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PHC3 Gene

protein-coding GIFtS: 48

GC03M167082

polyhomeotic homolog 3 (Drosophila)
(Previous name: polyhomeotic like 3 (Drosophila) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

		Products

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases & Descriptions
polyhomeotic homolog 3 (Drosophila)¹ ²		OTTHUMP00000213464²
EDR3¹ ² ³		polyhomeotic like 3²
FLJ12729¹ ²		DKFZp313K1221²
HPH3¹ ²		polyhomeotic-like protein 3²
FLJ12967¹ ²		MGC88144²
Early development regulatory protein 3² ³		OTTHUMP00000213468²
Homolog of polyhomeotic 3² ³		OTTHUMP00000213462²
polyhomeotic like 3 (Drosophila)¹		PH3³
early development regulator 3²		hPH3³

External Ids:	HGNC: 15682¹	Entrez Gene: 80012²	Ensembl: ENSG00000173889⁷	UniProtKB: Q8NDX5³

Export aliases for PHC3 gene to outside databases

Previous GC identifers: GC03M170863 GC03M171216 GC03M171135 GC03M171297 GC03M169804

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PHC3_HUMAN, Q8NDX5

Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the

transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts

via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',

rendering chromatin heritably changed in its expressibility

Gene Wiki entry for PHC3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the PHC3 gene promoter:
         YY1   Arnt   Nkx2-2   SREBP-1b   SREBP-1a   SREBP-1c   Max   c-Myc   XBP-1   PPAR-gamma1
         Other transcription factors

Search SABiosciences Chromatin IP Primers for PHC3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays for PHC3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3q26.2 Ensembl cytogenetic band: 3q26.2 HGNC cytogenetic band: 3q26.32

PHC3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PHC3 gene location

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03M167082: view genomic region (about GC identifiers)

Start:	167,175,971 bp from pter
End:	167,270,090 bp from pter
Size:	94,120 bases
Orientation:	minus strand

1 alternative location:

Chr3- 169,804,520-169,899,537

RefSeq DNA sequence:

NC_000003.11 NT_005612.16

(According to ¹UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PHC3_HUMAN, Q8NDX5 (See protein sequence)

Recommended Name: Polyhomeotic-like protein 3

Size: 983 amino acids; 106162 Da

Subunit: Component of chromatin-associated class II polycomb repressive complex 1 (PRC1/hPRC-H) at least composed of

PCGF2/RNF110, BMI1/PCGF4, CBX2/M33, CBX4/PC2, CBX8/PC3, PHC1, PHC2, PHC3, SCMH1, RING1 and RNF2/RING2

Subcellular location: Nucleus

Sequence caution: Sequence=CAI46090.1; Type=Erroneous initiation;

Secondary accessions: A2RRP9 Q5HYF0 Q6NSG2 Q8NFT7 Q8NFZ1 Q8TBM2 Q9H971 Q9H9I4

Alternative splicing: 6 isoforms: Q8NDX5-1 Q8NDX5-2 Q8NDX5-3 Q8NDX5-4 Q8NDX5-5 Q8NDX5-6

Explore the universe of human proteins at neXtProt for PHC3: NX_Q8NDX5

Post-translational modifications:

Phosphorylated upon DNA damage, probably by ATM or ATR¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_079223.3

ENSEMBL proteins:

ENSP00000420713 ENSP00000420271 ENSP00000417540 ENSP00000420294 ENSP00000420454 ENSP00000418377

ENSP00000418266 ENSP00000416863 ENSP00000418039 ENSP00000390924 ENSP00000417633 ENSP00000417860

ENSP00000419089 ENSP00000387414 ENSP00000417360 ENSP00000418835 ENSP00000419899

Human Recombinant Proteins

	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates
	GenScript Custom Purified and Recombinant Proteins Services for PHC3
	Novus Biologicals Protein for PHC3
	Novus Biologicals Lysate for PHC3
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins

1 Gene Ontology (GO) cellular component term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IEA	--

About this table

PHC3 for ontologies About GeneDecksing

Antibodies for PHC3:

	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for PHC3
	Browse R&D Systems for Antibodies
	Browse OriGene Antibodies
	GenScript Custom Superior Antibodies Services for PHC3
	Novus Biologicals Antibodies for PHC3
	Browse antibodies at Epitomics

Assays for PHC3:

	Browse Kits and Assays available from Millipore
	Browse ELISAs at Sigma-Aldrich
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for PHC3
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for PHC3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

