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PDE4DIP Gene

protein-coding   GIFtS: 56

GC01M119142
phosphodiesterase 4D interacting protein
(Previous name: cardiomyopathy associated 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CMYA2)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
phosphodiesterase 4D interacting protein1 2     CMYA22 3
MMGL1 2 3     cardiomyopathy associated 21
KIAA04771 3     DKFZp781J0542
KIAA04541 3     myomegalin2
Cardiomyopathy-associated protein 22 3     MGC754402
Phosphodiesterase 4D-interacting protein2 3     

External Ids:    HGNC: 155801   Entrez Gene: 96592   Ensembl: ENSG000001781047   UniProtKB: Q5VU433   

Export aliases for PDE4DIP gene to outside databases

Previous GC identifers: GC01P144477 GC01M141455 GC01M142582 GC01M142604 GC01M142606 GC01M142189 GC01M143563 GC01M144833


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE4DIP:
The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell.
Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several
transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43
Function: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes
(By similarity)

Gene Wiki entry for PDE4DIP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the PDE4DIP gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2   POU3F2 (N-Oct-5a)   ZID   Fra-1   c-Fos   c-Jun   JunB   JunD   AP-1   
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PDE4DIP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PDE4DIP 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q12   Ensembl cytogenetic band:  1q21.1   HGNC cytogenetic band: 1q21.1

PDE4DIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE4DIP gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M119142:  view genomic region     (about GC identifiers)

Start:
119,142,103 bp from pter
End:
119,150,668 bp from pter
Size:
8,566 bases
Orientation:
minus strand

1 alternative location:
Chr1- 144,833,168-145,076,186     
RefSeq DNA sequence:
NC_000001.10  NT_167185.1  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43 (See protein sequence)
Recommended Name: Myomegalin  
Size: 2346 amino acids; 265080 Da
Subunit: Interacts with PDE4D (By similarity)
Subcellular location: Golgi apparatus (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm.
Nucleus
Developmental stage: Expressed in fetal heart
Sequence caution: Sequence=AAH04860.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence; Sequence=BAA32299.2; Type=Erroneous initiation; Sequence=BAA32322.2; Type=Erroneous initiation;
Sequence=CAD91152.1; Type=Frameshift; Positions=1507;
Secondary accessions: A2RU15 O75042 O75065 Q2YDC1 Q5VU42 Q5VU44 Q5VU45 Q5VU46 Q5VU47 Q5VU48 Q5VU49
Q68DU2 Q6AZ93 Q6PK88 Q86T40 Q86TB2 Q8N3W0 Q8TAY9 Q9HCP2 Q9HCP3 Q9HCP4 Q9HCP5
Alternative splicing: 12 isoforms:  Q5VU43-1   Q5VU43-2   Q5VU43-3   Q5VU43-4   Q5VU43-5   Q5VU43-6   Q5VU43-7   Q5VU43-8   
Q5VU43-9   Q5VU43-10   Q5VU43-11   Q5VU43-12   

Explore the universe of human proteins at neXtProt for PDE4DIP: NX_Q5VU43 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (9 alternative transcripts): 
    NP_001002810.1  NP_001002811.1  NP_001002812.1  NP_001182189.1  NP_001182190.1  NP_001185761.1  NP_001185763.1  NP_055459.4  
    NP_071754.3  


    ENSEMBL proteins: 
    ENSP00000327209 ENSP00000358363 ENSP00000358360 ENSP00000358357 ENSP00000358355 ENSP00000316434 
    ENSP00000358353 ENSP00000358354 ENSP00000358351 ENSP00000358359 ENSP00000358366 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PDE4DIP
    GenScript Custom Purified and Recombinant Proteins Services for PDE4DIP 
    Novus Biologicals Protein for PDE4DIP
    Novus Biologicals Lysates for PDE4DIP
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634 nucleus IEA--
    GO:0005737 cytoplasm IEA--
    GO:0005794 Golgi apparatus IEA--
    GO:0005815 microtubule organizing center IEA--
    GO:0005856 cytoskeleton IEA--
    About this table

