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PEAK1 Gene

protein-coding   GIFtS: 27

GC15M054157

symbol from the EntrezGene Database
NOT approved by the HUGO Gene Nomenclature Committee (HGNC).
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases & Descriptions
Sugen kinase 2692 3     FLJ211402
KIAA20022 3     NKF3 kinase family member2
SGK2692     tyrosine-protein kinase SgK2692
pseudopodium enriched atypical kinase2     EC 2.7.10.23
FLJ344832     

External Ids:    Entrez Gene: 798342   Ensembl: ENSG000001735177   UniProtKB: Q9H7923   

Export aliases for PEAK1 gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

  --

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PEAK1
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PEAK1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q24.3   Ensembl cytogenetic band:  15q24.3   

PEAK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PEAK1 gene location

GeneLoc gene densities for chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M054157:  view genomic region     (about GC identifiers)

Start:
54,157,639 bp from pter
End:
54,325,227 bp from pter
Size:
167,589 bases
Orientation:
minus strand

1 alternative location:
Chr15- 77,400,471-77,544,873     

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
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UniProtKB/Swiss-Prot: SG269_HUMAN, Q9H792 (See protein sequence)
Recommended Name: Tyrosine-protein kinase SgK269  
Size: 1746 amino acids; 193106 Da
Sequence caution: Sequence=BAB15006.1; Type=Erroneous initiation; Sequence=BAC87076.1; Type=Erroneous initiation;
Secondary accessions: Q6ZS78 Q8NAZ4 Q8NCM3 Q8TEG7

Explore the universe of human proteins at neXtProt for PEAK1: NX_Q9H792 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_079052.2  

    ENSEMBL proteins: 
    ENSP00000309230 


    Human Recombinant Proteins 
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    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PEAK1 for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR017442 Se/Thr_prot_kinase-like_dom
     IPR011009 Kinase-like_dom
     IPR000719 Prot_kinase_cat_dom
     IPR008266 Tyr_prot_kinase_AS

    Graphical View of Domain Structure for InterPro Entry Q9H792

    ProtoNet protein and cluster: Q9H792

    1 Blocks protein family: IPB008266 Tyrosine protein kinase

    UniProtKB/Swiss-Prot: SG269_HUMAN, Q9H792
    Similarity: Belongs to the protein kinase superfamily
    Similarity: Contains 1 protein kinase domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI ,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: SG269_HUMAN, Q9H792
    Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate
    Enzyme Number (IUBMB): EC 2.7.10.2 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
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    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): PEAK1
    OriGene shRNA RFP (see all 6): PEAK1
    OriGene basic RS shRNA (see all 6): PEAK1
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    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PEAK1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PEAK1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PEAK1
    OriGene 3'-UTR clone: PEAK1 
    Browse MicroRNA Expression Plasmids 
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    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PEAK1 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004672 protein kinase activity ----
    GO:0004674 protein serine/threonine kinase activity ----
    GO:0004713 protein tyrosine kinase activity ----
    GO:0004715 non-membrane spanning protein tyrosine kinase activity IEA--
    About this table

    PEAK1 for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section

        SABiosciences Custom Pathway-Focused PCR Arrays for PEAK1 

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PEAK1

    1 Gene Ontology (GO) biological process term (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468 protein phosphorylation IEA--
    About this table

    PEAK1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section
    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PEAK1


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build ; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for PEAK1
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PEAK1
    Sigma-Aldrich shRNA Panels and shRNA for PEAK1
    OriGene 29mer shRNA kits in GFP-retroviral vector (see all 6): PEAK1
    OriGene shRNA RFP (see all 6): PEAK1
    OriGene basic RS shRNA (see all 6): PEAK1
    OriGene siRNA (see all 5): PEAK1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PEAK1 
    miRNA: Sigma-Aldrich microRNA Mimics for PEAK1
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PEAK1 
    Search SABiosciences for Assays for microRNAs that regulate PEAK1
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PEAK1
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PEAK1
    OriGene untagged cDNA clones in CMV expression vector (see all 2): PEAK1
    OriGene 3'-UTR Clone: PEAK1 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript Custom cDNA clone Services for PEAK1 
    Primers: OriGene genome-wide validated SYBR primer pairs: PEAK1
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for PEAK1

    REFSEQ mRNAs for PEAK1 gene: 

    NM_024776.2  

    24/141 AceView cDNA sequences (see all 141):

    BG108478 W73336 BM313769 BQ004525 AA375150 AI333649 AI277250 AA028136 
    BQ008784 BF439970 AI738877 BU675216 CN484011 AA845704 CK824061 W74595 
    BM876278 AI754811 BM149437 BF446350 AI634198 BM768527 AI200500 W73485 


