Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


Category   Symbol Source: HGNC EntrezGene Ensembl
GIFtS

Search by expression pattern Search by expression pattern



PI4KB Gene

protein-coding   GIFtS: 58

GC01M122642
phosphatidylinositol 4-kinase, catalytic, beta
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: PIK4CB)
Products    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section

Aliases & Descriptions
phosphatidylinositol 4-kinase, catalytic, beta1 2     PI4KIIIBETA2
PIK4CB2 3 5     phosphatidylinositol 4-kinase, wortmannin-sensitive2
PI4K-BETA1 2     OTTHUMP000000142852
PtdIns 4-kinase beta2 3     phosphatidylinositol 4-kinase beta2
PI4K922 3     OTTHUMP000000142842
NPIK2 3     DKFZp686O18202
pi4K921     PI4K-beta3
PI4KBETA2     EC 2.7.1.673
FLJ301292     PI4Kbeta3
type III phosphatidylinositol 4-kinase beta2     

External Ids:    HGNC: 89841   Entrez Gene: 52982   Ensembl: ENSG000001433937   UniProtKB: Q9UBF83   

Export aliases for PI4KB gene to outside databases

Previous GC identifers: GC01M149532 GC01M151264


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: PI4KB_HUMAN, Q9UBF8
Function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second
messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis,
possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity)

Gene Wiki entry for PI4KB

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 60), Regulatory elements and Epigenetics data according to Qiagen and/or SABiosciences)
About This Section

Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for PI4KB
         Other transcription factors

   Search SABiosciences Chromatin IP Primers for PI4KB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays 


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

PI4KB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
PI4KB gene location

GeneLoc gene densities for chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M122642:  view genomic region     (about GC identifiers)

Start:
122,642,356 bp from pter
End:
122,676,665 bp from pter
Size:
34,310 bases
Orientation:
minus strand

1 alternative location:
Chr1- 151,264,413-151,300,191     
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  

(According to 1UniProtKB, neXtProt, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Millipore, Sigma-Aldrich, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, and/or ProSpec,
Biochemical Assays by Millipore, Sigma-Aldrich, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Dec 2010 and Entrez Gene, Antibodies by Millipore, Sigma-Aldrich, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, and/or Epitomics)
About This Section

UniProtKB/Swiss-Prot: PI4KB_HUMAN, Q9UBF8 (See protein sequence)
Recommended Name: Phosphatidylinositol 4-kinase beta  
Size: 816 amino acids; 91379 Da
Subunit: Interacts with ARF1 and ARF3 in the Golgi complex, but not with ARF4, ARF5 or ARF6. Interacts with NCS1/FREQ
in a calcium-independent manner (By similarity). Interacts with CALN1/CABP8 and CALN2/CABP7; in a calcium-dependent
manner (By similarity). This binding competes with NCS1/FREQ binding (By similarity)
Subcellular location: Endomembrane system. Mitochondrion outer membrane; Peripheral membrane protein. Rough endoplasmic
reticulum membrane; Peripheral membrane protein. Golgi apparatus. Cytoplasm, perinuclear region. Note=Found in the
outer membrane of mitochondria and membranes of the rough endoplasmic reticulum. Recruited to the Golgi complex by the
small GTPase ARF to stimulate the synthesis of phosphatidylinositol 4,5-biphosphate (PIP2) on the Golgi complex
Sequence caution: Sequence=BAA21661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=CAH70326.1; Type=Erroneous gene model prediction; Sequence=EAW53450.1; Type=Erroneous gene model prediction;
Secondary accessions: B4DGI2 O15096 P78405 Q5VWB9 Q5VWC0 Q5VWC1 Q9BWR6
Alternative splicing: 3 isoforms:  Q9UBF8-1   Q9UBF8-2   Q9UBF8-3   

Explore the universe of human proteins at neXtProt for PI4KB: NX_Q9UBF8 

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins (4 alternative transcripts): 
    NP_001185702.1  NP_001185703.1  NP_001185704.1  NP_002642.1  


    ENSEMBL proteins: 
    ENSP00000413599 ENSP00000403488 ENSP00000410974 ENSP00000357867 ENSP00000391546 ENSP00000357868 
    ENSP00000376511 ENSP00000357866 ENSP00000394719 ENSP00000271657 ENSP00000357869 


