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OR8K5 Gene

protein-coding GIFtS: 38

GC11M055926

olfactory receptor, family 8, subfamily K, member 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
olfactory receptor, family 8, subfamily K, member 5¹ ²
Olfactory receptor OR11-174² ³
olfactory receptor 8K5²
OR11-174²

External Ids:	HGNC: 15315¹	Entrez Gene: 219453²	Ensembl: ENSG00000181752⁷	UniProtKB: Q8NH50³

Export aliases for OR8K5 gene to outside databases

Previous GC identifers: GC11U990399 GC11M055683

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for OR8K5:

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the

perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors

(GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many

neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of

odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the

olfactory receptor genes and proteins for this organism is independent of other organisms. (provided by RefSeq)

UniProtKB/Swiss-Prot: OR8K5_HUMAN, Q8NH50

Function: Odorant receptor (Potential)

Gene Wiki entry for OR8K5

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the OR8K5 gene promoter:
         Cdc5   PPAR-gamma2   PPAR-gamma1   POU2F1   FAC1   POU3F2   POU3F2 (N-Oct-5a)   POU3F2 (N-Oct-5b)   Meis-1   HOXA9B
         Other transcription factors

Search SABiosciences Chromatin IP Primers for OR8K5

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.1 Ensembl cytogenetic band: 11q12.1 HGNC cytogenetic band: 11q11

OR8K5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
OR8K5 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M055926: view genomic region (about GC identifiers)

Start:	55,926,873 bp from pter
End:	55,927,793 bp from pter
Size:	921 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000011.9 NT_167190.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: OR8K5_HUMAN, Q8NH50 (See protein sequence)

Recommended Name: Olfactory receptor 8K5

Size: 307 amino acids; 35190 Da

Subcellular location: Cell membrane; Multi-pass membrane protein

Secondary accessions: Q6IFB5

Explore the universe of human proteins at neXtProt for OR8K5: NX_Q8NH50

REFSEQ proteins: NP_001004058.2

ENSEMBL proteins:

ENSP00000323853

Human Recombinant Proteins

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2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

About this table

OR8K5 for ontologies About GeneDecksing

Antibodies for OR8K5:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

OR8K5 for domains About GeneDecksing

3 InterPro domains/families:

IPR017452 GPCR_Rhodpsn_supfam

IPR000725 Olfact_rcpt

IPR000276 7TM_GPCR_Rhodpsn

Graphical View of Domain Structure for InterPro Entry Q8NH50

ProtoNet protein and cluster: Q8NH50

1 Blocks protein family: IPB000725 Olfactory receptor signature

UniProtKB/Swiss-Prot: OR8K5_HUMAN, Q8NH50

Similarity: Belongs to the G-protein coupled receptor 1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
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UniProtKB/Swiss-Prot: OR8K5_HUMAN, Q8NH50

Function: Odorant receptor (Potential)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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Gene
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Cell
Lines:

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2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004872	receptor activity	IEA	--
GO:0004984	olfactory receptor activity	IEA	--

About this table

OR8K5 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

OR8K5 for pathways About GeneDecksing

1 Kegg Pathway (Kegg details for OR8K5):

hsa04740 Olfactory transduction

SABiosciences Custom Pathway-Focused PCR Arrays for OR8K5

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for OR8K5

3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007186	G-protein coupled receptor protein signaling pathway	--	--
GO:0007608	sensory perception of smell	IEA	--
GO:0050896	response to stimulus	IEA	--

About this table

OR8K5 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for OR8K5

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich siRNA for OR8K5 Browse shRNA at Sigma-Aldrich
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): OR8K5 OriGene shRNA RFP (see all 2): OR8K5 OriGene basic RS shRNA (see all 2): OR8K5 OriGene siRNA (see all 2): OR8K5
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of OR8K5

miRNA:		Browse microRNA Mimics at Sigma-Aldrich Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of OR8K5
		Search SABiosciences for Assays for microRNAs that regulate OR8K5

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: OR8K5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: OR8K5 OriGene untagged cDNA clones in CMV expression vector: OR8K5 Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
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Primers:		OriGene genome-wide validated SYBR primer pairs: OR8K5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR8K5: PPH60392A

REFSEQ mRNAs for OR8K5 gene:

NM_001004058.2

1 AceView cDNA sequence:

NM_001004058

highest scoring ESTs for OR8K5:

NM_001004058

Unigene Cluster for OR8K5:

Olfactory receptor, family 8, subfamily K, member 5

Hs.553626

Unigene Representative Sequence: NM_001004058

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000313447(uc010rja.1)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

OR8K5 expression in normal and diseased human tissues

¹ Data from GNF BioGPS
About these images

OR8K5 gene electronic northern expression

About these images

CGAP SAGE TAG: CTTAACCCTT

SOURCE GeneReport for Unigene cluster: Hs.553626

Primers:		OriGene genome-wide validated SYBR primer pairs: OR8K5 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for OR8K5: PPH60392A

SABiosciences Custom PCR Arrays for OR8K5

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for OR8K5 gene from 5 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
chimpanzee (Pan troglodytes)	LOC466549¹	--	similar to seven transmembrane helix receptor	99.11(n) 98.48(a)	466549 XM_521948.2 XP_521948.2
cow (Bos taurus)	LOC790274¹	--	similar to olfactory receptor, family 8, subfamily more	84.6(n) 83.17(a)	790274 XM_001256791.1 XP_001256792.1
rat (Rattus norvegicus)	Olr490¹	--	olfactory receptor 490	79.37(n) 77.2(a)	405253 NM_001000933.1 NP_001000933.1
mouse (Mus musculus)	Olfr1008^{1 , 5}	2 (49.68 cM)⁵	olfactory receptor 1008^{1, 5}	78.72(n)¹ 75.24(a)¹	258866¹ NM_146866.1¹ NP_667077.1¹ AY073224⁵ AY318203⁵
African clawed frog (Xenopus laevis)	AJ250757.1²	--	--	73.15(n)	AJ250757.1

About this table Species with no ortholog for OR8K5

ENSEMBL Gene Tree for OR8K5 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for OR8K5 gene

OR8K3²

OR8K5 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs2512774^1,2	C,F,A,	55926796(+)	`AATTAT/CCAAGT`	1	--	ng3¹		7		NS EA NA WA	476
rs2512938^1,2	C,F,A,	55927591(+)	`CAACAA/GAAGCC`	2	S F	mis¹ ref¹ ese³		13		NS EA NA	1238
rs7480694^1,2	C,F,	55929793(+)	`TCTTAC/TGGAAA`	1	--	ng5¹		6		NA EA WA	216
rs7928039^1,2	C,	55928994(+)	`AAACTA/GTTTCA`	1	--	ng5¹		2		NS WA	170
rs11227400^1,2	C,F,	55929181(+)	`AGTAAC/TGGAAT`	1	--	ng5¹ tfbs³		12		NS EA NA	1000
rs12288084^1,2	H	55929412(+)	`GATGTG/CGGAAG`	1	--	ng5¹ trp³		4		NS EA	412
rs34158282^1,2	--	55928736(+)	`TATCT-/CAAAAA`	1	--	ng5¹		0	--	--	--	--
rs34797061^1,2	C	55926576(+)	`TATTTG/TGGGGA`	1	--	ng3¹		0	--	--	--	--
rs35451824^1,2	--	55928669(+)	`AATTT-/TAAAGC`	1	--	ng5¹		0	--	--	--	--
rs35566076^1,2	C,F,	55928035(+)	`ATCAAT/CATTTG`	1	--	ng5¹		3		NA	96

About this table

HapMap Linkage Disequilibrium images for OR8K5 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for OR8K5: --

QIAGEN SeqTarget long-range PCR primers for resequencing OR8K5

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

2 PubMed articles for OR8K5 gene integrated from 7 sources:
(articles sorted by number of sources associating them with OR8K5)

The human olfactory receptor gene family. (PubMed id 14983052)^{1, 2} Malnic B.... Buck L.B. (2004)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )² Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 219453	HGNC: 15315	AceView: OR8K5	Ensembl:ENSG00000181752	euGenes: HUgn219453
ECgene: OR8K5	Kegg: 219453	H-InvDB: OR8K5

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
HORDE entry for OR8K5	The Human Olfactory Receptor Data Explorer at the Weizmann Institute of Science

Intellectual Property for OR8K5 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for OR8K5 gene:
Search GeneIP for patents involving OR8K5

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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OR8K5 Gene

protein-coding GIFtS: 38

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OR8K5 Gene

protein-coding GIFtS: 38

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