    PDE4DIP for ontologies           About GeneDecksing



    Antibodies for PDE4DIP: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for PDE4DIP
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PDE4DIP 
    Novus Biologicals Antibodies for PDE4DIP
    Browse antibodies at Epitomics

    Assays for PDE4DIP: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDE4DIP 
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for PDE4DIP 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PDE4DIP for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR010630 DUF1220
     IPR012943 Spindle_assoc

    Graphical View of Domain Structure for InterPro Entry Q5VU43

    ProtoNet protein and cluster: Q5VU43

    2 Blocks protein families:
    IPB001854 Ribosomal protein L29
    IPB012943 Spindle associated


    UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43
    Similarity: Contains 1 NBPF domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43
    Function: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes
    (By similarity)

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PDE4DIP
    Sigma-Aldrich shRNA for PDE4DIP
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 15): PDE4DIP
    OriGene shRNA RFP (see all 15): PDE4DIP
    OriGene basic RS shRNA (see all 15): PDE4DIP
    OriGene siRNA (see all 10): PDE4DIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PDE4DIP 
    miRNA:Sigma-Aldrich microRNA Mimics for PDE4DIP
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PDE4DIP 
    1 SABiosciences Assays for microRNA that regulate PDE4DIP:
    hsa-miR-339-5p

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): PDE4DIP
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): PDE4DIP
    OriGene untagged cDNA clones in CMV expression vector (see all 9): PDE4DIP
    OriGene 3'-UTR clone (see all 5): PDE4DIP 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PDE4DIP 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PDE4DIP 

    1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515 protein binding IPI18482256
    About this table

    PDE4DIP for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PDE4DIP 

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PDE4DIP

    4 Interacting proteins for PDE4DIP (Q5VU431, 2) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRNPP041561EBI-1105124,EBI-977302
    GFI1BQ5VTD92MINT-2867137
    ZNF512BQ96KM62MINT-60833
    --Q9WMX22MINT-7049699
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDE4DIP


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Sigma-Aldrich esiRNA and siRNA for PDE4DIP
    Sigma-Aldrich shRNA for PDE4DIP
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 15): PDE4DIP
    OriGene shRNA RFP (see all 15): PDE4DIP
    OriGene basic RS shRNA (see all 15): PDE4DIP
    OriGene siRNA (see all 10): PDE4DIP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PDE4DIP 
    miRNA: Sigma-Aldrich microRNA Mimics for PDE4DIP
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PDE4DIP 
    1 SABiosciences Assays for microRNA that regulate PDE4DIP:
    hsa-miR-339-5p
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): PDE4DIP
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): PDE4DIP
    OriGene untagged cDNA clones in CMV expression vector (see all 9): PDE4DIP
    OriGene 3'-UTR Clone (see all 5): PDE4DIP 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PDE4DIP 
    Primers: OriGene genome-wide validated SYBR primer pairs: PDE4DIP
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PDE4DIP: PPH22722A

    REFSEQ mRNAs for PDE4DIP gene (9 alternative transcripts): 

    NM_001002810.3  NM_001002811.1  NM_001002812.1  NM_001195260.1  NM_001195261.1  NM_001198832.1  NM_001198834.1  NM_014644.4  
    NM_022359.5  

    Additional cDNA sequence: AK124487.1 

    24/80 DOTS entries (see all 80):

    DT.100880361  DT.452896  DT.448155  DT.91983083  DT.91665329  DT.97818813  DT.99950187  DT.100880359 
    DT.95159277  DT.100030547  DT.97819830  DT.100880366  DT.100030544  DT.121435992  DT.100009110  DT.101971490 
    DT.121460398  DT.100030545  DT.100880360  DT.101973646  DT.107988  DT.121435399  DT.91781552  DT.95159276 

    24/400 AceView cDNA sequences (see all 400):

    AA775002 T31080 CR609046 BE550115 AA333456 CD365041 CB528730 AI264185 
    NM_001002811 AA335969 CB528428 BM917065 BQ673978 BC004860 AB007946 BQ653363 
    CD742658 BQ425354 AI821791 AL601222 F13113 AI130757 F26249 AI312019 

    highest scoring ESTs for PDE4DIP:

    AI939395 BC025406 BI552090 BI755883 CB153232 U51694 AB007923 AB007946 AI659612 BI667885 

    Unigene Clusters for PDE4DIP:

    Phosphodiesterase 4D interacting protein
    Hs.568247  [show with all ESTs], Hs.584841  [show with all ESTs], Hs.613082  [show with all ESTs], Hs.657490  [show with all ESTs]
    Unigene Representative Sequences: NM_014644, AL080213, AB042555, AK124487


    GeneLoc Exon Structure

    5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PDE4DIP (see all 16)

    ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d ^ 9 ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18 ^
    SP1:                                      -           -     -     -     -                             -     -           -                                       
    SP2:                                                                                                  -     -           -                                       
    SP3:                                                                                                  -     -           -                                       
    SP4:                                                                                                  -     -           -                                       
    SP5:                                                                                                  -     -           -                                       

    ExUns: 19 ^ 20 ^ 21 ^ 22 ^ 23 ^ 24 ^ 25a · 25b ^ 26 ^ 27 ^ 28 ^ 29a · 29b ^ 30 ^ 31a · 31b ^ 32 ^ 33a · 33b · 33c ^ 34 ^ 35a · 35b ^ 36 ^ 37 ^ 38 ^
    SP1:                                                                          -     -     -     -           -     -     -                 -                     
    SP2:                                                                          -     -     -     -           -     -     -                                       
    SP3:                                                                          -     -     -     -           -     -     -                                       
    SP4:                                                                          -     -     -     -                                                               
    SP5:                                                                          -     -     -     -                                                               

    ExUns: 39 ^ 40 ^ 41 ^ 42 ^ 43 ^ 44 ^ 45 ^ 46 ^ 47a · 47b ^ 48 ^ 49a · 49b ^ 50a · 50b ^ 51 ^ 52 ^ 53 ^ 54 ^ 55a · 55b
    SP1:                          -                             -           -                                                         
    SP2:                                                        -           -                                               -         
    SP3:                                                        -           -                                                         
    SP4:                                                                                                                              
    SP5:                                                                                                                              

    About this scheme

    ECgene alternative splicing isoforms for PDE4DIP
    18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):
    ENST00000469668(uc001elt.1 uc001elu.1) ENST00000466343 ENST00000460027
    ENST00000313382(uc001elx.3) ENST00000369356 ENST00000369354(uc001elv.3 uc001eme.1 uc001elw.3)
    ENST00000464924 ENST00000479369(uc001ema.2) ENST00000481227 ENST00000494734
    ENST00000369351(uc001emd.1) ENST00000369349(uc001emc.1) ENST00000313431(uc001emb.1 uc001emf.1)
    ENST00000491426 ENST00000467859 ENST00000479408 ENST00000496263 ENST00000496572


    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PDE4DIP expression in normal and diseased human tissues

