Aliases &
Descriptions
for PARP15 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| poly (ADP-ribose) polymerase family, member 151 2 | | MGC1267522 | | BAL32 3 5 | | OTTHUMP000002158012 | | FLJ405971 2 | | OTTHUMP000002158022 | | pART71 2 | | B-aggressive lymphoma 32 | | B-aggressive lymphoma protein 32 3 | | poly [ADP-ribose] polymerase 152 | | PARP-152 3 | | OTTHUMP000002156842 | | MGC1267502 | | EC 2.4.2.303 | | FLJ401962 | | |
Export aliases for PARP15 gene to outside databasesPrevious GC identifers: GC03P123817 GC03P122296 |
Summaries
for PARP15 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PARP15:
PARP15 is a macrodomain-containing transcriptional repressor with poly(ADP-ribose) polymerase activity (Aguiar et al.,2005 (PubMed 16061477)).(supplied by OMIM)
UniProtKB/Swiss-Prot: PAR15_HUMAN, Q460N3Function: Transcriptional repressor. Has ADP-ribosyltransferase activity
 summary
for PARP15: Poly (ADP-ribose) polymerase (PARP) catalyzes the post-translational modification of proteins by the
addition of multiple ADP-ribose moieties. PARP transfers ADP-ribose from nicotinamide dinucleotide (NAD) to
glu/asp residues on the substrate protein, and also polymerizes ADP-ribose to form long/branched chain
polymers. PARP inhibitors are being developed for use in a number of pathologies including cancer, diabetes,
stroke and cardiovascular disease.
|
Genomic Views
for PARP15 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PARP15 gene promoter:
Cart-1 JunD JunB Fra-1 c-Jun c-Fos AP-1 CUTL1 SREBP-1c SREBP-1b
Other transcription factors
Search SABiosciences Chromatin IP Primers for PARP15
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q21.1 Ensembl cytogenetic band: 3q21.1 HGNC cytogenetic band: 3q21PARP15 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03P119669: view genomic region
(about GC identifiers)
Start:
|
119,669,726 bp from pter |
End:
|
119,728,790 bp from pter |
Size:
|
59,065 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr3+ 122,296,449-122,357,894 |
RefSeq DNA sequence:- NC_000003.11 NT_005612.16
|
Proteins
for PARP15 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: PAR15_HUMAN, Q460N3 (See
protein sequence)Recommended Name: Poly [ADP-ribose] polymerase 15 Size: 656 amino acids; 72541 Da
Subcellular location: Nucleus (Probable)
PDB structures from  and Proteopedia  :3BLJ (3D)
3GEY (3D)
3KH6 (3D)
Secondary accessions: Q8N1K3Alternative splicing: 2 isoforms: Q460N3-1 Q460N3-2 Explore the universe of human proteins at neXtProt for PARP15: NX_Q460N3
REFSEQ proteins (2 alternative transcripts):
NP_001106995.1 NP_689828.1
ENSEMBL proteins: ENSP00000419488 ENSP00000308436 ENSP00000417785 ENSP00000417214
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005634 | nucleus |
IEA | -- |
About this table
PARP15 for ontologies About GeneDecksing
Antibodies for PARP15:
Assays for PARP15: |
Protein
Domains/
Families
for PARP15 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PARP15 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q460N3ProtoNet protein and cluster: Q460N3 UniProtKB/Swiss-Prot: PAR15_HUMAN, Q460N3Similarity: Contains 2 Macro domainsSimilarity: Contains 1 PARP catalytic domain |
Gene Function
for PARP15 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PAR15_HUMAN, Q460N3Function: Transcriptional repressor. Has ADP-ribosyltransferase activityCatalytic activity: NAD(+) + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptorEnzyme Number (IUBMB): EC 2.4.2.30
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003950 | NAD+ ADP-ribosyltransferase activity |
IEA | -- | | GO:0016757 | transferase activity, transferring glycosyl groups |
IEA | -- |
About this table
PARP15 for ontologies About GeneDecksing
|
Pathways & Interactions
for PARP15 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
PARP15 for pathways About GeneDecksing
1  Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for PARP15
SABiosciences Custom Pathway-Focused PCR Arrays for PARP15
Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PARP15
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PARP15
1 Gene Ontology (GO) biological process term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0045449 | regulation of transcription |
IEA | -- |
About this table
PARP15 for ontologies About GeneDecksing
|
Drugs & Compounds
for PARP15 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Compounds for PARP15 available from Tocris Bioscience
About this table
|
Transcripts
for PARP15 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PARP15 gene (2 alternative transcripts): NM_001113523.1 NM_152615.1 Additional cDNA sequence: AK097515.1 AK097916.1 AK309863.1 BC101701.1 BC101703.1 BC143573.1 BX647656.1 DQ063586.1 4 DOTS entries: DT.426458 DT.95316253 DT.100017244 DT.40129871 13 AceView cDNA sequences: AK097916 NM_152615 AA653813 AI018571 AA730275 CF121485 AK097515 AW801437 CF121503 BX647656 AA281399 BF376347 AW794740
 highest scoring ESTs for PARP15:AI018571 AK097916 BX647656 AA730275 AK097515 AW801437 CF121485 CF121503 DQ063586 NM_152615 Unigene Cluster for PARP15: Poly (ADP-ribose) polymerase family, member 15 Hs.120250 [show with all ESTs]Unigene Representative Sequence: BX647656
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000493645 ENST00000310366 ENST00000483793 ENST00000464300 ENST00000465304
ENST00000473627
|
Expression
for PARP15 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PARP15 expression in normal and diseased human tissues
1 / 2 2 probe-sets matching PARP15 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 1553380_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 1564310_a_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: TGTTTTTTGG
SOURCE GeneReport for Unigene cluster: Hs.120250
SABiosciences Custom PCR Arrays for PARP15
|
Orthologs
for PARP15 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PARP15 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
PARP151 |
-- |
poly (ADP-ribose) polymerase family, member 15 |
97.01(n)
95.86(a) |
460633 XM_001167586.1 XP_001167586.1 |
About this table Species with no ortholog for PARP15
ENSEMBL Gene Tree for PARP15 (if available) |
Paralogs
for PARP15 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PARP15 gene
- PARP92 PARP142 PARP102 TIPARP2
PARP15 for paralogs About GeneDecksing
|
Genomic Variants
for PARP15 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 3 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PARP15 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PARP15
1 CNV: 98425 | | QIAGEN SeqTarget long-range PCR primers for resequencing PARP15 |
|
Disorders & Mutations
for PARP15 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PARP15 for disorders About GeneDecksing
OMIM: 612066
Human Genome Epidemiology (HuGE) Navigator: PARP15 (2 documents)
Export disorders and mutations for PARP15 gene to outside databases
|
Medical News
for PARP15 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PARP15 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for PARP15 gene integrated from 7 sources:
(articles sorted by number of sources associating them with PARP15)- B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. (PubMed id 16061477)1, 2 Aguiar R.C.T.... Shipp M.A. (2005)
- The PARP superfamily. (PubMed id 15273990)1, 3 Ame J.C....de Murcia G. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
- Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for PARP15 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PARP15 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PARP15 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PARP15 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PARP15 gene:
Search GeneIP for patents involving PARP15
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PARP15 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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