Aliases &
Descriptions
for PELI1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases & Descriptions |
|---|
| pellino homolog 1 (Drosophila)1 2 | | pellino-12 | | Pellino-related intracellular-signaling molecule2 3 | | protein pellino homolog 12 | | pellino (Drosophila) homolog 11 | | PRISM3 | | MGC509902 | | Pellino-13 | | DKFZp686C181162 | | |
Export aliases for PELI1 gene to outside databasesPrevious GC identifers: GC02M064454 GC02M064277 GC02M064294 GC02M064231 GC02M064319 |
Summaries
for PELI1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: PELI1_HUMAN, Q96FA3Function: Scaffold protein involved in the IL-1 signaling pathway via its interaction with the complex containing IRAKkinases and TRAF6. Required for NF-kappa-B activation and IL-8 gene expression in response to IL-1
Gene Wiki entry for PELI1 |
Genomic Views
for PELI1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 60),
Regulatory elements and Epigenetics data according to
Qiagen and/or
SABiosciences)
About This Section
|
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the PELI1 gene promoter:
MEF-2A IRF-7A Egr-2 FOXL1 GR-alpha FOXI1 GATA-1 GATA-2 GATA-3 PPAR-gamma1
Other transcription factors
Search SABiosciences Chromatin IP Primers for PELI1
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PELI1  |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p13.3 Ensembl cytogenetic band: 2p14 HGNC cytogenetic band: 2p13.3PELI1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M064059: view genomic region
(about GC identifiers)
Start:
|
64,059,563 bp from pter |
End:
|
64,111,396 bp from pter |
Size:
|
51,834 bases |
Orientation:
|
minus strand |
1 alternative location:
| Chr2- 64,319,786-64,371,588 |
RefSeq DNA sequence:- NC_000002.11 NT_022184.15
|
Proteins
for PELI1 gene
(According to
1UniProtKB,
neXtProt,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological, and/or
ProSpec,
Biochemical Assays by
Millipore,
Sigma-Aldrich,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Dec 2010 and
Entrez Gene,
Antibodies by
Millipore,
Sigma-Aldrich,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals, and/or
Epitomics)
About This Section
|
UniProtKB/Swiss-Prot: PELI1_HUMAN, Q96FA3 (See
protein sequence)Recommended Name: Protein pellino homolog 1 Size: 418 amino acids; 46286 Da
Subunit: Found in a complex containing TRAF6, IRAK1 and IRAK4. Interacts with MAP3K7
Sequence caution: Sequence=AAH11419.1; Type=Erroneous initiation; Sequence=BAB55280.1; Type=Erroneous initiation;
Secondary accessions: Q96SM0 Q9GZY5 Q9HCX0Explore the universe of human proteins at neXtProt for PELI1: NX_Q96FA3
Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_065702.2
ENSEMBL proteins: ENSP00000351789
Human Recombinant Proteins
1 Gene Ontology (GO) cellular component term (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005829 | cytosol |
TAS | -- |
About this table
PELI1 for ontologies About GeneDecksing
Antibodies for PELI1:
Assays for PELI1: |
Protein
Domains/
Families
for PELI1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
PELI1 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96FA3ProtoNet protein and cluster: Q96FA3 UniProtKB/Swiss-Prot: PELI1_HUMAN, Q96FA3Similarity: Belongs to the pellino family |
Gene Function
for PELI1 gene
(According to UniProtKB,
IUBMB,and/or
Genatlas, Animal models from MGI Dec 24 2010,
shRNA from
OriGene,
Sigma-Aldrich,
RNAi from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Clones from Millipore,
Sigma-Aldrich,
OriGene,
GenScript,
Sino Biological,
Cell Lines from GenScript,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene.)
About This Section
|
UniProtKB/Swiss-Prot: PELI1_HUMAN, Q96FA3Function: Scaffold protein involved in the IL-1 signaling pathway via its interaction with the complex containing IRAKkinases and TRAF6. Required for NF-kappa-B activation and IL-8 gene expression in response to IL-1
2 Gene Ontology (GO) molecular function terms (GO ID links to tree view): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0004842 | ubiquitin-protein ligase activity |
IEA | -- | | GO:0005515 | protein binding |
IEA | -- |
About this table
PELI1 for ontologies About GeneDecksing
Animal Models: 4 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Peli1):
PELI1 for phenotypes About GeneDecksing
|
Pathways & Interactions
for PELI1 gene
(Pathways according to
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
PCR Arrays from
SABiosciences,
Proteins Network according to
SABiosciences,
Sigma-Aldrich,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Dec 2010 via
Entrez Gene).
