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PCDHA6 Gene

protein-coding   GIFtS: 45

GC05P135352
protocadherin alpha 6
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CNRS2)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
protocadherin alpha 61 2     CNRS22 3
CRNR21 2     protocadherin alpha-62
PCDH-ALPHA61 2     KIAA0345-like 82
CNR21 2     CNRN22
PCDH-alpha-62 3     

External Ids:    HGNC: 86721   Entrez Gene: 561422   Ensembl: ENSG000000818427   UniProtKB: Q9UN733   

Export aliases for PCDHA6 gene to outside databases

Previous GC identifers: GC05P140024 GC05P140753 GC05P140155 GC05P140210 GC05P140217 GC05P140172 GC05P140187 GC05P140321 GC05P140342


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCDHA6:
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on
chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene
clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and
consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons,
or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in
the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons
encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins
that most likely play a critical role in the establishment and function of specific cell-cell connections in the
brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature
has yet to be determined. (provided by RefSeq)

UniProtKB/Swiss-Prot: PCDA6_HUMAN, Q9UN73
Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of
specific neuronal connections in the brain

Gene Wiki entry for PCDHA6

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PCDHA6 gene promoter:
         Chx10   LCR-F1   CUTL1   C/EBPalpha   CHOP-10   Pax-2   SRF   c-Myc   Max1   E47   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PCDHA6

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PCDHA6 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31   Ensembl cytogenetic band:  5q31.3   HGNC cytogenetic band: 5q31

PCDHA6 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCDHA6 gene location

GeneLoc gene densities for chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05P135352:  view genomic region     (about GC identifiers)

Start:
135,352,390 bp from pter
End:
135,536,628 bp from pter
Size:
184,239 bases
Orientation:
plus strand

1 alternative location:
Chr5+ 140,206,816-140,391,929     

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PCDA6_HUMAN, Q9UN73 (See protein sequence)
Recommended Name: Protocadherin alpha-6 precursor  
Size: 950 amino acids; 102716 Da
Subcellular location: Isoform 1: Cell membrane; Single-pass type I membrane protein (By similarity)
Subcellular location: Isoform 2: Secreted (Potential)
Sequence caution: Sequence=AAF89691.1; Type=Erroneous initiation;
Secondary accessions: O75283 Q9NRT8
Alternative splicing: 3 isoforms:  Q9UN73-1   Q9UN73-2   Q9UN73-3   (Additional isoforms seem to exist)

Explore the universe of human proteins at neXtProt for PCDHA6: NX_Q9UN73 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (3 alternative transcripts): 
    NP_061732.1  NP_114036.1  NP_114037.1  


    ENSEMBL proteins: 
    ENSP00000378129 ENSP00000289630 ENSP00000378106 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PCDHA6
    GenScript Custom Purified and Recombinant Proteins Services for PCDHA6 
    Novus Biologicals Proteins for PCDHA6
    Novus Biologicals Lysates for PCDHA6
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    4 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576 extracellular region IEA--
    GO:0005886 plasma membrane IEA--
    GO:0005887 integral to plasma membrane TAS10380929
    GO:0016020 membrane ----
    About this table

    PCDHA6 for ontologies           About GeneDecksing



    Antibodies for PCDHA6: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PCDHA6
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PCDHA6 
    Novus Biologicals Antibodies for PCDHA6
    Browse antibodies at Epitomics

    Assays for PCDHA6: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PCDHA6 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PCDHA6 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR015919 Cadherin-like
     IPR013164 Cadherin_N
     IPR020894 Cadherin_CS
     IPR002126 Cadherin

    Graphical View of Domain Structure for InterPro Entry Q9UN73

    ProtoNet protein and cluster: Q9UN73

    1 Blocks protein family: IPB002126 Cadherin

    UniProtKB/Swiss-Prot: PCDA6_HUMAN, Q9UN73
    Similarity: Contains 6 cadherin domains


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PCDA6_HUMAN, Q9UN73
    Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of
    specific neuronal connections in the brain

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for PCDHA6
    Sigma-Aldrich shRNA Panels and shRNA for PCDHA6
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PCDHA6
    OriGene shRNA RFP (see all 3): PCDHA6
    OriGene basic RS shRNA (see all 3): PCDHA6
    OriGene siRNA (see all 3): PCDHA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PCDHA6 
    miRNA:Sigma-Aldrich microRNA Mimics for PCDHA6
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PCDHA6 
    8/37 SABiosciences Assays for microRNAs that regulate PCDHA6 (see all 37):
    hsa-miR-513a-5p hsa-miR-15a hsa-miR-106a hsa-miR-29a hsa-miR-570 hsa-miR-424 hsa-miR-93 hsa-miR-330-3p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): PCDHA6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): PCDHA6
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PCDHA6
    OriGene 3'-UTR clone (see all 2): PCDHA6 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): PCDHA6 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PCDHA6 