    Human Recombinant Proteins 
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate: PI4KB
    GenScript Custom Purified and Recombinant Proteins Services for PI4KB 
    Novus Biologicals Proteins for PI4KB
    Novus Biologicals Lysate for PI4KB
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins

    5/10 Gene Ontology (GO) cellular component terms (GO ID links to tree view) (see all 10):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737 cytoplasm IEA--
    GO:0005739 mitochondrion IEA--
    GO:0005741 mitochondrial outer membrane IEA--
    GO:0005768 endosome TAS9584208
    GO:0005783 endoplasmic reticulum IEA--
    About this table

    PI4KB for ontologies           About GeneDecksing



    Antibodies for PI4KB: 
    Millipore Mono- and Polyclonal Antibodies for the study of PI4KB
    Sigma-Aldrich Antibodies for PI4KB
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    GenScript Custom Superior Antibodies Services for PI4KB 
    Novus Biologicals Antibody for PI4KB
    Epitomics antibodies for PI4KB

    Assays for PI4KB: 
    Browse Kits and Assays available from Millipore
    Browse ELISAs at Sigma-Aldrich
    OriGene Custom Immunoassay Development 
    Browse OriGene Fluorogenic Cell Assay Kits 
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for PI4KB 
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs and CLIAs at Uscn 


    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    PI4KB for domains           About GeneDecksing

    4 InterPro domains/families:
     IPR011009 Kinase-like_dom
     IPR000403 PI3/4_kinase_cat
     IPR015433 PI_Kinase
     IPR018936 PI3/4_kinase_CS

    Graphical View of Domain Structure for InterPro Entry Q9UBF8

    ProtoNet protein and cluster: Q9UBF8

    1 Blocks protein family: IPB000403 Phosphatidylinositol 3- and 4-kinase

    UniProtKB/Swiss-Prot: PI4KB_HUMAN, Q9UBF8
    Similarity: Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily
    Similarity: Contains 1 PI3K/PI4K domain


    (According to UniProtKB, IUBMB,and/or Genatlas, Animal models from MGI Dec 24 2010,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Millipore, siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich, microRNA from Sigma-Aldrich, Qiagen, SABiosciences, Clones from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, Cell Lines from GenScript, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene.)
    About This Section

    UniProtKB/Swiss-Prot: PI4KB_HUMAN, Q9UBF8
    Function: Phosphorylates phosphatidylinositol (PI) in the first committed step in the production of the second
    messenger inositol-1,4,5,-trisphosphate (PIP). May regulate Golgi disintegration/reorganization during mitosis,
    possibly via its phosphorylation. Involved in Golgi-to-plasma membrane trafficking (By similarity)
    Catalytic activity: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
    Enzyme regulation: Inhibited by wortmannin. Increased kinase activity upon interaction with NCS1/FREQ (By similarity)
    Enzyme Number (IUBMB): EC 2.7.1.67 

    Inhib.
    RNA:
        
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for PI4KB
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PI4KB
    Sigma-Aldrich shRNA Panels and shRNA for PI4KB
    OriGene 29mer shRNA kits in GFP-retroviral vector: PI4KB
    OriGene shRNA RFP: PI4KB
    OriGene basic RS shRNA: PI4KB
    OriGene siRNA: PI4KB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PI4KB 
    miRNA:Sigma-Aldrich microRNA Mimics for PI4KB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PI4KB 
    1 SABiosciences Assays for microRNA that regulate PI4KB:
    hsa-miR-623

    Gene
    Editing:
    Browse CompoZr Knockout ZFN at Sigma-Aldrich 

    Clones:Browse Clones for the Expression of Recombinant Proteins Available from Millipore
    Browse iPSC Reprogramming Factors at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PI4KB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PI4KB
    OriGene untagged cDNA clones in CMV expression vector: PI4KB
    OriGene 3'-UTR clone: PI4KB 
    Browse MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PI4KB 
    Browse Sino Biological Human cDNA Clones

    Cell
    Lines:
      
    GenScript Custom overexpressing Cell Line Services for PI4KB 

    5/7 Gene Ontology (GO) molecular function terms (GO ID links to tree view) (see all 7):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166 nucleotide binding IEA--
    GO:0004430 1-phosphatidylinositol 4-kinase activity IEA--
    GO:0005488 binding ----
    GO:0005515 protein binding IPI17353931
    GO:0005524 ATP binding IEA--
    About this table

