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PDE4DIP Gene

protein-coding GIFtS: 56

GC01M119142

phosphodiesterase 4D interacting protein
(Previous name: cardiomyopathy associated 2 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CMYA2)

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
phosphodiesterase 4D interacting protein¹ ²		CMYA2² ³
MMGL¹ ² ³		cardiomyopathy associated 2¹
KIAA0477¹ ³		DKFZp781J054²
KIAA0454¹ ³		myomegalin²
Cardiomyopathy-associated protein 2² ³		MGC75440²
Phosphodiesterase 4D-interacting protein² ³

External Ids:	HGNC: 15580¹	Entrez Gene: 9659²	Ensembl: ENSG00000178104⁷	UniProtKB: Q5VU43³

Export aliases for PDE4DIP gene to outside databases

Previous GC identifers: GC01P144477 GC01M141455 GC01M142582 GC01M142604 GC01M142606 GC01M142189 GC01M143563 GC01M144833

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for PDE4DIP:

The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell.

Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several

transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq)

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Function: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes

(By similarity)

Gene Wiki entry for PDE4DIP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PDE4DIP gene promoter:
         POU3F2 (N-Oct-5b)   POU3F2   POU3F2 (N-Oct-5a)   ZID   Fra-1   c-Fos   c-Jun   JunB   JunD   AP-1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for PDE4DIP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PDE4DIP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q12 Ensembl cytogenetic band: 1q21.1 HGNC cytogenetic band: 1q21.1

PDE4DIP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDE4DIP gene location

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01M119142: view genomic region (about GC identifiers)

Start:	119,142,103 bp from pter
End:	119,150,668 bp from pter
Size:	8,566 bases
Orientation:	minus strand

1 alternative location:

Chr1- 144,833,168-145,076,186

RefSeq DNA sequence:

NC_000001.10 NT_167185.1

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43 (See protein sequence)

Recommended Name: Myomegalin

Size: 2346 amino acids; 265080 Da

Subunit: Interacts with PDE4D (By similarity)

Subcellular location: Golgi apparatus (By similarity). Cytoplasm, cytoskeleton, centrosome (By similarity). Cytoplasm.

Nucleus

Developmental stage: Expressed in fetal heart

Sequence caution: Sequence=AAH04860.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A

sequence; Sequence=BAA32299.2; Type=Erroneous initiation; Sequence=BAA32322.2; Type=Erroneous initiation;

Sequence=CAD91152.1; Type=Frameshift; Positions=1507;

Secondary accessions: A2RU15 O75042 O75065 Q2YDC1 Q5VU42 Q5VU44 Q5VU45 Q5VU46 Q5VU47 Q5VU48 Q5VU49

Q68DU2 Q6AZ93 Q6PK88 Q86T40 Q86TB2 Q8N3W0 Q8TAY9 Q9HCP2 Q9HCP3 Q9HCP4 Q9HCP5

Alternative splicing: 12 isoforms: Q5VU43-1 Q5VU43-2 Q5VU43-3 Q5VU43-4 Q5VU43-5 Q5VU43-6 Q5VU43-7 Q5VU43-8

Q5VU43-9 Q5VU43-10 Q5VU43-11 Q5VU43-12

Explore the universe of human proteins at neXtProt for PDE4DIP: NX_Q5VU43

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (9 alternative transcripts):

NP_001002810.1 NP_001002811.1 NP_001002812.1 NP_001182189.1 NP_001182190.1 NP_001185761.1 NP_001185763.1 NP_055459.4

NP_071754.3

ENSEMBL proteins:

ENSP00000327209 ENSP00000358363 ENSP00000358360 ENSP00000358357 ENSP00000358355 ENSP00000316434

ENSP00000358353 ENSP00000358354 ENSP00000358351 ENSP00000358359 ENSP00000358366

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene Protein Over-expression Lysate: PDE4DIP
	GenScript Custom Purified and Recombinant Proteins Services for PDE4DIP
	Novus Biologicals Protein for PDE4DIP
	Novus Biologicals Lysates for PDE4DIP
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