    2 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005509 calcium ion binding IEA--
    GO:0005515 protein binding IPI17474147
    About this table

    PCDHA6 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PCDHA6 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCDHA6

    5/23 Interacting proteins for PCDHA6 (ENSP000002896303 Q9UN731, 2) via UniProtKB, MINT, and/or STRING (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CRKP461081, 2EBI-1754181,EBI-886 MINT-7255122
    CASP3ENSP000003110323STRING: ENSP00000311032
    ATP5F1ENSP000003587373STRING: ENSP00000358737
    ATP5G2ENSP000003403153STRING: ENSP00000340315
    CASP10ENSP000002861863STRING: ENSP00000286186
    About this table

    3 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007155 cell adhesion IEA--
    GO:0007156 homophilic cell adhesion IEA--
    GO:0007399 nervous system development TAS10380929
    About this table

    PCDHA6 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PCDHA6


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich siRNA Panels and siRNA for PCDHA6
    Sigma-Aldrich shRNA Panels and shRNA for PCDHA6
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 3): PCDHA6
    OriGene shRNA RFP (see all 3): PCDHA6
    OriGene basic RS shRNA (see all 3): PCDHA6
    OriGene siRNA (see all 3): PCDHA6
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PCDHA6 
    miRNA: Sigma-Aldrich microRNA Mimics for PCDHA6
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PCDHA6 
    8/37 SABiosciences Assays for microRNAs that regulate PCDHA6 (see all 37):
    hsa-miR-513a-5p hsa-miR-15a hsa-miR-106a hsa-miR-29a hsa-miR-570 hsa-miR-424 hsa-miR-93 hsa-miR-330-3p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): PCDHA6
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): PCDHA6
    OriGene untagged cDNA clones in CMV expression vector (see all 3): PCDHA6
    OriGene 3'-UTR Clone (see all 2): PCDHA6 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 3): PCDHA6 
    Primers: OriGene genome-wide validated SYBR primer pairs: PCDHA6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PCDHA6: PPH60195A

    REFSEQ mRNAs for PCDHA6 gene (3 alternative transcripts): 

    NM_018909.2  NM_031848.1  NM_031849.1  

    24/261 AceView cDNA sequences (see all 261):

    NM_018901 AW470523 NM_031852 AL133883 NM_031497 NM_031864 AI452508 AF152486 
    AF169689 AF152476 BM970705 NM_031857 AW572498 AF152312 AI969295 NM_018898 
    AF152309 NM_031411 NM_018904 NM_031860 BM701560 CA436984 AF152477 AF169695 

    highest scoring ESTs for PCDHA6:

    BC019862 BC043441 AF152484 NM_031848 BF931752 BI547581 CA396936 AF152314 AF169694 BC036674 


    GeneLoc Exon Structure

    5/18 Alternative Splicing Database (ASD) splice patterns (SP) for PCDHA6 (see all 18)

    ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b ^ 16a · 16b
    SP1:                          -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -               
    SP2:              -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                       -               
    SP3:                                                                                      -     -     -     -     -                       -               
    SP4:                                                                                                        -     -                       -               
    SP5:                                                                                                              -                                       

    About this scheme

    ECgene alternative splicing isoforms for PCDHA6
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394633 ENST00000289630(uc011dab.1) ENST00000394608(uc003lha.2 uc003lhb.2 uc003lhd.2 uc003lhf.2 uc003lhi.2 uc003lhk.1 uc003lhl.2 uc003lhn.2 uc003lho.2 uc003lhq.2 uc003lhs.2)


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PCDHA6 expression in normal and diseased human tissues

    1  / 2  / 3

    6 probe-sets matching PCDHA6 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    224212_s_at2, 3 U133-B 15 0.91 0.10 -- -- AF169689 0.40 0.03 0.28 2
    211811_s_at2, 3 U133-A 1 0.82 1.00 -- -- AF152484 0.60 0.62 0.61 1
    223435_s_at2, 3 U133-B 15 0.82 0.10 -- -- AI268404 0.40 0.03 0.28 2
    224212_s_at2 U133Plus2 15 0.91 0.10 -- -- -- -- -- -- --
    211811_s_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    223435_s_at2 U133Plus2 15 0.82 0.10 -- -- -- -- -- -- --
    About this table
    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PCDHA6 gene expression
    PCDHA6 gene electronic northern expression
    PCDHA6 gene sage expression
    About these images

