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PCM1 Gene

protein-coding GIFtS: 56

GC08P016324

pericentriolar material 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
pericentriolar material 1¹ ²
PTC4¹ ² ⁵
PCM-1² ³
hPCM-1² ³
pericentriolar material 1 protein²

External Ids:	HGNC: 8727¹	Entrez Gene: 5108²	Ensembl: ENSG00000078674⁷	UniProtKB: Q15154³

Export aliases for PCM1 gene to outside databases

Previous GC identifers: GC08P017656 GC08P017843 GC08P017790 GC08P017824

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PCM1:

The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered

around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several

centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene

are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical

chronic myeloid leukemia and T-cell lymphoma. (provided by RefSeq)

UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154

Function: Required for centrosome assembly and function. Essential for the correct localization of several centrosomal

proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome

Gene Wiki entry for PCM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PCM1 gene promoter:
         Nkx3-1   Nkx3-1 v1   Nkx3-1 v4   Nkx3-1 v2   Nkx3-1 v3   SREBP-1a   SREBP-1c   SREBP-1b   E2F-5   E2F-4
         Other transcription factors

Search SABiosciences Chromatin IP Primers for PCM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PCM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 8p22-p21.3 Ensembl cytogenetic band: 8p22 HGNC cytogenetic band: 8p22-p21.3

PCM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PCM1 gene location

GeneLoc gene densities for chromosome 8 GeneLoc Exon Structure

GeneLoc location for GC08P016324: view genomic region (about GC identifiers)

Start:	16,324,235 bp from pter
End:	16,431,242 bp from pter
Size:	107,008 bases
Orientation:	plus strand

1 alternative location:

Chr8+ 17,780,349-17,887,453

RefSeq DNA sequence:

NC_000008.10 NT_167187.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154 (See protein sequence)

Recommended Name: Pericentriolar material 1 protein

Size: 2024 amino acids; 228533 Da

Subunit: Self-associates (By similarity). Interacts with BBS4, BBS8, CETN3, HAP1, NDE1 and NDEL1

Subcellular location: Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, centrosome. Cytoplasmic granule. Note=Localizes

to cytoplasmic granules which are enriched around the centrosome. This centrosomal enrichment requires microtubules

and dynein. The majority of the protein dissociates from the centrosome during metaphase and subsequently localizes to

the cleavage site in telophase

Sequence caution: Sequence=AAH27477.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=AAH65022.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence;

Sequence=BAC03656.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAC14882.1;

Type=Miscellaneous discrepancy; Note=Contaminating sequence;

Secondary accessions: Q58F13 Q6P1K7 Q8NB85 Q9BWC1 Q9H4A2

Alternative splicing: 3 isoforms: Q15154-1 Q15154-2 Q15154-3

Explore the universe of human proteins at neXtProt for PCM1: NX_Q15154

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_006188.3

ENSEMBL proteins:

ENSP00000431099 ENSP00000429054 ENSP00000428123 ENSP00000327077 ENSP00000428131 ENSP00000430521

ENSP00000382891 ENSP00000328332 ENSP00000404339 ENSP00000427863 ENSP00000315008 ENSP00000429941

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for PCM1
	Novus Biologicals Protein for PCM1
	Novus Biologicals Lysate for PCM1
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5/8 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000242	pericentriolar material	ISS	--
GO:0005737	cytoplasm	ISS	--
GO:0005813	centrosome	ISS	--
GO:0005829	cytosol	EXP	16462731
GO:0005856	cytoskeleton	IEA	--

About this table

PCM1 for ontologies About GeneDecksing

Antibodies for PCM1:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PCM1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for PCM1
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for PCM1
	Novus Biologicals Antibodies for PCM1
	Browse antibodies at Epitomics

Assays for PCM1:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PCM1
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PCM1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q15154

UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154

Similarity: Belongs to the PCM1 family

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154

Function: Required for centrosome assembly and function. Essential for the correct localization of several centrosomal

proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome

Induction: Expression is reduced in breast and ovarian cancer

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PCM1 Sigma-Aldrich shRNA for PCM1
		OriGene 29mer shRNA kits in GFP-retroviral vector: PCM1 OriGene shRNA RFP: PCM1 OriGene basic RS shRNA: PCM1 OriGene siRNA: PCM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PCM1

miRNA:		Sigma-Aldrich microRNA Mimics for PCM1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PCM1
		8/14 SABiosciences Assays for microRNAs that regulate PCM1 (see all 14):
		hsa-miR-768-3p hsa-miR-520d-5p hsa-miR-198 hsa-miR-202 hsa-miR-15a hsa-miR-128 hsa-miR-548e hsa-miR-497

