGX9

Function: Odorant receptor (Potential)

Gene Wiki entry for OR6P1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for OR6P1
Other transcription factors

Search SABiosciences Chromatin IP Primers for OR6P1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q23.1 Ensembl cytogenetic band: 1q23.1 HGNC cytogenetic band: 1q23.1

OR6P1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6P1 gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M158532: view genomic region (about GC identifiers)

Start:	158,532,444 bp from pter
End:	158,533,394 bp from pter
Size:	951 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000001.10 NT_004487.19

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: OR6P1_HUMAN, Q8NGX9 (See protein sequence)

Recommended Name: Olfactory receptor 6P1

Size: 317 amino acids; 35831 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q6IFR9

Explore the universe of human proteins at neXtProt for OR6P1: NX_Q8NGX9

REFSEQ proteins: NP_001153797.1

ENSEMBL proteins:

ENSP00000334721

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

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OR6P1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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OR6P1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_supfam

IPR015539 Olfact_rcpt_MOR103

IPR000725 Olfact_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGX9

ProtoNet protein and cluster: Q8NGX9

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR6P1_HUMAN, Q8NGX9

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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UniProtKB/Swiss-Prot: OR6P1_HUMAN, Q8NGX9

Function: Odorant receptor (Potential)

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Gene
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Cell
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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

About this table

OR6P1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
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SABiosciences Custom Pathway-Focused PCR Arrays for OR6P1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR6P1

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

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OR6P1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
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Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
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Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
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Primers:		OriGene genome-wide validated SYBR primer pairs: OR6P1 Browse OriGene validated miRNA SYBR primer pairs
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REFSEQ mRNAs for OR6P1 gene:

NM_001160325.1

Unigene Cluster for OR6P1:

Olfactory receptor, family 6, subfamily P, member 1

Hs.723122

Unigene Representative Sequence: NM_001160325

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000334632(uc010pim.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
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OR6P1 expression in normal and diseased human tissues

¹ Data from GNF BioGPS
About these images

OR6P1 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.723122

Primers:		OriGene genome-wide validated SYBR primer pairs: OR6P1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for OR6P1

SABiosciences Custom PCR Arrays for OR6P1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR6P1 gene from 1 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
mouse (Mus musculus)	Olfr414⁵	1 (81.01 cM)	olfactory receptor 414	--	BC106816

About this table Species with no ortholog for OR6P1

ENSEMBL Gene Tree for OR6P1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for OR6P1 gene

OR6B1² OR6Q1² OR6Y1² OR6B3² OR11L1² OR6A2² OR6B2²

OR6P1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs863343^1,2	C,F,	158534385(+)	`tgcccA/Gcagcc`	1	--	ng5¹		10		NS EA NA	906
rs863344^1,2	C,F,O,	158534831(+)	`GCATAG/ATTTTA`	1	--	ng5¹ tfbs³		15		NS EA NA	1138
rs863345^1,2	C,F,	158534982(+)	`ATCTAT/CTTTTT`	1	--	ng5¹		16		NS EA NA WA	1064
rs7512117^1,2	C,F,A,H,	158532064(+)	`ACTTAT/CGAAAT`	1	--	ng3¹		5		NA EA WA	220
rs7526514^1,2	C,F,A,	158532405(+)	`AAGATG/TCTGCT`	1	--	ng3¹		11		NA EA WA	362
rs7534112^1,2	C,F,A,H,	158532065(+)	`CTTACA/GAAATA`	1	--	ng3¹		6		NA EA WA	222
rs7534319^1,2	C,F,A,H,	158532295(+)	`ATAAAC/GTTTCA`	1	--	ng3¹		20		NS NA EA WA	884
rs10489836^1,2	C,F,	158532183(+)	`AGACTC/TTCCAC`	1	--	ng3¹		18		NS EA NA	1082
rs10489837^1,2	C,F,	158533017(+)	`CCACAG/AATGGC`	2	/I	ref¹ syn¹ ese³		9		NS EA	524
rs12037467^1,2	--	158532042(+)	`TTTTCG/TCATAT`	1	--	ng3¹		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for OR6P1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR6P1: --

QIAGEN SeqTarget long-range PCR primers for resequencing OR6P1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

4 PubMed articles for OR6P1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR6P1)

The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{1, 2} Gregory S.G.... Bentley D.R. (2006)
The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
A probabilistic classifier for olfactory receptor pseudogenes. (PubMed id 16939646)¹ Menashe I....Lancet D. (2006)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 128366	HGNC: 15036	Ensembl:ENSG00000186440	euGenes: HUgn128366	ECgene: OR6P1
H-InvDB: OR6P1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
HORDE entry for OR6P1	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR6P1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for OR6P1 gene:
Search GeneIP for patents involving OR6P1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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OR6P1 Gene

protein-coding GIFtS: 30

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OR6P1 Gene

protein-coding GIFtS: 30

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