PHC3 for domains About GeneDecksing

5 InterPro domains/families:

IPR010993 Sterile_alpha_motif_homology

IPR021129 SAM_type1

IPR013761 SAM_type

IPR001660 SAM

IPR012313 Znf_FCS

Graphical View of Domain Structure for InterPro Entry Q8NDX5

ProtoNet protein and cluster: Q8NDX5

1 Blocks protein family: IPB001660 Sterile alpha motif SAM

UniProtKB/Swiss-Prot: PHC3_HUMAN, Q8NDX5

Similarity: Contains 1 FCS-type zinc finger

Similarity: Contains 1 SAM (sterile alpha motif) domain

(According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
About This Section

UniProtKB/Swiss-Prot: PHC3_HUMAN, Q8NDX5

Function: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the

transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts

via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119',

rendering chromatin heritably changed in its expressibility

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PHC3 Sigma-Aldrich shRNA for PHC3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PHC3 OriGene shRNA RFP (see all 2): PHC3 OriGene basic RS shRNA (see all 2): PHC3 OriGene siRNA: PHC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PHC3

miRNA:		Sigma-Aldrich microRNA Mimics for PHC3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PHC3
		8/71 SABiosciences Assays for microRNAs that regulate PHC3 (see all 71):
		hsa-miR-579 hsa-miR-520f hsa-miR-520e hsa-miR-106a hsa-miR-485-3p hsa-miR-200a hsa-miR-519a hsa-miR-93

Gene
Editing:

Browse CompoZr Knockout ZFN at Sigma-Aldrich

Clones:		Browse Clones for the Expression of Recombinant Proteins Available from Millipore
		Browse iPSC Reprogramming Factors at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PHC3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PHC3 OriGene untagged cDNA clones in CMV expression vector (see all 3): PHC3 OriGene 3'-UTR clone: PHC3 Browse MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PHC3
		Browse Sino Biological Human cDNA Clones

Cell
Lines:

GenScript Custom overexpressing Cell Line Services for PHC3

3 Gene Ontology (GO) molecular function terms (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003677	DNA binding	IEA	--
GO:0008270	zinc ion binding	IEA	--
GO:0046872	metal ion binding	IEA	--

About this table

PHC3 for ontologies About GeneDecksing

(Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
About This Section

PHC3 for pathways About GeneDecksing

1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for PHC3

Role of Oct4 in Mammalian Embryonic Stem Cell Pluripotency

SABiosciences Custom Pathway-Focused PCR Arrays for PHC3

Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PHC3

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for PHC3

5/32 Interacting proteins for PHC3 (Q8NDX5²) via UniProtKB, MINT, and/or STRING (see all 32)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CBX2	Q14781²	MINT-8010325 MINT-8010390
CBX4	O00257²	MINT-8010325 MINT-8010390
CBX8	Q9HC52²	MINT-8010325 MINT-8010390
PHC1	P78364²	MINT-8010325 MINT-8010390
PHC2	Q8IXK0²	MINT-8010325 MINT-8010390

About this table

1 Gene Ontology (GO) biological process term (GO ID links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--

About this table

PHC3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse Small Molecules at Sigma-Aldrich

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for PHC3

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Millipore,
siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
About This Section

Inhib. RNA:		Browse for Gene Knock-down Tools from Millipore
		Browse Nano Scale siRNA at Sigma-Aldrich Sigma-Aldrich esiRNA and siRNA for PHC3 Sigma-Aldrich shRNA for PHC3
		OriGene 29mer shRNA kits in GFP-retroviral vector (see all 2): PHC3 OriGene shRNA RFP (see all 2): PHC3 OriGene basic RS shRNA (see all 2): PHC3 OriGene siRNA: PHC3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PHC3

miRNA:		Sigma-Aldrich microRNA Mimics for PHC3 Browse microRNA target validation systems at Sigma-Aldrich
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PHC3
		8/71 SABiosciences Assays for microRNAs that regulate PHC3 (see all 71):
		hsa-miR-579 hsa-miR-520f hsa-miR-520e hsa-miR-106a hsa-miR-485-3p hsa-miR-200a hsa-miR-519a hsa-miR-93

Clones:		Browse FLAG tag genes at Sigma-Aldrich
		OriGene GFP tagged cDNA clones in CMV expression vector: PHC3 OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PHC3 OriGene untagged cDNA clones in CMV expression vector (see all 3): PHC3 OriGene 3'-UTR Clone: PHC3 Browse OriGene MicroRNA Expression Plasmids
		GenScript Custom cDNA clone Services for PHC3

Primers:		OriGene genome-wide validated SYBR primer pairs: PHC3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PHC3: PPH08601A

REFSEQ mRNAs for PHC3 gene:

NM_024947.3

Additional cDNA sequence: BC131773.1

17 DOTS entries:

DT.97837426 DT.97774911 DT.75180698 DT.422499 DT.40261189 DT.100747176 DT.120885288 DT.100736556

DT.91889250 DT.406575 DT.100746203 DT.120885286 DT.204393 DT.91660475 DT.40221700 DT.75130554

DT.91816052

24/129 AceView cDNA sequences (see all 129):

AA362483 AI418979 CB158879 AI560883 AW473428 AI718462 BC070164 NM_024947

BC026001 AI339026 AA508639 AI680172 BG779367 AI275052 BX279867 BQ023311

AK022791 BX647868 H95610 AV710124 AA810014 AJ320486 AA278956 AW274510

highest scoring ESTs for PHC3:

AJ320486 AK022791 AK023029 AU126848 BC022325 BC070164 BM465699 BU171334 BX279867 AA210919

Unigene Clusters for PHC3:

Polyhomeotic homolog 3 (Drosophila)

Hs.529592 [show with all ESTs], Hs.694467

Unigene Representative Sequences: NM_024947, BC131773

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for PHC3

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11	^	12	^	13	^	14
SP1:
SP2:											-		-		-		-
SP3:					-

About this scheme

ECgene alternative splicing isoforms for PHC3
18/20 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 20):

ENST00000472330 ENST00000494943 ENST00000481639 ENST00000495893 ENST00000497658(uc003fgp.3 uc003fgq.3)

ENST00000465896 ENST00000474275(uc003fgo.1) ENST00000491258 ENST00000413540

ENST00000484931 ENST00000454294 ENST00000479467(uc003fgm.2) ENST00000466189

ENST00000467570 ENST00000436251 ENST00000497171 ENST00000486042 ENST00000484068

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Primers from OriGene and/or SABiosciences )
About This Section

PHC3 expression in normal and diseased human tissues

¹ / ² / ³

13 probe-sets matching PHC3 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
87668_at²^{, 3}	U95-E	1	0.81	1.00	0.19	0.35	AW016011	0.60	1.00	0.82	1
43936_at²^{, 3}	U95-B	1	0.56	1.00	0.79	2.12	AI042019	0.40	0.67	0.55	1
66503_at²^{, 3}	U95-C	1	0.56	1.00	0.96	0.77	AA810014	0.60	1.00	0.82	1
57819_at²^{, 3}	U95-C	1	0.44	1.00	0.89	0.83	AA400519	0.40	1.00	0.76	1
215521_at²^{, 3}	U133-A	1	0.82	1.00	--	--	AK023029	0.80	1.00	0.91	1
238693_at²^{, 3}	U133-B	1	0.55	1.00	--	--	AA165136	0.40	1.00	0.76	1
226508_at²^{, 3}	U133-B	1	0.46	1.00	--	--	AI042019	0.40	0.67	0.55	1
220328_at²^{, 3}	U133-A	1	0.46	1.00	--	--	NM_024947	0.40	1.00	0.76	1
1552644_a_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
215521_at²	U133Plus2	1	0.82	1.00	--	--	--	--	--	--	--
238693_at²	U133Plus2	1	0.55	1.00	--	--	--	--	--	--	--
226508_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--
220328_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

About this table

PHC3 for expression About GeneDecksing

Data from Genenote (Publications) and GNF BioGPS
About these images

PHC3 gene electronic northern expression

About these images

CGAP SAGE TAG: TGGGTCTGGA

SOURCE GeneReport for Unigene clusters: Hs.529592 Hs.694467

Primers:		OriGene genome-wide validated SYBR primer pairs: PHC3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay for PHC3: PPH08601A

SABiosciences Custom PCR Arrays for PHC3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for PHC3 gene from 5/8 species (see all 8)

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	PHC3¹	--	polyhomeotic homolog 3 (Drosophila)	95.37(n) 97.59(a)	488158 XM_545282.2 XP_545282.2
chimpanzee (Pan troglodytes)	PHC3¹	--	polyhomeotic homolog 3 (Drosophila)	99.87(n) 99.8(a)	460843 XM_516870.2 XP_516870.2
cow (Bos taurus)	PHC3¹	--	polyhomeotic homolog 3 (Drosophila)	94.03(n) 96.74(a)	534916 XM_614852.3 XP_614852.3
rat (Rattus norvegicus)	Phc3¹	--	polyhomeotic like 3 (Drosophila)	89.19(n) 94.39(a)	310258 XM_226976.4 XP_226976.3
mouse (Mus musculus)	Phc3^{1 , 5}	3 (14.36 cM)⁵	polyhomeotic-like 3 (Drosophila)^{1, 5}	89.35(n)¹ 93.57(a)¹	241915¹ NM_153421.1¹ NP_700470.1¹ AA967551⁵ AI427662⁵ (see all 23)