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000312493(uc002bcm.2 uc002bcn.2)

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build ), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PEAK1 expression in normal and diseased human tissues

    Data from GNF BioGPS
        About these images

    PEAK1 gene expression
    PEAK1 gene electronic northern expression
    PEAK1 gene sage expression
    About these images

    CGAP SAGE TAG: --
    Primers: OriGene genome-wide validated SYBR primer pairs: PEAK1
    Browse OriGene validated miRNA SYBR primer pairs 
    Search SABiosciences RT2 qPCR Primer Assays for PEAK1
        SABiosciences Custom PCR Arrays for PEAK1 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI , with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PEAK1 gene from 5/6 species (see all 6)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    LOC4876621   -- hypothetical LOC487662 85.42(n)
    86.01(a)
    487662  XM_544787.2  XP_544787.2 
    chimpanzee
    (Pan troglodytes)
    LOC4537671   -- hypothetical LOC453767 99.43(n)
    99.6(a)
    453767  XM_510688.2  XP_510688.2 
    rat
    (Rattus norvegicus)
    RGD13120261   -- similar to RIKEN cDNA C230081A13 85.88(n)
    86.89(a)
    315686  XM_236266.4  XP_236266.3 
    mouse
    (Mus musculus)
    C230081A13Rik1   -- RIKEN cDNA C230081A13 gene 86.37(n)
    86.78(a)
    244895  NM_172924.2  NP_766512.1 
    chicken
    (Gallus gallus)
    SGK2691   -- NKF3 kinase family member 74.19(n)
    74.06(a)
    415348  XM_413732.2  XP_413732.2 
    About this table        Species with no ortholog for PEAK1

    ENSEMBL Gene Tree for PEAK1 (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
    Paralogs for PEAK1 gene
    C19orf352  SGK2232  

    PEAK1 for paralogs           About GeneDecksing



    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/1161 NCBI SNPs in PEAK1 are shown (see all 1161)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 15 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs147261,2
    C,F,A,77400607(+) CAGAGA/GGGACC 1 -- ut3115Minor allele frequency- G:0.07MN NS EA NA WA 1158
    rs10158131,2
    C,F,A,77533274(-) GGGAAG/ATATAT 1 -- int17Minor allele frequency- A:0.17NS EA NA WA 624
    rs10621911,2
    --77514444(-) AGAATC/TCCTGT 1 -- int10--------
    rs11256171,2
    C,A,77532711(+) aatccA/Gagccc 1 -- int18Minor allele frequency- G:0.47MN NA EA 354
    rs12014761,2
    --77509453(-) gctaaA/Gactgc 1 -- int10--------
    rs12115081,2
    C77509278(-) tttaaG/Aaccat 1 -- int14Minor allele frequency- A:0.00NS EA 390
    rs12130161,2
    --77509324(-) gctgaA/Gattac 1 -- int10--------
    rs13559561,2
    C77524504(-) taaagA/Cgcgaa 1 -- int15Minor allele frequency- C:0.00MN NS EA 598
    rs13742011,2
    C,F,O,A,77477873(+) AATGAG/AGACTT 1 -- int111Minor allele frequency- A:0.19MN NS EA NA WA 954
    rs14463121,2
    C,F,O,A,77412189(-) TAGCTG/CTCTAG 1 -- int121Minor allele frequency- C:0.44NS MN NA EA WA 1070
    About this table

    HapMap Linkage Disequilibrium images for PEAK1 (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for PEAK1: --

    QIAGEN SeqTarget long-range PCR primers for resequencing PEAK1 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/13 PubMed articles for PEAK1 gene, integrated from 7 sources (see all 13):
    (articles sorted by number of sources associating them with PEAK1)
    1. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PubMed id 16572171)1, 2 Zody M.C....Nusbaum C. (2006)
    3. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (2005)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method. (PubMed id 12056414)1, 2 Ohara O.... Koseki H. (2002)
    6. The protein kinase complement of the human genome. (PubMed id 12471243)1, 2 Manning G.... Sudarsanam S. (2002)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PubMed id 19413330)2 Gauci S....Mohammed S. (2009)
    9. An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells. (PubMed id 19534553)2 Heibeck T.H.... Qian W.-J. (2009)
    10. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
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    OMIM
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 79834 AceView: KIAA2002 Ensembl:ENSG00000173517 euGenes: HUgn79834

    (According to HUGE)
    About This Section
    HUGE: KIAA2002

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PEAK1 gene:
    Search GeneIP for patents involving PEAK1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
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    About This Section

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