Aliases &
Descriptions
for PCDHGA5 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| protocadherin gamma subfamily A, 51 2 | | protocadherin gamma-A52 | | PCDH-GAMMA-A51 2 | | cadherin ME32 | | ME31 2 | | MGC1420202 | | CDH-GAMMA-A51 2 | | PCDH-gamma-A53 |
Export aliases for PCDHGA5 gene to outside databasesPrevious GC identifers: GC05P140560 GC05P141306 GC05P140704 GC05P140763 GC05P140783 GC05P140722 GC05P140816 GC05P140823 GC05P140840 GC05P140865 GC05P140891 GC05P140913 GC05P140925 GC05P140947 GC05P140968 GC05P140990 GC05P141021 GC05P141053 GC05P141083 |
Summaries
for PCDHGA5 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for PCDHGA5:
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked onchromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism maybe involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies.Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly relatedsubfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region,containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region,which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the commoncytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in theestablishment and function of specific cell-cell connections in the brain. Alternative splicing has been described forthe gamma cluster genes. (provided by RefSeq)
UniProtKB/Swiss-Prot: PCDG5_HUMAN, Q9Y5G8Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance ofspecific neuronal connections in the brain
|
Genomic Views
for PCDHGA5 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PCDHGA5 gene promoter:
NRSF form 1 NRSF form 2 CUTL1 FOXD1 POU2F2B POU2F2C oct-B3 POU2F1 POU2F2 POU2F2 (Oct-2.1)
Other transcription factors
Search SABiosciences Chromatin IP Primers for PCDHGA5
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PCDHGA5  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31 Ensembl cytogenetic band: 5q31.3 HGNC cytogenetic band: 5q31PCDHGA5 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05P135888: view genomic region
(about GC identifiers)
Start:
|
135,888,973 bp from pter |
End:
|
136,037,386 bp from pter |
Size:
|
148,414 bases |
Orientation:
|
plus strand |
1 alternative location:
| Chr5+ 140,743,898-140,892,546 |
|
Proteins
for PCDHGA5 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
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|
UniProtKB/Swiss-Prot: PCDG5_HUMAN, Q9Y5G8 (See
protein sequence)Recommended Name: Protocadherin gamma-A5 precursor Size: 931 amino acids; 100935 Da
Subcellular location: Cell membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: Q2M3F5 Q9Y5D2Alternative splicing: 2 isoforms: Q9Y5G8-1 Q9Y5G8-2 Explore the universe of human proteins at neXtProt for PCDHGA5: NX_Q9Y5G8
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins (2 alternative transcripts):
NP_061741.1 NP_114443.1
ENSEMBL proteins: ENSP00000429834
Human Recombinant Proteins
3 Gene Ontology (GO) cellular component terms (GO ID links to tree view): About this table
PCDHGA5 for ontologies About GeneDecksing
Antibodies for PCDHGA5:
Assays for PCDHGA5: |
Protein
Domains/
Families
for PCDHGA5 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
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|
PCDHGA5 for domains About GeneDecksing
5 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q9Y5G8ProtoNet protein and cluster: Q9Y5G8 1 Blocks protein family: IPB002126 Cadherin
UniProtKB/Swiss-Prot: PCDG5_HUMAN, Q9Y5G8Similarity: Contains 6 cadherin domains |
Gene Function
for PCDHGA5 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PCDG5_HUMAN, Q9Y5G8Function: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance ofspecific neuronal connections in the brain
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005509 | calcium ion binding |
IEA | -- | | GO:0005515 | protein binding |
-- | -- |
About this table
PCDHGA5 for ontologies About GeneDecksing
|
Pathways & Interactions
for PCDHGA5 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Custom Pathway-Focused PCR Arrays for PCDHGA5
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PCDHGA5
2 Gene Ontology (GO) biological process terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007155 | cell adhesion |
IEA | -- | | GO:0007156 | homophilic cell adhesion |
IEA | -- |
About this table
PCDHGA5 for ontologies About GeneDecksing
|
Drugs & Compounds
for PCDHGA5 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PCDHGA5
|
Transcripts
for PCDHGA5 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PCDHGA5 gene (2 alternative transcripts): NM_018918.2 NM_032054.1 24/737 AceView cDNA sequences (see all 737): BU145848 AL541160 BG820032 AF152513 AF152326 AF152319 AF152322 BM673359 BG055977 NM_032088 BE019030 BG152568 NM_032100 AB011160 BM549168 F07529 CA392536 AA682924 BE045804 BX480538 BQ026412 NM_002588 BU731047 C01812
 highest scoring ESTs for PCDHGA5:AF152512 NM_032054 AI885824 AW170647 AW629220 BG938633 BM740814 BM742071 BM757343 BM809961
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000518069
|
Expression
for PCDHGA5 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PCDHGA5 expression in normal and diseased human tissues
1 / 3 Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SABiosciences Custom PCR Arrays for PCDHGA5
|
Orthologs
for PCDHGA5 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PCDHGA5 gene from 4 species
About this table Species with no ortholog for PCDHGA5
ENSEMBL Gene Tree for PCDHGA5 (if available) |
Paralogs
for PCDHGA5 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PCDHGA5 gene
- PCDHGA62 PCDHGA112 PCDHGA102 PCDHGA12 PCDHG@2 PCDHGA122 PCDHB12 PCDHGA32
- PCDHGA72 PCDHGA82
PCDHGA5 for paralogs About GeneDecksing
|
Genomic Variants
for PCDHGA5 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for PCDHGA5
3 CNVs: 3578 69211 6450 | | QIAGEN SeqTarget long-range PCR primers for resequencing PCDHGA5 |
|
Disorders & Mutations
for PCDHGA5 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
PCDHGA5 for disorders About GeneDecksing
OMIM: 606292
Export disorders and mutations for PCDHGA5 gene to outside databases
|
Medical News
for PCDHGA5 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PCDHGA5 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
8 PubMed articles for PCDHGA5 gene integrated from 7 sources:
(articles sorted by number of sources associating them with PCDHGA5)- A striking organization of a large family of human neural cadherin- like cell adhesion genes. (PubMed id 10380929)1, 2, 3 Wu Q. and Maniatis T. (1999)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Comparative DNA sequence analysis of mouse and human protocadherin gene clusters. (PubMed id 11230163)1 Wu Q.... Maniatis T. (2001)
- Phylogenetic analysis of the cadherin superfamily allows identification of six major subfamilies besides several solitary members. (PubMed id 10835267)1 Nollet F....van Roy F. (2000)
- Large exons encoding multiple ectodomains are a characteristic feature of protocadherin genes. (PubMed id 10716726)1 Wu Q. and Maniatis T. (2000)
- Cadherin superfamily genes: functions, genomic organization, and neurologic diversity. (PubMed id 10817752)1 Yagi T. and Takeichi M. (2000)
- Identification of novel cadherins expressed in human melanoma cells. (PubMed id 9182820)1 Matsuyoshi N.... Imamura S. (1997)
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External Searches for PCDHGA5 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
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|
|
Genome Databases showing PCDHGA5 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PCDHGA5 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PCDHGA5 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PCDHGA5 gene:
Search GeneIP for patents involving PCDHGA5
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PCDHGA5 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
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