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PCM1 Gene

protein-coding   GIFtS: 56

GC08P016324
pericentriolar material 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
pericentriolar material 11 2
PTC41 2 5
PCM-12 3
hPCM-12 3
pericentriolar material 1 protein2

External Ids:    HGNC: 87271   Entrez Gene: 51082   Ensembl: ENSG000000786747   UniProtKB: Q151543   

Export aliases for PCM1 gene to outside databases

Previous GC identifers: GC08P017656 GC08P017843 GC08P017790 GC08P017824


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCM1:
The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered
around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several
centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene
are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical
chronic myeloid leukemia and T-cell lymphoma. (provided by RefSeq)

UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154
Function: Required for centrosome assembly and function. Essential for the correct localization of several centrosomal
proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome

Gene Wiki entry for PCM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PCM1 gene promoter:
         Nkx3-1   Nkx3-1 v1   Nkx3-1 v4   Nkx3-1 v2   Nkx3-1 v3   SREBP-1a   SREBP-1c   SREBP-1b   E2F-5   E2F-4   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PCM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PCM1 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21.3   Ensembl cytogenetic band:  8p22   HGNC cytogenetic band: 8p22-p21.3

PCM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCM1 gene location

GeneLoc gene densities for chromosome 8         GeneLoc Exon Structure

GeneLoc location for GC08P016324:  view genomic region     (about GC identifiers)

Start:
16,324,235 bp from pter
End:
16,431,242 bp from pter
Size:
107,008 bases
Orientation:
plus strand

1 alternative location:
Chr8+ 17,780,349-17,887,453     
RefSeq DNA sequence:
NC_000008.10  NT_167187.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154 (See protein sequence)
Recommended Name: Pericentriolar material 1 protein  
Size: 2024 amino acids; 228533 Da
Subunit: Self-associates (By similarity). Interacts with BBS4, BBS8, CETN3, HAP1, NDE1 and NDEL1
Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Cytoplasmic granule. Note=Localizes
to cytoplasmic granules which are enriched around the centrosome. This centrosomal enrichment requires microtubules
and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to
the cleavage site in telophase
Sequence caution: Sequence=AAH27477.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=AAH65022.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;
Sequence=BAC03656.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAC14882.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence;
Secondary accessions: Q58F13 Q6P1K7 Q8NB85 Q9BWC1 Q9H4A2
Alternative splicing: 3 isoforms:  Q15154-1   Q15154-2   Q15154-3   

Explore the universe of human proteins at neXtProt for PCM1: NX_Q15154 

Post-translational modifications:

  • Phosphorylated upon DNA damage, probably by ATM or ATR1
  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_006188.3  

    ENSEMBL proteins: 
    ENSP00000431099 ENSP00000429054 ENSP00000428123 ENSP00000327077 ENSP00000428131 ENSP00000430521 
    ENSP00000382891 ENSP00000328332 ENSP00000404339 ENSP00000427863 ENSP00000315008 ENSP00000429941 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for PCM1 
    Novus Biologicals Protein for PCM1
    Novus Biologicals Lysate for PCM1
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000242 pericentriolar material ISS--
    GO:0005737 cytoplasm ISS--
    GO:0005813 centrosome ISS--
    GO:0005829 cytosol EXP16462731
    GO:0005856 cytoskeleton IEA--
    About this table

    PCM1 for ontologies           About GeneDecksing



    Antibodies for PCM1: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PCM1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for PCM1 
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PCM1 
    Novus Biologicals Antibodies for PCM1
    Browse antibodies at Epitomics

    Assays for PCM1: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PCM1 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PCM1 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q15154

    UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154
    Similarity: Belongs to the PCM1 family


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154
    Function: Required for centrosome assembly and function. Essential for the correct localization of several centrosomal
    proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome
    Induction: Expression is reduced in breast and ovarian cancer

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PCM1
    Sigma-Aldrich shRNA for PCM1
    OriGene 29mer shRNA kits in GFP-retroviral vector: PCM1
    OriGene shRNA RFP: PCM1
    OriGene basic RS shRNA: PCM1
    OriGene siRNA: PCM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PCM1 
    miRNA:Sigma-Aldrich microRNA Mimics for PCM1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PCM1 
    8/14 SABiosciences Assays for microRNAs that regulate PCM1 (see all 14):
    hsa-miR-768-3p hsa-miR-520d-5p hsa-miR-198 hsa-miR-202 hsa-miR-15a hsa-miR-128 hsa-miR-548e hsa-miR-497

