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OR6Q1 Gene

protein-coding GIFtS: 38

GC11P057798

olfactory receptor, family 6, subfamily Q, member 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 6, subfamily Q, member 1¹ ²
Olfactory receptor OR11-226² ³
olfactory receptor 6Q1²
OR11-226²

External Ids:	HGNC: 15302¹	Entrez Gene: 219952²	Ensembl: ENSG00000172381⁷	UniProtKB: Q8NGQ2³

Export aliases for OR6Q1 gene to outside databases

Previous GC identifers: GC11U990412 GC11P057574 GC11P057555

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR6Q1:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: OR6Q1_HUMAN, Q8NGQ2

Function: Odorant receptor (Potential)

Gene Wiki entry for OR6Q1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR6Q1 gene promoter:
         AREB6
         Other transcription factors

Search SABiosciences Chromatin IP Primers for OR6Q1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q12.1

OR6Q1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR6Q1 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P057798: view genomic region (about GC identifiers)

Start:	57,798,425 bp from pter
End:	57,799,375 bp from pter
Size:	951 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000011.9 NT_167190.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: OR6Q1_HUMAN, Q8NGQ2 (See protein sequence)

Recommended Name: Olfactory receptor 6Q1

Size: 317 amino acids; 35736 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: B9EKW1 Q6IFH1 Q96R34

Explore the universe of human proteins at neXtProt for OR6Q1: NX_Q8NGQ2

REFSEQ proteins: NP_001005186.2

ENSEMBL proteins:

ENSP00000307734

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

About this table

OR6Q1 for ontologies About GeneDecksing

Antibodies for OR6Q1:

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Assays for OR6Q1:

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	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR6Q1 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_supfam

IPR000725 Olfact_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NGQ2

ProtoNet protein and cluster: Q8NGQ2

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR6Q1_HUMAN, Q8NGQ2

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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UniProtKB/Swiss-Prot: OR6Q1_HUMAN, Q8NGQ2

Function: Odorant receptor (Potential)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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Gene
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Cell
Lines:

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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

About this table

OR6Q1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

OR6Q1 for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for OR6Q1):

hsa04740 Olfactory transduction

SABiosciences Custom Pathway-Focused PCR Arrays for OR6Q1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR6Q1

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

About this table

OR6Q1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR6Q1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for OR6Q1 Browse shRNA at Sigma-Aldrich
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): OR6Q1 OriGene shRNA RFP (see all 2): OR6Q1 OriGene basic RS shRNA (see all 2): OR6Q1 OriGene siRNA (see all 2): OR6Q1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR6Q1

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR6Q1
		Search SABiosciences for Assays for microRNAs that regulate OR6Q1

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: OR6Q1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR6Q1 OriGene untagged cDNA clones in CMV expression vector: OR6Q1 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for OR6Q1

Primers:		OriGene genome-wide validated SYBR primer pairs: OR6Q1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR6Q1: PPH60370A

REFSEQ mRNAs for OR6Q1 gene:

NM_001005186.2

Additional cDNA sequence:

BC151146.1 BC151147.1

1 AceView cDNA sequence:

NM_001005186

highest scoring ESTs for OR6Q1:

NM_001005186 BI772562

Unigene Cluster for OR6Q1:

Olfactory receptor, family 6, subfamily Q, member 1

Hs.690432

Unigene Representative Sequence: BC151146

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000302622(uc010rjz.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR6Q1 expression in normal and diseased human tissues

¹ Data from GNF BioGPS
About these images

OR6Q1 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.690432

Primers:		OriGene genome-wide validated SYBR primer pairs: OR6Q1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR6Q1: PPH60370A