5 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0005794	Golgi apparatus	IEA	--
GO:0005815	microtubule organizing center	IEA	--
GO:0005856	cytoskeleton	IEA	--

About this table

PDE4DIP for ontologies About GeneDecksing

Antibodies for PDE4DIP:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PDE4DIP
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for PDE4DIP
	Novus Biologicals Antibodies for PDE4DIP
	Browse antibodies at Epitomics

Assays for PDE4DIP:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PDE4DIP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PDE4DIP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PDE4DIP for domains About GeneDecksing

2 InterPro domains/families:

IPR010630 DUF1220

IPR012943 Spindle_assoc

Graphical View of Domain Structure for InterPro Entry Q5VU43

ProtoNet protein and cluster: Q5VU43

2 Blocks protein families:

IPB001854 Ribosomal protein L29

IPB012943 Spindle associated

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Similarity: Contains 1 NBPF domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Function: May function as an anchor sequestering components of the cAMP-dependent pathway to Golgi and/or centrosomes

(By similarity)

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PDE4DIP Sigma-Aldrich shRNA for PDE4DIP
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 15): PDE4DIP OriGene shRNA RFP (see all 15): PDE4DIP OriGene basic RS shRNA (see all 15): PDE4DIP OriGene siRNA (see all 10): PDE4DIP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PDE4DIP

miRNA:		Sigma-Aldrich microRNA Mimics for PDE4DIP Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PDE4DIP
		1 SABiosciences Assays for microRNA that regulate PDE4DIP:
		hsa-miR-339-5p

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): PDE4DIP OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): PDE4DIP OriGene untagged cDNA clones in CMV expression vector (see all 9): PDE4DIP OriGene 3'-UTR clone (see all 5): PDE4DIP Browse MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PDE4DIP
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PDE4DIP

1 Gene Ontology (GO) molecular function term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005515	protein binding	IPI	18482256

About this table

PDE4DIP for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

SABiosciences Custom Pathway-Focused PCR Arrays for PDE4DIP

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for PDE4DIP

4 Interacting proteins for PDE4DIP (Q5VU43^{1, 2}) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PRNP	P04156¹	EBI-1105124,EBI-977302
GFI1B	Q5VTD9²	MINT-2867137
ZNF512B	Q96KM6²	MINT-60833
--	Q9WMX2²	MINT-7049699

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PDE4DIP

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PDE4DIP Sigma-Aldrich shRNA for PDE4DIP
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 15): PDE4DIP OriGene shRNA RFP (see all 15): PDE4DIP OriGene basic RS shRNA (see all 15): PDE4DIP OriGene siRNA (see all 10): PDE4DIP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PDE4DIP

miRNA:		Sigma-Aldrich microRNA Mimics for PDE4DIP Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PDE4DIP
		1 SABiosciences Assays for microRNA that regulate PDE4DIP:
		hsa-miR-339-5p

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector (see all 5): PDE4DIP OriGene Myc/DDK tagged cDNA clones in CMV expression vector (see all 5): PDE4DIP OriGene untagged cDNA clones in CMV expression vector (see all 9): PDE4DIP OriGene 3'-UTR Clone (see all 5): PDE4DIP Browse OriGene MicroRNA Expression Plasmids
		GenScript cDNA clones with any tag delivered in your preferred vector (see all 2): PDE4DIP

Primers:		OriGene genome-wide validated SYBR primer pairs: PDE4DIP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PDE4DIP: PPH22722A

REFSEQ mRNAs for PDE4DIP gene (9 alternative transcripts):

NM_001002810.3 NM_001002811.1 NM_001002812.1 NM_001195260.1 NM_001195261.1 NM_001198832.1 NM_001198834.1 NM_014644.4

NM_022359.5

Additional cDNA sequence: AK124487.1

24/80 DOTS entries (see all 80):

DT.100880361 DT.452896 DT.448155 DT.91983083 DT.91665329 DT.97818813 DT.99950187 DT.100880359

DT.95159277 DT.100030547 DT.97819830 DT.100880366 DT.100030544 DT.121435992 DT.100009110 DT.101971490

DT.121460398 DT.100030545 DT.100880360 DT.101973646 DT.107988 DT.121435399 DT.91781552 DT.95159276

24/400 AceView cDNA sequences (see all 400):