About this table Species with no ortholog for PHC3

ENSEMBL Gene Tree for PHC3 (if available)

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for PHC3 gene

PHC1² PHC2² SAMD7² SAMD11² PHC1B²

PHC3 for paralogs About GeneDecksing

(SNPs according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
About This Section

SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
Genomic Data				Transcription Related Data				Allele Frequencies
			--	--	--		--	--
rs879161^1,2	C,F,O,	169812115(-)	`AAGCCT/CTGTGT`	1	--	ut3¹		18		NS EA NA WA	870
rs888507^1,2	C,F,	169811039(-)	`GAATCC/GTTAGA`	1	--	ut3¹		5		MN NA EA	348
rs1052228^1,2	--	169813354(-)	`AAAAAG/CATTGT`	1	--	ut3¹		1		MN	184
rs1052229^1,2	--	169813096(-)	`TCATGT/ATCCAG`	1	--	ut3¹		1		MN	184
rs1273546^1,2	--	169867349(+)	`gtgatC/Tctcct`	1	--	int¹		0	--	--	--	--
rs1273547^1,2	--	169867359(+)	`tgcctA/Cagcct`	1	--	int¹		0	--	--	--	--
rs1273601^1,2	C,H	169893535(-)	`tggggT/Cttcac`	1	--	int¹		3		NA WA	6
rs1273602^1,2	C	169886328(-)	`gatccG/Acctgc`	1	--	int¹		6		NA WA	12
rs1352204^1,2	C,F,O,A,	169816510(+)	`TCTCAT/CGTCCT`	1	--	int¹		16		NS EA NA WA	1136
rs1386332^1,2	C,F,O,	169877827(+)	`CCTTTG/AACTAT`	1	--	int¹		19		MN NA NS EA	1593

About this table

HapMap Linkage Disequilibrium images for PHC3 (up to first 250kb)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for PHC3: --

QIAGEN SeqTarget long-range PCR primers for resequencing PHC3

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶UniProtKB/TrEMBL, and/or ⁷Novoseek)
About This Section

10/18 PubMed articles for PHC3 gene, integrated from 7 sources (see all 18):
(articles sorted by number of sources associating them with PHC3)

Identification and characterisation of novel mammalian homologues of Drosophila polyhomeoticpermits new insights into relationships between members of the polyhomeotic family. (PubMed id 12384788)^{1, 2, 3, 7} Tonkin E....Strachan T. (2002)
The core of the polycomb repressive complex is compositionally and functionally conserved in flies and humans. (PubMed id 12167701)^{1, 2, 3} Levine S.S....Kingston R.E. (2002)
Phosphoproteome analysis of the human mitotic spindle. (PubMed id 16565220)^{1, 2} Nousiainen M.... Koerner R. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{1, 2} Beausoleil S.A....Gygi S.P. (2004)
Polycomb group molecule PHC3 regulates polycomb compl ex composition and prognosis of osteosarcoma. (PubMed id 20491773)¹ Iwata S....Kamijo T. (2010)
Several distinct polycomb complexes regulate and co-l ocalize on the INK4a tumor suppressor locus. (PubMed id 19636380)¹ Maertens G.N....Peters G. (2009)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 80012	HGNC: 15682	AceView: PHC3	Ensembl:ENSG00000173889	euGenes: HUgn80012
ECgene: PHC3	H-InvDB: PHC3

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Intellectual Property for PHC3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from XenneX, Inc.)

About This Section

Patent Information for PHC3 gene:
Search GeneIP for patents involving PHC3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
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	Millipore Custom Antibody & Bulk Services
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	Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins

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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PHC3
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	GenScript Custom Purified and Recombinant Proteins Services for PHC3		GenScript Custom cDNA clones with any tag delivered in your preferred vector Services for PHC3
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Search for Antibodies & Assays

	Regulatory tfbs in PHC3 promoter
	Search Chromatin IP Primers for PHC3
	RT² qPCR Primer Assay for PHC3
	Search GNC Networks for PHC3
	Assays for microRNAs that regulate PHC3
	SABiosciences Custom PCR Arrays for PHC3

Search Tocris compounds for PHC3

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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
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	Proteins for PHC3
	Lysates for PHC3

Browse antibodies at Epitomics

Browse ProSpec Recombinant Proteins

ELISAs and CLIAs for PHC3

GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

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PHC3 gene at Home site.

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for PHC3 gene

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for PHC3 gene

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for PHC3 gene

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for PHC3 gene

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for PHC3 gene

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for PHC3 gene

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for PHC3 gene

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for PHC3 gene

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for PHC3 gene

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for PHC3 gene

Intellectual Property
for PHC3 gene

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for PHC3 gene