SABiosciences Custom PCR Arrays for OR6Q1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR6Q1 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC483486¹	--	similar to Olfactory receptor 6Q1	87.28(n) 89.27(a)	483486 XM_540604.1 XP_540604.1
chimpanzee (Pan troglodytes)	LOC466592¹	--	similar to seven transmembrane helix receptor	98.84(n) 97.48(a)	466592 XM_001145378.1 XP_001145378.1
cow (Bos taurus)	LOC511777¹	--	similar to Olfactory receptor 6Q1	78.79(n) 77.92(a)	511777 XM_589176.3 XP_589176.3
rat (Rattus norvegicus)	Olr1765¹	--	olfactory receptor 1765	54.86(n) 46.36(a)	302821 NM_001000489.1 NP_001000489.1
mouse (Mus musculus)	Olfr1321^{1 , 5}	X (26.04 cM)⁵	olfactory receptor 1321^{1, 5}	55.85(n)¹ 45.25(a)¹	236785¹ NM_207631.1¹ NP_997514.1¹ AY318526⁵ BC119046⁵ (see all 6)

About this table Species with no ortholog for OR6Q1

ENSEMBL Gene Tree for OR6Q1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OR6Q1 gene

OR6B1² OR6Y1² OR6B3² OR11L1² OR6A2² OR6B2² OR6P1²

OR6Q1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

UniProtKB/Swiss-Prot: OR6Q1_HUMAN, Q8NGQ2

Polymorphism: A single nucleotide deletion at position Leu-229 in the gene coding for this protein is responsible for

functional diversity thus producing a pseudogene. The deletion is more frequent in African-Americans than in

non-Africans

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs921135^1,2	C,F,A,H,	57798723(+)	`TGCTGA/GTTGCC`	2	D G	ref¹ mis¹		16		NS EA NA WA	1198
rs986053^1,2	C,F,A,H,	57796787(+)	`cctttC/Tcacag`	1	--	ng5¹		3		EA WA NA	142
rs1374570^1,2	C,F,A,	57799371(+)	`GAAGGG/CACAGT`	2	/A /G	mis¹ ref¹ ese³		16		MN NS EA NA WA	1240
rs2441958^1,2	C,F,	57796758(+)	`CTGAGG/AGACTT`	1	--	ng5¹		4		NA EA WA	212
rs2441959^1,2	C,F,	57797131(+)	`CTCATG/AGTCAC`	1	--	ng5¹		1		WA	50
rs2441960^1,2	C,F,A,	57797192(+)	`ACCCAA/GTTATG`	1	--	ng5¹		4		NA EA WA	212
rs2513705^1,2	C,F,	57796752(-)	`CTCAGG/CCCTCA`	1	--	ng5¹		3		NA EA	162
rs2513726^1,2	C,F,A,H,	57798942(+)	`ATTTTA/GTGGCC`	2	Y C	ref¹ mis¹ ese³		20		NS EA NA	1702
rs7123727^1,2	C,F,	57799183(+)	`GTGAGC/TCTCTT`	2	S	ref¹ syn¹		6		NA EA WA	216
rs7935880^1,2	C	57797129(+)	`CACTCA/CTGGTC`	1	--	ng5¹ tfbs³		0	--	--	--	--

About this table

HapMap Linkage Disequilibrium images for OR6Q1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR6Q1: --

QIAGEN SeqTarget long-range PCR primers for resequencing OR6Q1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

OR6Q1 for disorders About GeneDecksing

Human Gene Mutation Database (HGMD): OR6Q1

Export disorders and mutations for OR6Q1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

7 PubMed articles for OR6Q1 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR6Q1)

The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)^{1, 2} Fuchs T.... Shamir R. (2002)
Human chromosome 11 DNA sequence and analysis including novel gene identification. (PubMed id 16554811)² Taylor T.D....Sakaki Y. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Different noses for different people. (PubMed id 12730696)² Menashe I.... Gilad Y. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 219952	HGNC: 15302	AceView: OR6Q1	Ensembl:ENSG00000172381	euGenes: HUgn219952
ECgene: OR6Q1	Kegg: 219952	H-InvDB: OR6Q1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
HORDE entry for OR6Q1	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR6Q1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for OR6Q1 gene:
Search GeneIP for patents involving OR6Q1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR6Q1
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OR6Q1 Gene

protein-coding GIFtS: 38

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OR6Q1 Gene

protein-coding GIFtS: 38

Aliases & Descriptionsfor OR6Q1 gene

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