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PAAF1 Gene

protein-coding GIFtS: 47

GC11P069884

proteasomal ATPase-associated factor 1
(Previous name: WD repeat domain 71 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: WDR71)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
proteasomal ATPase-associated factor 1¹ ²		WDR71² ³
FLJ11848¹ ²		WD repeat-containing protein 71² ³
WD repeat domain 71¹ ²		PAAF²
Rpn14¹ ²		Protein G-16³

External Ids:	HGNC: 25687¹	Entrez Gene: 80227²	Ensembl: ENSG00000175575⁷	UniProtKB: Q9BRP4³

Export aliases for PAAF1 gene to outside databases

Previous GC identifers: GC11P073267 GC11P073588

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PAAF1_HUMAN, Q9BRP4

Function: Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory

complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes

the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes

provirus transcription efficiency

Gene Wiki entry for PAAF1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for PAAF1
Other transcription factors

Search SABiosciences Chromatin IP Primers for PAAF1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PAAF1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13.4 Ensembl cytogenetic band: 11q13.4 HGNC cytogenetic band: 11q13.4

PAAF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PAAF1 gene location

GeneLoc gene densities for chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11P069884: view genomic region (about GC identifiers)

Start:	69,884,132 bp from pter
End:	69,934,556 bp from pter
Size:	50,425 bases
Orientation:	plus strand

1 alternative location:

Chr11+ 73,588,033-73,638,779

RefSeq DNA sequence:

NC_000011.9 NT_167190.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PAAF1_HUMAN, Q9BRP4 (See protein sequence)

Recommended Name: Proteasomal ATPase-associated factor 1

Size: 392 amino acids; 42190 Da

Subunit: Interacts with PSMC1, PSMC2, PSMC3, PSMC4, PSMC5 and PSMC6. Interacts with HIV-1 Tat

Secondary accessions: A6NDR5 Q4G165 Q53HS9 Q7Z500 Q8TBU6 Q9HAB6

Alternative splicing: 2 isoforms: Q9BRP4-1 Q9BRP4-2

Explore the universe of human proteins at neXtProt for PAAF1: NX_Q9BRP4

REFSEQ proteins: NP_079431.1

ENSEMBL proteins:

ENSP00000311665 ENSP00000365564

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: PAAF1 OriGene Protein Over-expression Lysate: PAAF1
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	Novus Biologicals Protein for PAAF1
	Novus Biologicals Lysate for PAAF1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000502	proteasome complex	IEA	--

About this table

PAAF1 for ontologies About GeneDecksing

Antibodies for PAAF1:

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	Browse antibodies at Epitomics

Assays for PAAF1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PAAF1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PAAF1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PAAF1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR019782 WD40_repeat_2

IPR019775 WD40_repeat_CS

IPR011046 WD40_repeat-like_dom

IPR019781 WD40_repeat_sg

IPR001680 WD40_repeat

Graphical View of Domain Structure for InterPro Entry Q9BRP4

ProtoNet protein and cluster: Q9BRP4

UniProtKB/Swiss-Prot: PAAF1_HUMAN, Q9BRP4

Similarity: Belongs to the WD repeat PAAF1/RPN14 family

Similarity: Contains 5 WD repeats

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PAAF1_HUMAN, Q9BRP4

Function: Inhibits proteasome 26S assembly and proteolytic activity by impairing the association of the 19S regulatory

complex with the 20S core. In case of HIV-1 infection, recruited by viral Tat to the HIV-1 promoter, where it promotes

the recruitment of 19S regulatory complex through dissociation of the proteasome 26S. This presumably promotes

provirus transcription efficiency

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PAAF1 Sigma-Aldrich shRNA for PAAF1
		OriGene 29mer shRNA kits in GFP-retroviral vector: PAAF1 OriGene shRNA RFP: PAAF1 OriGene basic RS shRNA: PAAF1 OriGene siRNA: PAAF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PAAF1

miRNA:		Sigma-Aldrich microRNA Mimics for PAAF1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PAAF1
		6 SABiosciences Assays for microRNAs that regulate PAAF1:
		hsa-miR-30c hsa-miR-30a hsa-miR-146b-3p hsa-miR-30b hsa-miR-30d hsa-miR-30e

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PAAF1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PAAF1 OriGene untagged cDNA clones in CMV expression vector: PAAF1 OriGene 3'-UTR clone: PAAF1 Browse MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: PAAF1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PAAF1

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	17353931

About this table

PAAF1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for PAAF1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PAAF1

5/34 Interacting proteins for PAAF1 (Q9BRP4^{1, 2} ENSP00000365564³) via UniProtKB, MINT, and/or STRING (see all 34)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PSMC4	P43686¹^,², ENSP00000157812³	EBI-1056358,EBI-743997 MINT-7230300 STRING: ENSP00000157812
PSMC1	P62191¹^,²	EBI-1056358,EBI-357598 MINT-7230300
PSMC2	P35998¹^,²	EBI-1056358,EBI-359710 MINT-7230300
PSMC3	P17980¹^,²	EBI-1056358,EBI-359720 MINT-7230300
PSMC5	P62195¹^,²	EBI-1056358,EBI-357745 MINT-7230300