    1  / 2  / 3

    32 probe-sets matching PDE4DIP gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    49963_g_at2, 3 U95-B 3 1.00 0.92 0.45 0.94 AI821791 0.60 0.83 0.73 1
    39422_at2, 3 U95-A 2 1.00 0.91 0.99 1.27 AB007923 0.80 0.88 0.84 1
    57273_s_at2, 3 U95-C 2 1.00 0.81 0.99 1.55 AI634721 0.40 0.30 0.35 1
    47483_at2, 3 U95-B 2 1.00 0.78 0.97 1.02 AI659612 0.80 0.88 0.84 1
    32645_at2, 3 U95-A 1 0.94 1.00 0.92 0.79 AB007946 0.80 0.88 0.84 1
    33364_at2, 3 U95-A 3 0.88 0.79 0.99 0.84 U51694 0.80 1.00 0.91 1
    58358_r_at2 U95-C 2 0.50 0.62 0.89 1.09 -- -- -- -- --
    67292_at2, 3 U95-D 3 0.31 0.87 0.18 0.79 AI939395 0.80 1.00 0.91 1
    212392_s_at2, 3 U133-A 1 1.00 1.00 -- -- AI950145 0.60 1.00 0.82 1
    212390_at2, 3 U133-A 2 1.00 0.91 -- -- AB007923 0.80 0.88 0.84 1
    214130_s_at2, 3 U133-A 3 1.00 0.82 -- -- AI821791 0.60 0.83 0.73 1
    205872_x_at2, 3 U133-A 2 0.91 0.90 -- -- NM_022359 0.60 1.00 0.82 1
    210305_at2, 3 U133-A 2 0.91 0.85 -- -- AB042557 0.60 1.00 0.82 1
    214099_s_at2, 3 U133-A 1 0.82 1.00 -- -- AK001619 0.60 1.00 0.82 1
    215575_at2, 3 U133-A 1 0.46 1.00 -- -- AU157078 0.40 1.00 0.76 1
    209700_x_at2, 3 U133-A 1 0.46 1.00 -- -- AB042555 0.60 1.00 0.82 1
    232509_at2, 3 U133-B 1 0.36 1.00 -- -- AK024906 0.60 1.00 0.82 1
    236856_x_at2 U133-B 2 0.36 0.62 -- -- -- -- -- -- --
    214129_at2, 3 U133-A 1 0.27 1.00 -- -- AI821791 0.60 0.83 0.73 1
    211751_at*2, 3 U133-A NULL 0.00 0.00 -- -- BC005949 0.40 0.67 0.55 1
    212392_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    212390_at2 U133Plus2 2 1.00 0.91 -- -- -- -- -- -- --
    214130_s_at2 U133Plus2 3 1.00 0.82 -- -- -- -- -- -- --
    205872_x_at2 U133Plus2 2 0.91 0.90 -- -- -- -- -- -- --
    210305_at2 U133Plus2 2 0.91 0.85 -- -- -- -- -- -- --
    214099_s_at2 U133Plus2 1 0.82 1.00 -- -- -- -- -- -- --
    215575_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    209700_x_at2 U133Plus2 1 0.46 1.00 -- -- -- -- -- -- --
    232509_at2 U133Plus2 1 0.36 1.00 -- -- -- -- -- -- --
    236856_x_at2 U133Plus2 2 0.36 0.62 -- -- -- -- -- -- --
    214129_at2 U133Plus2 1 0.27 1.00 -- -- -- -- -- -- --
    211751_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    About this table

    PDE4DIP for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PDE4DIP gene expression
    PDE4DIP gene electronic northern expression
    PDE4DIP gene sage expression
    About these images

    CGAP SAGE TAG: AATAAAGTGG ATCCCAAAAA TAGTATTCTG

    SOURCE GeneReport for Unigene clusters: Hs.568247 Hs.584841 Hs.613082 Hs.657490

    Expression variation in blood from EXPOLDB for PDE4DIP

    UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43
    Tissue specificity: Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta

    Primers: OriGene genome-wide validated SYBR primer pairs: PDE4DIP
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PDE4DIP: PPH22722A
        SABiosciences Custom PCR Arrays for PDE4DIP 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PDE4DIP gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PDE4DIP1   -- phosphodiesterase 4D interacting protein 88.11(n)
    86.1(a)
    475817  XM_853294.1  XP_858387.1 
    chimpanzee
    (Pan troglodytes)
    PDE4DIP1   -- phosphodiesterase 4D interacting protein 91.43(n)
    89.34(a)
    457130  XM_001146341.1  XP_001146341.1 
    cow
    (Bos taurus)
    PDE4DIP1   -- phosphodiesterase 4D interacting protein 88.35(n)
    86.13(a)
    508547  XM_867519.2  XP_872612.2 
    rat
    (Rattus norvegicus)
    Pde4dip1   -- phosphodiesterase 4D interacting protein 82.19(n)
    78.78(a)
    64183  NM_022382.1  NP_071777.1 
    mouse
    (Mus musculus)
    Pde4dip1 , 5 3 (42.28 cM)5
    phosphodiesterase 4D interacting protein (myomegalin)1, 5 82.96(n)1
    81.03(a)1
    836791  NM_001039376.11  NP_001034465.11 
     AA7279465  AA9152035  (see all 46)
    About this table        Species with no ortholog for PDE4DIP