AA775002 T31080 CR609046 BE550115 AA333456 CD365041 CB528730 AI264185

NM_001002811 AA335969 CB528428 BM917065 BQ673978 BC004860 AB007946 BQ653363

CD742658 BQ425354 AI821791 AL601222 F13113 AI130757 F26249 AI312019

highest scoring ESTs for PDE4DIP:

AI939395 BC025406 BI552090 BI755883 CB153232 U51694 AB007923 AB007946 AI659612 BI667885

Unigene Clusters for PDE4DIP:

Phosphodiesterase 4D interacting protein

Hs.568247 [show with all ESTs], Hs.584841 [show with all ESTs], Hs.613082 [show with all ESTs], Hs.657490 [show with all ESTs]

Unigene Representative Sequences: NM_014644, AL080213, AB042555, AK124487

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for PDE4DIP (see all 16)

ExUns:	1a	·	1b	·	1c	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	·	8c	·	8d	^	9	^	10	^	11a	·	11b	·	11c	^	12	^	13	^	14	^	15	^	16	^	17a	·	17b	^	18	^
SP1:													-				-		-		-		-										-		-				-
SP2:																																	-		-				-
SP3:																																	-		-				-
SP4:																																	-		-				-
SP5:																																	-		-				-

ExUns:	19	^	20	^	21	^	22	^	23	^	24	^	25a	·	25b	^	26	^	27	^	28	^	29a	·	29b	^	30	^	31a	·	31b	^	32	^	33a	·	33b	·	33c	^	34	^	35a	·	35b	^	36	^	37	^	38	^
SP1:																									-		-		-		-				-		-		-						-
SP2:																									-		-		-		-				-		-		-
SP3:																									-		-		-		-				-		-		-
SP4:																									-		-		-		-
SP5:																									-		-		-		-

ExUns:	39	^	40	^	41	^	42	^	43	^	44	^	45	^	46	^	47a	·	47b	^	48	^	49a	·	49b	^	50a	·	50b	^	51	^	52	^	53	^	54	^	55a	·	55b
SP1:									-										-				-
SP2:																			-				-																-
SP3:																			-				-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for PDE4DIP
18/29 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 29):

ENST00000469668(uc001elt.1 uc001elu.1) ENST00000466343 ENST00000460027

ENST00000313382(uc001elx.3) ENST00000369356 ENST00000369354(uc001elv.3 uc001eme.1 uc001elw.3)

ENST00000464924 ENST00000479369(uc001ema.2) ENST00000481227 ENST00000494734

ENST00000369351(uc001emd.1) ENST00000369349(uc001emc.1) ENST00000313431(uc001emb.1 uc001emf.1)

ENST00000491426 ENST00000467859 ENST00000479408 ENST00000496263 ENST00000496572

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PDE4DIP expression in normal and diseased human tissues