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0044419	interspecies interaction between organisms	IEA	--

About this table

PAAF1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PAAF1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PAAF1 Sigma-Aldrich shRNA for PAAF1
		OriGene 29mer shRNA kits in GFP-retroviral vector: PAAF1 OriGene shRNA RFP: PAAF1 OriGene basic RS shRNA: PAAF1 OriGene siRNA: PAAF1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PAAF1

miRNA:		Sigma-Aldrich microRNA Mimics for PAAF1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PAAF1
		6 SABiosciences Assays for microRNAs that regulate PAAF1:
		hsa-miR-30c hsa-miR-30a hsa-miR-146b-3p hsa-miR-30b hsa-miR-30d hsa-miR-30e

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PAAF1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PAAF1 OriGene untagged cDNA clones in CMV expression vector: PAAF1 OriGene 3'-UTR Clone: PAAF1 Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clone with any tag delivered in your preferred vector: PAAF1

Primers:		OriGene genome-wide validated SYBR primer pairs: PAAF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PAAF1: PPH19414A

REFSEQ mRNAs for PAAF1 gene:

NM_025155.1

Additional cDNA sequence:

AF087895.1 AK021910.1 AK222501.1 AK225520.1 AK298258.1 AK309133.1 AK316394.1 BC006142.2

BC021541.1 BC028628.1 BC028677.1 BC045774.1 CR608221.1 CR621285.1 CR623159.1

8 DOTS entries:

DT.314939 DT.92424389 DT.100783361 DT.40312236 DT.102829423 DT.40106995 DT.120754813 DT.95069811

24/156 AceView cDNA sequences (see all 156):

AA262678 BC006142 AW872789 BC021541 BQ892987 CR608221 BQ425623 CA441979

NM_025155 AI033544 AA446420 CA405808 AW298592 CA437149 AU119812 AA746090

CK299821 BM670134 CR623159 AA279808 BM700121 CF145036 AW250388 N59205

Unigene Cluster for PAAF1:

Proteasomal ATPase-associated factor 1

Hs.525017 [show with all ESTs]

Unigene Representative Sequence: BC045774

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for PAAF1 (see all 6)

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14a	·	14b
SP1:									-				-								-
SP2:									-				-		-		-				-
SP3:													-		-						-
SP4:													-		-		-				-
SP5:

About this scheme

ECgene alternative splicing isoforms for PAAF1
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000310571(uc001ouk.1 uc001oul.1 uc009ytx.1 uc001oum.1 uc001oun.1)

ENST00000376384

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PAAF1 expression in normal and diseased human tissues

¹ / ²

5 probe-sets matching PAAF1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
50344_at²	U95-B	1	1.00	1.00	0.67	1.30	--	--	--	--	--
61748_at²	U95-C	1	0.44	1.00	0.92	0.71	--	--	--	--	--
218957_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
218957_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1568702_a_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--

About this table

PAAF1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PAAF1 gene electronic northern expression

About these images

CGAP SAGE TAG: GCGTTTAATG

SOURCE GeneReport for Unigene cluster: Hs.525017

UniProtKB/Swiss-Prot: PAAF1_HUMAN, Q9BRP4

Tissue specificity: Ubiquitously expressed, with highest levels in kidney, brain and testis

Primers:		OriGene genome-wide validated SYBR primer pairs: PAAF1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PAAF1: PPH19414A

SABiosciences Custom PCR Arrays for PAAF1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PAAF1 gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PAAF1¹	--	proteasomal ATPase-associated factor 1	93.28(n) 95.41(a)	476810 XM_534014.2 XP_534014.1
chimpanzee (Pan troglodytes)	PAAF1¹	--	proteasomal ATPase-associated factor 1	99.49(n) 98.72(a)	466705 XM_522104.2 XP_522104.2
cow (Bos taurus)	PAAF1¹	--	proteasomal ATPase-associated factor 1	93.96(n) 95.41(a)	533348 NM_001075990.1 NP_001069458.1
chicken (Gallus gallus)	PAAF1¹	--	proteasomal ATPase-associated factor 1	76.45(n) 82.14(a)	419061 NM_001030835.1 NP_001026006.1
worm (Caenorhabditis elegans)	Y39G10AR.9¹	--	hypothetical protein	43.54(n) 31(a)	171789 NM_058556.3 NP_490957.1