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PCM1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PCM1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PCM1
    OriGene 3'-UTR clone: PCM1 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PCM1 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PCM1 

    Genatlas biochemistry entry for PCM1:
    pericentriolar material 1

    3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005488 binding ----
    GO:0005515 protein binding IPI18772192
    GO:0042802 identical protein binding ISS--
    About this table

    PCM1 for ontologies           About GeneDecksing

    Animal Models: 1 MGI phenotypic allele for Pcm1 (no phenotypes)


    PCM1 for phenotypes           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PCM1 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PCM1

    5/68 Interacting proteins for PCM1 (ENSP000003270773 Q151541, 2) via UniProtKB, MINT, and/or STRING (see all 68)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CEP72Q9P2091STRING: ENSP00000264935 EBI-741421,EBI-739498
    BBS4Q96RK41EBI-741421,EBI-1805814
    GSK3BP498412MINT-4049759
    YWHAZP631042MINT-3295217
    CEP250ENSP000003484013STRING: ENSP00000348401
    About this table

    5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000086 G2/M transition of mitotic cell cycle TAS--
    GO:0000278 mitotic cell cycle TAS--
    GO:0022027 interkinetic nuclear migration ISS--
    GO:0034453 microtubule anchoring ISS--
    GO:0042384 cilium assembly IMP17574030
    About this table

    PCM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PCM1 for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PCM1
    1 Novoseek chemical compound relationship for PCM1 gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tyrosine 4.75 2 10980597 (1), 16091753 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PCM1
    Sigma-Aldrich shRNA for PCM1
    OriGene 29mer shRNA kits in GFP-retroviral vector: PCM1
    OriGene shRNA RFP: PCM1
    OriGene basic RS shRNA: PCM1
    OriGene siRNA: PCM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PCM1 
    miRNA: Sigma-Aldrich microRNA Mimics for PCM1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PCM1 
    8/14 SABiosciences Assays for microRNAs that regulate PCM1 (see all 14):
    hsa-miR-768-3p hsa-miR-520d-5p hsa-miR-198 hsa-miR-202 hsa-miR-15a hsa-miR-128 hsa-miR-548e hsa-miR-497
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PCM1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PCM1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PCM1
    OriGene 3'-UTR Clone: PCM1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PCM1 
    Primers: OriGene genome-wide validated SYBR primer pairs: PCM1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PCM1: PPH17387A

    REFSEQ mRNAs for PCM1 gene: 

    NM_006197.3  

    Additional cDNA sequence: 

    AF068293.1 AJ297349.1 AK091406.1 AK295856.1 AK301727.1 AK302378.1 AK307583.1 BC000453.2 
    BC027477.1 BC065022.1 BC098391.1 BC133052.1 BC140946.1 L27841.1 

    24 DOTS entries:

    DT.101976277  DT.65284974  DT.100653199  DT.95312120  DT.434342  DT.100875418  DT.95312136  DT.100738131 
    DT.92431659  DT.86995513  DT.65284852  DT.95312128  DT.120632476  DT.102832803  DT.120632425  DT.75113280 
    DT.120632443  DT.120632452  DT.120632463  DT.91796609  DT.100740083  DT.101972313  DT.40132839  DT.97798814 

    24/360 AceView cDNA sequences (see all 360):

    BI966701 BF939232 BM460315 AA773615 AL046024 CK430642 BM692791 BM671552 
    AA136212 CA436664 BP378555 BP354824 AL701164 AI523355 AI738786 AI651570 
    NM_006197 BU183194 BG944168 AL119599 AL046710 AL712077 AI122590 CA311685 

    highest scoring ESTs for PCM1:

    AA136212 AA136384 AA342787 AA669353 AA758728 AA765944 AA773615 AA781077 AA813291 AA846315 

    Unigene Cluster for PCM1:

    Pericentriolar material 1
    Hs.491148  [show with all ESTs]
    Unigene Representative Sequence: NM_006197


    GeneLoc Exon Structure

    5/23 Alternative Splicing Database (ASD) splice patterns (SP) for PCM1 (see all 23)

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b · 10c ^ 11a · 11b ^ 12a · 12b ^ 13a ·
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 13b ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20a · 20b · 20c ^ 21a · 21b · 21c ^ 22 ^ 23a · 23b ^ 24a · 24b ^ 25a · 25b · 25c · 25d ^ 26a · 26b ^
    SP1:                                                                                                                                                  -     -   
    SP2:                                                                                      -     -     -     -     -     -     -     -     -     -     -     -   
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                  -         
    SP5:                                                                                                                                                            