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PCM1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PCM1 OriGene untagged cDNA clones in CMV expression vector (see all 2): PCM1 OriGene 3'-UTR clone: PCM1 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PCM1
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PCM1

Genatlas biochemistry entry for PCM1:

pericentriolar material 1

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005488	binding	--	--
GO:0005515	protein binding	IPI	18772192
GO:0042802	identical protein binding	ISS	--

About this table

PCM1 for ontologies About GeneDecksing

Animal Models: 1 MGI phenotypic allele for Pcm1 (no phenotypes)

PCM1 for phenotypes About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for PCM1

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PCM1

5/68 Interacting proteins for PCM1 (ENSP00000327077³ Q15154^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 68)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CEP72	Q9P209¹	STRING: ENSP00000264935 EBI-741421,EBI-739498
BBS4	Q96RK4¹	EBI-741421,EBI-1805814
GSK3B	P49841²	MINT-4049759
YWHAZ	P63104²	MINT-3295217
CEP250	ENSP00000348401³	STRING: ENSP00000348401

About this table

5/8 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 8):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000086	G2/M transition of mitotic cell cycle	TAS	--
GO:0000278	mitotic cell cycle	TAS	--
GO:0022027	interkinetic nuclear migration	ISS	--
GO:0034453	microtubule anchoring	ISS	--
GO:0042384	cilium assembly	IMP	17574030

About this table

PCM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

PCM1 for compounds About GeneDecksing

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PCM1
1 Novoseek chemical compound relationship for PCM1 gene

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
tyrosine	4.75	2	10980597 (1), 16091753 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PCM1 Sigma-Aldrich shRNA for PCM1
		OriGene 29mer shRNA kits in GFP-retroviral vector: PCM1 OriGene shRNA RFP: PCM1 OriGene basic RS shRNA: PCM1 OriGene siRNA: PCM1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PCM1

miRNA:		Sigma-Aldrich microRNA Mimics for PCM1 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PCM1
		8/14 SABiosciences Assays for microRNAs that regulate PCM1 (see all 14):
		hsa-miR-768-3p hsa-miR-520d-5p hsa-miR-198 hsa-miR-202 hsa-miR-15a hsa-miR-128 hsa-miR-548e hsa-miR-497

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PCM1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PCM1 OriGene untagged cDNA clones in CMV expression vector (see all 2): PCM1 OriGene 3'-UTR Clone: PCM1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PCM1

Primers:		OriGene genome-wide validated SYBR primer pairs: PCM1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PCM1: PPH17387A

REFSEQ mRNAs for PCM1 gene:

NM_006197.3

Additional cDNA sequence:

AF068293.1 AJ297349.1 AK091406.1 AK295856.1 AK301727.1 AK302378.1 AK307583.1 BC000453.2

BC027477.1 BC065022.1 BC098391.1 BC133052.1 BC140946.1 L27841.1

24 DOTS entries:

DT.101976277 DT.65284974 DT.100653199 DT.95312120 DT.434342 DT.100875418 DT.95312136 DT.100738131

DT.92431659 DT.86995513 DT.65284852 DT.95312128 DT.120632476 DT.102832803 DT.120632425 DT.75113280

DT.120632443 DT.120632452 DT.120632463 DT.91796609 DT.100740083 DT.101972313 DT.40132839 DT.97798814

24/360 AceView cDNA sequences (see all 360):

BI966701 BF939232 BM460315 AA773615 AL046024 CK430642 BM692791 BM671552

AA136212 CA436664 BP378555 BP354824 AL701164 AI523355 AI738786 AI651570

NM_006197 BU183194 BG944168 AL119599 AL046710 AL712077 AI122590 CA311685

highest scoring ESTs for PCM1:

AA136212 AA136384 AA342787 AA669353 AA758728 AA765944 AA773615 AA781077 AA813291 AA846315

Unigene Cluster for PCM1:

Pericentriolar material 1

Hs.491148 [show with all ESTs]

Unigene Representative Sequence: NM_006197

GeneLoc Exon Structure

5/23 Alternative Splicing Database (ASD) splice patterns (SP) for PCM1 (see all 23)

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6a	·	6b	^	7	^	8	^	9a	·	9b	^	10a	·	10b	·	10c	^	11a	·	11b	^	12a	·	12b	^	13a	·
SP1:
SP2:
SP3:
SP4:
SP5:

ExUns:	13b	^	14a	·	14b	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20a	·	20b	·	20c	^	21a	·	21b	·	21c	^	22	^	23a	·	23b	^	24a	·	24b	^	25a	·	25b	·	25c	·	25d	^	26a	·	26b	^
SP1:																																																	-		-
SP2:																													-		-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:																																																	-
SP5:

ExUns:	27	^	28a	·	28b	^	29	^	30a	·	30b	^	31	^	32a	·	32b	^	33	^	34a	·	34b	^	35	^	36a	·	36b	^	37	^	38a	·	38b	^	39	^	40	^	41	^	42	^	43
SP1:	-		-		-																-
SP2:	-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP3:
SP4:	-		-		-
SP5:																	-				-

About this scheme

ECgene alternative splicing isoforms for PCM1
18/27 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 27):

ENST00000519253 ENST00000522275 ENST00000518762 ENST00000518537 ENST00000524356

ENST00000518936 ENST00000325083 ENST00000518930 ENST00000517730 ENST00000522998

ENST00000524203 ENST00000517836 ENST00000523896 ENST00000518877 ENST00000517545

ENST00000524226 ENST00000523540 ENST00000521338

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PCM1 expression in normal and diseased human tissues

¹ / ² / ³

18 probe-sets matching PCM1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36682_at²^{, 3}	U95-A	1	1.00	1.00	0.90	0.62	L27841	0.80	1.00	0.91	1
77262_at²^{, 3}	U95-E	1	1.00	1.00	0.72	1.84	AI601149	0.20	1.00	0.72	1
73078_s_at²^{, 3}	U95-E	1	1.00	1.00	0.76	0.61	AA931266	0.80	1.00	0.91	1
51300_s_at²^{, 3}	U95-B	1	1.00	1.00	0.57	1.01	AA922289	0.80	1.00	0.91	1
76161_r_at²^{, 3}	U95-E	1	0.44	1.00	-0.03	1.01	R42580	0.20	1.00	0.72	1
51305_r_at²^{, 3}	U95-B	1	0.38	1.00	-0.22	0.22	AA922289	0.80	1.00	0.91	1
202174_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_006197	0.40	1.00	0.76	1
228905_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE672700	0.20	1.00	0.72	1
214937_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI924817	0.80	1.00	0.91	1
209997_x_at²^{, 3}	U133-A	1	0.91	1.00	--	--	BC000453	0.60	1.00	0.82	1
209996_x_at²^{, 3}	U133-A	1	0.73	1.00	--	--	AA931266	0.80	1.00	0.91	1
214118_x_at²^{, 3}	U133-A	1	0.73	1.00	--	--	AI205598	0.80	1.00	0.91	1
202174_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
228905_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
214937_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209997_x_at²	U133Plus2	1	0.91	1.00	--	--	--	--	--	--	--
209996_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--
214118_x_at²	U133Plus2	1	0.73	1.00	--	--	--	--	--	--	--

About this table

PCM1 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PCM1 gene electronic northern expression

About these images

CGAP SAGE TAG: ATGAACAGGT

SOURCE GeneReport for Unigene cluster: Hs.491148

Expression variation in blood from EXPOLDB for PCM1

UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154

Tissue specificity: Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid

Primers:		OriGene genome-wide validated SYBR primer pairs: PCM1 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PCM1: PPH17387A

SABiosciences Custom PCR Arrays for PCM1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PCM1 gene from 5/10 species (see all 10)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PCM1¹	--	pericentriolar material 1	92.15(n) 91.94(a)	475618 XM_851292.1 XP_856385.1
chimpanzee (Pan troglodytes)	PCM1¹	--	pericentriolar material 1	99.59(n) 99.31(a)	464020 XM_001143824.1 XP_001143824.1
cow (Bos taurus)	PCM1¹	--	pericentriolar material 1	90.42(n) 89.77(a)	525337 XM_864234.2 XP_869327.2
rat (Rattus norvegicus)	Pcm1¹	--	pericentriolar material 1	88.41(n) 89.14(a)	81740 XM_001057686.1 XP_001057686.1
mouse (Mus musculus)	Pcm1^{1 , 5}	8 (23.89 cM)⁵	pericentriolar material 1^{1, 5}	89.05(n)¹ 89.29(a)¹	18536¹ NM_023662.2¹ NP_076151.1¹ AA529562⁵ AB029291⁵ (see all 25)