    PI4KB for ontologies           About GeneDecksing


    (Pathways according to Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB, Sets of similar genes according to GeneDecks, PCR Arrays from SABiosciences, Proteins Network according to SABiosciences, Sigma-Aldrich, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Dec 2010 via Entrez Gene).
    About This Section


    PI4KB for pathways           About GeneDecksing

    1 Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Pathway for  PI4KB
        Inositol Phosphate Metabolism

    3 Kegg Pathways  (Kegg details for PI4KB):
        hsa00562 Inositol phosphate metabolism
    hsa01100 Metabolic pathways
    hsa04070 Phosphatidylinositol signaling system

        SABiosciences Custom Pathway-Focused PCR Arrays for PI4KB 

        Sigma-Aldrich "Your Favorite Gene" (powered by Ingenuity) Molecular Interaction Network for PI4KB
        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for PI4KB

    5/43 Interacting proteins for PI4KB (ENSP000003578693 Q9UBF81, 2) via UniProtKB, MINT, and/or STRING (see all 43)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAQP273481, 2EBI-1053214,EBI-359854 MINT-8007601 MINT-50361
    YWHABP319461, 2EBI-1053214,EBI-359815 MINT-50347
    YWHAGP619811, 2EBI-1053214,EBI-359832 MINT-50353
    SFNP319472MINT-3975529
    NCS1ENSP000003614753STRING: ENSP00000361475
    About this table

    4 Gene Ontology (GO) biological process terms (GO ID links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006661 phosphatidylinositol biosynthetic process TAS9020160
    GO:0006898 receptor-mediated endocytosis TAS9584208
    GO:0007165 signal transduction TAS9020160
    GO:0048015 phosphoinositide-mediated signaling IEA--
    About this table

    PI4KB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    PI4KB for compounds           About GeneDecksing

    Browse Small Molecules at Sigma-Aldrich
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for PI4KB
    3 Novoseek chemical compound relationships for PI4KB gene
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphatidylinositol 76.8 21 9405935 (3), 17088255 (2), 16837555 (2), 9020160 (2) (see all 11)
    wortmannin 61.5 1 9020160 (1)
    lipid 22 4 17088255 (1), 16606619 (1), 16912074 (1), 11526106 (1)
    About this table



    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 228 Homo sapiens; Dec 8 2010) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Millipore,
    siRNAs from Sigma-Aldrich, OriGene, Qiagen, Super-pooled esiRNAs from Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene, microRNA from Sigma-Aldrich, Qiagen, SABiosciences,
    Tagged/untagged cDNA clones from OriGene, Sigma-Aldrich, GenScript, Primers from OriGene and/or SABiosciences)
    About This Section

    Inhib.
    RNA:
         
    Browse for Gene Knock-down Tools from Millipore
    Sigma-Aldrich Nano Scale siRNA for PI4KB
    Sigma-Aldrich siRNA Panels and esiRNA and siRNA for PI4KB
    Sigma-Aldrich shRNA Panels and shRNA for PI4KB
    OriGene 29mer shRNA kits in GFP-retroviral vector: PI4KB
    OriGene shRNA RFP: PI4KB
    OriGene basic RS shRNA: PI4KB
    OriGene siRNA: PI4KB
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PI4KB 
    miRNA: Sigma-Aldrich microRNA Mimics for PI4KB
    Browse microRNA target validation systems at Sigma-Aldrich 
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PI4KB 
    1 SABiosciences Assays for microRNA that regulate PI4KB:
    hsa-miR-623
    Clones: Browse FLAG tag genes at Sigma-Aldrich
    OriGene GFP tagged cDNA clones in CMV expression vector: PI4KB
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector: PI4KB
    OriGene untagged cDNA clones in CMV expression vector: PI4KB
    OriGene 3'-UTR Clone: PI4KB 
    Browse OriGene MicroRNA Expression Plasmids 
    GenScript cDNA clone with any tag delivered in your preferred vector: PI4KB 
    Primers: OriGene genome-wide validated SYBR primer pairs: PI4KB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PI4KB: PPH12952A

    REFSEQ mRNAs for PI4KB gene (4 alternative transcripts): 

    NM_001198773.1  NM_001198774.1  NM_001198775.1  NM_002651.2  

    Additional cDNA sequence: 