About This Section
|
SABiosciences Pathway-Focused PCR Array including PELI1: PAHS-018A
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for PELI1
1 Interacting protein for PELI1 (Q96FA32 ENSP000003517893) via UniProtKB, MINT, and/or STRINGAbout this table
5/9 Gene Ontology (GO) biological process terms (GO ID links to tree view) (see all 9): | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0001819 | positive regulation of cytokine production |
IEA | -- | | GO:0030890 | positive regulation of B cell proliferation |
IEA | -- | | GO:0031398 | positive regulation of protein ubiquitination |
IEA | -- | | GO:0032496 | response to lipopolysaccharide |
IEA | -- | | GO:0034141 | positive regulation of toll-like receptor 3 signaling pathway |
IEA | -- |
About this table
PELI1 for ontologies About GeneDecksing
|
Drugs & Compounds
for PELI1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for PELI1
|
Transcripts
for PELI1 gene(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
Millipore,
siRNAs from
Sigma-Aldrich,
OriGene,
Qiagen,
Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
microRNA from Sigma-Aldrich,
Qiagen,
SABiosciences,
Tagged/untagged cDNA clones from
OriGene,
Sigma-Aldrich,
GenScript,
Primers from
OriGene and/or
SABiosciences)
About This Section
|
REFSEQ mRNAs for PELI1 gene: NM_020651.3 Additional cDNA sequence: AF086327.1 AF300987.1 AF302505.1 AJ278859.1 AK022261.1 AK026714.1 AK027668.1 AK312441.1 AY364257.1 BC011419.1 BC050019.1 BC050533.1 BC063611.1 BX649152.1 10 DOTS entries: DT.101979601 DT.115900 DT.421586 DT.40194907 DT.100739832 DT.100765232 DT.100659585 DT.432262 DT.95279257 DT.95279258 24/203 AceView cDNA sequences (see all 203): AA760841 AA649012 AW169621 BQ897912 BX649152 CA941447 BC011419 BF726098 BM673279 BP430927 CA941726 BE466752 F01839 AA939157 BX280442 AA346565 BC063611 BM791468 AK022261 BX116801 AW770838 BM992606 BM970082 AI867442
 highest scoring ESTs for PELI1:AF300987 AF302505 AL043980 BC050019 BC050533 BC063611 BF356469 BF795695 BF967290 BF979439 Unigene Cluster for PELI1: Pellino homolog 1 (Drosophila) Hs.727530 [show with all ESTs]Unigene Representative Sequence: AF302505
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for PELI1 (see all 8)
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 |
|---|
|
| SP1: | | | | | | | | | - | | | | | | - | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | | | - | | - | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | - | | - | | | | - | | | | | | | | | | | | | |
About this scheme
ECgene alternative splicing isoforms for PELI1
4 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000494203 ENST00000358912(uc002scr.3 uc002scs.3 uc002sct.3 uc002scu.1)
ENST00000468869 ENST00000466177
|
Expression
for PELI1 gene
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 228 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Primers from
OriGene and/or
SABiosciences
)
About This Section
| PELI1 expression in normal and diseased human tissues
1 / 2 / 3 8 probe-sets matching PELI1 gene
Affymetrix
probe-set |
Array |
GeneAnnot data |
GeneNote data |
GeneTide data |
| # genes |
Sensitivity |
Specificity |
Correlation |
Length |
Gb_Accession |
Consensus |
Uniqueness |
Score |
Rank |
| 54982_at2, 3
|
U95-B |
1 |
1.00 |
1.00 |
0.70 |
1.40 |
AL043980 |
0.80 |
1.00 |
0.91 |
1 |
| 87415_at2, 3
|
U95-E |
1 |
0.56 |
1.00 |
0.55 |
0.61 |
W73083 |
0.60 |
1.00 |
0.82 |
1 |
| 218319_at2, 3
|
U133-A |
1 |
1.00 |
1.00 |
-- |
-- |
NM_020651 |
0.60 |
1.00 |
0.82 |
1 |
| 232304_at*2, 3
|
U133-B |
1 |
0.55 |
1.00 |
-- |
-- |
AK026714 |
0.40 |
1.00 |
0.76 |
1 |
| 232213_at*2, 3
|
U133-B |
1 |
0.46 |
1.00 |
-- |
-- |
AU147506 |
0.40 |
1.00 |
0.76 |
1 |
| 218319_at2
|
U133Plus2 |
1 |
1.00 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 232304_at*2
|
U133Plus2 |
1 |
0.55 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
| 232213_at*2
|
U133Plus2 |
1 |
0.46 |
1.00 |
-- |
-- |
-- |
-- |
