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PEAK1 Gene

protein-coding GIFtS: 27

GC15M054157

symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
Sugen kinase 269² ³		FLJ21140²
KIAA2002² ³		NKF3 kinase family member²
SGK269²		tyrosine-protein kinase SgK269²
pseudopodium enriched atypical kinase²		EC 2.7.10.2³
FLJ34483²

External Ids:	Entrez Gene: 79834²	Ensembl: ENSG00000173517⁷	UniProtKB: Q9H792³

Export aliases for PEAK1 gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for PEAK1
Other transcription factors

Search SABiosciences Chromatin IP Primers for PEAK1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.3 Ensembl cytogenetic band: 15q24.3

PEAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEAK1 gene location

GeneLoc gene densities for chromosome 15 GeneLoc Exon Structure

GeneLoc location for GC15M054157: view genomic region (about GC identifiers)

Start:	54,157,639 bp from pter
End:	54,325,227 bp from pter
Size:	167,589 bases
Orientation:	minus strand

1 alternative location:

Chr15- 77,400,471-77,544,873

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: SG269_HUMAN, Q9H792 (See protein sequence)

Recommended Name: Tyrosine-protein kinase SgK269

Size: 1746 amino acids; 193106 Da

Sequence caution: Sequence=BAB15006.1; Type=Erroneous initiation; Sequence=BAC87076.1; Type=Erroneous initiation;

Secondary accessions: Q6ZS78 Q8NAZ4 Q8NCM3 Q8TEG7

Explore the universe of human proteins at neXtProt for PEAK1: NX_Q9H792

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_079052.2

ENSEMBL proteins:

ENSP00000309230

Human Recombinant Proteins

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Assays for PEAK1:

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PEAK1 for domains About GeneDecksing

4 InterPro domains/families:

IPR017442 Se/Thr_prot_kinase-like_dom

IPR011009 Kinase-like_dom

IPR000719 Prot_kinase_cat_dom

IPR008266 Tyr_prot_kinase_AS

Graphical View of Domain Structure for InterPro Entry Q9H792

ProtoNet protein and cluster: Q9H792

1 Blocks protein family: IPB008266 Tyrosine protein kinase

UniProtKB/Swiss-Prot: SG269_HUMAN, Q9H792

Similarity: Belongs to the protein kinase superfamily

Similarity: Contains 1 protein kinase domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI ,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: SG269_HUMAN, Q9H792

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate

Enzyme Number (IUBMB): EC 2.7.10.2

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
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		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): PEAK1 OriGene shRNA RFP (see all 6): PEAK1 OriGene basic RS shRNA (see all 6): PEAK1 OriGene siRNA (see all 5): PEAK1
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miRNA:		Sigma-Aldrich microRNA Mimics for PEAK1 Browse microRNA target validation systems at Sigma-Aldrich
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Gene
Editing:

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Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
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		OriGene GFP tagged cDNA clones in CMV expression vector: PEAK1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PEAK1 OriGene untagged cDNA clones in CMV expression vector (see all 2): PEAK1 OriGene 3'-UTR clone: PEAK1 Browse MicroRNA Expression Plasmids
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Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PEAK1

5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004672	protein kinase activity	--	--
GO:0004674	protein serine/threonine kinase activity	--	--
GO:0004713	protein tyrosine kinase activity	--	--
GO:0004715	non-membrane spanning protein tyrosine kinase activity	IEA	--

About this table

PEAK1 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
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SABiosciences Custom Pathway-Focused PCR Arrays for PEAK1

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PEAK1

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006468	protein phosphorylation	IEA	--

About this table

PEAK1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PEAK1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build ; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Sigma-Aldrich Nano Scale siRNA for PEAK1 Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PEAK1 Sigma-Aldrich shRNA Panels and shRNA for PEAK1
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): PEAK1 OriGene shRNA RFP (see all 6): PEAK1 OriGene basic RS shRNA (see all 6): PEAK1 OriGene siRNA (see all 5): PEAK1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PEAK1

miRNA:		Sigma-Aldrich microRNA Mimics for PEAK1 Browse microRNA target validation systems at Sigma-Aldrich
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Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PEAK1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PEAK1 OriGene untagged cDNA clones in CMV expression vector (see all 2): PEAK1 OriGene 3'-UTR Clone: PEAK1 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PEAK1

Primers:		OriGene genome-wide validated SYBR primer pairs: PEAK1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for PEAK1

REFSEQ mRNAs for PEAK1 gene:

NM_024776.2

24/141 AceView cDNA sequences (see all 141):

BG108478 W73336 BM313769 BQ004525 AA375150 AI333649 AI277250 AA028136

BQ008784 BF439970 AI738877 BU675216 CN484011 AA845704 CK824061 W74595

BM876278 AI754811 BM149437 BF446350 AI634198 BM768527 AI200500 W73485

GeneLoc Exon Structure

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000312493(uc002bcm.2 uc002bcn.2)

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build ), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PEAK1 expression in normal and diseased human tissues

Data from GNF BioGPS
About these images

PEAK1 gene electronic northern expression

About these images

CGAP SAGE TAG: --

Primers:		OriGene genome-wide validated SYBR primer pairs: PEAK1 Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays for PEAK1

SABiosciences Custom PCR Arrays for PEAK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI , with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PEAK1 gene from 5/6 species (see all 6)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	LOC487662¹	--	hypothetical LOC487662	85.42(n) 86.01(a)	487662 XM_544787.2 XP_544787.2
chimpanzee (Pan troglodytes)	LOC453767¹	--	hypothetical LOC453767	99.43(n) 99.6(a)	453767 XM_510688.2 XP_510688.2
rat (Rattus norvegicus)	RGD1312026¹	--	similar to RIKEN cDNA C230081A13	85.88(n) 86.89(a)	315686 XM_236266.4 XP_236266.3
mouse (Mus musculus)	C230081A13Rik¹	--	RIKEN cDNA C230081A13 gene	86.37(n) 86.78(a)	244895 NM_172924.2 NP_766512.1
chicken (Gallus gallus)	SGK269¹	--	NKF3 kinase family member	74.19(n) 74.06(a)	415348 XM_413732.2 XP_413732.2

About this table Species with no ortholog for PEAK1

ENSEMBL Gene Tree for PEAK1 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PEAK1 gene

C19orf35² SGK223²

PEAK1 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 15 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs14726^1,2	C,F,A,	77400607(+)	`CAGAGA/GGGACC`	1	--	ut3¹		15		MN NS EA NA WA	1158
rs1015813^1,2	C,F,A,	77533274(-)	`GGGAAG/ATATAT`	1	--	int¹		7		NS EA NA WA	624
rs1062191^1,2	--	77514444(-)	`AGAATC/TCCTGT`	1	--	int¹		0	--	--	--	--
rs1125617^1,2	C,A,	77532711(+)	`aatccA/Gagccc`	1	--	int¹		8		MN NA EA	354
rs1201476^1,2	--	77509453(-)	`gctaaA/Gactgc`	1	--	int¹		0	--	--	--	--
rs1211508^1,2	C	77509278(-)	`tttaaG/Aaccat`	1	--	int¹		4		NS EA	390
rs1213016^1,2	--	77509324(-)	`gctgaA/Gattac`	1	--	int¹		0	--	--	--	--
rs1355956^1,2	C	77524504(-)	`taaagA/Cgcgaa`	1	--	int¹		5		MN NS EA	598
rs1374201^1,2	C,F,O,A,	77477873(+)	`AATGAG/AGACTT`	1	--	int¹		11		MN NS EA NA WA	954
rs1446312^1,2	C,F,O,A,	77412189(-)	`TAGCTG/CTCTAG`	1	--	int¹		21		NS MN NA EA WA	1070

About this table

HapMap Linkage Disequilibrium images for PEAK1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PEAK1: --

QIAGEN SeqTarget long-range PCR primers for resequencing PEAK1

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/13 PubMed articles for PEAK1 gene, integrated from 7 sources (see all 13):
(articles sorted by number of sources associating them with PEAK1)

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)^{1, 2} Zody M.C....Nusbaum C. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)^{1, 2} Ohara O.... Koseki H. (2002)
The protein kinase complement of the human genome. (PubMed id 12471243)^{1, 2} Manning G.... Sudarsanam S. (2002)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)² Gauci S....Mohammed S. (2009)
An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. (PubMed id 19534553)² Heibeck T.H.... Qian W.-J. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

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Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 79834

AceView: KIAA2002

Ensembl:ENSG00000173517

euGenes: HUgn79834

(According to HUGE)
About This Section

HUGE: KIAA2002

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for PEAK1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

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Patent Information for PEAK1 gene:
Search GeneIP for patents involving PEAK1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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PEAK1 Gene

protein-coding GIFtS: 27

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PEAK1 Gene

protein-coding GIFtS: 27

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