¹ / ² / ³

32 probe-sets matching PDE4DIP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
49963_g_at²^{, 3}	U95-B	3	1.00	0.92	0.45	0.94	AI821791	0.60	0.83	0.73	1
39422_at²^{, 3}	U95-A	2	1.00	0.91	0.99	1.27	AB007923	0.80	0.88	0.84	1
57273_s_at²^{, 3}	U95-C	2	1.00	0.81	0.99	1.55	AI634721	0.40	0.30	0.35	1
47483_at²^{, 3}	U95-B	2	1.00	0.78	0.97	1.02	AI659612	0.80	0.88	0.84	1
32645_at²^{, 3}	U95-A	1	0.94	1.00	0.92	0.79	AB007946	0.80	0.88	0.84	1
33364_at²^{, 3}	U95-A	3	0.88	0.79	0.99	0.84	U51694	0.80	1.00	0.91	1
58358_r_at²	U95-C	2	0.50	0.62	0.89	1.09	--	--	--	--	--
67292_at²^{, 3}	U95-D	3	0.31	0.87	0.18	0.79	AI939395	0.80	1.00	0.91	1
212392_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AI950145	0.60	1.00	0.82	1
212390_at²^{, 3}	U133-A	2	1.00	0.91	--	--	AB007923	0.80	0.88	0.84	1
214130_s_at²^{, 3}	U133-A	3	1.00	0.82	--	--	AI821791	0.60	0.83	0.73	1
205872_x_at²^{, 3}	U133-A	2	0.91	0.90	--	--	NM_022359	0.60	1.00	0.82	1
210305_at²^{, 3}	U133-A	2	0.91	0.85	--	--	AB042557	0.60	1.00	0.82	1
214099_s_at²^{, 3}	U133-A	1	0.82	1.00	--	--	AK001619	0.60	1.00	0.82	1
215575_at²^{, 3}	U133-A	1	0.46	1.00	--	--	AU157078	0.40	1.00	0.76	1
209700_x_at²^{, 3}	U133-A	1	0.46	1.00	--	--	AB042555	0.60	1.00	0.82	1
232509_at²^{, 3}	U133-B	1	0.36	1.00	--	--	AK024906	0.60	1.00	0.82	1
236856_x_at²	U133-B	2	0.36	0.62	--	--	--	--	--	--	--
214129_at²^{, 3}	U133-A	1	0.27	1.00	--	--	AI821791	0.60	0.83	0.73	1
211751_at*²^{, 3}	U133-A	NULL	0.00	0.00	--	--	BC005949	0.40	0.67	0.55	1
212392_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
212390_at²	U133Plus2	2	1.00	0.91	--	--	--	--	--	--	--
214130_s_at²	U133Plus2	3	1.00	0.82	--	--	--	--	--	--	--
205872_x_at²	U133Plus2	2	0.91	0.90	--	--	--	--	--	--	--
210305_at²	U133Plus2	2	0.91	0.85	--	--	--	--	--	--	--
214099_s_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
215575_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--
209700_x_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--
232509_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--
236856_x_at²	U133Plus2	2	0.36	0.62	--	--	--	--	--	--	--
214129_at²	U133Plus2	1	0.27	1.00	--	--	--	--	--	--	--
211751_at*²	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

About this table

PDE4DIP for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PDE4DIP gene electronic northern expression

About these images

CGAP SAGE TAG: AATAAAGTGG ATCCCAAAAA TAGTATTCTG

SOURCE GeneReport for Unigene clusters: Hs.568247 Hs.584841 Hs.613082 Hs.657490

Expression variation in blood from EXPOLDB for PDE4DIP

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Tissue specificity: Highly expressed in heart and skeletal muscle and to a lower extent in brain and placenta

Primers:		OriGene genome-wide validated SYBR primer pairs: PDE4DIP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PDE4DIP: PPH22722A

SABiosciences Custom PCR Arrays for PDE4DIP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PDE4DIP gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PDE4DIP¹	--	phosphodiesterase 4D interacting protein	88.11(n) 86.1(a)	475817 XM_853294.1 XP_858387.1
chimpanzee (Pan troglodytes)	PDE4DIP¹	--	phosphodiesterase 4D interacting protein	91.43(n) 89.34(a)	457130 XM_001146341.1 XP_001146341.1
cow (Bos taurus)	PDE4DIP¹	--	phosphodiesterase 4D interacting protein	88.35(n) 86.13(a)	508547 XM_867519.2 XP_872612.2
rat (Rattus norvegicus)	Pde4dip¹	--	phosphodiesterase 4D interacting protein	82.19(n) 78.78(a)	64183 NM_022382.1 NP_071777.1
mouse (Mus musculus)	Pde4dip^{1 , 5}	3 (42.28 cM)⁵	phosphodiesterase 4D interacting protein (myomegalin)^{1, 5}	82.96(n)¹ 81.03(a)¹	83679¹ NM_001039376.1¹ NP_001034465.1¹ AA727946⁵ AA915203⁵ (see all 46)

About this table Species with no ortholog for PDE4DIP

ENSEMBL Gene Tree for PDE4DIP (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for PDE4DIP gene

