Aliases &
Descriptions
for OSGIN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| oxidative stress induced growth inhibitor 11 2 | | huOKL382 3 | | OKL381 2 3 | | oxidative stress-induced growth inhibitor 12 | | BDGI1 2 | | bone marrow stromal cell-derived growth inhibitor2 | | Ovary, kidney and liver protein 382 3 | | pregnancy induced growth inhibitor2 | | Pregnancy-induced growth inhibitor OKL382 3 | | |
Export aliases for OSGIN1 gene to outside databasesPrevious GC identifers: GC16P082541 GC16P083982 |
Summaries
for OSGIN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0Function: Regulates the differentiation and proliferation of normal cells through the regulation of cell death
|
Genomic Views
for OSGIN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 Search SABiosciences Regulatory transcription factor binding sites for OSGIN1
Other transcription factors
Search SABiosciences Chromatin IP Primers for OSGIN1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.3 Ensembl cytogenetic band: 16q23.3 HGNC cytogenetic band: 16q23.3OSGIN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P069733: view genomic region
(about GC identifiers)
Start:
|
69,733,881 bp from pter |
End:
|
69,751,578 bp from pter |
Size:
|
17,698 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr16+ 83,982,672-83,999,937 |
RefSeq DNA sequence:- NC_000016.9 NT_010498.15
|
Proteins
for OSGIN1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0 (See
protein sequence)Recommended Name: Oxidative stress-induced growth inhibitor 1 Size: 560 amino acids; 60820 Da
Miscellaneous: Loss of OSGIN1 protein disturbs the balance between cell growth, differentiation, and cell death innormal tissue, resulting in uncontrolled growth and formation of tumors
Sequence caution: Sequence=AAF06662.1; Type=Frameshift; Positions=493, 523, 534, 554; Sequence=AAK01722.2;Type=Erroneous gene model prediction;
Secondary accessions: Q86UQ1 Q96S88 Q9BZ70Alternative splicing: 3 isoforms: Q9UJX0-1 Q9UJX0-2 Q9UJX0-3 Explore the universe of human proteins at neXtProt for OSGIN1: NX_Q9UJX0
REFSEQ proteins (3 alternative transcripts):
NP_037502.3 NP_892025.1 NP_892026.1
ENSEMBL proteins: ENSP00000376983 ENSP00000355374 ENSP00000343376
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
About this table
OSGIN1 for ontologies About GeneDecksing
Antibodies for OSGIN1:
Assays for OSGIN1: |
Protein
Domains/
Families
for OSGIN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
OSGIN1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UJX0ProtoNet protein and cluster: Q9UJX0 UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0Similarity: Belongs to the OKL38 family |
Gene Function
for OSGIN1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0Function: Regulates the differentiation and proliferation of normal cells through the regulation of cell deathInduction: By pregnancy
1 Gene Ontology (GO) molecular function term (GO ID links to tree view): About this table
OSGIN1 for ontologies About GeneDecksing
|
Pathways & Interactions
for OSGIN1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including OSGIN1: PAHS-041A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for OSGIN1
4 Gene Ontology (GO) biological process terms (GO ID links to tree view): About this table
OSGIN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for OSGIN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for OSGIN1
|
Transcripts
for OSGIN1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for OSGIN1 gene (3 alternative transcripts): NM_013370.3 NM_182980.2 NM_182981.2 Additional cDNA sequence: AF191740.1 AK290383.1 AY037158.1 AY258066.1 AY258067.1 AY258068.1 BC020434.1 BC032476.1 BC093687.1 BC113417.1 6 DOTS entries: DT.100766000 DT.100787074 DT.100787073 DT.95262661 DT.95262659 DT.100787075 24/201 AceView cDNA sequences (see all 201): CD366665 BQ956581 BC000286 CA844162 AI982883 BM725835 CA867400 BU072788 BC052592 CR626099 CA447981 AW166765 BU741097 AI924315 N74699 CD366355 CK819852 AA825219 BQ012584 BM976436 AI672395 AK124050 AW952184 AI283870
 highest scoring ESTs for OSGIN1:AI814233 AA341901 AA341902 AA401724 AA581497 AA610203 AA632417 AA772635 AF191740 AI139636 Unigene Cluster for OSGIN1: Oxidative stress induced growth inhibitor 1 Hs.128055 [show with all ESTs]Unigene Representative Sequence: NM_013370