    AB005910.1 AJ011121.1 AJ011122.1 AJ011123.1 AK054691.1 AK294606.1 AK311292.1 AL832188.1 
    BC000029.2 BC040300.1 U81802.1 

    20 DOTS entries:

    DT.100789314  DT.91732673  DT.95164401  DT.100789310  DT.92447953  DT.40116651  DT.40116652  DT.100789312 
    DT.40228881  DT.95164368  DT.121443478  DT.100789313  DT.95164376  DT.95164384  DT.100789321  DT.91888741 
    DT.95086435  DT.95164403  DT.95175851  DT.95296261 

    24/345 AceView cDNA sequences (see all 345):

    BM280311 CA448406 BM724017 AI480161 AU124604 BX377194 AI932421 AW294991 
    CD364520 BU146373 AA398314 BC000029 BQ233736 NM_002651 CA495291 AI632412 
    BQ019020 AA436529 AI127718 BU683500 BM792445 T34792 BF448100 BM983449 

    Unigene Cluster for PI4KB:

    Phosphatidylinositol 4-kinase, catalytic, beta
    Hs.632465  [show with all ESTs]
    Unigene Representative Sequence: BC040300


    GeneLoc Exon Structure

    5/14 Alternative Splicing Database (ASD) splice patterns (SP) for PI4KB (see all 14)

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b · 9c ^ 10 ^ 11 ^ 12a · 12b ^ 13a ·
    SP1:                          -     -     -     -     -                                         -                             -                                 
    SP2:                                                                                -           -                             -                                 
    SP3:                                                  -                                         -                             -                                 
    SP4:                          -     -     -     -     -                             -           -                             -                                 
    SP5:                                                                                                                                                            

    ExUns: 13b · 13c ^ 14a · 14b · 14c ^ 15 ^ 16a · 16b · 16c · 16d
    SP1:                          -     -                           
    SP2:                          -     -                           
    SP3:                          -     -                           
    SP4:                          -     -                           
    SP5:                          -                                 

    About this scheme

    ECgene alternative splicing isoforms for PI4KB
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000430800 ENST00000414081 ENST00000455060 ENST00000469239 ENST00000368873
    ENST00000446339 ENST00000368874(uc001exu.2 uc010pcw.1 uc009wmq.1)
    ENST00000392756 ENST00000368872 ENST00000460323 ENST00000489223 ENST00000438243
    ENST00000271657 ENST00000368875(uc001exr.2 uc001exs.2 uc001ext.2)
    ENST00000489889

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 228 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Primers from OriGene and/or SABiosciences )
    About This Section

    PI4KB expression in normal and diseased human tissues

    1  / 2

    8 probe-sets matching PI4KB gene

    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    146_at2 U95-A 1 1.00 1.00 0.49 1.16 -- -- -- -- --
    71609_at2 U95-E 1 0.50 1.00 0.93 0.85 -- -- -- -- --
    210417_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    206138_s_at2 U133-A 1 1.00 1.00 -- -- -- -- -- -- --
    206139_at2 U133-A 1 0.55 1.00 -- -- -- -- -- -- --
    210417_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    206138_s_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --
    206139_at2 U133Plus2 1 0.55 1.00 -- -- -- -- -- -- --
    About this table

    PI4KB for expression           About GeneDecksing

    Data from Genenote  (Publications) and GNF BioGPS
        About these images
    PI4KB gene expression
    PI4KB gene electronic northern expression
    PI4KB gene sage expression
    About these images

    CGAP SAGE TAG: TGGAATTCCC

    SOURCE GeneReport for Unigene cluster: Hs.632465

    UniProtKB/Swiss-Prot: PI4KB_HUMAN, Q9UBF8
    Tissue specificity: Widely expressed with highest levels in heart, skeletal muscle, pancreas, testis and ovary. Weakly
    expressed in liver

    Primers: OriGene genome-wide validated SYBR primer pairs: PI4KB
    Browse OriGene validated miRNA SYBR primer pairs 
    SABiosciences RT2 qPCR Primer Assay for PI4KB: PPH12952A
        SABiosciences Custom PCR Arrays for PI4KB 


    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Dec 24 2010, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section