CDK5RAP2²

PDE4DIP for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
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SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs3733^1,2	C	144851506(-)	`GACAGC/GGTGGG`	1	--	ut3¹ ese³		0	--	--	--	--
rs3734^1,2	C,F	144851543(-)	`TGCTAA/TCGCCA`	1	--	ut3¹		4		MN NA	378
rs3736^1,2	C,F	144851554(+)	`ACATAA/TATAAA`	1	--	ut3¹ ese³		3		NA	8
rs8947^1,2	C,F,A	144851484(-)	`GAAAGT/CCTTTT`	1	--	ut3¹		4		MN NA	374
rs9536^1,2	F	144851460(-)	`AGCAAG/AATGTG`	1	--	ut3¹		4		NA EA	218
rs10943^1,2	C,F,	144851537(-)	`CGCCAT/CATATT`	1	--	ut3¹		4		MN NA	378
rs11447^1,2	C,F	144890833(-)	`ATTATA/GAGTTA`	3	--	ut3¹ int¹ ese³		4		MN NA	380
rs13247^1,2	C,F	144851467(-)	`TTGTTA/TAAGCA`	1	--	ut3¹ ese³		2		NA	6
rs113252^1,2	C,F,A	144913035(-)	`aaaaaT/Attttt`	3	--	int¹ trp³		5		EA NS NA WA	184
rs472277^1,2	C,F,A	145057895(-)	`GCAGTG/AGCACA`	1	--	int¹		6		EA NS NA	182

About this table

HapMap Linkage Disequilibrium images for PDE4DIP (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 38 variations for PDE4DIP
15/27 CNVs (see all 27): 6780 34695 31652 39008 0685 69888 0387 34696 58332 23199 60883 3310 97496 2324 69883
11 Indels: 59955 44445 97497 59954 63036 60884 59956 44443 39655 44444 39654

QIAGEN SeqTarget long-range PCR primers for resequencing PDE4DIP

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
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PDE4DIP for disorders About GeneDecksing

OMIM: 608117

UniProtKB/Swiss-Prot: MYOME_HUMAN, Q5VU43

Note=A chromosomal aberration involving PDE4DIP may be the cause of a myeloproliferative disorder (MBD)

associated with eosinophilia. Translocation t(1;5)(q23;q33) that forms a PDE4DIP-PDGFRB fusion protein

Human Genome Epidemiology (HuGE) Navigator: PDE4DIP (1 document)

Export disorders and mutations for PDE4DIP gene to outside databases

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/23 PubMed articles for PDE4DIP gene, integrated from 7 sources (see all 23):
(articles sorted by number of sources associating them with PDE4DIP)

Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. (PubMed id 9455484)^{1, 2, 3} Seki N.... Ohara O. (1997)
Isolation of novel heart-specific genes using the BodyMap database. (PubMed id 11374908)^{1, 2, 7} Soejima H.... Mukai T. (2001)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Myomegalin is a novel protein of the golgi/centrosome that interacts with a cyclic nucleotide phosphodiesterase. (PubMed id 11134006)^{1, 3} Verde I....Conti M. (2001)
Serum anti-myomegalin antibodies in patients with esophageal squamous cell carcinoma. (PubMed id 17143517)^{1, 7} Shimada H....Hiwasa T. (2007)
Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. (PubMed id 12907457)^{2, 7} Wilkinson K.... Aguiar R.C.T. (2003)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Protein microarray analysis identifies human cellular prion protein interactors. (PubMed id 18482256)¹ Satoh J....Tabunoki H. (2009)
Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)¹ Barbe L....Andersson-Svahn H. (2008)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9659	HGNC: 15580	AceView: PDE4DIP	Ensembl:ENSG00000178104	euGenes: HUgn9659
ECgene: PDE4DIP	H-InvDB: PDE4DIP

(According to HUGE)
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HUGE: KIAA0477 KIAA0454

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for PDE4DIP	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for PDE4DIP gene
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Patent Information for PDE4DIP gene:
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GeneCards and IP:
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