Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



PDPK2 Gene

pseudogene   GIFtS: 21

GC16M002609

symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
3-phosphoinositide dependent protein kinase 1 pseudogene2
EC 2.7.11.13

External Ids:    Entrez Gene: 6536502   Ensembl: ENSG000002059187   UniProtKB: Q6A1A23   

Export aliases for PDPK2 gene to outside databases

Previous GC identifer: GC16M002607


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PDPK2_HUMAN, Q6A1A2
Function: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a
general role in signaling processes and in development (By similarity)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PDPK2
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PDPK2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.3   Ensembl cytogenetic band:  16p13.3   

PDPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PDPK2 gene location

GeneLoc gene densities for chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M002609:  view genomic region     (about GC identifiers)

Start:
2,666,121 bp from pter
End:
2,693,297 bp from pter
Size:
27,177 bases
Orientation:
minus strand

1 alternative location:
Chr16- 2,624,840-2,652,010     

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PDPK2_HUMAN, Q6A1A2 (See protein sequence)
Recommended Name: Putative 3-phosphoinositide-dependent protein kinase 2  
Size: 396 amino acids; 44765 Da
Subcellular location: Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity)
Caution: Could be the product of a pseudogene

Explore the universe of human proteins at neXtProt for PDPK2: NX_Q6A1A2 

Post-translational modifications:

  • Phosphorylated on tyrosine and serine/threonine (By similarity)1
  • View phosphorylation sites using PhosphoSite2




  • ENSEMBL proteins: 
    ENSP00000371763 ENSP00000387522 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    GenScript Custom Purified and Recombinant Proteins Services for PDPK2 
    Novus Biologicals Protein for PDPK2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    2 Gene Ontology (GO) cellular component terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm ----
    GO:0016020 membrane ----
    About this table

    PDPK2 for ontologies           About GeneDecksing



    Antibodies for PDPK2: 
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse Antibodies at Sigma-Aldrich
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PDPK2 
    Novus Biologicals Antibody for PDPK2
    Browse antibodies at Epitomics

    Assays for PDPK2: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PDPK2 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PDPK2 for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_prot_kinase_dom
     IPR017442 Se/Thr_prot_kinase-like_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_prot_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q6A1A2

    ProtoNet protein and cluster: Q6A1A2

    UniProtKB/Swiss-Prot: PDPK2_HUMAN, Q6A1A2
    Similarity: Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDK1 subfamily
    Similarity: Contains 1 protein kinase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI ,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PDPK2_HUMAN, Q6A1A2
    Function: Phosphorylates and activates not only PKB/AKT, but also PKA, PKC-zeta, RPS6KA1 and RPS6KB1. May play a
    general role in signaling processes and in development (By similarity)
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme Number (IUBMB): EC 2.7.11.1 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Browse siRNA at Sigma-Aldrich
    Browse shRNA at Sigma-Aldrich
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PDPK2 
    miRNA:Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PDPK2 
    Search SABiosciences for Assays for microRNAs that regulate PDPK2

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PDPK2 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PDPK2 

    5 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding ----
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0005524 ATP binding ----
    GO:0016740 transferase activity ----
    About this table

    PDPK2 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PDPK2 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PDPK2

    5/16 Interacting proteins for PDPK2 (ENSP000003717633) via UniProtKB, MINT, and/or STRING (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PRKCIENSP000002957973STRING: ENSP00000295797
    AKT1ENSP000002702023STRING: ENSP00000270202
    AKT2ENSP000003094283STRING: ENSP00000309428
    AKT3ENSP000002638263STRING: ENSP00000263826
    INPP5DENSP000003525753STRING: ENSP00000352575
    About this table

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation ----
    About this table

    PDPK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PDPK2


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build ; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Browse Nano Scale siRNA at Sigma-Aldrich
    Browse siRNA at Sigma-Aldrich
    Browse shRNA at Sigma-Aldrich
    Browse OriGene 29mer shRNA kits
    Browse OriGene siRNA
    Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PDPK2 
    miRNA: Browse microRNA Mimics at Sigma-Aldrich
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PDPK2 
    Search SABiosciences for Assays for microRNAs that regulate PDPK2
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    Browse OriGene untagged/tagged cDNA clones in CMV expression vector
    Browse 3'-UTR reporter clones for miRNA target validation 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PDPK2 
    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for PDPK2

    highest scoring ESTs for PDPK2:

    AA568707 AA601893 AA872372 AI904957 BE006785 BE162718 BE876364 BG571705 BI036580 BQ345442 


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382326(uc002cqz.1) ENST00000436606

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build ), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PDPK2 expression in normal and diseased human tissues

     / 3 Data from Genenote  (Publications) and GNF BioGPS
        About these images

    PDPK2 gene expression
    PDPK2 gene electronic northern expression
    PDPK2 gene sage expression
    About these images

    CGAP SAGE TAG: --
    Primers:Browse OriGene genome-wide validated SYBR primer pairs
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for PDPK2
        SABiosciences Custom PCR Arrays for PDPK2 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI , with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PDPK2 gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    baker's yeast
    (Saccharomyces cerevisiae)
    PKH1(YDR490C)4 4(1434261-1431961) Serine/threonine protein kinase involved in sphingolipid-mediated more   -- 852101  NP_010778.1 
    About this table        Species with no ortholog for PDPK2

    ENSEMBL Gene Tree for PDPK2 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PDPK2 gene
    PDPK12  

    PDPK2 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section
    Search QIAGEN SeqTarget long-range PCR primers for resequencing for PDPK2 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section
      --

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 653650 Ensembl:ENSG00000205918 euGenes: HUgn653650

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PDPK2 gene:
    Search GeneIP for patents involving PDPK2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Browse siRNAs at Sigma-Aldrich Browse antibodies at Sigma-Aldrich
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Browse shRNAs at Sigma-Aldrich Browse microRNA Mimics at Sigma-Aldrich
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Browse Nano Scale siRNA at Sigma-Aldrich
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Search OriGene for PDPK2

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PDPK2
     Search QIAGEN SeqTarget long-range PCR primers for resequencing for PDPK2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     Search QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PDPK2
     GenScript Custom Purified and Recombinant Proteins Services for PDPK2 GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for PDPK2
     GenScript Custom Assay Services for PDPK2 GenScript Custom Superior Antibodies Services for PDPK2
     GenScript Custom overexpressing Cell Line Services for PDPK2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for PDPK2
     Search Chromatin IP Primers for PDPK2
     Search RT2 qPCR Primer Assays for PDPK2
     Search GNC Networks for PDPK2
     Search for Assays for microRNAs that regulate PDPK2
     SABiosciences Custom PCR Arrays for PDPK2
     Search Tocris compounds for PDPK2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for PDPK2
     Proteins for PDPK2
     Browse antibodies at Epitomics
     Browse ProSpec Recombinant Proteins

     Browse ELISAs and CLIAs at Uscn
           

    GeneCards Homepage - Last full update: 30 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    PDPK2 gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4