    CGAP SAGE TAG: --
    Primers: OriGene genome-wide validated SYBR primer pairs: PCDHA6
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PCDHA6: PPH60195A
        SABiosciences Custom PCR Arrays for PCDHA6 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PCDHA6 gene from 4 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PCDHA61   -- protocadherin alpha 6 86.3(n)
    84.71(a)
    607224  XM_843838.1  XP_848931.1 
    cow
    (Bos taurus)
    PCDHA61   -- protocadherin alpha 6 84.76(n)
    84.51(a)
    616024  XM_867987.2  XP_873080.2 
    rat
    (Rattus norvegicus)
    Pcdha61   -- protocadherin alpha 6 83.16(n)
    85.2(a)
    393088  NM_199506.1  NP_955800.1 
    mouse
    (Mus musculus)
    Pcdha61 , 5 18 (19.46 cM)5
    protocadherin alpha 61, 5 83.62(n)1
    85.41(a)1
    129371  NM_007767.21  NP_031793.11 
     AY0137645  BC0548135  (see all 9)
    About this table        Species with no ortholog for PCDHA6

    ENSEMBL Gene Tree for PCDHA6 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PCDHA6 gene
    PCDHAC12  PCDHAC22  PCDHA22  PCDHA122  PCDHGB42  PCDHA52  PCDHGB12  PCDHA12  
    PCDHA112  PCDHGB22  PCDHGC32  PCDHA72  ENSG000002537882  PCDHGB62  PCDHGC52  PCDHA82  
    PCDHGC42  PCDHA132  PCDHA102  PCDHA92  PCDHA32  PCDHGB72  PCDHA42  

    PCDHA6 for paralogs           About GeneDecksing


    Pseudogenes
    1 related pseudogene



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 22 variations for PCDHA6
         15/21 CNVs (see all 21): 93255 32748 1701 64320 53833 59240 3578 31248 31250 81058 31249 64319 62437 51579 37968
         1 Indel: 64317
    QIAGEN SeqTarget long-range PCR primers for resequencing PCDHA6 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PCDHA6 for disorders           About GeneDecksing

    OMIM: 606312


    Export disorders and mutations for PCDHA6 gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/11 PubMed articles for PCDHA6 gene, integrated from 7 sources (see all 11):
    (articles sorted by number of sources associating them with PCDHA6)
    1. A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PubMed id 10380929)1, 2, 3 Wu Q. and Maniatis T. (1999)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. The DNA sequence and comparative analysis of human chromosome 5. (PubMed id 15372022)1, 2 Schmutz J.... Rubin E.M. (2004)
    4. Genomic organization of the family of CNR cadherin genes in mice and humans. (PubMed id 10662547)1, 3 Sugino H....Yagi T. (2000)
    5. Systematic identification of SH3 domain-mediated human protein-protein interactions by peptide array target screening. (PubMed id 17474147)1 Wu C....Li S.S. (2007)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PubMed id 11230163)1 Wu Q.... Maniatis T. (2001)
    8. Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)1 Nollet F....van Roy F. (2000)
    9. Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PubMed id 10716726)1 Wu Q. and Maniatis T. (2000)
    10. Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PubMed id 10817752)1 Yagi T. and Takeichi M. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 56142 HGNC: 8672 AceView: PCDHA9 Ensembl:ENSG00000081842 euGenes: HUgn56142
    ECgene: PCDHA6 H-InvDB: PCDHA6

    (According to HUGE)
    About This Section
    HUGE: KIAA0345-like 8

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PCDHA6 gene:
    Search GeneIP for patents involving PCDHA6

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for PCDHA6 Antibodies for PCDHA6
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for PCDHA6 microRNA Mimics for PCDHA6
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
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     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PCDHA6
     SeqTarget long-range PCR primers for resequencing PCDHA6
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PCDHA6
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PCDHA6
     GenScript Custom Purified and Recombinant Proteins Services for PCDHA6 GenScript cDNA clones with any tag delivered in your preferred vector for PCDHA6
     GenScript Custom Assay Services for PCDHA6 GenScript Custom Superior Antibodies Services for PCDHA6
     GenScript Custom overexpressing Cell Line Services for PCDHA6 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in PCDHA6 promoter
     Search Chromatin IP Primers for PCDHA6
     RT2 qPCR Primer Assay for PCDHA6
     Search GNC Networks for PCDHA6
     Assays for microRNAs that regulate PCDHA6
     SABiosciences Custom PCR Arrays for PCDHA6
     Search Tocris compounds for PCDHA6
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for PCDHA6
     Proteins for PCDHA6
     Lysates for PCDHA6
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     Browse ELISAs and CLIAs at Uscn
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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