About this table Species with no ortholog for PAAF1

ENSEMBL Gene Tree for PAAF1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 11 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs635962^1,2	--	73628869(+)	`cgagaA/Ccatgc`	1	--	int¹		0	--	--	--	--
rs636286^1,2	--	73628880(+)	`cactgC/Tgctcc`	1	--	int¹		0	--	--	--	--
rs825863^1,2	--	73628663(+)	`tgtaaC/Tcccag`	1	--	int¹		0	--	--	--	--
rs825864^1,2	--	73628677(+)	`tttggA/Gaggcc`	1	--	int¹		0	--	--	--	--
rs935985^1,2	C,F,A,	73638306(-)	`CAGTTC/TAAAGG`	1	--	int¹		18		EA MN NS NA WA	2896
rs935986^1,2	C,F,A,H,	73631272(-)	`aaaaaA/Tatata`	1	--	int¹		4		NA EA WA	168
rs935987^1,2	C,F,	73631150(-)	`ccttaC/Tatttg`	1	--	int¹		5		NS EA WA	470
rs935988^1,2	C,F,A,	73630929(-)	`agtatC/Actttc`	1	--	int¹		12		NS EA NA WA	808
rs935989^1,2	C,F,A,	73625162(+)	`CTGAGG/TTATCT`	1	--	int¹		5		NS EA WA	470
rs1132819^1,2	F	73591611(+)	`CCTGTA/GGTCCC`	1	--	int¹		1		MN	184

About this table

HapMap Linkage Disequilibrium images for PAAF1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PAAF1: --

QIAGEN SeqTarget long-range PCR primers for resequencing PAAF1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/15 PubMed articles for PAAF1 gene, integrated from 7 sources (see all 15):
(articles sorted by number of sources associating them with PAAF1)

Proteasomal ATPase-associated factor 1 negatively regulates proteasome activity by interacting with proteasomal ATPases. (PubMed id 15831487)^{1, 2, 3, 7} Park Y.... Yoon J.-B. (2005)
The proteasome regulates HIV-1 transcription by both proteolytic and nonproteolytic mechanisms. (PubMed id 17289585)^{1, 2, 3} Lassot I....Kiernan R.E. (2007)
Lower expression of catalytic and structural subunits of the proteasome contributes to decreased proteolysis in peripheral blood T lymphocytes during aging. (PubMed id 17317272)^{1, 3} Ponnappan S....Ponnappan U. (2007)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Mass spectrometric characterization of the affinity-purified human 26S proteasome complex. (PubMed id 17323924)² Wang X.... Huang L. (2007)
Large-scale mapping of human protein-protein interactions by mass spectrometry. (PubMed id 17353931)¹ Ewing R.M.... Figeys D. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 80227	HGNC: 25687	AceView: FLJ11848	Ensembl:ENSG00000175575	euGenes: HUgn80227
ECgene: PAAF1	H-InvDB: PAAF1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Intellectual Property for PAAF1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for PAAF1 gene:
Search GeneIP for patents involving PAAF1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
About This Section

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for PAAF1		Antibodies for PAAF1
	Super-pooled esiRNAs for PAAF1		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for PAAF1		microRNA Mimics for PAAF1
	"Your Favorite Gene" Pathways and Molecular Interaction Networks		Browse Nano Scale siRNA at Sigma-Aldrich
	Browse iPSC Reprogramming Factors at Sigma-Aldrich		Browse small molecules at Sigma-Aldrich
	Browse FLAG tag genes at Sigma-Aldrich		Browse ELISAs at Sigma-Aldrich
	Browse microRNA Target Validation Systems at Sigma-Aldrich		Browse CompoZr Knockout ZFN at Sigma-Aldrich
	feedback

	Antibodies		Cell Culture Products
	ELISAs		Flow Cytometry Kits
	Primer Pairs		Kinase Activity Assays/Reagents
	ELISpot Kits/Development Modules		TFB/Immunoprecipitation Assays
	Apoptosis Detection Kits/Reagents		Protease Activity Assays/Reagents
	DNA Damage/Repair Kits/Reagents		Multiplex/Array Assay Kits/Reagents
	Cell Selection/Detection Kits/Reagents		ELISA/Assay Development Kits/Reagents
	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Lysates
	Western blot validated antibodies
	shRNA in GFP-retroviral vector
	siRNA
	Custom Immunoassay Development
	Fluorogenic Cell Assay Kits
	miRNA Primers for qPCR Assays
	3' UTR Clones for miRNA Target Studies
	miRNA Expression Plasmids

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PAAF1
	SeqTarget long-range PCR primers for resequencing PAAF1
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PAAF1
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PAAF1

	GenScript Custom Purified and Recombinant Proteins Services for PAAF1		GenScript cDNA clones with any tag delivered in your preferred vector for PAAF1
	GenScript Custom Assay Services for PAAF1		GenScript Custom Superior Antibodies Services for PAAF1
	GenScript Custom overexpressing Cell Line Services for PAAF1		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

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	RT² qPCR Primer Assay for PAAF1
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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Browse antibodies at Epitomics

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ELISAs and CLIAs for PAAF1

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

PAAF1 gene at Home site.

hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4

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PAAF1 Gene

protein-coding GIFtS: 47

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PAAF1 Gene

protein-coding GIFtS: 47

Aliases & Descriptionsfor PAAF1 gene

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for PAAF1 gene

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for PAAF1 gene

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for PAAF1 gene

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for PAAF1 gene

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for PAAF1 gene

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for PAAF1 gene

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