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for OSGIN1
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9 | ^ | 10a | · | 10b |
|---|
|
| SP1: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for OSGIN1
3 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000393306(uc002fhc.2) ENST00000361711(uc002fhb.2) ENST00000343939(uc002fha.2)
|
Expression
for OSGIN1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| OSGIN1 expression in normal and diseased human tissues
1 / 2 / 3 3 probe-sets matching OSGIN1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 44580_at2, 3
|
U95-B |
1 |
0.94 |
1.00 |
1.00 |
1.00 |
AI814233 |
1.00 |
0.90 |
0.95 |
1 |
| 219475_at2, 3
|
U133-A |
1 |
0.55 |
1.00 |
-- |
-- |
NM_013370 |
0.60 |
0.83 |
0.73 |
1 |
| 219475_at2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
OSGIN1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: GGGCCGCTGG
SOURCE GeneReport for Unigene cluster: Hs.128055
UniProtKB/Swiss-Prot: OSGI1_HUMAN, Q9UJX0Tissue specificity: Ubiquitous. Highest expression in the ovary, testis, kidney, and liver
SABiosciences Expression via Pathway-Focused PCR Array including OSGIN1: PAHS-041A
|
Orthologs
for OSGIN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for OSGIN1 gene from 5/7 species (see all 7)
About this table Species with no ortholog for OSGIN1
ENSEMBL Gene Tree for OSGIN1 (if available) |
Paralogs
for OSGIN1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for OSGIN1 gene
- OSGIN22
OSGIN1 for paralogs About GeneDecksing
|
Genomic Variants
for OSGIN1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 16 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for OSGIN1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for OSGIN1
6 CNVs: 77443 88251 77444 29665 88249 88250
2 Indels: 45473 77442 | | QIAGEN SeqTarget long-range PCR primers for resequencing OSGIN1 |
|
Disorders & Mutations
for OSGIN1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
OSGIN1 for disorders About GeneDecksing
OMIM: 607975
Human Genome Epidemiology (HuGE) Navigator: OSGIN1 (2 documents)
Export disorders and mutations for OSGIN1 gene to outside databases
|
Medical News
for OSGIN1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for OSGIN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/11 PubMed articles for OSGIN1 gene, integrated from 7 sources (see all 11):
(articles sorted by number of sources associating them with OSGIN1)- Genomic structure of human OKL38 gene and its differential expression in kidney carcinogenesis. (PubMed id 14570898)1, 2, 3 Ong C.K.... Huynh H.T. (2004)
- Cloning and characterization of a novel pregnancy-induced growth inhibitor in mammary gland. (PubMed id 11459809)1, 2, 3 Huynh H.T.... Chan T.W.M. (2001)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Assessment of a polymorphism of SDK1 with hypertensio n in Japanese Individuals. (PubMed id 19851296)1 Oguri M....Yamada Y. (2010)
- Association of genetic variants with hemorrhagic stro ke in Japanese individuals. (PubMed id 20198315)1 Yoshida T....Yamada Y. (2010)
- Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. (PubMed id 18499678)1 Yao H....Wang Y. (2008)
- The role of 5' untranslated region in translational suppression of OKL38 mRNA in hepatocellular carcinoma. (PubMed id 16924236)1 Ong C.K....Huynh H. (2007)
- Bone marrow stromal cell-derived growth inhibitor inhibits growth and migration of breast cancer cells via induction of cell cycle arrest and apoptosis. (PubMed id 15569677)1 Wang T....Cao X. (2005)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1 Bonaldo M.F.... Soares M.B. (1996)
|
External Searches for OSGIN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing OSGIN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing OSGIN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing OSGIN1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for OSGIN1 gene:
Search GeneIP for patents involving OSGIN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for OSGIN1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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