    Orthologs for PI4KB gene from 5/17 species (see all 17)
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    dog
    (Canis familiaris)
    PI4KB1   -- phosphatidylinositol 4-kinase, catalytic, beta 93.13(n)
    97.82(a)
    483196  XM_540314.2  XP_540314.2 
    chimpanzee
    (Pan troglodytes)
    PI4KB1   -- phosphatidylinositol 4-kinase, catalytic, beta 99.63(n)
    99.63(a)
    457291  XM_001171600.1  XP_001171600.1 
    cow
    (Bos taurus)
    PI4KB1   -- phosphatidylinositol 4-kinase, catalytic, beta 93.47(n)
    99.25(a)
    286846  NM_174783.2  NP_777208.1 
    rat
    (Rattus norvegicus)
    Pi4kb1   -- phosphatidylinositol 4-kinase, catalytic, beta 92.57(n)
    97.67(a)
    81747  NM_031083.1  NP_112345.1 
    mouse
    (Mus musculus)
    Pi4kb1 , 5 3 (40.74 cM)5
    phosphatidylinositol 4-kinase, catalytic, beta polypeptide1, 5 92.55(n)1
    98.5(a)1
    1076501  NM_175356.11  NP_780565.11 
     AA4378225  AI6455495  (see all 20)
    About this table        Species with no ortholog for PI4KB

    ENSEMBL Gene Tree for PI4KB (if available)

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section
      --

    (SNPs according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Resequencing Primers from Qiagen)
    About This Section

    10/225 NCBI SNPs in PI4KB are shown (see all 225)
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidChr 1 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ----------
    rs9436371,2
    C,F,O,A,151283019(+) ATGGAC/TCTTCC 1 -- int1 trp317Minor allele frequency- T:0.38EA NA NS WA 914
    rs10568471,2
    C,F,A,151288172(-) CCTGAT/CACAGG 2 /D ref1 syn119Minor allele frequency- C:0.47EA MN NA NS WA 2820
    rs15366171,2
    C,F,A,151280400(+) GAAAGG/CAGCTG 1 -- int115Minor allele frequency- C:0.35NS EA NA WA 2144
    rs17523791,2
    C,F,151288391(+) CCCACG/ATCCTC 2 /D ref1 syn119Minor allele frequency- A:0.02EA NA MN NS WA 892
    rs17523821,2
    C,F,A,151295475(+) AAACGG/AGTAAG 1 -- int116Minor allele frequency- A:0.11NS EA NA WA 1050
    rs17523881,2
    C,F,O,A,151282841(+) TAGTGA/CAGTTC 1 -- int130Minor allele frequency- C:0.10EA MN NS NA WA 4884
    rs17805841,2
    151267521(+) GAGTGG/CAGCTG 1 -- int14Minor allele frequency- C:0.25EA NA MN 246
    rs17805861,2
    C,F,151279855(+) ACAAAG/ACCCAA 1 -- int19Minor allele frequency- A:0.12NS EA NA WA 530
    rs18047931,2
    --151265143(-) CAGCTG/TTGGGG 1 -- ut310--------
    rs20317971,2
    C,F,A,H,151278505(+) TTAGGG/ATACTT 1 -- int122Minor allele frequency- A:0.27NS EA NA WA 1426
    About this table

    HapMap Linkage Disequilibrium images for PI4KB (up to first 250kb)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for PI4KB
         3 CNVs: 8332 74705 64926

    QIAGEN SeqTarget long-range PCR primers for resequencing PI4KB 

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, LSDB, HGMD, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    PI4KB for disorders           About GeneDecksing

    OMIM: 602758

    Human Genome Epidemiology (HuGE) Navigator: PI4KB (1 document)

    Export disorders and mutations for PI4KB gene to outside databases

    (Possibly Related Articles in Doctor's Guide)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6UniProtKB/TrEMBL, and/or 7Novoseek)
    About This Section