-- |
-- |
-- |
About this table
PELI1 for expression About GeneDecksing
Data from
Genenote
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: CTTTGTGACT
SOURCE GeneReport for Unigene cluster: Hs.727530
SABiosciences Expression via Pathway-Focused PCR Array including PELI1: PAHS-018A
|
Orthologs
for PELI1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Dec 24 2010,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for PELI1 gene from 5/11 species (see all 11)
About this table Species with no ortholog for PELI1
ENSEMBL Gene Tree for PELI1 (if available) |
Paralogs
for PELI1 gene(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for PELI1 gene
- PELI22 PELI32
PELI1 for paralogs About GeneDecksing
|
Genomic Variants
for PELI1 gene(SNPs according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Chr 2 pos | Sequence | Recs | AA
Chg | Type | More | Recs | Allele
freq | Pop | Total
sample | More |
|---|
About this tableHapMap Linkage Disequilibrium images for PELI1 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 8 variations for PELI1
8 CNVs: 8374 89690 2387 30951 78574 67895 4288 3362 | | QIAGEN SeqTarget long-range PCR primers for resequencing PELI1 |
|
Disorders & Mutations
for PELI1 gene
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
LSDB, HGMD, GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Medical News
for PELI1 gene(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for PELI1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6UniProtKB/TrEMBL, and/or
7Novoseek)
About This Section
|
10/18 PubMed articles for PELI1 gene, integrated from 7 sources (see all 18):
(articles sorted by number of sources associating them with PELI1)- Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping. (PubMed id 11306823)1, 2, 3, 7 Resch K.... Schmitt-John T. (2001)
- Pellino 1 is required for interleukin-1 (IL-1)-mediated signaling through its interaction with the IL-1 receptor-associated kinase 4 (IRAK4)-IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. (PubMed id 12496252)1, 2, 7 Jiang Z.... Li X. (2003)
- Smad6 negatively regulates interleukin 1-receptor-Toll-like receptor signaling through direct interaction with the adaptor Pellino-1. (PubMed id 16951688)1, 3 Choi K.C....Park S.H. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Pellino2 activates the mitogen activated protein kinase pathway. (PubMed id 12804775)1, 2 Jensen L.E. and Whitehead A.S. (2003)
- Pellino-related sequences from Caenorhabditis elegans and Homo sapiens. (PubMed id 11132151)1, 2 Rich T.... Trowsdale J. (2000)
- Kinase-active interleukin-1 receptor-associated kinases promote polyubiquitination and degradation of the Pellino family: direct evidence for PELLINO proteins being ubiquitin-protein isopeptide ligases. (PubMed id 17675297)1, 7 Butler M.P....Moynagh P.N. (2007)
- The IRAK-catalysed activation of the E3 ligase function of Pellino isoforms induces the Lys63-linked polyubiquitination of IRAK1. (PubMed id 17997719)1, 7 Ordureau A....Cohen P. (2008)
- Pellino 3b negatively regulates interleukin-1-induced TAK1-dependent NF kappaB activation. (PubMed id 18326498)1 Xiao H....Li X. (2008)
|
External Searches for PELI1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing PELI1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing PELI1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing PELI1 gene(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for PELI1 gene:
Search GeneIP for patents involving PELI1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for PELI1 gene(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or
Enzo Life Sciences)
About This Section
|
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| | | |
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 |  |  |  | |
| |  | Search Tocris compounds for PELI1 |
| |  |  |  |  | | | | |
 | | | ELISAs and CLIAs for PELI1 |
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