About this table Species with no ortholog for PCM1

ENSEMBL Gene Tree for PCM1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 8 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs3760^1,2	C,F,A,H,	17886345(+)	`GAACTC/TGTTGA`	1	--	ut3¹		11	MN EA NS NA WA	430
rs10283^1,2	C,F,A,	17885406(-)	`AAAATC/GAAGAC`	1	--	ut3¹		10	MN NS EA NA WA	666
rs106294^1,2	C,F,O,A,	17782692(-)	`AAGGTA/GTAACA`	1	--	int¹		13	NS EA NA WA	1062
rs172298^1,2	C	17822231(+)	`CTTCTA/GACAGT`	2	N D	ref¹ mis¹		5	MN NS EA	602
rs208020^1,2	C,F,O,	17880917(+)	`AAAATG/AGCTTA`	1	--	int¹		92	NS EA NA PA EU CA WA	4998
rs208021^1,2	C,F,O,A,	17879392(+)	`ctctgA/Caatga`	1	--	int¹		15	MN NS EA NA WA	1242
rs208022^1,2	C,F,O,A,H,	17879028(+)	`aacagT/Gagcaa`	1	--	int¹		16	NS EA NA WA	1196
rs208023^1,2	C,F,A,H,	17878882(+)	`tttctA/Gccacc`	1	--	int¹		18	MN NS EA NA WA	1422
rs208025^1,2	C,F,O,	17878170(+)	`GAGCAG/AGACAT`	1	--	int¹		11	NS NA EA WA	452
rs208026^1,2	C,F,	17878155(+)	`TAGAGG/AAGAAA`	1	--	int¹ trp³		11	EA NS NA WA	1632

About this table

HapMap Linkage Disequilibrium images for PCM1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for PCM1
1 Indel: 95298

QIAGEN SeqTarget long-range PCR primers for resequencing PCM1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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PCM1 for disorders About GeneDecksing

OMIM: 600299 disorders: 188550

UniProtKB/Swiss-Prot: PCM1_HUMAN, Q15154

Defects in PCM1 are a cause of thyroid papillary carcinoma (TPC) [MIM:188550]. TPC is a common tumor of the

thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary

carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of

fibrous stroma that is covered with a surface layer of neoplastic epithelial cells. Note=A chromosomal aberration

involving PCM1 is found in thyroid papillary carcinomas. Translocation t(8;10)(p21.3;q11.2) with RET links the protein

kinase domain of RET to the major portion of PCM1

Note=A chromosomal aberration involving PCM1 is found in a variety of hematological malignancies including

atypical chronic myeloid leukemia (atypical CML) and T-cell lymphoma. Translocation t(8;9)(p22;p24) with JAK2 links

the protein kinase domain of JAK2 to the major portion of PCM1

Human Gene Mutation Database (HGMD): PCM1
Human Genome Epidemiology (HuGE) Navigator: PCM1 (9 documents)

Export disorders and mutations for PCM1 gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
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10/65 PubMed articles for PCM1 gene, integrated from 7 sources (see all 65):
(articles sorted by number of sources associating them with PCM1)

PCM-1, A 228-kD centrosome autoantigen with a distinct cell cycle distribution. (PubMed id 8120099)^{1, 2, 3, 7} Balczon R.... Zimmer W.E. (1994)
Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation. (PubMed id 15659651)^{1, 2, 3, 7} Hames R.S.... Fry A.M. (2005)
Assembly of centrosomal proteins and microtubule organization depends on PCM-1. (PubMed id 12403812)^{1, 2, 7} Dammermann A. and Merdes A. (2002)
The t(8;9)(p22;p24) translocation in atypical chronic myeloid leukaemia yields a new PCM1-JAK2 fusion gene. (PubMed id 16091753)^{1, 2, 7} Bousquet M.... Brousset P. (2005)
RET/PCM-1: a novel fusion gene in papillary thyroid carcinoma. (PubMed id 10980597)^{1, 2, 7} Corvi R.... Romeo G. (2000)
Nudel contributes to microtubule anchoring at the mother centriole and is involved in both dynein-dependent and -independent centrosomal protein assembly. (PubMed id 16291865)^{1, 2, 7} Guo J.... Zhu X. (2006)
Inhibition of centrosome protein assembly leads to p53-dependent exit from the cell cycle. (PubMed id 16943179)^{1, 2, 7} Srsen V.... Merdes A. (2006)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{1, 2} Beausoleil S.A.... Gygi S.P. (2006)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{1, 2} Nousiainen M.... Koerner R. (2006)
A combination of cytomorphology, cytogenetic analysis, fluorescence in situ hybridization and reverse transcriptase polymerase chain reaction for establishing clonality in cases of persisting hypereosinophilia. (PubMed id 16769584)^{1, 2} Bacher U.... Schoch C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5108	HGNC: 8727	AceView: PCM1	Ensembl:ENSG00000078674	euGenes: HUgn5108
ECgene: PCM1	H-InvDB: PCM1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PCM1	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PCM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for PCM1 gene:
Search GeneIP for patents involving PCM1

GeneCards and IP:
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