    ExUns: 27 ^ 28a · 28b ^ 29 ^ 30a · 30b ^ 31 ^ 32a · 32b ^ 33 ^ 34a · 34b ^ 35 ^ 36a · 36b ^ 37 ^ 38a · 38b ^ 39 ^ 40 ^ 41 ^ 42 ^ 43
    SP1:  -     -     -                                               -                                                                           
    SP2:  -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                                       
    SP3:                                                                                                                                          
    SP4:  -     -     -                                                                                                                           
    SP5:                                                  -           -                                                                           

    About this scheme

    ECgene alternative splicing isoforms for PCM1
    18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):
    ENST00000519253 ENST00000522275 ENST00000518762 ENST00000518537 ENST00000524356
    ENST00000518936 ENST00000325083 ENST00000518930 ENST00000517730 ENST00000522998
    ENST00000524203 ENST00000517836 ENST00000523896 ENST00000518877 ENST00000517545
    ENST00000524226 ENST00000523540 ENST00000521338

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PCM1 expression in normal and diseased human tissues

    1  / 2  / 3

    18 probe-sets matching PCM1 gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    36682_at2, 3 U95-A 1 1.00 1.00 0.90 0.62 L27841 0.80 1.00 0.91 1
    77262_at2, 3 U95-E 1 1.00 1.00 0.72 1.84 AI601149 0.20 1.00 0.72 1
    73078_s_at2, 3 U95-E 1 1.00 1.00 0.76 0.61 AA931266 0.80 1.00 0.91 1
    51300_s_at2, 3 U95-B 1 1.00 1.00 0.57 1.01 AA922289 0.80 1.00 0.91 1
    76161_r_at2, 3 U95-E 1 0.44 1.00 -0.03 1.01 R42580 0.20 1.00 0.72 1
    51305_r_at2, 3 U95-B 1 0.38 1.00 -0.22 0.22 AA922289 0.80 1.00 0.91 1
    202174_s_at2, 3 U133-A 1 1.00 1.00 -- -- NM_006197 0.40 1.00 0.76 1
    228905_at2, 3 U133-B 1 1.00 1.00 -- -- BE672700 0.20 1.00 0.72 1
    214937_x_at2, 3 U133-A 1 1.00 1.00 -- -- AI924817 0.80 1.00 0.91 1
    209997_x_at2, 3 U133-A 1 0.91 1.00 -- -- BC000453 0.60 1.00 0.82 1
    209996_x_at2, 3 U133-A 1 0.73 1.00 -- -- AA931266 0.80 1.00 0.91 1
    214118_x_at2, 3 U133-A 1 0.73 1.00 -- -- AI205598 0.80 1.00 0.91 1
    202174_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    228905_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    214937_x_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    209997_x_at2 U133Plus2 1 0.91 1.00 -- -- -- -- -- -- --
    209996_x_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    214118_x_at2 U133Plus2 1 0.73 1.00 -- -- -- -- -- -- --
    About this table

    PCM1 for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PCM1 gene expression
    PCM1 gene electronic northern expression
    PCM1 gene sage expression
    About these images

    CGAP SAGE TAG: ATGAACAGGT

    SOURCE GeneReport for Unigene cluster: Hs.491148

    Expression variation in blood from EXPOLDB for PCM1

    UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154
    Tissue specificity: Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid

    Primers: OriGene genome-wide validated SYBR primer pairs: PCM1
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PCM1: PPH17387A
        SABiosciences Custom PCR Arrays for PCM1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PCM1 gene from 5/10 species (see all 10)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PCM11   -- pericentriolar material 1 92.15(n)
    91.94(a)
    475618  XM_851292.1  XP_856385.1 
    chimpanzee
    (Pan troglodytes)
    PCM11   -- pericentriolar material 1 99.59(n)
    99.31(a)
    464020  XM_001143824.1  XP_001143824.1 
    cow
    (Bos taurus)
    PCM11   -- pericentriolar material 1 90.42(n)
    89.77(a)
    525337  XM_864234.2  XP_869327.2 
    rat
    (Rattus norvegicus)
    Pcm11   -- pericentriolar material 1 88.41(n)
    89.14(a)
    81740  XM_001057686.1  XP_001057686.1 
    mouse
    (Mus musculus)
    Pcm11 , 5 8 (23.89 cM)5
    pericentriolar material 11, 5 89.05(n)1
    89.29(a)1
    185361  NM_023662.21  NP_076151.11 
     AA5295625  AB0292915  (see all 25)
    About this table        Species with no ortholog for PCM1

