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OR8B2 Gene

protein-coding GIFtS: 36

GC11M124252

olfactory receptor, family 8, subfamily B, member 2
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 8, subfamily B, member 2¹ ²
Olfactory receptor OR11-309² ³
OR11-309²
olfactory receptor 8B2²
olfactory receptor OR11-310²
OR11-310²

External Ids:	HGNC: 8471¹	Entrez Gene: 26595²	Ensembl: ENSG00000204293⁷	UniProtKB: Q96RD0³

Export aliases for OR8B2 gene to outside databases

Previous GC identifers: GC11U990230 GC11M123757

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR8B2:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: OR8B2_HUMAN, Q96RD0

Function: Odorant receptor (Potential)

Gene Wiki entry for OR8B2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR8B2 gene promoter:
         POU3F2   CUTL1   Bach1   NF-E2   NF-E2 p45   POU2F1   c-Jun   Fra-1   AP-1   JunD
         Other transcription factors

Search SABiosciences Chromatin IP Primers for OR8B2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q24.1 Ensembl cytogenetic band: 11q24.2 HGNC cytogenetic band: 11q24.1

OR8B2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR8B2 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M124252: view genomic region (about GC identifiers)

Start:	124,252,301 bp from pter
End:	124,253,239 bp from pter
Size:	939 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.9 NT_033899.8

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: OR8B2_HUMAN, Q96RD0 (See protein sequence)

Recommended Name: Olfactory receptor 8B2

Size: 313 amino acids; 35272 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q8NGH2

Explore the universe of human proteins at neXtProt for OR8B2: NX_Q96RD0

REFSEQ proteins: NP_001005468.1

ENSEMBL proteins:

ENSP00000364152

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

About this table

OR8B2 for ontologies About GeneDecksing

Antibodies for OR8B2:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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OR8B2 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_supfam

IPR000725 Olfact_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q96RD0

ProtoNet protein and cluster: Q96RD0

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR8B2_HUMAN, Q96RD0

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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UniProtKB/Swiss-Prot: OR8B2_HUMAN, Q96RD0

Function: Odorant receptor (Potential)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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Cell
Lines:

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Genatlas biochemistry entry for OR8B2:

olfactory receptor,family 8,subfamily B,member 2,G protein coupled receptor superfamily

2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

About this table

OR8B2 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for OR8B2

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR8B2

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

About this table

OR8B2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

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Browse Tocris compounds for OR8B2

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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		OriGene 29mer shRNA kits in GFP-retroviral vector: OR8B2 OriGene shRNA RFP: OR8B2 OriGene basic RS shRNA: OR8B2 OriGene siRNA: OR8B2
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miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR8B2
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Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: OR8B2 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR8B2 OriGene untagged cDNA clones in CMV expression vector: OR8B2 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
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		SABiosciences RT² qPCR Primer Assay for OR8B2: PPH57892A

REFSEQ mRNAs for OR8B2 gene:

NM_001005468.1

highest scoring ESTs for OR8B2:

AA938983 NM_001005468

Unigene Cluster for OR8B2:

Olfactory receptor, family 8, subfamily B, member 2

Hs.576944

Unigene Representative Sequence: NM_001005468

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000375013(uc010sai.1 uc001qab.3)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR8B2 expression in normal and diseased human tissues

¹ Data from GNF BioGPS
About these images

OR8B2 gene electronic northern expression

About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.576944

Primers:		OriGene genome-wide validated SYBR primer pairs: OR8B2 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR8B2: PPH57892A

SABiosciences Custom PCR Arrays for OR8B2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR8B2 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC489325¹	--	similar to olfactory receptor 906	72.29(n) 72.08(a)	489325 XM_844477.1 XP_849570.1
chimpanzee (Pan troglodytes)	LOC466833¹	--	similar to seven transmembrane helix receptor	98.19(n) 97.12(a)	466833 XM_522233.2 XP_522233.1
cow (Bos taurus)	LOC511657¹	--	similar to seven transmembrane helix receptor	86.95(n) 86.51(a)	511657 XM_589039.3 XP_589039.3
rat (Rattus norvegicus)	Olr1231¹	--	olfactory receptor 1231	83.28(n) 83.39(a)	405099 NM_001000813.1 NP_001000813.1
mouse (Mus musculus)	Olfr147¹	--	olfactory receptor 147	81.58(n) 82.43(a)	258869 NM_146869.1 NP_667080.1

About this table Species with no ortholog for OR8B2

ENSEMBL Gene Tree for OR8B2 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OR8B2 gene

OR8B3¹ ²

OR8B2 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs470202^1,2	--	124252617(-)	`TATCAC/TGGTAC`	2	T M	ref¹ mis¹ ese³		0	--	--	--	--
rs470625^1,2	--	124252626(+)	`TATTAA/GTACCC`	2	T I	ref¹ mis¹ ese³		0	--	--	--	--
rs470787^1,2	--	124254106(+)	`CTATCC/TTGATA`	1	--	ng5¹		0	--	--	--	--
rs480634^1,2	C,F,O,A,	124255126(+)	`CATTTT/CAAGAC`	1	--	ng5¹		9		NA EA WA	358
rs480798^1,2	C,F,A,	124255184(+)	`AAGGCA/GTCTAT`	1	--	ng5¹		10		NS EA NA WA	632
rs503220^1,2	C	124252422(+)	`CAGAAA/GAAACT`	2	S F	ref¹ mis¹ ese³		1		WA	2
rs530704^1,2	C,F,A,	124253147(+)	`ACTAGA/GAACAG`	2	F	syn¹ ref¹ ese³		5		NS EA WA	358
rs530740^1,2	C,F,A,	124253161(+)	`AAAGAG/AGGGTT`	2	/L /F	ref¹ mis¹ trp³		4		EA NS WA	256
rs530765^1,2	C,	124253170(+)	`TTGCCG/AGAACT`	2	/R /W	ref¹ mis¹ ese³		1		WA	2
rs567239^1,2	C,F,O,A,	124254813(+)	`GCAGTA/GTTAGC`	1	--	ng5¹		21		NA NS EA WA	1210

About this table

HapMap Linkage Disequilibrium images for OR8B2 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR8B2: --

QIAGEN SeqTarget long-range PCR primers for resequencing OR8B2

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

3 PubMed articles for OR8B2 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR8B2)

The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
DEFOG: a practical scheme for deciphering families of genes. (PubMed id 12213199)^{1, 2} Fuchs T.... Shamir R. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 26595	HGNC: 8471	Ensembl:ENSG00000204293	euGenes: HUgn26595	ECgene: OR8B2
H-InvDB: OR8B2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
HORDE entry for OR8B2	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR8B2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for OR8B2 gene:
Search GeneIP for patents involving OR8B2

GeneCards and IP:
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(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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OR8B2 Gene

protein-coding GIFtS: 36

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OR8B2 Gene

protein-coding GIFtS: 36

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