    10/46 PubMed articles for PI4KB gene, integrated from 7 sources (see all 46):
    (articles sorted by number of sources associating them with PI4KB)
    1. Cloning and characterization of a wortmannin-sensitive human phosphatidylinositol 4-kinase. (PubMed id 9020160)1, 2, 3, 7 Meyers R. and Cantley L.C. (1997)
    2. Complementary DNA cloning and chromosomal mapping of a novel phosphatidylinositol kinase gene. (PubMed id 9405938)1, 2, 3 Saito T....Hori T.-A. (1997)
    3. Identification and characterization of a novel human phosphatidylinositol 4-kinase. (PubMed id 9405935)1, 2, 7 Suzuki K.... Horie M. (1997)
    4. Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites. (PubMed id 11277933)1, 2, 7 Suer S.... Heilmeyer L.M.G. Jr. (2001)
    5. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    6. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Mammalian phosphatidylinositol 4-kinases. (PubMed id 12749687)1, 2 Heilmeyer L.M.G. Jr.... Szivak I. (2003)
    10. ARF mediates recruitment of PtdIns-4-OH kinase-beta and stimulates synthesis of PtdIns(4,5)P2 on the Golgi complex. (PubMed id 10559940)1, 2 Godi A.... De Matteis M.A. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 5298 HGNC: 8984 AceView: PIK4CB Ensembl:ENSG00000143393 euGenes: HUgn5298
    ECgene: PI4KB Kegg: 5298 H-InvDB: PI4KB

    (According to HUGE)
    About This Section
      --

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
      --

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from XenneX, Inc.)
    About This Section
    Patent Information for PI4KB gene:
    Search GeneIP for patents involving PI4KB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays by Millipore, Sigma-Aldrich, R&D Systems, Qiagen, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Epitomics, ProSpec, Uscn,
    Clones available from Millipore, Sigma-Aldrich, OriGene, GenScript, Sino Biological, PCR Arrays from SABiosciences, Drugs and/or compounds by Sigma-Aldrich, Tocris Bioscience, and/or Enzo Life Sciences)
    About This Section

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services

     Predesigned and custom siRNAs for PI4KB Antibodies for PI4KB
     Super-pooled esiRNAs for PI4KB Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for PI4KB microRNA Mimics for PI4KB
     "Your Favorite Gene" Pathways and Molecular Interaction Networks Nano Scale siRNA for PI4KB
     Browse iPSC Reprogramming Factors at Sigma-Aldrich Browse small molecules at Sigma-Aldrich
     Browse FLAG tag genes at Sigma-Aldrich Browse ELISAs at Sigma-Aldrich
     Browse microRNA Target Validation Systems at Sigma-Aldrich Browse CompoZr Knockout ZFN at Sigma-Aldrich
    feedback
      
     Antibodies   Cell Culture Products  
     ELISAs   Flow Cytometry Kits  
     Primer Pairs   Kinase Activity Assays/Reagents  
     ELISpot Kits/Development Modules   TFB/Immunoprecipitation Assays  
     Apoptosis Detection Kits/Reagents   Protease Activity Assays/Reagents  
     DNA Damage/Repair Kits/Reagents   Multiplex/Array Assay Kits/Reagents  
     Cell Selection/Detection Kits/Reagents   ELISA/Assay Development Kits/Reagents  
     Phosphatase Activity Assays/Reagents   Recombinant/Natural Proteins  
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Lysates
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     siRNA
     Custom Immunoassay Development
     Fluorogenic Cell Assay Kits
     miRNA Primers for qPCR Assays
     3' UTR Clones for miRNA Target Studies
     miRNA Expression Plasmids

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of PI4KB
     SeqTarget long-range PCR primers for resequencing PI4KB
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing of PI4KB
     GenScript Custom Purified and Recombinant Proteins Services for PI4KB GenScript cDNA clones with any tag delivered in your preferred vector for PI4KB
     GenScript Custom Assay Services for PI4KB GenScript Custom Superior Antibodies Services for PI4KB
     GenScript Custom overexpressing Cell Line Services for PI4KB CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Search Regulatory tfbs for PI4KB
     Search Chromatin IP Primers for PI4KB
     RT2 qPCR Primer Assay for PI4KB
     GNC Network for PI4KB
     Assays for microRNAs that regulate PI4KB
     SABiosciences Custom PCR Arrays for PI4KB
     Search Tocris compounds for PI4KB
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     Antibodies for PI4KB
     Proteins for PI4KB
     Lysates for PI4KB
     Antibodies for PI4KB
     Browse ProSpec Recombinant Proteins

     Browse ELISAs and CLIAs at Uscn
           

    GeneCards Homepage - Last full update: 31 Dec 2010 - Incremental updates: 9 Jan 2011 , 10 Jan 2011

    View Random Gene

    Category
    GIFtS Group
    The GeneCards human gene database gene index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    PI4KB gene at Home site.
    hostname: www-ab3 db genecards_305 index build: 81e solr: 1.4