    ENSEMBL Gene Tree for PCM1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1459 NCBI SNPs in PCM1 are shown (see all 1459)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 8 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs37601,2
    C,F,A,H,17886345(+) GAACTC/TGTTGA 1 -- ut3111Minor allele frequency- T:0.30MN EA NS NA WA 430
    rs102831,2
    C,F,A,17885406(-) AAAATC/GAAGAC 1 -- ut3110Minor allele frequency- G:0.33MN NS EA NA WA 666
    rs1062941,2
    C,F,O,A,17782692(-) AAGGTA/GTAACA 1 -- int113Minor allele frequency- G:0.08NS EA NA WA 1062
    rs1722981,2
    C17822231(+) CTTCTA/GACAGT 2 N D ref1 mis15Minor allele frequency- G:0.00MN NS EA 602
    rs2080201,2
    C,F,O,17880917(+) AAAATG/AGCTTA 1 -- int192Minor allele frequency- A:0.05NS EA NA PA EU CA WA 4998
    rs2080211,2
    C,F,O,A,17879392(+) ctctgA/Caatga 1 -- int115Minor allele frequency- C:0.21MN NS EA NA WA 1242
    rs2080221,2
    C,F,O,A,H,17879028(+) aacagT/Gagcaa 1 -- int116Minor allele frequency- G:0.26NS EA NA WA 1196
    rs2080231,2
    C,F,A,H,17878882(+) tttctA/Gccacc 1 -- int118Minor allele frequency- G:0.34MN NS EA NA WA 1422
    rs2080251,2
    C,F,O,17878170(+) GAGCAG/AGACAT 1 -- int111Minor allele frequency- A:0.28NS NA EA WA 452
    rs2080261,2
    C,F,17878155(+) TAGAGG/AAGAAA 1 -- int1 trp311Minor allele frequency- A:0.31EA NS NA WA 1632
    About this table

    HapMap Linkage Disequilibrium images for PCM1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for PCM1
         1 Indel: 95298

    QIAGEN SeqTarget long-range PCR primers for resequencing PCM1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PCM1 for disorders           About GeneDecksing

    OMIM: 600299   disorders: 188550  

    UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154

  • Defects in PCM1 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the
  • thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary
    carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of
    fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration
    involving PCM1 is found in thyroid papillary carcinomas. Translocation t(8;10)(p21.3;q11.2) with RET links the protein
    kinase domain of RET to the major portion of PCM1
  • Note=A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including
  • atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma. Translocation t(8;9)(p22;p24) with JAK2 links
    the protein kinase domain of JAK2 to the major portion of PCM1

    Human Gene Mutation Database (HGMD): PCM1
    Human Genome Epidemiology (HuGE) Navigator: PCM1 (9 documents)

    Export disorders and mutations for PCM1 gene to outside databases


    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/65 PubMed articles for PCM1 gene, integrated from 7 sources (see all 65):
    (articles sorted by number of sources associating them with PCM1)
    1. PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. (PubMed id 8120099)1, 2, 3, 7 Balczon R.... Zimmer W.E. (1994)
    2. Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. (PubMed id 15659651)1, 2, 3, 7 Hames R.S.... Fry A.M. (2005)
    3. Assembly of centrosomal proteins and microtubule organization depends on PCM-1. (PubMed id 12403812)1, 2, 7 Dammermann A. and Merdes A. (2002)
    4. The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. (PubMed id 16091753)1, 2, 7 Bousquet M.... Brousset P. (2005)
    5. RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma. (PubMed id 10980597)1, 2, 7 Corvi R.... Romeo G. (2000)
    6. Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. (PubMed id 16291865)1, 2, 7 Guo J.... Zhu X. (2006)
    7. Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. (PubMed id 16943179)1, 2, 7 Srsen V.... Merdes A. (2006)
    8. A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)1, 2 Beausoleil S.A.... Gygi S.P. (2006)
    9. Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)1, 2 Nousiainen M.... Koerner R. (2006)
    10. A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia. (PubMed id 16769584)1, 2 Bacher U.... Schoch C. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5108 HGNC: 8727 AceView: PCM1 Ensembl:ENSG00000078674 euGenes: HUgn5108
    ECgene: PCM1 H-InvDB: PCM1

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PCM1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PCM1 gene:
    Search GeneIP for patents involving PCM1

    GeneCards and IP:
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     ELISAs and CLIAs for PCM1
           

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