    ENSEMBL Gene Tree for PDE4DIP (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PDE4DIP gene
    CDK5RAP22  

    PDE4DIP for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/3911 NCBI SNPs in PDE4DIP are shown (see all 3911)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs37331,2
    C144851506(-) GACAGC/GGTGGG 1 -- ut31 ese30--------
    rs37341,2
    C,F144851543(-) TGCTAA/TCGCCA 1 -- ut314Minor allele frequency- T:0.17MN NA 378
    rs37361,2
    C,F144851554(+) ACATAA/TATAAA 1 -- ut31 ese33Minor allele frequency- T:0.38NA 8
    rs89471,2
    C,F,A144851484(-) GAAAGT/CCTTTT 1 -- ut314Minor allele frequency- C:0.28MN NA 374
    rs95361,2
    F144851460(-) AGCAAG/AATGTG 1 -- ut314Minor allele frequency- A:0.37NA EA 218
    rs109431,2
    C,F,144851537(-) CGCCAT/CATATT 1 -- ut314Minor allele frequency- C:0.50MN NA 378
    rs114471,2
    C,F144890833(-) ATTATA/GAGTTA 3 -- ut31 int1 ese34Minor allele frequency- G:0.50MN NA 380
    rs132471,2
    C,F144851467(-) TTGTTA/TAAGCA 1 -- ut31 ese32Minor allele frequency- T:0.33NA 6
    rs1132521,2
    C,F,A144913035(-) aaaaaT/Attttt 3 -- int1 trp35Minor allele frequency- A:0.02EA NS NA WA 184
    rs4722771,2
    C,F,A145057895(-) GCAGTG/AGCACA 1 -- int16Minor allele frequency- A:0.10EA NS NA 182
    About this table

    HapMap Linkage Disequilibrium images for PDE4DIP (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 38 variations for PDE4DIP
         15/27 CNVs (see all 27): 6780 34695 31652 39008 0685 69888 0387 34696 58332 23199 60883 3310 97496 2324 69883
         11 Indels: 59955 44445 97497 59954 63036 60884 59956 44443 39655 44444 39654

    QIAGEN SeqTarget long-range PCR primers for resequencing PDE4DIP 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PDE4DIP for disorders           About GeneDecksing

    OMIM: 608117

    UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43
  • Note=A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD)
  • associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein

    Human Genome Epidemiology (HuGE) Navigator: PDE4DIP (1 document)

    Export disorders and mutations for PDE4DIP gene to outside databases


    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/23 PubMed articles for PDE4DIP gene, integrated from 7 sources (see all 23):
    (articles sorted by number of sources associating them with PDE4DIP)
    1. Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)1, 2, 3 Seki N.... Ohara O. (1997)
    2. Isolation of novel heart-specific genes using the BodyMap database. (PubMed id 11374908)1, 2, 7 Soejima H.... Mukai T. (2001)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. (PubMed id 11134006)1, 3 Verde I....Conti M. (2001)
    5. Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma. (PubMed id 17143517)1, 7 Shimada H....Hiwasa T. (2007)
    6. Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. (PubMed id 12907457)2, 7 Wilkinson K.... Aguiar R.C.T. (2003)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)1 Satoh J....Tabunoki H. (2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 9659 HGNC: 15580 AceView: PDE4DIP Ensembl:ENSG00000178104 euGenes: HUgn9659
    ECgene: PDE4DIP H-InvDB: PDE4DIP

    (According to HUGE)
    About This Section
    HUGE: KIAA0477 KIAA0454

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for PDE4DIP Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PDE4DIP gene:
    Search GeneIP for patents involving PDE4DIP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

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     Regulatory tfbs in PDE4DIP promoter
     Search Chromatin IP Primers for PDE4DIP
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     ELISAs and CLIAs for PDE4DIP
           

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